Yoshinori Ito

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi Cardiovascular disease mortality and serum carotenoid levels: a Japanese population-based follow-up study
    Yoshinori Ito
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    J Epidemiol 16:154-60. 2006
  2. ncbi A population-based follow-up study on mortality from cancer or cardiovascular disease and serum carotenoids, retinol and tocopherols in Japanese inhabitants
    Yoshinori Ito
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, 466 8550 Japan
    Asian Pac J Cancer Prev 7:533-46. 2006
  3. doi Immunologic and virologic analyses in pediatric liver transplant recipients with chronic high Epstein-Barr virus loads
    Kensei Gotoh
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Infect Dis 202:461-9. 2010
  4. ncbi Smoking and serum CA19-9 levels according to Lewis and secretor genotypes
    Sayo Kawai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 123:2880-4. 2008
  5. ncbi Epstein-Barr virus nuclear antigen 1-specific CD4+ T cells directly kill Epstein-Barr virus-carrying natural killer and T cells
    Ayako Demachi-Okamura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 99:1633-42. 2008
  6. ncbi Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study)
    Takaaki Kondo
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 20 Daikominami 1 chome, Nagoya, Japan
    Cancer Causes Control 18:229-34. 2007
  7. ncbi Time spent walking or exercising and blood levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3): A large-scale cross-sectional study in the Japan Collaborative Cohort study
    Kenji Wakai
    Department of Preventive Medicine, Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    Asian Pac J Cancer Prev 10:23-7. 2009
  8. ncbi Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan
    Koji Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncology 68:454-61. 2005
  9. ncbi Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Int 55:566-71. 2013
  10. ncbi A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study
    Koji Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Cancer Sci 95:602-7. 2004

Detail Information

Publications118 found, 100 shown here

  1. ncbi Cardiovascular disease mortality and serum carotenoid levels: a Japanese population-based follow-up study
    Yoshinori Ito
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    J Epidemiol 16:154-60. 2006
    ..Some observational epidemiologic studies suggest that dietary and serum carotenoids are associated with reduced cardiovascular disease mortality...
  2. ncbi A population-based follow-up study on mortality from cancer or cardiovascular disease and serum carotenoids, retinol and tocopherols in Japanese inhabitants
    Yoshinori Ito
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, 466 8550 Japan
    Asian Pac J Cancer Prev 7:533-46. 2006
    ..To investigate whether high serum levels of carotenoids can reduce mortality rates, a population-based follow-up study was conducted among Japanese inhabitants...
  3. doi Immunologic and virologic analyses in pediatric liver transplant recipients with chronic high Epstein-Barr virus loads
    Kensei Gotoh
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Infect Dis 202:461-9. 2010
    ..Long-term Epstein-Barr virus (EBV) monitoring for potentially life-threatening posttransplant lymphoproliferative disorder (PTLD) has identified asymptomatic patients who maintain high EBV loads over long periods...
  4. ncbi Smoking and serum CA19-9 levels according to Lewis and secretor genotypes
    Sayo Kawai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 123:2880-4. 2008
    ..When hemoglobin A1c was further adjusted, the association became stronger (p = 0.0027). In addition to polymorphic variations, some components of cigarette smoke may influence the production or destruction of CA19-9...
  5. ncbi Epstein-Barr virus nuclear antigen 1-specific CD4+ T cells directly kill Epstein-Barr virus-carrying natural killer and T cells
    Ayako Demachi-Okamura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 99:1633-42. 2008
    ....
  6. ncbi Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study)
    Takaaki Kondo
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 20 Daikominami 1 chome, Nagoya, Japan
    Cancer Causes Control 18:229-34. 2007
    ..To determine the relationship of body mass index (BMI) and BMI changes during adulthood to lung cancer mortality in a large-sized Japanese cohort...
  7. ncbi Time spent walking or exercising and blood levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3): A large-scale cross-sectional study in the Japan Collaborative Cohort study
    Kenji Wakai
    Department of Preventive Medicine, Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    Asian Pac J Cancer Prev 10:23-7. 2009
    ..048). Our findings may partly explain the protective effects of physical activity against several sites of cancer...
  8. ncbi Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan
    Koji Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncology 68:454-61. 2005
    ..To elucidate whether leptin is involved in the etiology of female colorectal cancer...
  9. ncbi Risk factors for poor outcome in congenital cytomegalovirus infection and neonatal herpes on the basis of a nationwide survey in Japan
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Int 55:566-71. 2013
    ..Congenital cytomegalovirus (CMV) infection and neonatal herpes are major mother-to-child infections, and analyses of the important clinical issues, including risk factors for prognosis, are essential...
  10. ncbi A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: findings from the JACC study
    Koji Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Cancer Sci 95:602-7. 2004
    ....
  11. ncbi Comparison of urinary concentrations of 3-phenoxybenzoic acid among general residents in rural and suburban areas and employees of pest control firms
    Akiko Kimata
    Program in Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Higashi ku, Nagoya, Japan
    Int Arch Occup Environ Health 82:1173-8. 2009
    ....
  12. ncbi Diet and colorectal cancer mortality: results from the Japan Collaborative Cohort Study
    Masayo Kojima
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho, Nagoya, Japan
    Nutr Cancer 50:23-32. 2004
    ..Further investigation is therefore necessary to confirm the association between diet and colorectal cancer, especially by subsites and gender...
  13. ncbi Immunogenicity of inactivated seasonal influenza vaccine in adult and pediatric liver transplant recipients over two seasons
    Michio Suzuki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Microbiol Immunol 57:715-22. 2013
    ..Influenza infection was more frequent in pediatric recipients. Long-term response to preceding vaccinations appeared to be insufficient in both groups. ..
  14. doi Clinical and virological characteristics of 15 patients with chronic active Epstein-Barr virus infection treated with hematopoietic stem cell transplantation
    Kensei Gotoh
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Infect Dis 46:1525-34. 2008
    ..Recently, hematopoietic stem cell transplantation (HSCT) has been introduced and has the potential to become a standard treatment, although guidelines for HSCT to treat chronic active EBV infection have not yet been proposed...
  15. ncbi Study profile on baseline survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study)
    Emi Morita
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Japan
    Nagoya J Med Sci 73:187-95. 2011
    ..Current drinkers included 74.9% (n=1099) of males and 45.9% (n=1699) of females. Lifestyle data and specimens were successfully collected to examine any associations among disease biomarkers, lifestyles, and genotypes...
  16. ncbi Alcohol consumption and colorectal cancer risk: findings from the JACC Study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 15:S173-9. 2005
    ..Because alcohol drinking is a potential risk factor for colorectal cancer, the trend in alcohol consumption in Japan may partly explain the increase in incidence and mortality rates of this malignancy until 1990-1995...
  17. doi Significant association between methylenetetrahydrofolate reductase 677T allele and hyperuricemia among adult Japanese subjects
    Simon Itou
    Division of Thoracic Surgery, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
    Nutr Res 29:710-5. 2009
    ..This new view may partly explain the inconsistent results on the association of the MTHFR polymorphism with SUA...
  18. doi Quantitative analysis of Epstein-Barr virus (EBV)-related gene expression in patients with chronic active EBV infection
    Seiko Iwata
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gen Virol 91:42-50. 2010
    ..Quantifying EBV gene expression is useful in clarifying the pathogenesis of CAEBV infection and may provide information regarding a patient's disease prognosis, as well as possible therapeutic interventions...
  19. ncbi Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: a prospective study
    Masayo Kojima
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Epidemiol 161:462-71. 2005
    ..No adverse effects of high serum levels of omega-6 polyunsaturated fatty acids on colorectal cancer risk were detected...
  20. ncbi Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnesses
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
    J Med Virol 81:1399-402. 2009
    ..8 x 10(2) copies/ml of whole blood, respectively, suggesting that the viruses were associated with the clinical condition. Recognizing that coinfection with these viruses may modulate the clinical course of disease is important...
  21. ncbi Attributable and absolute risk of lung cancer death by smoking status: findings from the Japan Collaborative Cohort Study
    Masahiko Ando
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 105:249-54. 2003
    ..For all current smokers, immediate cessation is encouraged because it offers the only realistic way to avoid a substantial increase in lung cancer mortality brought about by further continuation of smoking...
  22. ncbi Full-length EBNA1 mRNA-transduced dendritic cells stimulate cytotoxic T lymphocytes recognizing a novel HLA-Cw*0303- and -Cw*0304-restricted epitope on EBNA1-expressing cells
    Yoshinori Ito
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Gen Virol 88:770-80. 2007
    ..These data demonstrate that EBNA1 mRNA-transduced DCs may be useful tools for inducing EBNA1-specific CTLs that might be of clinical interest for CTL therapy of EBV-associated malignancies...
  23. pmc Significant association between Helicobacter pylori infection and serum C-reactive protein
    Yoshiko Ishida
    Department of Preventive Medicine, Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Med Sci 5:224-9. 2008
    ..Helicobacter pylori (H. pylori) infection in gastric mucosa may cause systemic inflammatory reaction. This study aimed to examine the association between the infection and serum high sensitivity C-reactive protein (hsCRP)...
  24. doi The effect of β-carotene on lumbar osteophyte formation
    Shiro Imagama
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Spine (Phila Pa 1976) 36:2293-8. 2011
    ..Cross-sectional cohort study of elderly people...
  25. doi Identification of Epstein-Barr virus-infected CD27+ memory B-cells in liver or stem cell transplant patients
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gen Virol 92:2590-5. 2011
    ..88, P < 0.0001). The FISH assay enabled us to characterize EBV-infected cells and perform a quantitative analysis in patients with EBV infection after stem cell/liver transplantation...
  26. ncbi Intake frequency of fish and serum levels of long-chain n-3 fatty acids: a cross-sectional study within the Japan Collaborative Cohort Study
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    J Epidemiol 15:211-8. 2005
    ..Whether reported fish consumption reflects the fatty acid intake, however, has to be elucidated...
  27. ncbi Characterization of murine CD160+ CD8+ T lymphocytes
    Kunio Tsujimura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Immunol Lett 106:48-56. 2006
    ..These results together show that CD160 is expressed on the majority of CD8(+) memory T cells as well as recently activated CD8(+) T cells...
  28. ncbi Identification of an HLA-A24-restricted cytotoxic T lymphocyte epitope from human papillomavirus type-16 E6: the combined effects of bortezomib and interferon-gamma on the presentation of a cryptic epitope
    Satoko Morishima
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 120:594-604. 2007
    ..Thus, these findings together indicate that E6(49-57) is a candidate epitope for immunotherapy and immunological monitoring of such patients...
  29. ncbi Correlations of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation
    Tomonori Kato
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Japan
    Cell Immunol 288:53-9. 2014
    ..Although further investigation is required to clarify the association between IL-6 level and CMV infection in more patients, IL-6 might be a useful biomarker of persistent CMV infection after allogeneic HSCT...
  30. doi Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection
    Yoshihiko Kawano
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 208:771-9. 2013
    ..MicroRNAs (miRNAs) are small noncoding RNAs, and EBV encodes multiple miRNAs. Because plasma contains sufficiently stable miRNAs, circulating EBV-associated miRNA profiles were investigated as novel biomarkers in CAEBV infection...
  31. doi Clinical indicators of depression among ambulatory cancer patients undergoing chemotherapy
    Tatsuo Akechi
    Department of Psychiatry and Cognitive Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Jpn J Clin Oncol 42:1175-80. 2012
    ..This study aimed to investigate clinical indicators of depression among randomly selected ambulatory patients with cancer who were receiving chemotherapy...
  32. ncbi Bortezomib induces apoptosis in T lymphoma cells and natural killer lymphoma cells independent of Epstein-Barr virus infection
    Seiko Iwata
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Cancer 129:2263-73. 2011
    ..Bortezomib had a greater killing effect on EBV-infected cells. These results indicate that bortezomib killed T or NK lymphoma cells by inducing apoptosis, regardless of the presence or absence of EBV...
  33. doi Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7
    Kaoru Wada
    Deparmtent of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Microbiol Immunol 53:22-9. 2009
    ..The detection rate for each viral DNA was 6.7% for HSV, 9.5% for HHV-6, and 1.9% for HHV-7. These results indicate that our system is reliable and may be useful for the rapid diagnosis of viral encephalitis/encephalopathy...
  34. ncbi One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection
    Naomi Kubota
    Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Virol Methods 147:26-36. 2008
    ..Because of its rapidity, sensitivity, and specificity, this new assay can be used for quantitative analyses of the latency patterns of EBV infection and the switch from latency to lytic viral replication...
  35. ncbi Modification of the effect of smoking on cholesterol in Japanese carriers of a PTPN11 polymorphism
    Rieko Okada
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Mol Med Report 1:595-8. 2008
    ..039; HDL-C, p=0.020). These data suggest that cigarette smoking might alter the metabolism of cholesterol in Japanese PTPN11 AA genotype carriers...
  36. doi Comparison of the levels of human herpesvirus 6 (HHV-6) DNA and cytokines in the cerebrospinal fluid and serum of children with HHV-6 encephalopathy
    Shinji Kawabe
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 82:1410-5. 2010
    ..038). The distribution of these cytokines differed between CSF and serum. The high CSF concentration of IL-8 could play an important role in the pathogenesis of encephalopathy...
  37. doi Association of serum carotenoids, retinol, and tocopherols with radiographic knee osteoarthritis: possible risk factors in rural Japanese inhabitants
    Taisuke Seki
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Orthop Sci 15:477-84. 2010
    ..To determine the association between serum antioxidants and radiographic knee osteoarthritis, we undertook a cross-sectional investigation in a community-based study in Japan...
  38. ncbi Epstein-Barr virus (EBV) latent membrane protein-1-specific cytotoxic T lymphocytes targeting EBV-carrying natural killer cell malignancies
    Ayako Demachi-Okamura
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Eur J Immunol 36:593-602. 2006
    ..Overall, these data suggest that immunotherapy targeting LMP1 in EBV-associated NK lymphomas and CAEBV might serve as an alternative treatment modality...
  39. doi Oncology nurses' recognition of supportive care needs and symptoms of their patients undergoing chemotherapy
    Tomohiro Nakaguchi
    Nagoya City University Hospital, Nagoya, Aichi, Japan
    Jpn J Clin Oncol 43:369-76. 2013
    ..To assess the accuracy of oncology nurses' recognition of supportive care needs and symptoms of their patients undergoing chemotherapy...
  40. doi Progressive hearing loss following acquired cytomegalovirus infection in an immunocompromised child
    Ken Kato
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Japan
    Am J Otolaryngol 34:89-92. 2013
    ..This case demonstrates the possibility that, under the immunodeficiency, the acquired CMV infection causes progressive sensorineural hearing loss...
  41. doi Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases
    Shinji Kawabe
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 103:1481-8. 2012
    ....
  42. doi Antitumor activities of valproic acid on Epstein-Barr virus-associated T and natural killer lymphoma cells
    Seiko Iwata
    Departments of Virology Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 103:375-81. 2012
    ..These results indicate that VPA has antitumor effects on T and NK lymphoma cells and that VPA and bortezomib may have synergistic effects, irrespective of the presence of EBV...
  43. doi Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients
    Yuka Torii
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Vaccine 29:4187-9. 2011
    ..These findings suggest that pediatric liver transplant patients may respond safely to inactivated 2009 H1N1 influenza vaccines in a manner similar to immunocompetent children...
  44. doi Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan
    Jun Ueyama
    Program in Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461 8673, Japan
    Environ Res 109:175-80. 2009
    ..Further nationwide studies covering different seasons and age distribution are needed to monitor the urinary 3-PBA levels in Japan...
  45. pmc Multiplex real-time PCR assay for simultaneous quantification of BK polyomavirus, JC polyomavirus, and adenovirus DNA
    Yasuhito Funahashi
    Department of Urology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Clin Microbiol 48:825-30. 2010
    ..Since this new assay is rapid, sensitive, and specific, it can be used for quantitative analyses of viruses in urine and serum samples after transplantation...
  46. ncbi EBV-associated T/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases
    Hiroshi Kimura
    Departments of Virology, Nagoya University Graduate School of Medicine, Japan
    Blood 119:673-86. 2012
    ..These data depict clinical characteristics of systemic EBV(+) T/NK-LPD and provide insight into the diagnostic and therapeutic approaches for distinct disease...
  47. ncbi Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease
    Hiroshi Kimura
    Department of Virology Nagoya University Graduate School of Medicine, Nagoya, Japan
    Rev Med Virol 18:305-19. 2008
    ..The EBV real-time PCR assay system must be standardised for large-scale studies and international comparisons...
  48. doi Oligonucleotide microarray analysis of gene expression profiles followed by real-time reverse-transcriptase polymerase chain reaction assay in chronic active Epstein-Barr virus infection
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 197:663-6. 2008
    ..These genes may be associated with the inflammatory reaction or with cell proliferation...
  49. ncbi Identification of Epstein-Barr virus (EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases
    Hiroshi Kimura
    Department of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 200:1078-87. 2009
    ....
  50. ncbi SLC22A12 W258X frequency according to serum uric acid level among Japanese health checkup examinees
    Sayaka Kuriki
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nagoya J Med Sci 73:41-8. 2011
    ..The observed SUA level changes in individuals with 258WX suggested that lifestyle factors could influence the levels of those with 258WX...
  51. pmc Relationship between dietary habits and urinary concentrations of 3-phenoxybonzoic acid in a middle-aged and elderly general population in Japan
    Akiko Kimata
    Program in Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, 1 1 20 Daikominami, Higashi ku, Nagoya, 461 8673, Japan
    Environ Health Prev Med 14:173-9. 2009
    ..We have examined the relationship between the intake frequency of selected items of vegetables and fruits and urinary metabolites of pyrethroid pesticides in a healthy general population...
  52. doi Long-term parvovirus B19 infections with genetic drift after cord blood transplantation complicated by persistent CD4+ lymphocytopenia
    Michio Suzuki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya Gunma Prefectural Institute of Public Health and Environmental Sciences, Gunma Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan
    J Pediatr Hematol Oncol 36:e65-8. 2014
    ..The resulting changes of the nonstructural 1 structure may have altered antigenicity of the virus and could play a role in the pathogenesis of persistent infection under immunocompromised conditions...
  53. doi Causes of vertical transmission of hepatitis B virus under the at-risk prevention strategy in Japan
    Yuka Torii
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Microbiol Immunol 57:118-21. 2013
    ..These data suggest clear limitations to the at-risk strategy in Japan and the possibility that the increase in genotype A may influence vertical transmission of HBV...
  54. doi Demonstration of type II latency in T lymphocytes of Epstein-Barr Virus-associated hemophagocytic lymphohistiocytosis
    Yoshinori Ito
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 60:326-8. 2013
    ..EBV genes EBNA1, LMP1, LMP2, EBER1, BARTs were detected, suggesting a latency type II gene expression pattern in this case...
  55. doi Increased levels of cytokines and high-mobility group box 1 are associated with the development of severe pneumonia, but not acute encephalopathy, in 2009 H1N1 influenza-infected children
    Yoshinori Ito
    Department of Pediatrics, Nagoya University, Graduate School of Medicine, and Nagoya Ekisaikai Hospital, Nagoya, Japan
    Cytokine 56:180-7. 2011
    ..The 2009 A(H1N1) influenza virus has caused a large outbreak, and resulted in major complications of severe pneumonia and acute encephalopathy in the pediatric population in Japan...
  56. doi Effectiveness and safety of inactivated influenza vaccination in pediatric liver transplant recipients over three influenza seasons
    Kensei Gotoh
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Pediatr Transplant 15:112-6. 2011
    ..These findings suggest that pediatric liver transplant patients may respond safely to inactivated seasonal influenza vaccines in a similar manner to healthy children, and effectiveness varies among influenza seasons...
  57. ncbi Genotype announcement to Japanese smokers who attended a health checkup examination
    Nobuyuki Hamajima
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    J Epidemiol 16:45-7. 2006
    ..Genotype announcement may be one of the effective methods to induce smoking cessation, but the studies are limited throughout the world...
  58. doi Gene expression profiling reveals upregulated UCA1 and BMF in gallbladder epithelia of children with pancreaticobiliary maljunction
    Kenitiro Kaneko
    Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Pediatr Gastroenterol Nutr 52:744-50. 2011
    ..No study has analyzed overall changes in genetic expression beginning during childhood in gallbladder epithelia with pancreaticobiliary maljunction...
  59. ncbi Profile of the JACC study
    Akiko Tamakoshi
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Epidemiol 15:S4-8. 2005
    ..A large-scale population-based cohort study would offer the best evidence of a relation between lifestyle and cancer...
  60. ncbi Association between decreased kidney function and endotoxin receptor CD14 C-159T polymorphism among Japanese health check-up examinees
    Rieko Okada
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Ren Fail 29:967-72. 2007
    ..This study was conducted to determine whether this polymorphism is associated with decreased kidney function...
  61. doi CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya, Aichi 466 8650, Japan
    Int J Hematol 93:779-81. 2011
    ..Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD...
  62. ncbi Possible interactions of the endothelial constitutive nitric oxide synthase genotype with alcohol drinking and walking time for high serum uric acid levels among Japanese
    Kazuko Nishio
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Metabolism 54:1302-8. 2005
    ..These findings would be informative for men with high SUA levels...
  63. ncbi Associations between serum C-reactive protein (CRP) levels and polymorphisms of CRP, interleukin 1B, and tumor necrosis factor genes among Japanese health checkup examinees
    Masato Kikuchi
    Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Asian Pac J Cancer Prev 8:87-92. 2007
    ..Since the biological mechanism is not clear, further investigations are required to confirm the association...
  64. pmc Association of abdominal circumference with serum nitric oxide concentration in healthy population
    Takaaki Kondo
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 20 Daikominami I chome, Higashi ku, 461 8673, Nagoya, Japan
    Environ Health Prev Med 11:321-5. 2006
    ..We determined the relationship between abdominal circumference and the concentration of nitric oxide (NO), an endothelial cell product known to play an important role in the regulation of vascular tone and thrombocyte activations...
  65. doi Kinetics of Epstein-Barr virus load and virus-specific CD8+ T cells in acute infectious mononucleosis
    Yo Hoshino
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan
    J Clin Virol 50:244-6. 2011
    ..The actual contribution of EBV-specific CD8(+) T cells in reducing EBV load, however, is not known...
  66. ncbi High prevalence of HER-2/neu and p53 overexpression in inflammatory breast cancer
    Masataka Sawaki
    Department of Medical Oncology, Cancer Institute Hospital and Cancer Chemotherapy Center, Japanese Foundation for Cancer Research
    Breast Cancer 13:172-8. 2006
    ..We have summarized a single-center experience involving IBC patients. Our objectives are to clarify molecular alterations of HER-2/neu and p53 in IBC and to investigate the prognostic factors...
  67. ncbi Rapid detection of herpes simplex virus DNA in cerebrospinal fluid: comparison between loop-mediated isothermal amplification and real-time PCR
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Med Microbiol Immunol 194:181-5. 2005
    ..Although further improvement is necessary for the wide spread use, the LAMP method might be applicable to diagnosis of HSV infection of the central nervous system...
  68. doi Multicenter evaluation of prototype real-time PCR assays for Epstein-Barr virus and cytomegalovirus DNA in whole blood samples from transplant recipients
    Yoshinori Ito
    Pediatrics Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Microbiol Immunol 54:516-22. 2010
    ..Such standardization will help to standardize the diagnosis and monitoring of diseases associated with EBV and CMV...
  69. ncbi Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2
    Hiroshi Kimura
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Med Virol 67:349-53. 2002
    ..These results suggest that quantitation of HSV viral load may be useful for assessing the prognosis, and may provide additional information for the management of neonatal HSV infection...
  70. doi Clinical characteristics of norovirus gastroenteritis among hospitalized children in Japan
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Microbiol Immunol 56:756-9. 2012
    ..Norovirus was detected as frequently as rotavirus in hospitalized pediatric gastroenteritis patients. Our results suggest that norovirus gastroenteritis among hospitalized young children is not less severe than rotavirus gastroenteritis...
  71. ncbi Unrelated bone marrow transplantation induced long-term remission in a patient with life-threatening Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis
    Akane Kunitomi
    Department of Hematology, Meitetsu Hospital, Nagoya, Japan
    J Clin Exp Hematop 51:57-61. 2011
    ..Although there is no consensus regarding allogeneic stem cell transplantation for EBV-HLH, it is the treatment of choice for aggressive EBV-HLH when the patient is refractory to intensive chemotherapy...
  72. doi Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza
    Rieko Ohta
    Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Microbiol Immunol 55:191-8. 2011
    ....
  73. ncbi A prospective study on the possible association between having children and colon cancer risk: findings from the JACC Study
    Koji Tamakoshi
    Department of Public Health Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Sci 95:243-7. 2004
    ..From these prospective data, having children may reduce risk of colon cancer among women, but not among men, suggesting that modifications of hormone profiles secondary to pregnancies may influence female colon cancer risk...
  74. ncbi Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 190:494-8. 2004
    ..It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection...
  75. ncbi Comparison of real-time and nested PCR assays for detection of herpes simplex virus DNA
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
    Microbiol Immunol 48:411-5. 2004
    ..Quantification of HSV DNA by real-time PCR was useful for diagnosing and monitoring patients with HSV encephalitis and neonatal HSV infection...
  76. pmc Replication of Epstein-Barr virus primary infection in human tonsil tissue explants
    Kensei Gotoh
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 6:e25490. 2011
    ..These data suggest that this model has potential for use in the pathological analysis of local tissues at the time of primary infection, as well as for screening novel antiviral agents...
  77. pmc Association of serum NO( x ) level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan
    Jun Ueyama
    Program in Radiological and Medical Laboratory Science, Nagoya University Graduate School of Medicine, 1 1 20 Daikominami, Higashi ku, Nagoya, 461 8673, Japan
    Environ Health Prev Med 13:36-42. 2008
    ..The aim of this study was to determine whether the serum nitrite plus nitrate (NO( x )) level correlates with biomarkers that are known components of the metabolic syndrome (MetS)...
  78. pmc Simultaneous quantification of Epstein-Barr virus, cytomegalovirus, and human herpesvirus 6 DNA in samples from transplant recipients by multiplex real-time PCR assay
    Kaoru Wada
    Department of Virology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Clin Microbiol 45:1426-32. 2007
    ..These results demonstrate that whole blood is more suitable for the quantification of EBV DNA in transplant patients. However, a cutoff value with clinical relevance still needs to be determined...
  79. ncbi Systemic cytokine responses in patients with influenza-associated encephalopathy
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Dis 188:690-8. 2003
    ..These results suggest that influenza-associated encephalopathy might be a consequence of systemic immune responses...
  80. ncbi Interferon-gamma differentially regulates susceptibility of lung cancer cells to telomerase-specific cytotoxic T lymphocytes
    Kouhei Tajima
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 110:403-12. 2004
    ....
  81. ncbi Serum insulin-like growth factors, insulin-like growth factor-binding protein-3, and risk of lung cancer death: a case-control study nested in the Japan Collaborative Cohort (JACC) Study
    Kenji Wakai
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Cancer Res 93:1279-86. 2002
    ..A higher level of circulating IGFBP-3 and / or IGF-II may decrease lung cancer risk. Elevated serum IGF-I may increase the risk, but this could partly be attributable to latent tumors...
  82. ncbi Relationship between serum carotenoids and hyperglycemia: a population-based cross-sectional study
    Koji Suzuki
    Department of Public Health, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    J Epidemiol 12:357-66. 2002
    ..22-0.65), 0.35 (0.21-0.59), 0.57 (0.35-0.93), 0.35 (0.20-0.59), and 0.88 (0.54-1.46) for high HbA1c, respectively. In conclusion, intake of vegetables and fruits rich in carotenoids might be a protective factor against hyperglycemia...
  83. ncbi Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study
    Koji Suzuki
    Department of Public Health, Fujita Health University School of Health Sciences, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Cancer Epidemiol Biomarkers Prev 13:1781-7. 2004
    ..045). Analyses restricted to colon cancer cases and corresponding controls yielded similar relationships between serum oxLDL and oLAB levels and risk. In conclusion, higher levels of serum oxLDL may increase risk of colorectal cancer...
  84. ncbi Serum antioxidants and subsequent mortality rates of all causes or cancer among rural Japanese inhabitants
    Yoshinori Ito
    Department of Public Health, Fujita Health University School of Health Sciences, Toyoake, Japan
    Int J Vitam Nutr Res 72:237-50. 2002
    ..However, high serum levels of tocopherols and retinol did not demonstrate clear associations with either low mortality rates from all causes or cancer of all sites...
  85. ncbi Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) study
    Yoshinori Ito
    Department of Public Health, Fujita Health University School of Health Sciences, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192
    Cancer Sci 94:57-63. 2003
    ..the lowest quartile was 0.39 (95% CI, 0.19-0.79). Higher serum levels of carotenoids such as alpha- and beta-carotenes may play a role in preventing death from lung cancer among Japanese...
  86. ncbi Dietary habits and risk of urothelial cancer death in a large-scale cohort study (JACC Study) in Japan
    Fumio Sakauchi
    Department of Public Health, Sapporo Medical University School of Medicine, Japan
    Nutr Cancer 50:33-9. 2004
    ..It was suggested that urothelial cancer death could be potentially preventable by smoking cessation and regular intake of milk and fruit...
  87. ncbi Smoking and colorectal cancer in a non-Western population: a prospective cohort study in Japan
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    J Epidemiol 13:323-32. 2003
    ..The risk of colorectal cancer in relation to smoking habits has been examined mostly in Caucasians, and evidence for other ethnic groups is still scarce...
  88. ncbi Improvement in the prognosis of Japanese breast cancer patients from 1946 to 2001--an institutional review
    Masataka Yoshimoto
    Department of Breast Surgery, Cancer Institute Hospital, Kami Ikebukuro 1 37 1, Toshima ku, Tokyo 170 8455, Japan
    Jpn J Clin Oncol 34:457-62. 2004
    ..Breast cancer has emerged as one of the most frequent malignancies among Japanese women; however, the long-term survival of Japanese breast cancer patients is uncertain...
  89. ncbi Absence of associations between influenza-associated encephalopathy and human herpesvirus 6 or human herpesvirus 7
    Jun ichi Kawada
    Department of Pediatrics, Nagoya University School of Medicine, Japan
    Pediatr Infect Dis J 22:115-9. 2003
    ..AIM To confirm or refute the association between influenza-associated encephalopathy and HHV-6 or HHV-7...
  90. ncbi The relationship between smoking habits and serum levels of 8-OHdG, oxidized LDL antibodies, Mn-SOD and carotenoids in rural Japanese residents
    Koji Suzuki
    Department of Public Health, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    J Epidemiol 13:29-37. 2003
    ..Serum levels of 8-OHdG, oLAB, and carotenoids may be useful biomarkers of oxidative conditions affected by smoking...
  91. ncbi Efficacy and safety of trastuzumab as a single agent in heavily pretreated patients with HER-2/neu-overexpressing metastatic breast cancer
    Masataka Sawaki
    Department of Medical Oncology, Cancer Institute Hospital and Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan
    Tumori 90:40-3. 2004
    ..It became available in Japan in June 2001. This study focuses on the efficacy and safety of trastuzumab as a single agent in second-third line treatment of HER2/neu-overexpressing metastatic breast cancer...
  92. ncbi Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    J Clin Oncol 26:3727-34. 2008
    ..A large and systematic study is needed to address these important issues...
  93. ncbi Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men
    Kotaro Ozasa
    Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kamigyo ku, Kyoto 602 8566, Japan
    Cancer Sci 95:65-71. 2004
    ..39, 95% CI; 0.13, 0.89, trend P = 0.02 for the first dataset). Their effects seemed to be independent of serum sex hormones. In conclusion, serum genistein, daidzein, and equol seemed to dose-dependently reduce prostate cancer risk...
  94. ncbi Relationship between obesity and serum markers of oxidative stress and inflammation in Japanese
    Koji Suzuki
    Department of Public Health, Fujita Health University School of Health Sciences, Toyoake, Aichi 470 1192, Japan
    Asian Pac J Cancer Prev 4:259-66. 2003
    ....
  95. ncbi Perceived psychologic stress and colorectal cancer mortality: findings from the Japan Collaborative Cohort Study
    Masayo Kojima
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Psychosom Med 67:72-7. 2005
    ..The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study...
  96. ncbi Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: effect modification by sex for carotenoids
    Kenji Wakai
    Division of Epidemiology and Prevention, Aichi Cancer Center Institute, Nagoya 464 8681, Japan
    Nutr Cancer 51:13-24. 2005
    ..010) and 0.29 (0.07-1.17; trend P = 0.098), respectively. The effects of some carotenoids on colorectal cancer risk may be modified by sex or by factors associated with sex, including smoking and drinking habits...
  97. ncbi Efficacy and safety of trastuzumab plus capecitabine in heavily pretreated patients with HER2-positive metastatic breast cancer
    Tomo Osako
    Department of Medical Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 10 6, Ariake, Koto ku, Tokyo 135 8550, Japan
    Cancer Chemother Pharmacol 62:159-64. 2008
    ..We retrospectively evaluated the efficacy and safety of combination therapy of trastuzumab plus capecitabine in heavily pretreated patients with HER2-positive metastatic breast cancer (MBC)...
  98. ncbi Association of abdominal obesity with decreased serum levels of carotenoids in a healthy Japanese population
    Koji Suzuki
    Department of Public Health, School of Health Sciences, Fujita Health University, 1 98 Dengakugakubo Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Clin Nutr 25:780-9. 2006
    ..Few epidemiological studies have investigated the relationship between abdominal adiposity and serum levels of carotenoids. This study investigated the relationship between total and abdominal obesity and serum levels of carotenoids...
  99. ncbi Alcohol consumption and lung cancer mortality in Japanese men: results from Japan collaborative cohort (JACC) study
    Yoshikazu Nishino
    Division of Epidemiology, Miyagi Cancer Center Research Institute, Japan
    J Epidemiol 16:49-56. 2006
    ..The relationship between alcohol consumption and increased risk of lung cancer is controversial. This study was set up to investigate the association between alcohol consumption and death from lung cancer in a large Japanese cohort...
  100. ncbi Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study
    Tatsuhiko Kubo
    Department of Clinical Epidemiology, University of Occupational and Environmental Health, Kitakyushu, Japan
    Am J Epidemiol 164:549-55. 2006
    ..2, 7.7), whereas fixed-night work was associated with a small and nonsignificant increase in risk. This report is the first known to reveal a significant relation between rotating-shift work and prostate cancer...
  101. ncbi Effectiveness of cervical cancer screening over cervical cancer mortality among Japanese women
    Khandoker Aklimunnessa
    Department of Public Health, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Jpn J Clin Oncol 36:511-8. 2006
    ..Therefore, the present study evaluated the association of CC mortality with self-reported CC screening and some other factors by a nationwide cohort study...