Genjiro Kimura

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. pmc Post-load hyperglycemia as an important predictor of long-term adverse cardiac events after acute myocardial infarction: a scientific study
    Shuichi Kitada
    Department of Cardiology, National Cardiovascular Center, Osaka, Japan
    Cardiovasc Diabetol 9:75. 2010
  2. ncbi request reprint Clinical pathology and treatment of renin-angiotensin system 2. Chronic kidney disease and the renin-angiotensin system
    Genjiro Kimura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Intern Med 46:1295-8. 2007
  3. ncbi request reprint Oral carbonaceous absorbent modifies renal function of renal ablation model without affecting plasma renin-angiotensin system or protein intake
    Keiji Horike
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Clin Exp Nephrol 7:120-4. 2003
  4. ncbi request reprint Glomerular function reserve and sodium sensitivity
    Genjiro Kimura
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Clin Exp Nephrol 9:102-13. 2005
  5. doi request reprint Patients with renal dysfunction require a longer duration until blood pressure dips during the night
    Michio Fukuda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hypertension 52:1155-60. 2008
  6. ncbi request reprint Relationship between renal function, aortic stiffness and left ventricular function in patients with coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Circ J 73:1740-5. 2009
  7. doi request reprint Predictors of proteinuria reduction by monotherapy with an angiotensin receptor blocker, olmesartan
    Minamo Ono
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Renin Angiotensin Aldosterone Syst 13:239-43. 2012
  8. doi request reprint Reduced renal function is associated with combined increases in ventricular-systolic stiffness and arterial load in patients undergoing cardiac catheterization for coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Heart Vessels 26:10-6. 2011
  9. ncbi request reprint Circadian rhythm of urinary potassium excretion in patients with CKD
    Toshiyuki Miura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Clin Nephrol 78:169-73. 2012
  10. ncbi request reprint Lack of inertia force of late systolic aortic flow is a cause of left ventricular isolated diastolic dysfunction in patients with coronary artery disease
    Takayuki Yoshida
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Am Coll Cardiol 48:983-91. 2006

Detail Information

Publications111 found, 100 shown here

  1. pmc Post-load hyperglycemia as an important predictor of long-term adverse cardiac events after acute myocardial infarction: a scientific study
    Shuichi Kitada
    Department of Cardiology, National Cardiovascular Center, Osaka, Japan
    Cardiovasc Diabetol 9:75. 2010
    ..In this study, we evaluated the relationship between glucometabolic status and MACE in patients after AMI, and determined the critical level of 2 h post-load plasma glucose that may be used to predict MACE...
  2. ncbi request reprint Clinical pathology and treatment of renin-angiotensin system 2. Chronic kidney disease and the renin-angiotensin system
    Genjiro Kimura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Intern Med 46:1295-8. 2007
  3. ncbi request reprint Oral carbonaceous absorbent modifies renal function of renal ablation model without affecting plasma renin-angiotensin system or protein intake
    Keiji Horike
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Clin Exp Nephrol 7:120-4. 2003
    ..Although it has been repeatedly shown that the oral carbonaceous absorbent AST-120 ameliorates the progression of chronic renal failure, the mechanisms remain unknown...
  4. ncbi request reprint Glomerular function reserve and sodium sensitivity
    Genjiro Kimura
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Clin Exp Nephrol 9:102-13. 2005
    ..I truly anticipate that new methods to assess glomerular hemodynamics in humans will be developed in the near future...
  5. doi request reprint Patients with renal dysfunction require a longer duration until blood pressure dips during the night
    Michio Fukuda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hypertension 52:1155-60. 2008
    ..The prolonged duration until BP dip during sleep seems an essential component of the nondipper pattern of the circadian BP rhythm...
  6. ncbi request reprint Relationship between renal function, aortic stiffness and left ventricular function in patients with coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Circ J 73:1740-5. 2009
    ..There are plausible reasons to hypothesize that increased aortic stiffness and left ventricular (LV) dysfunction may occur in early renal insufficiency...
  7. doi request reprint Predictors of proteinuria reduction by monotherapy with an angiotensin receptor blocker, olmesartan
    Minamo Ono
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Renin Angiotensin Aldosterone Syst 13:239-43. 2012
    ..In the present study, we tested whether the effects of monotherapy with an angiotensin receptor blocker (ARB) to lower proteinuria could be restricted by reduced GFR...
  8. doi request reprint Reduced renal function is associated with combined increases in ventricular-systolic stiffness and arterial load in patients undergoing cardiac catheterization for coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Heart Vessels 26:10-6. 2011
    ..In conclusion, reduced renal function may be associated with combined increases in ventricular-systolic stiffness and arterial load in known or suspected CAD patients with normal EF...
  9. ncbi request reprint Circadian rhythm of urinary potassium excretion in patients with CKD
    Toshiyuki Miura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Clin Nephrol 78:169-73. 2012
    ..However, the circadian rhythm of urinary potassium excretion has not been studied in relation to renal dysfunction...
  10. ncbi request reprint Lack of inertia force of late systolic aortic flow is a cause of left ventricular isolated diastolic dysfunction in patients with coronary artery disease
    Takayuki Yoshida
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Am Coll Cardiol 48:983-91. 2006
    ..We investigated whether a lack of inertia force of late systolic aortic flow and/or apical asynergy provoke early diastolic dysfunction in patients with coronary artery disease (CAD)...
  11. ncbi request reprint Polynocturia in chronic kidney disease is related to natriuresis rather than to water diuresis
    Michio Fukuda
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    Nephrol Dial Transplant 21:2172-7. 2006
    ..In the present study, we investigated whether nocturnal polyuria in CKD was due to the inability to concentrate urine, as previously proposed, or based on osmotic diuresis mainly by natriuresis...
  12. ncbi request reprint Both HDL3 and HDL2 exert a powerful anti-oxidative and protective effect against acceleration of oxidative modification of LDL by ascorbic acid
    Nagahiko Sakuma
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:75-9. 2005
    ..If there is an augmented oxidative modification of LDL due to ascorbic acid in vivo, HDL3 or HDL2 may thus have an important role in inhibiting this ascorbic acid-accelerated oxidation of LDL...
  13. doi request reprint Peak mitral annular velocity during early diastole and propagation velocity of early diastolic filling flow are not interchangeable as the parameters of left ventricular early diastolic function
    Hiroumi Mizuno
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Cardiol 101:1467-71. 2008
    ..Both parameters are not interchangeable as those of LV early diastolic function. Vp may be a noninvasive parameter of LV elastic recoil...
  14. doi request reprint Angiotensin II type 1 receptor blocker, olmesartan, restores nocturnal blood pressure decline by enhancing daytime natriuresis
    Michio Fukuda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    J Hypertens 26:583-8. 2008
    ..In this study, we investigated whether an angiotensin II receptor blocker, olmesartan, could restore night-time blood pressure fall...
  15. doi request reprint Impact of lipid profile and high blood pressure on endothelial damage
    Tomonori Sugiura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    J Clin Lipidol 5:460-6. 2011
    ..We investigated the impact of lipid profiles and high blood pressure on damage...
  16. doi request reprint Excessive blood pressure elevation upon awakening involves an exaggerated cardiac response to slight physical activity: a possible mechanism underlying the risk of 'morning surge'
    Yoshimasa Wakamatsu
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Science, Nagoya, Aichi, Japan
    Blood Press Monit 17:198-203. 2012
    ..We hypothesize that individuals with such a blood pressure abnormality receive a cardiovascular overload, even from slight physical activities that are frequently undertaken in daily life...
  17. ncbi request reprint Plasma N-terminal pro-brain natriuretic peptide levels identifying left ventricular diastolic dysfunction in patients with preserved ejection fraction
    Hiroo Sonoda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Circ J 76:2599-605. 2012
    ..Diagnosis of left ventricular (LV) diastolic dysfunction by blood testing is expedient in the clinical setting...
  18. doi request reprint Morning hypertension in chronic kidney disease is sustained type, but not surge type
    Masashi Mizuno
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Blood Press Monit 17:20-3. 2012
    ..We investigated whether or not morning hypertension (BP 2 h after awakening >135/85 mmHg) in chronic kidney disease (CKD) was sustained type with a prolonged DT...
  19. pmc Increased reactive oxygen metabolites is associated with cardiovascular risk factors and vascular endothelial damage in middle-aged Japanese subjects
    Tomonori Sugiura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Vasc Health Risk Manag 7:475-82. 2011
    ..The present study sought to investigate the usefulness of derivative reactive oxygen metabolites (d-ROM) as an oxidative stress marker for detecting endothelial damage in the clinical setting in subjects with early-stage atherosclerosis...
  20. ncbi request reprint Nocturnal blood pressure is elevated with natriuresis and proteinuria as renal function deteriorates in nephropathy
    Michio Fukuda
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Kidney Int 65:621-5. 2004
    ..In the present study, we investigated the relationship between glomerular filtration rate and circadian rhythms of these parameters in patients with glomerulopathy...
  21. doi request reprint Relation of plasma levels of adiponectin to left ventricular diastolic dysfunction in patients undergoing cardiac catheterization for coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan
    Am J Cardiol 108:1081-5. 2011
    ..In conclusion, we found that decreased adiponectin levels were associated with LV diastolic dysfunction in patients with known or suspected coronary artery disease...
  22. ncbi request reprint Impact of arterial load on left ventricular diastolic function in patients undergoing cardiac catheterization for coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Circ J 74:1900-5. 2010
    ..Animal and small human studies have shown that an acute increase in LV afterload adversely impacts on LV early diastolic relaxation, but little is known about its chronic effect on diastolic function...
  23. ncbi request reprint Prognostic value of nonlinear heart rate dynamics in hemodialysis patients with coronary artery disease
    Hidekatsu Fukuta
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Kidney Int 64:641-8. 2003
    ..Although altered nonlinear heart rate dynamics predicts death in patients with coronary artery disease (CAD), its prognostic value in chronic hemodialysis patients with CAD is unknown...
  24. ncbi request reprint Low birth weight and end-stage renal disease: demographic analysis by region in Japan
    Tadashi Ichikawa
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University, Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    Clin Exp Nephrol 16:596-603. 2012
    ..We examined regional distribution in the incidence of low birth weight (LBW), a surrogate for low nephron number,in our search for an explanation...
  25. ncbi request reprint Regional differences in end-stage renal disease and amount of protein intake in Japan
    Masahiro Motokawa
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    J Ren Nutr 17:118-25. 2007
    ..We examined regional differences in the amounts of dietary nutrient intake, especially protein in our search for an explanation...
  26. doi request reprint Usefulness of plasma brain natriuretic peptide measurement and tissue Doppler imaging in identifying isolated left ventricular diastolic dysfunction without heart failure
    Toshihiko Goto
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Cardiol 106:87-91. 2010
    ....
  27. doi request reprint Impaired myocardial oxidative metabolism in the remote normal region in patients in the chronic phase of myocardial infarction and left ventricular remodeling
    Nobuyuki Ohte
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    J Nucl Cardiol 16:73-81. 2009
    ..Left ventricular (LV) remodeling occurs in the remote normal region in the LVs after myocardial infarction (MI) and is closely involved in heart failure...
  28. doi request reprint Renoprotective effect of calcium channel blockers in combination with an angiotensin receptor blocker in elderly patients with hypertension. A randomized crossover trial between benidipine and amlodipine
    Koichi Miyagawa
    Department of Internal Medicine, Nagoya Kosein Geriatric Hospital, Nagoya, Japan
    Clin Exp Hypertens 32:1-7. 2010
    ..The results suggest the importance of selecting medications used in combination with ARB in hypertensive patients with chronic kidney disease...
  29. ncbi request reprint The role of apically directed intraventricular isovolumic relaxation flow in speeding early diastolic left ventricular filling
    Atsumi Yanada
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Japan
    J Am Soc Echocardiogr 16:1226-30. 2003
    ..70, P <.001). Good LV systolic performance augments LV early diastolic filling directly, mediated by IRF. A faster IRF velocity may play a role in delivering good LV systolic performance to LV early diastolic filling...
  30. doi request reprint Is salt intake an independent risk factor of stroke mortality? Demographic analysis by regions in Japan
    Tatsuya Tomonari
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Am Soc Hypertens 5:456-62. 2011
    ..03-1.06) for the intermediate four regions and 1.25 (95% CI, 1.23-1.27) for the four regions with highest salt intake. These findings suggest that salt intake may have an adverse effect on stroke mortality independently of BP...
  31. doi request reprint Correlation between left ventricular end-diastolic pressure and peak left atrial wall strain during left ventricular systole
    Kazuaki Wakami
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Am Soc Echocardiogr 22:847-51. 2009
    ..This study investigates the effect of LV end-diastolic pressure on LA wall tension during LV systole...
  32. doi request reprint Renal dysfunction impairs circadian variation of endothelial function in patients with essential hypertension
    Koji Yamamoto
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    J Am Soc Hypertens 4:265-71. 2010
    ..Nocturnal blood pressure is elevated, and evening endothelial function deteriorates in parallel with a decline in renal function in hypertensive patients...
  33. ncbi request reprint Paradoxical brain embolism caused by pulmonary arteriovenous fistula and coincident pulmonary embolism--a case report
    Hiromichi Miyabe
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Japan
    Angiology 55:577-81. 2004
    ..The authors encountered a very rare case of paradoxical brain embolism resulting from pulmonary arteriovenous fistula and coincident pulmonary embolism. Enhanced computed tomography was useful for diagnosing this infrequent condition...
  34. ncbi request reprint Elevated plasma levels of B-type natriuretic Peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Int Heart J 50:301-12. 2009
    ..001). In conclusion, elevated BNP levels are independently associated with higher RDW in patients with CAD. Neurohumoral activation may be a mechanistic link between increased RDW and adverse clinical outcomes in this population...
  35. ncbi request reprint Anemia is an independent predictor for elevated plasma levels of natriuretic peptides in patients undergoing cardiac catheterization for coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Circ J 72:212-7. 2008
    ..It is unknown whether the association of anemia with elevated plasma levels of B-type and atrial natriuretic peptides (BNP and ANP) is mediated by the hemodynamic effects of anemia...
  36. ncbi request reprint Different regional dynamics of end-stage renal disease in Japan by different causes
    Nobuo Kato
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Nephrology (Carlton) 10:400-4. 2005
    ....
  37. ncbi request reprint Relationship between blood pressure obtained from the upper arm with a cuff-type sphygmomanometer and central blood pressure measured with a catheter-tipped micromanometer
    Nobuyuki Ohte
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Heart Vessels 22:410-5. 2007
    ..However, random variation in the two measurements was rather large. This is considered to be caused by the random error in the single measurement with the cuff-type sphygmomanometer...
  38. ncbi request reprint Usefulness of plasma brain-type natriuretic peptide level to differentiate left ventricular diastolic dysfunction from preserved diastolic function in patients with systolic dysfunction
    Toshihiko Goto
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Cardiol 95:1383-5. 2005
    ....
  39. ncbi request reprint Evaluation of whole left ventricular systolic performance and local myocardial systolic function in patients with prior myocardial infarction using global long-axis myocardial strain
    Nobuyuki Ohte
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Cardiol 94:929-32. 2004
    ..The evaluation of LV wall function using this parameter suggests that previous myocardial infarction (MI) causes long-axis myocardial function in remote normal LV walls, as well as in walls with MI, to deteriorate...
  40. ncbi request reprint Effects of oral glucose intake on gastric myoelectrical activity and gastric emptying
    Naoko Misu
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    J Smooth Muscle Res 40:169-76. 2004
    ..The EGG power ratio was significantly larger after glucose than water intake, with delayed gastric emptying in the former case. These results suggest that glucose is one of the components responsible for postprandial gastric motility...
  41. ncbi request reprint Circadian blood pressure rhythm is disturbed by nephrectomy
    Norihiko Goto
    Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan
    Hypertens Res 28:301-6. 2005
    ..Non-dipping of BP seems the consequence of the loss of renal function, rather than the cause...
  42. ncbi request reprint [Integrated care and expected outcomes over the progression of CKD (chronic kidney disease)]
    Genjiro Kimura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 66:1807-13. 2008
    ..I anticipate that the incidence of ESRD will be reduced in near future in Japan as seen in diabetic nephropathy in Denmark and USA. We must act now to accomplish this important issue: integrated care of CKD...
  43. ncbi request reprint Low cardiac output in a case of constrictive pericarditis with protein-losing enteropathy
    Shohei Kikuchi
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan
    Intern Med 52:75-9. 2013
    ..We herein report the importance of evaluating a low cardiac output in addition to established Doppler echocardiographic findings for making a diagnosis of CP coexistent with protein-losing enteropathy...
  44. pmc Bilirubin as a prognostic marker in patients with pulmonary arterial hypertension
    Yasuko Takeda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    BMC Pulm Med 10:22. 2010
    ..However, few studies have examined this relationship in patients with pulmonary arterial hypertension (PAH)...
  45. ncbi request reprint [Salt restriction in treatment of diabetes mellitus]
    Masahiro Motokawa
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 63:417-23. 2005
  46. ncbi request reprint Impaired gastric motility and its relationship to gastrointestinal symptoms in patients with chronic renal failure
    Makoto Hirako
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Nagoya 467 8601, Japan
    J Gastroenterol 40:1116-22. 2005
    ..The aim of this study was to elucidate the relationship between gastric motility and GI symptoms in patients with CRF...
  47. ncbi request reprint Relationship between effective arterial elastance, total vascular resistance, and augmentation index at the ascending aorta and left ventricular diastolic function in older women
    Toshihiko Goto
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Circ J 77:123-9. 2013
    ..Heart failure with preserved ejection fraction (HFpEF) is frequently observed in older women. Increased arterial stiffness in this population may be a cause of HFpEF...
  48. pmc Pulmonary venous occlusion and death in pulmonary arterial hypertension: survival analyses using radiographic surrogates
    Yasuko Takeda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    BMC Pulm Med 11:47. 2011
    ..Such obstruction more commonly accompanies connective tissue disorder (CTD)-associated PAH than idiopathic PAH. However, few researchers have gauged the risk of death involving obstruction of the pulmonary veins...
  49. doi request reprint Salt sensitivity and circadian rhythm of blood pressure: the keys to connect CKD with cardiovascular events
    Genjiro Kimura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hypertens Res 33:515-20. 2010
    ..Salt sensitivity and circadian rhythm of BP are the keys to understanding the connections between cardiovascular and renal complications...
  50. ncbi request reprint Myocardial fiber shortening in the circumferential direction produces left ventricular wall thickening during contraction
    Takafumi Kato
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Tohoku J Exp Med 222:175-81. 2010
    ..75, p<0.05) and outer (r=0.61, p<0.05) layers. We conclude that shortening of LV circumferential myocardial fiber and incompressibility of myocardium produce LV wall thickening during contraction...
  51. ncbi request reprint Glomerular capillary tenascin staining in renal allografts and its correlation with capillary loop 'double contours', proteinuria and graft outcome
    Michio Fukuda
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Nephron Clin Pract 96:c115-22. 2004
    ..Tenascin-C (TN), a component of extracellular matrix, is known to be overexpressed in various conditions...
  52. doi request reprint Duration until nighttime blood pressure fall indicates excess sodium retention
    Michio Fukuda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Chronobiol Int 29:1412-7. 2012
    ..Shortening DT correlated directly with the increase in daytime urinary sodium excretion (Study 2). DT can be used as a preliminary indicator of sodium retention...
  53. doi request reprint Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling
    Nobuyuki Ohte
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Eur J Nucl Med Mol Imaging 39:1246-53. 2012
    ..Accordingly, we assessed β-AR density with a focus on the remote noninfarcted region...
  54. doi request reprint Geographic differences in the increasing ESRD rate have disappeared in Japan
    Tamaki Wakamatsu-Yamanaka
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    Clin Exp Nephrol 15:708-13. 2011
    ..It was recently demonstrated that the incidence of ESRD due to diabetic nephropathy is declining in both Europe and USA. Therefore, we investigated the increasing ESRD rate and its geographic difference in Japan...
  55. ncbi request reprint Pathophysiology of antihypertensive therapy with diuretics
    Michio Fukuda
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Hypertens Res 29:645-53. 2006
    ..Low-dose diuretics will continue to be an important agent in the treatment of hypertension, mostly in combination with vasodilators such as modulators of the reninangiotensin system and calcium channel blockers...
  56. ncbi request reprint Evaluation of fatty acid beta-oxidation in patients with prior myocardial infarction in relation to myocardial blood flow, total oxidative metabolism, and left ventricular wall motion
    Hiromichi Miyabe
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, and Department of Radiology, Nagoya City Sports and Rehabilitation Center, Japan
    Circ J 69:1459-65. 2005
    ..Fatty acid metabolism in patients with myocardial infarction (MI) who undergo coronary reperfusion has not been fully elucidated and was investigated in the present study using positron emission tomography...
  57. ncbi request reprint Low incidence of cardiac events in statin-administered patients in CAG study
    Tomoaki Saeki
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Atheroscler Thromb 16:172-8. 2009
    ..The effect of statins in preventing cardiac events in Japanese coronary artery disease (CAD) patients was studied in a retrospective investigation of 148 patients diagnosed with CAD by coronary angiography (CAG)...
  58. ncbi request reprint Maps of end-stage renal disease and amounts of angiotensin-converting enzyme inhibitors prescribed in Japan
    Takeshi Usami
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Kidney Int 64:1445-9. 2003
    ..Here, we examined regional differences in the amounts of expenses spent on antihypertensives, especially angiotensin-converting enzyme (ACE) inhibitors, in our search for an explanation...
  59. ncbi request reprint Myocardial radial strain in early diastole is useful for assessing left ventricular early diastolic function: comparison with invasive parameters
    Kazuaki Wakami
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Am Soc Echocardiogr 21:446-51. 2008
    ..We investigated the relationship between peak myocardial radial strain during early diastole and LV early diastolic function...
  60. ncbi request reprint Hypothesis on renal mechanism of non-dipper pattern of circadian blood pressure rhythm
    Michio Fukuda
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    Med Hypotheses 67:802-6. 2006
    ..Therefore, as renal function deteriorates, longer duration may be required before BP begins to dip during night. Non-dipping may be one mechanism causing cardiovascular events in chronic kidney disease...
  61. doi request reprint Salt sensitivity and nondippers in chronic kidney disease
    Michio Fukuda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Curr Hypertens Rep 14:382-7. 2012
    ..Large-scale studies are needed to explore whether these interventions can decrease the risks...
  62. doi request reprint Angiotensin receptor blockers regulate the synchronization of circadian rhythms in heart rate and blood pressure
    Ryo Sato
    aDepartment of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya bAsahi Rosai Hospital, Japan Labour Health and Welfare Organization, Aichi, Japan
    J Hypertens 31:1233-8. 2013
    ..The sympathetic nervous system plays an important role in blood pressure regulation even in the early stages of chronic kidney disease (CKD)...
  63. doi request reprint Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis
    Tomonori Sugiura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Tokyo, Japan
    Coron Artery Dis 23:234-8. 2012
    ..The purpose of this study was to investigate the plasma levels of serotonin, S1P, and their clinical relationships with vascular endothelial function in patients with early atherosclerosis...
  64. pmc Prognostic value of left ventricular diastolic dysfunction in patients undergoing cardiac catheterization for coronary artery disease
    Hidekatsu Fukuta
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi Mizuho cho Mizuho ku, Nagoya 467 8601, Japan
    Cardiol Res Pract 2012:243735. 2012
    ....
  65. ncbi request reprint [Hypermagnesemia and its association with hypothyroidism]
    Yuichi Shirasawa
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medicine Sciences, Nagoya
    Nihon Naika Gakkai Zasshi 94:967-8. 2005
  66. ncbi request reprint Two cases with renal infarction diagnosed in the early course using contrast-enhanced CT
    Tetsuro Yoshida
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Japan
    Hypertens Res 27:523-6. 2004
    ..Renal infarction could be diagnosed in the early course, even in cases with incomplete occlusion of the renal arteries and normal renal function...
  67. ncbi request reprint Proposal for mapping renal failure in Japan and its application for strategy to arrest endstage renal disease
    Takeshi Usami
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Clin Exp Nephrol 10:8-12. 2006
    ..Thus, much effort will be encouraged for the further analysis of regional differences in ESRD dynamics...
  68. ncbi request reprint Reverse redistribution phenomenon on rest (99m)Tc-tetrofosmin myocardial single photon emission computed tomography involves impaired left ventricular contraction in patients with acute myocardial infarction
    Kazuyuki Kurokawa
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Japan
    Circ J 67:830-4. 2003
    ..0+/-7.2%). In patients with acute myocardial infarction, the regions showing the RR phenomenon on (99m)Tc-tetrofosmin SPECT have severely impaired LV wall contraction after exercise...
  69. doi request reprint [Calcium antagonists: current and future applications based on new evidence. Renal protective action of calcium channel blockers]
    Genjiro Kimura
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Calcium 20:94-9. 2010
    ..Therefore, renal protection by Ca channel blockers remains in debate. We will discuss the renal protective action of new Ca channel blockers, which can dilate postglomerular efferent arterioles...
  70. ncbi request reprint Malignant nature of cardiac liposarcoma revealed by fluorine-18 fluorodeoxyglucose positron emission tomographic imaging
    Toshihiko Goto
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Japan
    Intern Med 51:1367-70. 2012
    ..The final diagnosis was made histopathologically following surgery. Treatment with carbon ion radiotherapy was applied, but failed to induce tumor regression...
  71. ncbi request reprint [Hypertensive nephrosclerosis]
    Michio Fukuda
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 62:357-62. 2004
  72. ncbi request reprint [Significance of urea kinetics in hemodialysis]
    Tadashi Ichikawa
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 62:196-202. 2004
  73. ncbi request reprint [Hypertension and renal dysfunction]
    Tamaki Yamanaka
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 64:196-200. 2006
  74. doi request reprint Within-person variation of the plasma concentration of B-type natriuretic peptide: safety range in stable patients with heart failure
    Yasuko Takeda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
    Am Heart J 157:97-101. 2009
    ..In this study, we estimated the safety range of within-person variation in the plasma concentration of BNP in outpatients with stable heart failure...
  75. ncbi request reprint Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation
    Katsushi Koyama
    Department of Internal Medicine and Pathophysiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Nephrol Dial Transplant 17:916-22. 2002
    ....
  76. ncbi request reprint Gastric myoelectrical activity in patients with recurrent gastric or duodenal ulcers
    Takeshi Kamiya
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Science, Nagoya 467 8601, Japan
    J Smooth Muscle Res 39:1-10. 2003
    ..These findings suggest that abnormal gastric myoelectrical activity plays an important role in the pathophysiology of recurrent GU rather than DU...
  77. ncbi request reprint Gastric motility in patients with recurrent gastric ulcers
    Takeshi Kamiya
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Smooth Muscle Res 38:1-9. 2002
    ..These findings suggest that abnormal gastric motility, including gastric electrical abnormalities and delayed gastric emptying, plays an important role in the pathophysiology of recurrent gastric ulcers...
  78. ncbi request reprint The mechanism of emergence and clinical significance of apically directed intraventricular flow during isovolumic relaxation
    Nobuyuki Ohte
    Third Department of Internal Medicine, Nagoya City University Medical School, Japan
    J Am Soc Echocardiogr 15:715-22. 2002
    ..Absence of apically directed intraventricular flow during isovolumic relaxation is a manifestation of LV apical asynergy and global LV dysfunction from end systole to early diastole...
  79. ncbi request reprint Circadian rhythm of atrioventricular conduction predicts long-term survival in patients with chronic atrial fibrillation
    Junichiro Hayano
    Third Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
    Chronobiol Int 19:633-48. 2002
    ..001). We conclude that the blunted circadian rhythm of AV conduction is an independent risk for cardiac death in patients with chronic AF...
  80. ncbi request reprint Myocardial oxidative metabolism in remote normal regions in the left ventricles with remodeling after myocardial infarction: effect of beta-adrenoceptor blockers
    Nobuyuki Ohte
    Third Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
    J Nucl Med 43:780-5. 2002
    ..However, the characteristics of such regions are not fully understood. Thus, we investigated this issue from the standpoint of myocardial oxidative metabolism using (11)C-acetate PET...
  81. doi request reprint B-type natriuretic peptide levels and cardiovascular risk in patients with diastolic dysfunction on chronic haemodialysis: cross-sectional and observational studies
    Hiroyuki Takase
    Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan
    Nephrol Dial Transplant 26:683-90. 2011
    ..In the present study, we tested the hypothesis that left ventricular diastolic dysfunction increases BNP levels and can predict cardiovascular events in patients on chronic haemodialysis without apparent cardiac disease...
  82. doi request reprint Uric acid levels predict future development of chronic kidney disease
    Hiroo Sonoda
    Department of Cardio Renal Medicine and Hypertension, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Nephrol 33:352-7. 2011
    ..Increased uric acid levels are associated with kidney dysfunction. We tested the hypothesis that uric acid level predicts future development of chronic kidney disease (CKD) in the general population...
  83. ncbi request reprint [Blood pressure lowering effects of DASH diet as a life style modification]
    Takafumi Kato
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 64:437-43. 2006
  84. ncbi request reprint Solitary fibrous tumor of the uterus producing high-molecular-weight insulin-like growth factor II and associated with hypoglycemia
    Kazuko Wakami
    Department of Pathology, Nagoya City University Medical School, Kawasumi 1, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Int J Gynecol Pathol 24:79-84. 2005
    ..Western blotting of the tumor extract revealed the presence of big IGF-II, the molecular weight of which was similar to that of aberrant serum IGF-II. To our knowledge, this is the first case of uterine solitary fibrous tumor...
  85. doi request reprint Nifedipine improves endothelial function: role of endothelial progenitor cells
    Tomonori Sugiura
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hypertension 52:491-8. 2008
    ..These results demonstrate that nifedipine preserves endothelial integrity in patients with hypertension, at least partly, by enhancing EPC numbers and activity...
  86. ncbi request reprint [Renal failure--nephrosclerosis]
    Takeshi Usami
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 63:149-54. 2005
  87. ncbi request reprint Clinical usefulness of carotid arterial wave intensity in assessing left ventricular systolic and early diastolic performance
    Nobuyuki Ohte
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Heart Vessels 18:107-11. 2003
    ..WI is a noninvasively obtained, clinically useful parameter for the evaluation of LV systolic and early diastolic performance at the same time...
  88. ncbi request reprint Effects of the Dietary Approaches to Stop Hypertension (DASH) diet on the pressure-natriuresis relationship
    Sachie Akita
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Hypertension 42:8-13. 2003
    ..5+/-3.4 vs 64.9+/-13.1 [mmol/d]/mm Hg, P=0.0002) without significantly shifting the x-intercept (94.1+/-0.5 vs 93.2+/-0.6 mm Hg, NS) of the relationship. These data suggest a natriuretic action of the DASH diet...
  89. ncbi request reprint Regional variation in end-stage renal disease
    Takeshi Usami
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Curr Opin Nephrol Hypertens 11:343-6. 2002
    ..Thus, much effort is required in further analysis of regional differences in end-stage renal disease dynamics...
  90. ncbi request reprint Complement fragment C4d deposition in peritubular capillaries in acute humoral rejection after ABO blood group-incompatible human kidney transplantation
    Masako Kato
    The Third Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
    Transplantation 75:663-5. 2003
    ..Complement fragment C4d deposition in peritubular capillaries (PTC), which is a sensitive indicator for activation of the classical complement pathway, was studied to establish the pathologic diagnostic indicator of AHR...
  91. ncbi request reprint [Short time hemodialysis]
    Kazuko Wakami
    Department of Internal Medicine and Pathophysiology, Nagoya City University Graduate School of Medical Sciences
    Nihon Rinsho 62:168-71. 2004
  92. ncbi request reprint Tl-201 washout rate in remote normal regions in patients with prior myocardial infarction and left ventricular remodeling
    Toshihiko Goto
    Departmernt of Internal Medicine and Pathophysiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya City 467 8601, Japan
    J Nucl Cardiol 12:179-85. 2005
    ..Thus, we investigated this issue from the viewpoint of myocardial Tl-201 dynamics...
  93. doi request reprint Impact of blood pressure control on cardiovascular events in 26,512 Japanese hypertensive patients: the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study, a prospective nationwide observational study
    Kazuaki Shimamoto
    Sapporo Medical University School of Medicine, Sapporo, Japan
    Hypertens Res 31:469-78. 2008
    ..BP was controlled below 140/90 mmHg in a half of the very elderly hypertensive patients in this study, and these patients also had a lower incidence of CV events...
  94. ncbi request reprint Left ventricular hypertrophy is a risk factor independent of hypertension in survival of hemodialyzed patients
    Satoko Nakamura
    Department of Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    Ren Fail 24:175-86. 2002
    ..This finding, together with those above from Cox's model and logistic analysis strongly suggests that risk from left ventricular hypertrophy is independent of, but one from heart enlargement is dependent on hypertension...
  95. ncbi request reprint [Progress in nephrology during this year: Kidney and hypertension]
    Genjiro Kimura
    Nihon Jinzo Gakkai Shi 50:16-20. 2008
  96. ncbi request reprint A pathophysiologic study of tako-tsubo cardiomyopathy with F-18 fluorodeoxyglucose positron emission tomography
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Gifu Prefectural Government TAJIMI Hospital, 5 161 Maehata, Tajimi, Gifu 5078522, Japan
    Eur Heart J 28:2598-604. 2007
    ..AIMS; Our study aims to investigate the pathophysiologic mechanism underlying tako-tsubo cardiomyopathy using F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)...
  97. ncbi request reprint Disturbed circadian rhythm of urinary albumin excretion in non-dipper type of essential hypertension
    Masataka Nishimura
    Division of Nephrology, National Cardiovascular Center, Osaka, Japan
    Am J Nephrol 22:455-62. 2002
    ..Renal sodium handling may contribute to determining the circadian rhythm of blood pressure, and furthermore an elevated glomerular capillary hydraulic pressure during the night may enhance the nocturnal albumin excretion in non-dippers...
  98. ncbi request reprint Prognostic value of heart rate variability in patients with end-stage renal disease on chronic haemodialysis
    Hidekatsu Fukuta
    Third Department of Internal Medicine, Nagoya City University Medical School, 1 Kawasumi Mizuho cho Mizuho ku, Nagoya 467 8601, Japan
    Nephrol Dial Transplant 18:318-25. 2003
    ..Although decreased heart rate variability (HRV) is an independent predictor of death in various populations, its prognostic value in patients with end-stage renal disease on chronic haemodialysis is unknown...
  99. ncbi request reprint Antihypertensive drugs and renal protection
    Michio Fukuda
    JAMA 289:1102-3; author reply 1103. 2003
  100. ncbi request reprint [The kidney and hypertension]
    Genjiro Kimura
    Nihon Jinzo Gakkai Shi . 2007
  101. ncbi request reprint Association of gene polymorphisms with myocardial infarction in individuals with different lipid profiles
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
    Int J Mol Med 20:581-90. 2007
    ..Stratification of subjects according to lipid profiles may thus be important for personalized prevention of MI based on genetic information...