Affiliation: Nagoya University
- Yajima I, Kumasaka M, Ohnuma S, Ohgami N, Naito H, Shekhar H, et al. Arsenite-mediated promotion of anchorage-independent growth of HaCaT cells through placental growth factor. J Invest Dermatol. 2015;135:1147-1156 pubmed publisher..Thus, this study proposed a molecular mechanism for arsenite-mediated development of skin cancer. ..
- Konishi H, Ohgami N, Matsushita A, Kondo Y, Aoyama Y, Kobayashi M, et al. Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice. Neuroscience. 2017;351:15-23 pubmed publisher..These results demonstrated that DT has ototoxic action on C57BL/6 mice during the juvenile period, but not thereafter, and the hearing loss was due to degeneration of inner and outer HCs by unknown DT-related mechanisms. ..
- Yajima I, Kumasaka M, Iida M, Oshino R, Tanihata H, Al Hossain A, et al. Arsenic-mediated hyperpigmentation in skin via NF-kappa B/endothelin-1 signaling in an originally developed hairless mouse model. Arch Toxicol. 2017;91:3507-3516 pubmed publisher..Our results suggest that interaction between keratinocytes and melanocytes in the skin through ET-1 and its receptor contributes to arsenic-mediated skin pigmentation, a hallmark of arsenicosis. ..
- Li X, Ohgami N, Omata Y, Yajima I, Iida M, Oshino R, et al. Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice. Sci Rep. 2017;7:6844 pubmed publisher..Thus, our combined study showed that oral exposure to As caused hearing loss in young people and young mice. ..