Hiroshi Inagaki

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. ncbi request reprint Clonality assay of hematopoietic disorders: significance of the buccal epithelium as non-hematopoietic control and of 95% rejection limit as a novel criterion for monoclonality
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Cancer Res 92:1305-12. 2001
  2. ncbi request reprint Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter Pylori eradication and detection of API2-MALT1 fusion
    Hiroshi Inagaki
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Surg Pathol 28:1560-7. 2004
  3. ncbi request reprint Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathologic study of 24 asian cases
    Chunmei Li
    Department of Pathology, Nagoya City Unviersity Medical School, Nagoya, Japan
    Am J Surg Pathol 27:1061-9. 2003
  4. ncbi request reprint Mucosa-associated lymphoid tissue lymphoma: molecular pathogenesis and clinicopathological significance
    Hiroshi Inagaki
    Department of Pathology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    Pathol Int 57:474-84. 2007
  5. pmc Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features
    Hiroshi Inagaki
    Department s of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Am J Pathol 160:1435-43. 2002
  6. ncbi request reprint Association of SYT-SSX fusion types with proliferative activity and prognosis in synovial sarcoma
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Mod Pathol 13:482-8. 2000
  7. ncbi request reprint Detection of API2-MALT1 fusion transcripts in cytologic specimens of patients with pulmonary mucosa-associated lymphoid tissue lymphoma
    Hiroshi Inagaki
    Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya
    Int J Hematol 82:59-62. 2005
  8. ncbi request reprint Prognostic significance of CD44v6 in diffuse large B-cell lymphoma
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Mod Pathol 12:546-52. 1999
  9. ncbi request reprint Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Histochem Cell Biol 113:37-41. 2000
  10. doi request reprint Prognostic significance of p27Kip1, Ki-67, and CRTC1-MAML2 fusion transcript in mucoepidermoid carcinoma: a molecular and clinicopathologic study of 101 cases
    Satoru Miyabe
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Nagoya, Japan
    J Oral Maxillofac Surg 67:1432-41. 2009

Detail Information

Publications76

  1. ncbi request reprint Clonality assay of hematopoietic disorders: significance of the buccal epithelium as non-hematopoietic control and of 95% rejection limit as a novel criterion for monoclonality
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Cancer Res 92:1305-12. 2001
    ....
  2. ncbi request reprint Gastric MALT lymphomas are divided into three groups based on responsiveness to Helicobacter Pylori eradication and detection of API2-MALT1 fusion
    Hiroshi Inagaki
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Surg Pathol 28:1560-7. 2004
    ..This 3-group categorization may be helpful for a comprehensive understanding of gastric MALT lymphoma...
  3. ncbi request reprint Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathologic study of 24 asian cases
    Chunmei Li
    Department of Pathology, Nagoya City Unviersity Medical School, Nagoya, Japan
    Am J Surg Pathol 27:1061-9. 2003
    ....
  4. ncbi request reprint Mucosa-associated lymphoid tissue lymphoma: molecular pathogenesis and clinicopathological significance
    Hiroshi Inagaki
    Department of Pathology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
    Pathol Int 57:474-84. 2007
    ..The focus of the present review is on the recent progress made in elucidating MALT lymphomagenesis and its clinicopathological impact, especially in terms of the effect of API2-MALT1 fusion on this unique tumor...
  5. pmc Primary thymic extranodal marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue type exhibits distinctive clinicopathological and molecular features
    Hiroshi Inagaki
    Department s of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Am J Pathol 160:1435-43. 2002
    ....
  6. ncbi request reprint Association of SYT-SSX fusion types with proliferative activity and prognosis in synovial sarcoma
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Mod Pathol 13:482-8. 2000
    ..These data suggested that SYT-SSX fusion type is associated with tumor cell proliferative activity and prognosis of patients who have SS...
  7. ncbi request reprint Detection of API2-MALT1 fusion transcripts in cytologic specimens of patients with pulmonary mucosa-associated lymphoid tissue lymphoma
    Hiroshi Inagaki
    Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya
    Int J Hematol 82:59-62. 2005
    ..The detection of API2-MALT1 fusion as carried out with these specimens would be useful as an ancillary assay for the diagnosis, staging, and follow-up of pulmonary MALT lymphoma...
  8. ncbi request reprint Prognostic significance of CD44v6 in diffuse large B-cell lymphoma
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Mod Pathol 12:546-52. 1999
    ....
  9. ncbi request reprint Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Histochem Cell Biol 113:37-41. 2000
    ..Northern blot analysis showed that DRPs were differentially expressed in the mouse and human intestines, supporting the results of ISH. These data suggest that DRPs play a role not only in the CNS but also in the ENS...
  10. doi request reprint Prognostic significance of p27Kip1, Ki-67, and CRTC1-MAML2 fusion transcript in mucoepidermoid carcinoma: a molecular and clinicopathologic study of 101 cases
    Satoru Miyabe
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Nagoya, Japan
    J Oral Maxillofac Surg 67:1432-41. 2009
    ..In the present study, we investigated the prognostic significance of p27Kip1, Ki-67, and CRTC1 (also called MECT1, TORC1, and WAMTP1)-MAML2 fusion in MEC...
  11. doi request reprint Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma
    Takahisa Nakayama
    Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Mod Pathol 22:1575-81. 2009
    ..Mucoepidermoid carcinomas possessing CRTC3-MAML2 fusion may be associated with favorable clinicopathological features and patients may be younger than those with CRTC1-MAML2 fusion or those with no detectable gene fusion...
  12. doi request reprint A complement-dependent cytotoxicity-enhancing anti-CD20 antibody mediating potent antitumor activity in the humanized NOD/Shi-scid, IL-2Rγ(null) mouse lymphoma model
    Fumihiko Sato
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
    Cancer Immunol Immunother 59:1791-800. 2010
    ..In the near future, the efficacy of this type of CDC-enhancing antibody will be determined in clinical trials in humans...
  13. ncbi request reprint CXC chemokine receptor 3 and CC chemokine receptor 4 expression in T-cell and NK-cell lymphomas with special reference to clinicopathological significance for peripheral T-cell lymphoma, unspecified
    Takashi Ishida
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Cancer Res 10:5494-500. 2004
    ..We suggest that a specific therapy targeting the CCR4 molecule may be developed as an alternative treatment for patients with CCR4-positive tumors...
  14. ncbi request reprint Immunoglobulin VH gene analysis in gastric MALT lymphomas
    Hidenori Sakuma
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Mod Pathol 20:460-6. 2007
    ..pylori-associated, B cell subset and may not often progress to those that are inflammation-independent (Groups B and C). Although considered to be common in this tumor, ongoing mutation may be infrequent when assessed by strict criteria...
  15. ncbi request reprint Prognostic significance of NPM-ALK fusion transcript overexpression in ALK-positive anaplastic large-cell lymphoma
    Chunmei Li
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Mod Pathol 20:648-55. 2007
    ..Overexpression of the NPM-ALK fusion transcript may be associated with a poor prognosis of the patients with ALK(+) anaplastic large-cell lymphomas...
  16. ncbi request reprint p16/INK4a gene methylation is a frequent finding in pulmonary MALT lymphomas at diagnosis
    Hisashi Takino
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Mod Pathol 18:1187-92. 2005
    ..These findings suggest that p16 methylation is not associated with tumor progression, but may be an early event in MALT lymphomagenesis that might be maintained through the progression of the tumor...
  17. doi request reprint Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo
    Asahi Ito
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467 8601, Japan
    J Immunol 183:4782-91. 2009
    ..Furthermore, the potent ADCC mediated by defucosylated anti-CCR4 mAb, observed here in vivo in humanized mice, will be exploited in clinical trials in the near future...
  18. ncbi request reprint Defucosylated anti CC chemokine receptor 4 monoclonal antibody combined with immunomodulatory cytokines: a novel immunotherapy for aggressive/refractory Mycosis fungoides and Sezary syndrome
    Hiroki Yano
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Clin Cancer Res 13:6494-500. 2007
    ....
  19. ncbi request reprint API2-MALT1 fusion gene in colorectal lymphoma
    Sumie Takase Sakugawa
    Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Mod Pathol 16:1232-41. 2003
    ..Thus, API2-MALT1-positive tumors should be cared for as a more aggressive subgroup and be followed for a longer time...
  20. ncbi request reprint Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege
    Takashi Ishida
    Department of Internal Medicine and Molecular Science and Clinical Pathology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho chou, Mizuho ku, Nagoya shi, Aichi, Japan
    Cancer Res 66:5716-22. 2006
    ....
  21. ncbi request reprint CC chemokine receptor 4-positive diffuse large B-cell lymphoma involving the skin: a case report
    Takashi Ishida
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Japan
    Int J Hematol 82:148-51. 2005
    ..To the best of our knowledge, this report is the first of a CCR4-positive B-cell lymphoma. The present case provides new insights into the pathogenesis of skin involvement in B-cell lymphomas...
  22. ncbi request reprint Gastric low-grade B-cell MALT lymphoma: treatment, response, and genetic alteration
    Tsuneya Nakamura
    Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
    J Gastroenterol 38:921-9. 2003
    ..Investigation in the future will clarify this issue and establish the clinical implication of such genetic alteration as the predictive factor for gastric MALT lymphoma...
  23. ncbi request reprint Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome
    Takashi Ishida
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Science, Nagoya 467 8601, Japan
    Clin Cancer Res 9:3625-34. 2003
    ..Multivariate analysis confirmed that CCR4 expression was an independent and significant prognostic factor (P < 0.05). Thus, our finding may provide a novel insight into not only the biological but also the clinical features of ATLL...
  24. pmc API2-MALT1 fusion defines a distinctive clinicopathologic subtype in pulmonary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
    Mitsukuni Okabe
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Am J Pathol 162:1113-22. 2003
    ..Aberrant nuclear BCL10 expression may have a possible role as a tool to screen for this API2-MALT1 fusion. A large-scale study with a long follow-up is necessary to establish the prognostic significance of API2-MALT1 fusion...
  25. doi request reprint Clinicopathological significance of MAML2 gene split in mucoepidermoid carcinoma
    Haruna Noda
    Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Sci 104:85-92. 2013
    ..The presence of the MAML2 gene split defines a distinct mucoepidermoid carcinoma subset that is associated clinicopathologically with favorable tumor features...
  26. doi request reprint Angioimmunoblastic T-cell lymphoma mice model
    Fumihiko Sato
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    Leuk Res 37:21-7. 2013
    ..This is the first report of reconstituting follicular helper T (TFH) function in AITL cells in an experimental model, and this is consistent with the theory that TFH cell is the cell of origin of AITL tumor cells...
  27. doi request reprint Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma
    Susumu Suzuki
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Japan
    Cancer Sci 103:1764-73. 2012
    ..The present study not only provides a strong rationale for exploiting Tax as a possible target for ATL immunotherapy but also contributes to our understanding of the immunopathogenesis of ATL...
  28. doi request reprint Characterization of chromosomal aberrations in thymic MALT lymphoma
    Satoru Kominato
    Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Pathol Int 62:93-8. 2012
    ..In conclusion, the present study showed that thymic MALT lymphoma has a characteristic pattern of chromosomal aberrations that may be similar to those of other autoimmune-associated MALT lymphomas...
  29. ncbi request reprint Follicular lymphoma frequently originates in the salivary gland
    Satoko Nakamura
    Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Pathol Int 56:576-83. 2006
    ..The observed differences in age of onset, background of autoimmune disease, and lesion site suggests that the pathogenesis of FL may differ from that of MALT lymphoma...
  30. ncbi request reprint MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma
    Mitsukuni Okabe
    Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Clin Cancer Res 12:3902-7. 2006
    ..This fusion transcript has been frequently detected in mucoepidermoid carcinoma and shown to be involved in the transformation of epithelial cells. However, its clinicopathologic significance remains unclear...
  31. doi request reprint Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model
    Asahi Ito
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi, Japan
    Cancer Immunol Immunother 58:1195-206. 2009
    ..The second aim was to evaluate ADCC mediated in these humanized mice by the defucosylated anti-CC chemokine receptor 4 (CCR4) monoclonal antibody (mAb) which we have developed and which is now in phase I clinical trials...
  32. doi request reprint Autologous Tax-specific CTL therapy in a primary adult T cell leukemia/lymphoma cell-bearing NOD/Shi-scid, IL-2Rγnull mouse model
    Ayako Masaki
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    J Immunol 191:135-44. 2013
    ..The present study contributes to research on adoptive CTL therapy, which should be applicable to several types of cancer...
  33. ncbi request reprint The CC chemokine receptor 4 as a novel specific molecular target for immunotherapy in adult T-Cell leukemia/lymphoma
    Takashi Ishida
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan
    Clin Cancer Res 10:7529-39. 2004
    ....
  34. doi request reprint Forkhead box P1 overexpression and its clinicopathologic significance in peripheral T-cell lymphoma, not otherwise specified
    Seiji Yamada
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Hum Pathol 43:1322-7. 2012
    ..The clinicopathologic significance of forkhead box P1 overexpression in peripheral T-cell lymphoma, not otherwise specified, may be different from that in B-cell lymphomas...
  35. doi request reprint Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma
    Yoshihide Okumura
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Histopathology 59:90-7. 2011
    ..The aim of study was to evaluate the impact of CRTC1-MAML2 and CRTC3-MAML2 fusions on the histological classification of mucoepidermoid carcinoma (MEC) of the salivary glands and on the prognosis of patients...
  36. ncbi request reprint Immunoglobulin VH genes in thymic MALT lymphoma are biased toward a restricted repertoire and are frequently unmutated
    Megumi Yoshida
    Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    J Pathol 208:415-22. 2006
    ..The observed patterns of V(H) usage and mutations suggested that specific antigens may play a pathologically relevant role in the genesis or progression of thymic MALT lymphoma...
  37. doi request reprint Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathological study of cases from Asia, Germany, and the United States
    Hisashi Takino
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Mod Pathol 21:1517-26. 2008
    ..Borrelia infection and API2-MALT1 fusion are not significant in this tumor. Methylation of DAPK and p16(INK4a) genes is a frequent event in this lymphoma at its initial presentation, but may not be associated with tumor progression...
  38. doi request reprint Analysis of API2-MALT1 fusion, trisomies, and immunoglobulin VH genes in pulmonary mucosa-associated lymphoid tissue lymphoma
    Hongjing Xia
    Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467 8601, Japan
    Hum Pathol 42:1297-304. 2011
    ..This observation suggests that these gene abnormalities may occur in microenvironments found before or outside of follicular germinal centers...
  39. doi request reprint Primary mucosa-associated lymphoid tissue lymphoma of the prostate: tumor relapse 7 years after local therapy
    Chunmei Li
    Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Pathol Int 58:191-5. 2008
    ..The present case suggests that despite tumor recurrence, prostatic MALT lymphoma is indolent, and function-preserving therapy is warranted...
  40. ncbi request reprint Small-cell lung cancer arising after chemotherapy for a patient with lymphoma of pulmonary mucosa-associated lymphoid tissue-a case report
    Makoto Nakao
    Department of Medical Oncology and Immunology, Nagoya City University School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Gan To Kagaku Ryoho 36:1711-4. 2009
    ..To our knowledge, this is a rare case of small cell lung cancer arising from the treatment of lymphoma of pulmonary MALT...
  41. doi request reprint Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma
    Hiroki Yano
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Cancer Sci 99:2309-14. 2008
    ..When a combination of CPT-11 and bortezomib was administered, the subcutaneous tumors completely disappeared. Thus, clinical trials on CPT-11 in patients with relapsed or refractory MM are warranted...
  42. ncbi request reprint Involvement of the chromosomal translocation t(11;18) in some mucosa-associated lymphoid tissue lymphomas and diffuse large B-cell lymphomas of the ocular adnexa: evidence from multiplex reverse transcriptase-polymerase chain reaction and fluorescence in
    Shinichi Takada
    Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Mod Pathol 16:445-52. 2003
    ..These findings indicate a possibility that at least in the ocular adnexa, some diffuse large B-cell lymphomas are derived from mucosa-associated lymphoid tissue lymphomas...
  43. doi request reprint Thymic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue: a gene methylation study
    Hisashi Takino
    Department of Anatomic Pathology and Molecular Diagnostics, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Leuk Lymphoma 54:1742-6. 2013
    ..This study suggests that methylation of tumor suppressor genes may play an important role in thymic MALT lymphoma...
  44. doi request reprint Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia / lymphoma
    Takashi Ishida
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Cancer Sci 104:647-50. 2013
    ..We are currently conducting a clinical trial of mogamulizumab for CCR4-negative solid cancers (UMIN000010050), specifically aiming to deplete Treg cells...
  45. ncbi request reprint Spontaneous regression of intraoral mucosa-associated lymphoid tissue lymphoma: molecular study of a case
    Hidenori Sakuma
    Department of Pathology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Pathol Int 56:331-5. 2006
    ..When minimal residual disease is detected, close follow up is necessary for early detection of the tumor relapse...
  46. doi request reprint Girdin, a regulator of cell motility, is a potential prognostic marker for esophageal squamous cell carcinoma
    Takahiro Shibata
    Department of Gastroenterological Surgery, Nagoya City University, Nagoya, Aichi 4678601, Japan
    Oncol Rep 29:2127-32. 2013
    ..The levels of Girdin expression correlated inversely with the survival of ESCC patients. Therefore, in ESCC, Girdin may be a prognostic marker and may serve as a therapeutic target as well...
  47. ncbi request reprint MUM1/IRF4 expression is an unfavorable prognostic factor in B-cell chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)
    Masato Ito
    Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601
    Jpn J Cancer Res 93:685-94. 2002
    ..The biological role and mechanism of action of MUM1 in B-CLL / SLL need to be clarified for the development of therapies for patients with the poor prognostic subtype...
  48. doi request reprint Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study
    Takashi Ishida
    Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho chou, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
    J Clin Oncol 30:837-42. 2012
    ....
  49. ncbi request reprint Frequent occurrence of CCND1 deregulation in patients with early stages of plasma cell dyscrasia
    Kazuhisa Miura
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Science, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Sci 94:350-4. 2003
    ..This suggests to us that cyclin D1 deregulation due to the presence of t(11;14) is involved in the early development of plasma cell neoplasms, and that this event alone is not enough for the development of symptomatic myeloma...
  50. doi request reprint A case of cutaneous malignant fibrous histiocytoma with multiple organ metastases
    Shuji Suzuki
    Department of Geriatric and Environmental Dermatology, Graduate School of Medical, Nagoya City University, Nagoya, Japan
    Kaohsiung J Med Sci 29:111-5. 2013
    ..The patient was diagnosed with malignant fibrous histiocytoma, stage IV and died 8 weeks after the first visit due to respiratory failure. Cutaneous malignant fibrous histiocytoma has a poor prognosis resulting in death...
  51. ncbi request reprint Clonality analysis of different histological components in combined small cell and non-small cell carcinoma of the lung
    Takayuki Murase
    Department of Pathology, Nagoya City University Medical School, Japan
    Hum Pathol 34:1178-84. 2003
    ..This tumorigenesis process may explain the relative rarity of combined small cell and non-small cell carcinoma, which occurs primarily in the peripheral lung, an infrequent site of squamous cell carcinoma...
  52. doi request reprint Bath-PUVA therapy decreases infiltrating CCR4-expressing tumor cells and regulatory T cells in patients with mycosis Fungoides
    Hiroshi Kato
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Clin Lymphoma Myeloma Leuk 13:273-80. 2013
    ..In patients with psoriasis, bath-PUVA induces circulating regulatory T cells (Tregs), which suppress effector T cells. To understand the mechanisms in MF, we analyzed lesion-infiltrating cells before and after bath-PUVA therapy...
  53. ncbi request reprint A patient with gastric adenosquamous carcinoma with intraperitoneal free cancer cells who remained recurrence-free with postoperative S-1 chemotherapy
    Masahide Ebi
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Japan
    Intern Med 51:3125-9. 2012
    ..Postoperative chemotherapy with S-1 monotherapy is effective for treating adenosquamous carcinoma of the stomach with CY1 and might contribute to long-term survival...
  54. doi request reprint Diffuse large B cell lymphoma with an interfollicular pattern of proliferation shows a favourable prognosis: a study of the Osaka Lymphoma Study Group
    Naoki Wada
    Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Histopathology 60:924-32. 2012
    ..Diffuse large B cell lymphoma (DLBCL) occasionally shows an interfollicular pattern of proliferation (DLBCL-IF) preserving lymphoid follicles. In this study, clinicopathological findings in 31 cases of DLBCL-IF were analysed...
  55. doi request reprint Analysis of VH gene rearrangement and somatic hypermutation in type 1 autoimmune pancreatitis
    Fumihiro Okumura
    Departments of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Pathol Int 62:318-23. 2012
    ..1%) (P= 0.010). Our study suggests that an increased rate of unmutated or less mutated VH genes may be characteristic of type 1 AIP and might play a role in the development of this disease...
  56. ncbi request reprint p185(HER-2/neu) and p21(CIP1/WAF1) expression in primary tumors and lymph node metastases in non-small cell lung cancer
    Kenji Akita
    Second Department of Internal Medicine, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Jpn J Cancer Res 93:1007-11. 2002
    ..However we failed to detect any correlation between p185(HER-2/neu) and p21(CIP1/WAF1) expression. Our results suggested that expression of both p185(HER-2/neu) and p21(CIP1/WAF1) is concordant between primary and metastatic tumors...
  57. ncbi request reprint Influence of histochemical and immunohistochemical stains on polymerase chain reaction
    T Murase
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Mod Pathol 13:147-51. 2000
    ..The immunohistochemical visualization with DAB or new fuchsin yields no unfavorable effects. A successful PCR amplification may not be expected in sections that are pretreated in a microwave oven or pressure cooker...
  58. pmc API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Am J Pathol 158:699-706. 2001
    ..Our multiplex RT-PCR assay, which can be used for routinely-processed paraffin samples, should serve as a useful molecular tool for clarifying the clinicopathological significance of API2-MALT1 fusion in MALT lymphoma...
  59. ncbi request reprint Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis
    T Eimoto
    Department of Pathology, Nagoya City University School of Medicine, Kawasumi, Mizuho ku, Nagoya 467 8601, Japan
    Histopathology 40:46-57. 2002
    ..We report two such cases in which the tumour cells showed a prominent rhabdomyoblastic differentiation and analyse whether these tumours retain an epithelial nature at least in part...
  60. ncbi request reprint The CCR4 as a novel-specific molecular target for immunotherapy in Hodgkin lymphoma
    T Ishida
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Mizuho chou, Mizuho ku, Nagoya shi, Aichi, Japan
    Leukemia 20:2162-8. 2006
    ..Collectively, this study strongly indicates that anti-CCR4 mAb could be a novel treatment modality for patients with CCR4-positive HL...
  61. ncbi request reprint Successful treatment of nasal T-cell lymphoma with a combination of local irradiation and high-dose chemotherapy
    Takaomi Sanda
    Second Department of Internal Medicine, Nagoya City University Medical School, Nagoya, Japan
    Int J Hematol 75:195-200. 2002
    ..This therapy resulted in CR. Our results suggest that this lymphoma subtype may be cured by means of intensive treatment soon after diagnosis...
  62. ncbi request reprint Prognostic significance of p27 and Ki-67 expression in mucoepidermoid carcinoma of the intraoral minor salivary gland
    M Okabe
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Mod Pathol 14:1008-14. 2001
    ..These data suggest that p27 may be useful in estimating prognosis of the patients who have mucoepidermoid carcinoma of the intraoral minor salivary gland...
  63. ncbi request reprint Primary ureteral mucosa-associated lymphoid tissue (MALT) lymphoma--pathological and radiological findings
    Masaki Hara
    Department of Radiology, Nagoya City University Medical School, Kawasumi, Japan
    Radiat Med 20:41-4. 2002
    ..We suggest that it is useful for the differential diagnosis of ureter masses that some MALT lymphomas may show a low signal intensity on T2-weighted MR images...
  64. doi request reprint Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma
    Kazuhito Yamamoto
    Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Aichi, Japan
    J Clin Oncol 28:1591-8. 2010
    ..This phase I study assessed the safety, pharmacokinetics, recommended phase II dose and efficacy of KW-0761 in patients with relapsed CCR4-positive adult T-cell leukemia-lymphoma (ATL) or peripheral T-cell lymphoma (PTCL)...
  65. ncbi request reprint rDLG6: a novel homolog of Drosophila DLG expressed in rat brain
    H Inagaki
    Department of Chemistry, National Industrial Research Institute of Nagoya, 1 1 Hirate cho, Kita ku, Nagoya, 462 8510, Japan
    Biochem Biophys Res Commun 265:462-8. 1999
    ..GST pull-down assays showed that the PDZ domain of rDLG6 protein binds to the C-terminus of the AMPA (alpha-Amino-3-hydroxy-5-Methyl-isoxazole-4-Propionic Acid) receptor GluR2 subunit...
  66. pmc Reactive lymphoid hyperplasia of the liver in a patient with colon cancer: report of two cases
    Hiroki Takahashi
    Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya, Japan
    BMC Gastroenterol 6:25. 2006
    ..Reactive lymphoid hyperplasia (RLH) of the liver is very rarely reported, and we encountered two cases of RLH of the liver in a patient with colon cancer...
  67. ncbi request reprint Nasal NK-cell lymphoma followed by relapse in the uterine cervix
    Takayuki Murase
    Department of Pathology, Nagoya City University Medical School, Nagoya, Japan
    Leuk Lymphoma 43:203-6. 2002
    ..This case may be of value in elucidating the biological behavior and natural history of NK-cell lymphoma...
  68. doi request reprint Analysis of VH gene rearrangement and somatic hypermutation in Sjogren's syndrome and IgG4-related sclerosing sialadenitis
    H Sakuma
    Department of Pathology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan
    Scand J Immunol 72:44-9. 2010
    ..0001, respectively). This finding suggests that some autoantibodies encoded by germline or less mutated VH genes may fail to be eliminated and could play a role in the development of SS and IgG4-related sclerosing sialadenitis...
  69. ncbi request reprint Aldolase C is localized in neuroendocrine cells
    H Inagaki
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Experientia 44:749-51. 1988
    ..Aldolase C was found to be localized in various types of neuroendocrine cells; in the pituitary gland, thyroid, pancreas, adrenal gland, bronchus, and gastrointestinal tract...
  70. ncbi request reprint Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-gamma (MIG) gene expression in B-cell malignancy
    M Uranishi
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Leukemia 19:1471-8. 2005
    ..Leukemia (2005) 19, 1471-1478. doi:10.1038/sj.leu.2403833; published online 16 June 2005...
  71. ncbi request reprint Osteoprotegerin levels before and after renal transplantation
    T Sato
    Department of Transplant Surgery, Nagoya 2nd Red Cross Hospital, Nagoya, Japan
    Am J Kidney Dis 38:S175-7. 2001
    ..Serum OPG declines for the first 2 weeks after RTX owing to functioning allograft and decreases again for the next 2 weeks because of steroids and possible immunosuppressive agents...
  72. ncbi request reprint Rapid development of diffuse large B-Cell lymphoma after successful eradication of Helicobacter pylori for gastric MALT lymphoma
    Masahiro Iwano
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Am J Gastroenterol 101:2878-83. 2006
    ..pylori eradication for low-grade MALT lymphoma...
  73. ncbi request reprint Human immunodeficiency virus (HIV)-negative, API2-MALT1 fusion-negative bronchus-associated lymphoid tissue (BALT) lymphoma in a young male
    Masashi Okamoto
    Second Department of Medicine, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Japan
    Leuk Lymphoma 45:2165-8. 2004
    ..It appears necessary to clarify whether atopy might play a role in the pathogenesis of API2-MALT1(-) BALT lymphoma for HIV(-) young patients who do not exhibit any other antecedent chronic antigenic stimulations...
  74. ncbi request reprint Characteristics of gastric B-cell lymphoma of mucosa-associated lymphoid tissue type involving multiple organs
    Masahiro Iwano
    Department of Gastroenterology and Endoscopic Medicine, Kyoto University Hospital, 54 Shogoin, Sakyo, 606 8507, Kyoto, Japan
    J Gastroenterol 39:739-46. 2004
    ..Mucosa-associated lymphoid tissue (MALT) lymphoma involving multiple organs is not well characterized...
  75. ncbi request reprint Diffuse large B-cell lymphoma with extra Bcl-2 gene signals detected by FISH analysis is associated with a "non-germinal center phenotype"
    Shigeru Kusumoto
    Hematology Division, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Am J Surg Pathol 29:1067-73. 2005
    ..The DLBCLs with Bcl-2 protein overexpression were classified into at least two heterogeneous molecular groups, based on the results of the FISH analysis...
  76. ncbi request reprint Clinical implications of nodal marginal zone B-cell lymphoma among Japanese: study of 65 cases
    Masaru Kojima
    Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan
    Cancer Sci 98:44-9. 2007
    ..DLBCL + MALT type exhibited significantly poorer 5-year overall survival than the splenic variant. The recognition of DLBCL + MALT type appears important. No API2-MALT1 fusion transcript was detected in any of the 14 cases examined...