Research Topics
Genomes and Genes | Kazuhiro IshiguroSummaryAffiliation: Nagoya University Country: Japan Publications
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Publications
Novel mouse model of colitis characterized by hapten-protein visualizationKazuhiro Ishiguro
Department of Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Biotechniques 49:641-8. 2010....- Novel application of 4-nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole to visualize lysosomes in live cellsKazuhiro Ishiguro
Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Biotechniques 45:465, 467-8. 2008..These findings indicate a novel application of NBD-PZ to visualize lysosomes in live cells, a strategy that offers substantial cost savings over commercially available lysosomal probes... 
Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivationKazuhiro Ishiguro
Molecular Biology and Pathogenesis of Gastroenterology, School of Medicine, Nagoya University, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, Japan
Toxicol Appl Pharmacol 217:35-42. 2006..These findings suggest that Paeonol enema may be useful for the treatment of colitis...
Novel application of low pH-dependent fluorescent dyes to examine colitisKazuhiro Ishiguro
Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
BMC Gastroenterol 10:4. 2010..We explored the novel application of low pH-dependent fluorescent dyes for fluorescence observation of crypt structure and inflammatory cell infiltration in the colon...- Acetate inhibits NFAT activation in T cells via importin beta1 interferenceKazuhiro Ishiguro
Molecular Biology and Pathogenesis of Gastroenterology, School of Medicine, Nagoya University, Nagoya, Japan
Eur J Immunol 37:2309-16. 2007..These findings indicate for the first time that acetate inhibits NFAT activation by interfering with the interaction between NFAT and importin beta1 in T cells and that acetate can potentially act as an anti-inflammatory agent... - Ginger ingredients reduce viability of gastric cancer cells via distinct mechanismsKazuhiro Ishiguro
Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Biochem Biophys Res Commun 362:218-23. 2007.... - Specific reaction of alpha,beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damageKazuhiro Ishiguro
Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
FEBS Lett 582:3531-6. 2008..In addition, alpha,beta-unsaturated carbonyl compounds are more reactive with sulfhydryl groups in tubulin than in 2-mercaptoethanol, dithiothreitol, glutathione and papain, a cysteine protease... - Dehydrocorydaline inhibits elevated mitochondrial membrane potential in lipopolysaccharide-stimulated macrophagesKazuhiro Ishiguro
Department of Advanced Research of Gastroenterology, Nagoya University Graduate School of Medicine, Tsurumai cho 65, Showa Ku, Nagoya, Aichi, 466 8550, Japan
Int Immunopharmacol 11:1362-7. 2011..Mode of dehydrocorydaline action indicates that elevated mitochondrial membrane potential may be a novel target to specifically reduce viability and suppress cytokine production in LPS-stimulated macrophages... - Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase IIKazuhiro Ishiguro
Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Mol Immunol 44:2095-100. 2007..These findings suggest that CaMKII modulates NF-kappaB activation via phosphorylating Bcl10 as well as Carma1... - Confocal endomicroscopy in patients with ulcerative colitisOsamu Watanabe
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
J Gastroenterol Hepatol 23:S286-90. 2008..We examined patients with ulcerative colitis (UC) using confocal endoscopy and investigated the features of confocal endomicroscopic images of inflamed and non-inflamed rectal mucosa... - Relationships between Helicobacter pylori infection status, endoscopic, histopathological findings, and cytokine production in the duodenum of Crohn's disease patientsTakafumi Ando
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
J Gastroenterol Hepatol 23:S193-7. 2008..We examined Helicobacter pylori infection status, endoscopic and histopathological findings, and cytokine production in the duodenum of CD patients in comparison with controls... - Potential role for matrix metalloproteinase-3 in gastric ulcer healingMakoto Tomita
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
Digestion 79:23-9. 2009..Here, we compared MMP-3 levels with those of tissue inhibitor of metalloproteinases (TIMP)-1 and several inflammatory cytokines in gastric ulcer (GU) patients... - Helicobacter pylori infection upregulates interleukin-18 production from gastric epithelial cellsMasaaki Shimada
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya Memorial Hospital, Showa Ku, Nagoya, Japan
Eur J Gastroenterol Hepatol 20:1144-50. 2008..Helicobacter pylori infection induces a biased T helper type 1 (Th1) response that produces IFN-gamma and Fas ligand (FasL). Th1 cytokines are associated with apoptosis in the gastric epithelial cells... - Restriction-modification systems may be associated with Helicobacter pylori virulenceTakafumi Ando
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Gastroenterol Hepatol 25:S95-8. 2010..pylori pathogenicity. Further study should investigate the roles of H. pylori R-M systems... - Value of colonoscopy for prediction of prognosis in patients with ulcerative colitisTakafumi Ando
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya 4668550, Japan
World J Gastroenterol 14:2133-8. 2008..Magnifying colonoscopy is useful for the evaluation of disease activity and for predicting relapse in patients with UC... - Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitisDaisuke Ishikawa
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
BMC Gastroenterol 11:29. 2011..We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity... - Relationship between nutritional therapy and surgery in Crohn's diseaseHironao Takahashi
Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
Hepatogastroenterology 56:1044-8. 2009..We evaluated the relationship between an elemental diet and the period that patients spent without intestinal resection... - Enteral nutrition decreases hospitalization rate in patients with Crohn's diseaseOsamu Watanabe
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Gastroenterol Hepatol 25:S134-7. 2010..We investigated the effectiveness of EN with an elemental diet with regard to the avoidance of hospitalization... - A case of cytomegalovirus enterocolitis diagnosed by the double-balloon enteroscopyTakayoshi Fujita
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Hepatogastroenterology 55:2087-90. 2008..We herein report the effectiveness of transrectal double-balloon enteroscopy for the diagnosis of cytomegalo-virus enterocolitis... - Clinicopathological study of colorectal cancer occurring in patients with ulcerative colitis: results from a single hospital in JapanTakayoshi Fujita
Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
Hepatogastroenterology 57:487-92. 2010..The aim of this study was to identify the clinicopathological features of ulcerative colitis-related CRC in a consecutive series of patients at a single hospital in central Japan... - Magnifying chromoscopy, a novel and useful technique for colonoscopy in ulcerative colitisTakafumi Ando
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
World J Gastroenterol 13:2523-8. 2007..A relatively new method, magnifying chromoscopy, is thought to be useful for the early detection and diagnosis of dysplasia and colitic cancer, as well as the prediction of relapse... - Cutting edge: tubulin α functions as an adaptor in NFAT-importin β interactionKazuhiro Ishiguro
Department of Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
J Immunol 186:2710-3. 2011..In conclusion, tubulin α functions as an adaptor in NFAT-importin β interaction, and this function is regulated by acetate-induced acetylation... - Immunological status of the stomach in inflammatory bowel disease--comparison between ulcerative colitis and Crohn's diseaseTakafumi Ando
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Digestion 77:145-9. 2008..Recently, however, upper gastrointestinal lesions have been reported in UC patients. In this study, we investigated the immunological status of the stomach in UC or CD patients... - Characterization of bacterial biota in the distal esophagus of Japanese patients with reflux esophagitis and Barrett's esophagusNing Liu
Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
BMC Infect Dis 13:130. 2013..Here, we investigated bacterial composition in the distal esophagus in subjects with a normal esophagus, reflux esophagitis, and Barrett's esophagus... - Intestinal cancers occurring in patients with Crohn's diseaseToru Kamiya
Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Gastroenterol Hepatol 27:103-7. 2012..The aim of this study was to identify the clinical picture of CD-associated intestinal cancer in a consecutive series of patients with CD and to stress the importance of surveillance... - Rebamipide enema therapy as a treatment for patients with active distal ulcerative colitisRyuichi Furuta
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Gastroenterol Hepatol 22:261-7. 2007..The aim of the present study was to assess the clinical efficacy and safety of a novel Rebamipide enema therapy in UC patients... - Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein inductionMotofusa Hasegawa
Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Nagoya J Med Sci 74:123-31. 2012..In conclusion, GGA attenuates viability reductions and caspase-3 activation in CDDP-treated cells by suppressing the elevation of intracellular p53 content without HSP induction... - Syndecan-4 as a molecule involved in defense mechanismsKazuhiro Ishiguro
Department of Biochemistry and Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Glycoconj J 19:315-8. 2002..Therefore, augmentation of TGF-beta function by induced syndecan-4 was suggested as a mechanism of the suppressive action of syndecan-4 against endotoxin shock... - Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese populationTakafumi Ando
Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
Helicobacter 10:379-84. 2005..The long-term benefit of Helicobacter pylori eradication treatment that includes metronidazole on peptic ulcer disease in Japan is unclear. We investigated the rate of H. pylori re-infection and ulcer relapse after H. pylori eradication... - Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient miceMasamitsu Yanada
First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
Blood 99:2455-8. 2002..The AT+/- mouse thus is a useful model for studying the effect of environmental or genetic risk factors on thrombogenesis... - The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell deathShahrooz Rabizadeh
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biol Chem 279:29247-54. 2004..Thus, in addition to its positive role in the proliferative outputs of active Ras, the CNK1 scaffold protein, through its binding of a RASSF1A.MST complex, also participates in the proapoptotic signaling initiated by active Ras... - Nore1B regulates TCR signaling via Ras and Carma1Kazuhiro Ishiguro
Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Cell Signal 18:1647-54. 2006..Together, these findings suggest that endogenous Nore1B recruits active Ras to the APC-T cell interface and mediates the interaction between Ras and Carma1... - Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activationKazuhiro Ishiguro
Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Cell Biol 26:5497-508. 2006..These results provide a novel function for CaMKII in TCR signaling and CARMA1-induced NF-kappaB activation... - Discs large (Dlg1) complexes in lymphocyte activationRamnik Xavier
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
J Cell Biol 166:173-8. 2004..Attenuation of antigen receptor signaling appears to be a complex, highly orchestrated event that involves the mutual segregation of important elements of the early signaling complex... - Homer-3 regulates activation of serum response element in T cells via its EVH1 domainKazuhiro Ishiguro
Department of Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA
Blood 103:2248-56. 2004..These findings suggest that Homer-3 may be involved in the regulation of SRE activation in T cells via interaction between its EVH1 domain and C/EBP beta... - Causal role of Helicobacter pylori infection in gastric cancerTakafumi Ando
World J Gastroenterol 12:181-6. 2006..The seminal discovery of H pylori as the leading cause of gastric cancer should lead to effective eradication strategies. Prevention of gastric cancer requires better screening strategies to identify candidates for eradication...