Kazuhiro Ishiguro

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. doi request reprint Novel mouse model of colitis characterized by hapten-protein visualization
    Kazuhiro Ishiguro
    Department of Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biotechniques 49:641-8. 2010
  2. ncbi request reprint Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, Japan
    Toxicol Appl Pharmacol 217:35-42. 2006
  3. ncbi request reprint Acetate inhibits NFAT activation in T cells via importin beta1 interference
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, School of Medicine, Nagoya University, Nagoya, Japan
    Eur J Immunol 37:2309-16. 2007
  4. ncbi request reprint Dehydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages
    Kazuhiro Ishiguro
    Department of Advanced Research of Gastroenterology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Int Immunopharmacol 11:1362-7. 2011
  5. ncbi request reprint Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Biochem Biophys Res Commun 362:218-23. 2007
  6. ncbi request reprint Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Mol Immunol 44:2095-100. 2007
  7. doi request reprint Specific reaction of alpha,beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    FEBS Lett 582:3531-6. 2008
  8. doi request reprint Novel application of 4-nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole to visualize lysosomes in live cells
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Biotechniques 45:465, 467-8. 2008
  9. pmc Novel application of low pH-dependent fluorescent dyes to examine colitis
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    BMC Gastroenterol 10:4. 2010
  10. doi request reprint Confocal endomicroscopy in patients with ulcerative colitis
    Osamu Watanabe
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Gastroenterol Hepatol 23:S286-90. 2008

Collaborators

Detail Information

Publications40

  1. doi request reprint Novel mouse model of colitis characterized by hapten-protein visualization
    Kazuhiro Ishiguro
    Department of Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biotechniques 49:641-8. 2010
    ....
  2. ncbi request reprint Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, Japan
    Toxicol Appl Pharmacol 217:35-42. 2006
    ..These findings suggest that Paeonol enema may be useful for the treatment of colitis...
  3. ncbi request reprint Acetate inhibits NFAT activation in T cells via importin beta1 interference
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, School of Medicine, Nagoya University, Nagoya, Japan
    Eur J Immunol 37:2309-16. 2007
    ..These findings indicate for the first time that acetate inhibits NFAT activation by interfering with the interaction between NFAT and importin beta1 in T cells and that acetate can potentially act as an anti-inflammatory agent...
  4. ncbi request reprint Dehydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophages
    Kazuhiro Ishiguro
    Department of Advanced Research of Gastroenterology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Int Immunopharmacol 11:1362-7. 2011
    ..Mode of dehydrocorydaline action indicates that elevated mitochondrial membrane potential may be a novel target to specifically reduce viability and suppress cytokine production in LPS-stimulated macrophages...
  5. ncbi request reprint Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Biochem Biophys Res Commun 362:218-23. 2007
    ....
  6. ncbi request reprint Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Mol Immunol 44:2095-100. 2007
    ..These findings suggest that CaMKII modulates NF-kappaB activation via phosphorylating Bcl10 as well as Carma1...
  7. doi request reprint Specific reaction of alpha,beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    FEBS Lett 582:3531-6. 2008
    ..In addition, alpha,beta-unsaturated carbonyl compounds are more reactive with sulfhydryl groups in tubulin than in 2-mercaptoethanol, dithiothreitol, glutathione and papain, a cysteine protease...
  8. doi request reprint Novel application of 4-nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole to visualize lysosomes in live cells
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Biotechniques 45:465, 467-8. 2008
    ..These findings indicate a novel application of NBD-PZ to visualize lysosomes in live cells, a strategy that offers substantial cost savings over commercially available lysosomal probes...
  9. pmc Novel application of low pH-dependent fluorescent dyes to examine colitis
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    BMC Gastroenterol 10:4. 2010
    ..We explored the novel application of low pH-dependent fluorescent dyes for fluorescence observation of crypt structure and inflammatory cell infiltration in the colon...
  10. doi request reprint Confocal endomicroscopy in patients with ulcerative colitis
    Osamu Watanabe
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Gastroenterol Hepatol 23:S286-90. 2008
    ..We examined patients with ulcerative colitis (UC) using confocal endoscopy and investigated the features of confocal endomicroscopic images of inflamed and non-inflamed rectal mucosa...
  11. doi request reprint Relationships between Helicobacter pylori infection status, endoscopic, histopathological findings, and cytokine production in the duodenum of Crohn's disease patients
    Takafumi Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Gastroenterol Hepatol 23:S193-7. 2008
    ..We examined Helicobacter pylori infection status, endoscopic and histopathological findings, and cytokine production in the duodenum of CD patients in comparison with controls...
  12. ncbi request reprint Dipeptidyl peptidase-4 inhibitor anagliptin facilitates restoration of dextran sulfate sodium-induced colitis
    Shunya Mimura
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Scand J Gastroenterol 48:1152-9. 2013
    ..These findings suggest a new and novel therapeutic approach for the treatment of IBD...
  13. doi request reprint Potential role for matrix metalloproteinase-3 in gastric ulcer healing
    Makoto Tomita
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Digestion 79:23-9. 2009
    ..Here, we compared MMP-3 levels with those of tissue inhibitor of metalloproteinases (TIMP)-1 and several inflammatory cytokines in gastric ulcer (GU) patients...
  14. pmc Helicobacter pylori infection upregulates interleukin-18 production from gastric epithelial cells
    Masaaki Shimada
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya Memorial Hospital, Showa Ku, Nagoya, Japan
    Eur J Gastroenterol Hepatol 20:1144-50. 2008
    ..Helicobacter pylori infection induces a biased T helper type 1 (Th1) response that produces IFN-gamma and Fas ligand (FasL). Th1 cytokines are associated with apoptosis in the gastric epithelial cells...
  15. pmc Value of colonoscopy for prediction of prognosis in patients with ulcerative colitis
    Takafumi Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya 4668550, Japan
    World J Gastroenterol 14:2133-8. 2008
    ..Magnifying colonoscopy is useful for the evaluation of disease activity and for predicting relapse in patients with UC...
  16. doi request reprint Restriction-modification systems may be associated with Helicobacter pylori virulence
    Takafumi Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 25:S95-8. 2010
    ..pylori pathogenicity. Further study should investigate the roles of H. pylori R-M systems...
  17. pmc Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis
    Daisuke Ishikawa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Gastroenterol 11:29. 2011
    ..We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity...
  18. ncbi request reprint Relationship between nutritional therapy and surgery in Crohn's disease
    Hironao Takahashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hepatogastroenterology 56:1044-8. 2009
    ..We evaluated the relationship between an elemental diet and the period that patients spent without intestinal resection...
  19. ncbi request reprint A case of cytomegalovirus enterocolitis diagnosed by the double-balloon enteroscopy
    Takayoshi Fujita
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hepatogastroenterology 55:2087-90. 2008
    ..We herein report the effectiveness of transrectal double-balloon enteroscopy for the diagnosis of cytomegalo-virus enterocolitis...
  20. doi request reprint Enteral nutrition decreases hospitalization rate in patients with Crohn's disease
    Osamu Watanabe
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 25:S134-7. 2010
    ..We investigated the effectiveness of EN with an elemental diet with regard to the avoidance of hospitalization...
  21. ncbi request reprint Clinicopathological study of colorectal cancer occurring in patients with ulcerative colitis: results from a single hospital in Japan
    Takayoshi Fujita
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hepatogastroenterology 57:487-92. 2010
    ..The aim of this study was to identify the clinicopathological features of ulcerative colitis-related CRC in a consecutive series of patients at a single hospital in central Japan...
  22. ncbi request reprint Magnifying chromoscopy, a novel and useful technique for colonoscopy in ulcerative colitis
    Takafumi Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    World J Gastroenterol 13:2523-8. 2007
    ..A relatively new method, magnifying chromoscopy, is thought to be useful for the early detection and diagnosis of dysplasia and colitic cancer, as well as the prediction of relapse...
  23. doi request reprint Cutting edge: tubulin α functions as an adaptor in NFAT-importin β interaction
    Kazuhiro Ishiguro
    Department of Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Immunol 186:2710-3. 2011
    ..In conclusion, tubulin α functions as an adaptor in NFAT-importin β interaction, and this function is regulated by acetate-induced acetylation...
  24. ncbi request reprint Immunological status of the stomach in inflammatory bowel disease--comparison between ulcerative colitis and Crohn's disease
    Takafumi Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Digestion 77:145-9. 2008
    ..Recently, however, upper gastrointestinal lesions have been reported in UC patients. In this study, we investigated the immunological status of the stomach in UC or CD patients...
  25. pmc Characterization of bacterial biota in the distal esophagus of Japanese patients with reflux esophagitis and Barrett's esophagus
    Ning Liu
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    BMC Infect Dis 13:130. 2013
    ..Here, we investigated bacterial composition in the distal esophagus in subjects with a normal esophagus, reflux esophagitis, and Barrett's esophagus...
  26. doi request reprint Intestinal cancers occurring in patients with Crohn's disease
    Toru Kamiya
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 27:103-7. 2012
    ..The aim of this study was to identify the clinical picture of CD-associated intestinal cancer in a consecutive series of patients with CD and to stress the importance of surveillance...
  27. ncbi request reprint Rebamipide enema therapy as a treatment for patients with active distal ulcerative colitis
    Ryuichi Furuta
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 22:261-7. 2007
    ..The aim of the present study was to assess the clinical efficacy and safety of a novel Rebamipide enema therapy in UC patients...
  28. doi request reprint Alteration of gene expression and DNA methylation in drug-resistant gastric cancer
    Osamu Maeda
    Department of Advanced Research of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Oncol Rep 31:1883-90. 2014
    ..There are alterations of gene expression and DNA methylation in drug-resistant gastric cancer; they may be related to mechanisms of drug resistance and may be useful as biomarkers of gastric cancer drug sensitivity...
  29. pmc Importance of appropriate pharmaceutical management in pregnant women with ulcerative colitis
    Masaki Ujihara
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    BMC Res Notes 6:210. 2013
    ..Ulcerative colitis (UC) often occurs in women of childbearing age. Compared to Western countries, however, few studies have investigated the impact of UC on the progress of pregnancy in Asian populations...
  30. ncbi request reprint Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein induction
    Motofusa Hasegawa
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nagoya J Med Sci 74:123-31. 2012
    ..In conclusion, GGA attenuates viability reductions and caspase-3 activation in CDDP-treated cells by suppressing the elevation of intracellular p53 content without HSP induction...
  31. doi request reprint Suppressive action of acetate on interleukin-8 production via tubulin-α acetylation
    Kazuhiro Ishiguro
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan
    Immunol Cell Biol . 2014
    ..These findings reveal a novel action of acetate via tubulin-α acetylation in epithelial cells of the colonic mucosa.Immunology and Cell Biology advance online publication, 29 April 2014; doi:10.1038/icb.2014.31...
  32. ncbi request reprint Syndecan-4 as a molecule involved in defense mechanisms
    Kazuhiro Ishiguro
    Department of Biochemistry and Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Glycoconj J 19:315-8. 2002
    ..Therefore, augmentation of TGF-beta function by induced syndecan-4 was suggested as a mechanism of the suppressive action of syndecan-4 against endotoxin shock...
  33. ncbi request reprint Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese population
    Takafumi Ando
    Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Helicobacter 10:379-84. 2005
    ..The long-term benefit of Helicobacter pylori eradication treatment that includes metronidazole on peptic ulcer disease in Japan is unclear. We investigated the rate of H. pylori re-infection and ulcer relapse after H. pylori eradication...
  34. ncbi request reprint Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice
    Masamitsu Yanada
    First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Blood 99:2455-8. 2002
    ..The AT+/- mouse thus is a useful model for studying the effect of environmental or genetic risk factors on thrombogenesis...
  35. pmc Nore1B regulates TCR signaling via Ras and Carma1
    Kazuhiro Ishiguro
    Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Cell Signal 18:1647-54. 2006
    ..Together, these findings suggest that endogenous Nore1B recruits active Ras to the APC-T cell interface and mediates the interaction between Ras and Carma1...
  36. ncbi request reprint The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death
    Shahrooz Rabizadeh
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 279:29247-54. 2004
    ..Thus, in addition to its positive role in the proliferative outputs of active Ras, the CNK1 scaffold protein, through its binding of a RASSF1A.MST complex, also participates in the proapoptotic signaling initiated by active Ras...
  37. pmc Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation
    Kazuhiro Ishiguro
    Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell Biol 26:5497-508. 2006
    ..These results provide a novel function for CaMKII in TCR signaling and CARMA1-induced NF-kappaB activation...
  38. pmc Discs large (Dlg1) complexes in lymphocyte activation
    Ramnik Xavier
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Cell Biol 166:173-8. 2004
    ..Attenuation of antigen receptor signaling appears to be a complex, highly orchestrated event that involves the mutual segregation of important elements of the early signaling complex...
  39. ncbi request reprint Causal role of Helicobacter pylori infection in gastric cancer
    Takafumi Ando
    World J Gastroenterol 12:181-6. 2006
    ..The seminal discovery of H pylori as the leading cause of gastric cancer should lead to effective eradication strategies. Prevention of gastric cancer requires better screening strategies to identify candidates for eradication...
  40. ncbi request reprint Homer-3 regulates activation of serum response element in T cells via its EVH1 domain
    Kazuhiro Ishiguro
    Department of Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA
    Blood 103:2248-56. 2004
    ..These findings suggest that Homer-3 may be involved in the regulation of SRE activation in T cells via interaction between its EVH1 domain and C/EBP beta...