Research Topics
Genomes and Genes | Takashi IshidaSummaryAffiliation: Nagoya City University Country: Japan Publications
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Publications
Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: a nationwide retrospective studyTakashi Ishida
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Blood 120:1734-41. 2012..In conclusion, allogeneic HSCT not only with MAC but also with RIC is an effective treatment resulting in long-term survival in selected patients with ATL...
Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II studyTakashi Ishida
Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
J Clin Oncol 30:837-42. 2012....
CC chemokine receptor 4-positive diffuse large B-cell lymphoma involving the skin: a case reportTakashi Ishida
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Japan
Int J Hematol 82:148-51. 2005..To the best of our knowledge, this report is the first of a CCR4-positive B-cell lymphoma. The present case provides new insights into the pathogenesis of skin involvement in B-cell lymphomas...
Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilegeTakashi Ishida
Department of Internal Medicine and Molecular Science and Clinical Pathology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho chou, Mizuho ku, Nagoya shi, Aichi, Japan
Cancer Res 66:5716-22. 2006....
Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse modelAsahi Ito
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi, Japan
Cancer Immunol Immunother 58:1195-206. 2009..The second aim was to evaluate ADCC mediated in these humanized mice by the defucosylated anti-CC chemokine receptor 4 (CCR4) monoclonal antibody (mAb) which we have developed and which is now in phase I clinical trials...
The CCR4 as a novel-specific molecular target for immunotherapy in Hodgkin lymphomaT Ishida
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Mizuho chou, Mizuho ku, Nagoya shi, Aichi, Japan
Leukemia 20:2162-8. 2006..Collectively, this study strongly indicates that anti-CCR4 mAb could be a novel treatment modality for patients with CCR4-positive HL...
Antibody therapy for Adult T-cell leukemia-lymphomaTakashi Ishida
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi 467 8601, Japan
Int J Hematol 94:443-52. 2011..The prognosis of ATL patients should be improved in the near future with clinical applications of novel treatment strategies, including those involving KW-0761 and other promising antibody therapies targeting CD25 or CD30...
A complement-dependent cytotoxicity-enhancing anti-CD20 antibody mediating potent antitumor activity in the humanized NOD/Shi-scid, IL-2Rγ(null) mouse lymphoma modelFumihiko Sato
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
Cancer Immunol Immunother 59:1791-800. 2010..In the near future, the efficacy of this type of CDC-enhancing antibody will be determined in clinical trials in humans...
Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivoAsahi Ito
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
J Immunol 183:4782-91. 2009..Furthermore, the potent ADCC mediated by defucosylated anti-CCR4 mAb, observed here in vivo in humanized mice, will be exploited in clinical trials in the near future...
Defucosylated anti CC chemokine receptor 4 monoclonal antibody combined with immunomodulatory cytokines: a novel immunotherapy for aggressive/refractory Mycosis fungoides and Sezary syndromeHiroki Yano
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
Clin Cancer Res 13:6494-500. 2007....
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCCAtsushi Inagaki
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
Int J Cancer 125:212-21. 2009..The ULBPs could be valuable diagnostic biological markers and significant targets for immunotherapy to improve efficacy not only of rituximab but also of other therapeutic mAbs...
CXC chemokine receptor 3 and CC chemokine receptor 4 expression in T-cell and NK-cell lymphomas with special reference to clinicopathological significance for peripheral T-cell lymphoma, unspecifiedTakashi Ishida
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Clin Cancer Res 10:5494-500. 2004..We suggest that a specific therapy targeting the CCR4 molecule may be developed as an alternative treatment for patients with CCR4-positive tumors...
Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphomaToshihiko Ishii
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
Clin Cancer Res 16:1520-31. 2010..The second aim was to fully elucidate the mechanism of antibody-dependent cellular cytotoxicity (ADCC) mediated by this defucosylated monoclonal antibody...
The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphomaTakashi Ishida
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
Clin Cancer Res 10:7529-39. 2004....
Bortezomib-induced apoptosis in mature T-cell lymphoma cells partially depends on upregulation of Noxa and functional repression of Mcl-1Masaki Ri
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi, Japan
Cancer Sci 100:341-8. 2009..Taken together, we conclude that bortezomib-induced apoptosis in ATLL and CTCL cells at least partly depends on the upregulation of Noxa and functional repression of Mcl-1, as is also the case in MM and malignant melanoma...
Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcomeTakashi Ishida
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Science, Nagoya 467-8601, Japan
Clin Cancer Res 9:3625-34. 2003..Multivariate analysis confirmed that CCR4 expression was an independent and significant prognostic factor (P < 0.05). Thus, our finding may provide a novel insight into not only the biological but also the clinical features of ATLL...
Angioimmunoblastic T-cell lymphoma mice modelFumihiko Sato
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi 467 8601, Japan
Leuk Res 37:21-7. 2013..This is the first report of reconstituting follicular helper T (TFH) function in AITL cells in an experimental model, and this is consistent with the theory that TFH cell is the cell of origin of AITL tumor cells...
Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphomaSusumu Suzuki
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Japan
Cancer Sci 103:1764-73. 2012..The present study not only provides a strong rationale for exploiting Tax as a possible target for ATL immunotherapy but also contributes to our understanding of the immunopathogenesis of ATL...
Regulatory T-cell function of adult T-cell leukemia/lymphoma cellsHiroki Yano
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Mizuho chou, Mizuho ku, Nagoya shi, Aichi, Japan
Int J Cancer 120:2052-7. 2007..e., how HTLV-1-infected cells can survive in the face of host immune responses. It also adds to our understanding of ATLL patients' severely immunocompromised state...
Reactivation of hepatitis B virus in HBsAg-negative patients with multiple myeloma: two case reportsTatsuya Yoshida
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, 467 8601, Japan
Int J Hematol 91:844-9. 2010..Establishment of a standard strategy to prevent HBV reactivation is important for myeloma patients receiving systemic chemotherapy...
Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphomaChunmei Li
Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Mod Pathol 20:648-55. 2007..Overexpression of the NPM-ALK fusion transcript may be associated with a poor prognosis of the patients with ALK(+) anaplastic large-cell lymphomas...
The Asn505 mutation of the c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarityJianmin Ding
Department of Medical Oncology and Immunology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
Blood 114:3325-8. 2009..This finding provides a new insight into the mechanism of disease causation by mutations in the TMD of cytokine/hematopoietic receptors...
Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: high interleukin-5 and -10 levels are significant unfavorable prognostic factorsAtsushi Inagaki
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya-shi, Aichi, Japan
Int J Cancer 118:3054-61. 2006..Measurement of serum IL-5 and IL-10 levels is useful for predicting the prognosis and for determining a suitable treatment strategy for ATLL patients...
Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myelomaHiroki Yano
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
Cancer Sci 99:2309-14. 2008..When a combination of CPT-11 and bortezomib was administered, the subcutaneous tumors completely disappeared. Thus, clinical trials on CPT-11 in patients with relapsed or refractory MM are warranted...
Forkhead box P1 overexpression and its clinicopathologic significance in peripheral T-cell lymphoma, not otherwise specifiedSeiji Yamada
Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
Hum Pathol 43:1322-7. 2012..The clinicopathologic significance of forkhead box P1 overexpression in peripheral T-cell lymphoma, not otherwise specified, may be different from that in B-cell lymphomas...
Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphomaKazuhito Yamamoto
Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Aichi, Japan
J Clin Oncol 28:1591-8. 2010..This phase I study assessed the safety, pharmacokinetics, recommended phase II dose and efficacy of KW-0761 in patients with relapsed CCR4-positive adult T-cell leukemia-lymphoma (ATL) or peripheral T-cell lymphoma (PTCL)...
Immunopathogenesis of lymphoma: focus on CCR4Takashi Ishida
Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
Cancer Sci 102:44-50. 2011....
Association of SYT-SSX fusion types with proliferative activity and prognosis in synovial sarcomaH Inagaki
Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
Mod Pathol 13:482-8. 2000..These data suggested that SYT-SSX fusion type is associated with tumor cell proliferative activity and prognosis of patients who have SS...
Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous systemH Inagaki
Department of Pathology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
Histochem Cell Biol 113:37-41. 2000..Northern blot analysis showed that DRPs were differentially expressed in the mouse and human intestines, supporting the results of ISH. These data suggest that DRPs play a role not only in the CNS but also in the ENS...
Influence of histochemical and immunohistochemical stains on polymerase chain reactionT Murase
Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
Mod Pathol 13:147-51. 2000..The immunohistochemical visualization with DAB or new fuchsin yields no unfavorable effects. A successful PCR amplification may not be expected in sections that are pretreated in a microwave oven or pressure cooker...
Prognostic significance of CD44v6 in diffuse large B-cell lymphomaH Inagaki
Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
Mod Pathol 12:546-52. 1999....
Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysisT Eimoto
Department of Pathology, Nagoya City University School of Medicine, Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
Histopathology 40:46-57. 2002..We report two such cases in which the tumour cells showed a prominent rhabdomyoblastic differentiation and analyse whether these tumours retain an epithelial nature at least in part...
API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimensH Inagaki
Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
Am J Pathol 158:699-706. 2001..Our multiplex RT-PCR assay, which can be used for routinely-processed paraffin samples, should serve as a useful molecular tool for clarifying the clinicopathological significance of API2-MALT1 fusion in MALT lymphoma...
Clonality assay of hematopoietic disorders: significance of the buccal epithelium as non-hematopoietic control and of 95% rejection limit as a novel criterion for monoclonalityH Inagaki
Department of Pathology, Nagoya City University Medical School, Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
Jpn J Cancer Res 92:1305-12. 2001....
CCR4 as a novel molecular target for immunotherapy of cancerTakashi Ishida
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-chou, Mizuho-ku, Nagoya-shi Aichi, 467-8601, Japan
Cancer Sci 97:1139-46. 2006....
Prognostic significance of p27 and Ki-67 expression in mucoepidermoid carcinoma of the intraoral minor salivary glandM Okabe
Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
Mod Pathol 14:1008-14. 2001..These data suggest that p27 may be useful in estimating prognosis of the patients who have mucoepidermoid carcinoma of the intraoral minor salivary gland...
Frequent occurrence of CCND1 deregulation in patients with early stages of plasma cell dyscrasiaKazuhisa Miura
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Science, Mizuho ku, Nagoya 467 8601, Japan
Cancer Sci 94:350-4. 2003..This suggests to us that cyclin D1 deregulation due to the presence of t(11;14) is involved in the early development of plasma cell neoplasms, and that this event alone is not enough for the development of symptomatic myeloma...
rDLG6: a novel homolog of Drosophila DLG expressed in rat brainH Inagaki
Department of Chemistry, National Industrial Research Institute of Nagoya, 1 1 Hirate cho, Kita ku, Nagoya, 462 8510, Japan
Biochem Biophys Res Commun 265:462-8. 1999..GST pull-down assays showed that the PDZ domain of rDLG6 protein binds to the C-terminus of the AMPA (alpha-Amino-3-hydroxy-5-Methyl-isoxazole-4-Propionic Acid) receptor GluR2 subunit...
Analysis of VH gene rearrangement and somatic hypermutation in Sjogren's syndrome and IgG4-related sclerosing sialadenitisH Sakuma
Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
Scand J Immunol 72:44-9. 2010..0001, respectively). This finding suggests that some autoantibodies encoded by germline or less mutated VH genes may fail to be eliminated and could play a role in the development of SS and IgG4-related sclerosing sialadenitis...
Aldolase C is localized in neuroendocrine cellsH Inagaki
Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
Experientia 44:749-51. 1988..Aldolase C was found to be localized in various types of neuroendocrine cells; in the pituitary gland, thyroid, pancreas, adrenal gland, bronchus, and gastrointestinal tract...
Osteoprotegerin levels before and after renal transplantationT Sato
Department of Transplant Surgery, Nagoya 2nd Red Cross Hospital, Nagoya, Japan
Am J Kidney Dis 38:S175-7. 2001..Serum OPG declines for the first 2 weeks after RTX owing to functioning allograft and decreases again for the next 2 weeks because of steroids and possible immunosuppressive agents...
Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-gamma (MIG) gene expression in B-cell malignancyM Uranishi
Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Leukemia 19:1471-8. 2005..Leukemia (2005) 19, 1471-1478. doi:10.1038/sj.leu.2403833; published online 16 June 2005...
Effects of contractile activity on mitochondrial transcription factor A expression in skeletal muscleJ W Gordon
Kinesiology and Health Science, Faculty of Pure and Applied Science, York University, Toronto, Ontario, Canada
J Appl Physiol 90:389-96. 2001..This was accompanied by increased mitochondrial transcript levels and elevated COX activity. These data support the role of Tfam as a regulatory protein involved in contractile activity-induced mitochondrial biogenesis...
Differences in radiographic findings between scaphoid fracture patternsH Inagaki
Department of Hand Surgery, Nagoya University School of Medicine, Nagoya 466 8550, Japan
Hand Surg 9:197-202. 2004..No differences were evident between the two fracture patterns with respect to prevalence of dorsal intercalated segment instability deformity...
