Toshiya Inada

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Relationship between catechol-O-methyltransferase polymorphism and treatment-resistant schizophrenia
    Toshiya Inada
    Department of Psychiatry and Psychobiology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Am J Med Genet B Neuropsychiatr Genet 120:35-9. 2003
  2. ncbi request reprint No association found between the type 1 sigma receptor gene polymorphisms and methamphetamine abuse in the Japanese population: a collaborative study by the Japanese Genetics Initiative for Drug Abuse
    T Inada
    Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann N Y Acad Sci 1025:27-33. 2004
  3. ncbi request reprint Cytochrome P450 II D6 gene polymorphisms and the neuroleptic-induced extrapyramidal symptoms in Japanese schizophrenic patients
    Toshiya Inada
    National Institute of Mental Health, National Center of Neurology and Psychiatry, Chiba, Japan
    Psychiatr Genet 13:163-8. 2003
  4. ncbi request reprint Efficacy of diazepam as an anti-anxiety agent: meta-analysis of double-blind, randomized controlled trials carried out in Japan
    Toshiya Inada
    Department of Psychiatry and Psychobiology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Nagoya, Japan
    Hum Psychopharmacol 18:483-7. 2003
  5. ncbi request reprint Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis
    Tomohiro Urata
    TUM Gene Inc, Chiba, Japan
    Neurosci Lett 414:209-12. 2007
  6. ncbi request reprint Association of SOX10 with schizophrenia in the Japanese population
    Nobuhisa Maeno
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Psychiatr Genet 17:227-31. 2007
  7. ncbi request reprint An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population
    Xiaofei Ji
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nagoya J Med Sci 70:11-7. 2008
  8. doi request reprint Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1040-6. 2008
  9. doi request reprint An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population
    Shinichi Saito
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neuroreport 19:471-3. 2008
  10. doi request reprint Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population
    Itaru Kushima
    Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:786-91. 2010

Detail Information

Publications76

  1. ncbi request reprint Relationship between catechol-O-methyltransferase polymorphism and treatment-resistant schizophrenia
    Toshiya Inada
    Department of Psychiatry and Psychobiology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Am J Med Genet B Neuropsychiatr Genet 120:35-9. 2003
    ....
  2. ncbi request reprint No association found between the type 1 sigma receptor gene polymorphisms and methamphetamine abuse in the Japanese population: a collaborative study by the Japanese Genetics Initiative for Drug Abuse
    T Inada
    Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann N Y Acad Sci 1025:27-33. 2004
    ..This study suggests that type 1 sigma receptor gene is unlikely to play a major role in substance abuse liability and/or the development of MAP psychosis...
  3. ncbi request reprint Cytochrome P450 II D6 gene polymorphisms and the neuroleptic-induced extrapyramidal symptoms in Japanese schizophrenic patients
    Toshiya Inada
    National Institute of Mental Health, National Center of Neurology and Psychiatry, Chiba, Japan
    Psychiatr Genet 13:163-8. 2003
    ..The purpose of this study was to examine whether the neuroleptic-induced extrapyramidal symptoms are associated with the CYP2D6 activity...
  4. ncbi request reprint Efficacy of diazepam as an anti-anxiety agent: meta-analysis of double-blind, randomized controlled trials carried out in Japan
    Toshiya Inada
    Department of Psychiatry and Psychobiology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Nagoya, Japan
    Hum Psychopharmacol 18:483-7. 2003
    ..Caution should be exercised in assessing these results, however, since this is the first meta-analysis showing the significant effectiveness of diazepam in the treatment of neurosis or psychosomatic disease...
  5. ncbi request reprint Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis
    Tomohiro Urata
    TUM Gene Inc, Chiba, Japan
    Neurosci Lett 414:209-12. 2007
    ..0547). The present results suggest that a combination of polymorphisms of MAO-A, COMT, and DRD3 might affect personality traits in Japanese women...
  6. ncbi request reprint Association of SOX10 with schizophrenia in the Japanese population
    Nobuhisa Maeno
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Psychiatr Genet 17:227-31. 2007
    ..The SOX10 gene is located on chromosome 22q13.1, a region repeatedly reported to show positive signals in linkage studies on schizophrenia...
  7. ncbi request reprint An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population
    Xiaofei Ji
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nagoya J Med Sci 70:11-7. 2008
    ..05). These results suggest that HTR3B is involved in the development of TRS in the Japanese population...
  8. doi request reprint Association study between polymorphisms in glutathione-related genes and methamphetamine use disorder in a Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1040-6. 2008
    ..The present study suggests that the polymorphism of the GSTT1 gene might be a genetic risk factor of the development of METH psychosis in a Japanese population...
  9. doi request reprint An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population
    Shinichi Saito
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neuroreport 19:471-3. 2008
    ..Our results suggest that TACR3 is unlikely to be related to the development of schizophrenia in the Japanese population...
  10. doi request reprint Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population
    Itaru Kushima
    Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:786-91. 2010
    ..Taken together, we could not strongly show that common SNPs in the BRD1 gene account for a substantial proportion of the genetic risk for schizophrenia in the Japanese population...
  11. doi request reprint A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population
    Yoshihito Ito
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neurosci Lett 438:70-5. 2008
    ..Our findings suggest that FXYD6 is unlikely to be related to the development of schizophrenia in a Japanese population...
  12. ncbi request reprint A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects
    Takayoshi Koide
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Hum Genet 55:469-72. 2010
    ..39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects...
  13. ncbi request reprint Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis
    Daisuke Matsuzawa
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Am J Psychiatry 164:1105-14. 2007
    ..Based on the interaction of PICK1 with dopamine transporter, it is of particular interest to investigate the association between the PICK1 gene and methamphetamine abusers...
  14. doi request reprint Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population
    Xiaofei Ji
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurosci Lett 435:95-8. 2008
    ..041). The present results support further research to examine the relationship between HTR3A polymorphism and the development of TRS in the Japanese population...
  15. doi request reprint Gene-wide association study between the methylenetetrahydrofolate reductase gene (MTHFR) and schizophrenia in the Japanese population, with an updated meta-analysis on currently available data
    Akira Yoshimi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Schizophr Res 124:216-22. 2010
    ..However, since our meta-analysis results demonstrated strong support for association of rs1801133 with schizophrenia, further replication studies based on a gene-wide approach need to be considered...
  16. ncbi request reprint Association study between vesicle-associated membrane protein 2 gene polymorphisms and fluvoxamine response in Japanese major depressive patients
    Shinichi Saito
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Aichi, Japan
    Neuropsychobiology 54:226-30. 2006
    ..The purpose of this study was to investigate whether the VAMP2 gene is associated with clinical responses to a specific antidepressant, fluvoxamine...
  17. ncbi request reprint Gap junction coding genes and schizophrenia: a genetic association study
    Branko Aleksic
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa Ku, Tsurumai cho, 65, 466 8550, Nagoya, Aichi, Japan
    J Hum Genet 52:498-501. 2007
    ..Allele-, genotype- and haplotype-wise association did not yield statistically significant results. These data do not suggest that Panx2 or Cx36 could increase the risk of schizophrenia in the Japanese population...
  18. ncbi request reprint Association study between the transferrin gene and schizophrenia in the Japanese population
    Nobuhisa Maeno
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuroreport 18:517-20. 2007
    ..The present results suggest that the transferrin gene is not related to the development of schizophrenia in the Japanese population...
  19. doi request reprint Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population
    Itaru Kushima
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Aichi, Japan
    J Hum Genet 55:133-6. 2010
    ..No significant association was detected for bipolar disorder. In conclusion, our data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46...
  20. ncbi request reprint Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population
    Nagahide Takahashi
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Schizophr Res 83:179-83. 2006
    ..007). These results suggest that the CHGA gene is associated with the risk of developing schizophrenia in the Japanese population...
  21. ncbi request reprint Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder
    Nagisa Aoyama
    Department of Medical Technology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Alcohol Clin Exp Res 30:1644-9. 2006
    ..Moreover, SLC22A3 (which encodes OCT3) is a candidate gene for MAP dependence because it is located within a chromosomal region associated with substance dependence...
  22. pmc Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel-based morphometry and mutation screening
    Branko Aleksic
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Schizophr Bull 39:720-8. 2013
    ..02). These findings demonstrate that VAV3 can be seen as novel candidate gene for schizophrenia in which both rare and common variants may be related to increased genetic risk for schizophrenia in Japanese population...
  23. pmc Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients
    Takayoshi Koide
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 7:e36836. 2012
    ....
  24. ncbi request reprint The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population
    Hinako Usui
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, and Ichihara Hospital, Chiba, Japan
    Schizophr Res 88:245-50. 2006
    ..These findings suggest that CNP and OLIG2 are unlikely to be related to the development of schizophrenia in the Japanese population...
  25. doi request reprint No association between the protein tyrosine phosphatase, receptor-type, Z Polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population
    Yoshihito Ito
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Aichi, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1013-8. 2008
    ..Our results therefore suggest that PTPRZ1 is unlikely to be related to the development of schizophrenia in the Japanese population...
  26. doi request reprint Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects
    Yukako Nakamura
    Department of Psychiatry, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi, Japan
    J Hum Genet 55:838-41. 2010
    ..In terms of serotonin receptor 2A gene polymorphisms and maternal overprotection, our findings suggest the existence of a gene-environmental interaction that influences HA...
  27. ncbi request reprint No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population
    Branko Aleksic
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Showa Ku, Tsurumai cho, 65, Nagoya, Aichi 466 8550, Japan
    J Hum Genet 53:863-6. 2008
    ..We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor...
  28. doi request reprint Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population
    Branko Aleksic
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Schizophr Res 118:113-7. 2010
    ..However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia...
  29. pmc Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility
    Itaru Kushima
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Schizophr Bull 38:552-60. 2012
    ..5) in kalrn or ephb1...
  30. ncbi request reprint Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Addict Biol 10:145-8. 2005
    ..038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese...
  31. ncbi request reprint No association between monoamine oxidase A promoter polymorphism and personality traits in Japanese females
    Yuko Hakamata
    Department of Psychology and Human Developmental Sciences, Nagoya University, Graduate School of Education and Human Development, Japan
    Neurosci Lett 389:121-3. 2005
    ..There was no association between any personality trait and MAO-A genotype. The present results do not support the hypothesis that MAO-A gene polymorphism is related to certain personality traits in females...
  32. ncbi request reprint Association between chromogranin b gene polymorphisms and schizophrenia in the Japanese population
    Yoshimi Iijima
    National Institute of Mental Health YI, National Center of Neurology and Psychiatry, Ichikawa, Chiba, Japan
    Biol Psychiatry 56:10-7. 2004
    ....
  33. ncbi request reprint A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population
    Tasuku Hashimoto
    Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    Am J Med Genet B Neuropsychiatr Genet 135:5-9. 2005
    ..Our findings suggest that the polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population...
  34. ncbi request reprint Association study between Apolipoprotein L and schizophrenia by exhaustive and rule-based combination analysis for identification of multilocus interactions
    Yasuyuki Tomita
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Biosci Bioeng 103:303-10. 2007
    ....
  35. ncbi request reprint Extrapyramidal symptom profiles assessed with the Drug-Induced Extrapyramidal Symptom Scale: comparison with Western scales in the clinical double-blind studies of schizophrenic patients treated with either olanzapine or haloperidol
    Toshiya Inada
    National Center of Neurology and Psychiatry, Japan
    Int Clin Psychopharmacol 18:39-48. 2003
    ..This preliminary and retrospective work suggests that the DIEPSS can be used to operationally define the presence or absence, and make the clinical diagnosis, of specific EPS syndromes...
  36. ncbi request reprint An association study between catechol-O-methyl transferase gene polymorphism and methamphetamine psychotic disorder
    Atsuko Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, and Ichihara Hospital, Chiba, Japan
    Psychiatr Genet 16:133-8. 2006
    ..This study aimed to investigate whether a functional polymorphism of the catechol-O-methyl transferase gene would be involved in the development of these psychiatric states...
  37. pmc A case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the Japanese population
    Masahiro Banno
    Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Aichi Ken, Japan
    PLoS ONE 6:e28929. 2011
    ..Moreover, hemizygosity of NETO1 was shown to be associated with autistic-like behavior in humans...
  38. ncbi request reprint No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Biol Psychiatry 56:376-8. 2004
    ....
  39. ncbi request reprint Methamphetamine psychosis in which tardive dystonia was successfully treated with clonazepam
    Nobutomo Yamamoto
    Department of Psychiatry, Shimofusa Psychiatric Medical Center, Chiba City, Chiba, Japan
    Psychiatry Clin Neurosci 61:691-4. 2007
    ..Tardive dystonia is currently treated on a trial-and-error basis. Accumulation of further cases similar to the present one is very important for establishing an effective treatment...
  40. ncbi request reprint No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population
    Shinichi Saito
    Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Neurosci Lett 374:21-4. 2005
    ..Because our sample size provided quite high power, ZDHHC8 may not play a major role in Japanese schizophrenia. And our results did not support the gender-specific effect of this SNP...
  41. ncbi request reprint Extrapyramidal symptom profiles in Japanese patients with schizophrenia treated with olanzapine or haloperidol
    Toshiya Inada
    Department of Geriatric Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Ichikawa, Japan
    Schizophr Res 57:227-38. 2002
    ..The results from this study suggest that olanzapine, as in Caucasian populations, is a safe treatment in Japanese patients chronically ill with schizophrenia...
  42. ncbi request reprint The inter-rater reliability of the Japanese version of the Montgomery-Asberg depression rating scale (MADRS) using a structured interview guide for MADRS (SIGMA)
    Nagahide Takahashi
    Department of Psychiatry and Psychobiology, Nagoya University, Graduate School of Medicine, Japan
    Hum Psychopharmacol 19:187-92. 2004
    ..00, while those achieved by three raters ranged from 0.85 to 1.00. The present results suggest that SIGMA is a potentially useful interview guide for assessing ten symptoms of MADRSJ precisely in patients with a depressive disorder...
  43. ncbi request reprint Regional brain cerebral glucose metabolism and temperament: a positron emission tomography study
    Yuko Hakamata
    Department of Psychology and Human Developmental Sciences, Nagoya University, Graduate School of Education and Human Development, Nagoya, Japan
    Neurosci Lett 396:33-7. 2006
    ..The various aspects of temperament may have biological bases in the specific brain regions. The accumulation of results from studies of this kind should provide further evidence connecting personality traits with their biological bases...
  44. ncbi request reprint Association study between brain-derived neurotrophic factor gene polymorphisms and methamphetamine abusers in Japan
    Kanako Itoh
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 132:70-3. 2005
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299:1/suppmat/index.html...
  45. doi request reprint A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia
    Tsuyuka Ohtsuki
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Schizophr Res 101:9-16. 2008
    ..The GRM7 gene is located on human chromosome 3p26, which has been suggested by linkage analysis to contain a susceptibility locus for schizophrenia...
  46. doi request reprint Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia
    Toshiya Inada
    Seiwa Hospital, Institute of Neuropsychiatry, Benten cho 91, Shinjuku ku, Tokyo, Japan
    Pharmacogenet Genomics 18:317-23. 2008
    ..In this study, a genome-wide association screening was done to identify the pathway(s) in which genetic variations influence susceptibility to neuroleptic-induced TD...
  47. doi request reprint Genome-wide association for methamphetamine dependence: convergent results from 2 samples
    George R Uhl
    Molecular Neurobiology Branch, National Institutes of Health Intramural Program, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Arch Gen Psychiatry 65:345-55. 2008
    ..We can improve understanding of human methamphetamine dependence, and possibly our abilities to prevent and treat this devastating disorder, by identifying genes whose allelic variants predispose to methamphetamine dependence...
  48. doi request reprint Large-scale case-control study of a functional polymorphism in the glutamate receptor, metabotropic 3 gene in patients with schizophrenia
    Ayako Nunokawa
    Psychiatry Clin Neurosci 62:239-40. 2008
  49. doi request reprint No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population
    Kunihiro Kawashima
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1327-31. 2008
    ..However, these associations could not be confirmed in the second-set analysis. These results suggest that the SNARE complex-related genes do not play a major role in susceptibility to schizophrenia in the Japanese population...
  50. doi request reprint Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia
    Masashi Ikeda
    Department of Psychiatry, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Hum Mol Genet 17:3212-22. 2008
    ..Our results suggest that YWHAE is a possible susceptibility gene that functions protectively in schizophrenia...
  51. ncbi request reprint Cytochrome P450 2D6 polymorphism and character traits
    Eiji Suzuki
    Department of Psychiatry, Kitasato University School of Medicine, Kanagawa, Japan
    Psychiatr Genet 13:111-3. 2003
    ..The dopamine system is suggested to play a role in determining normal character. The purpose of this study was to examine whether character traits are dependent on cytochrome P450 2D6 activity...
  52. pmc Are the cochrane group registers comprehensive? A case study of Japanese psychiatry trials
    Toshi A Furukawa
    Department of Psychiatry, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya 467 8601 Japan
    BMC Med Res Methodol 2:6. 2002
    ..The Cochrane Controlled Trials Register is one attempt to remedy this and now contains more than 300,000 citations. However we are still unsure if it provides comprehensive coverage, particularly for non-English trials...
  53. ncbi request reprint No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Schizophr Res 78:127-30. 2005
    ..Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis...
  54. doi request reprint Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
    Schizophr Res 101:1-8. 2008
    ..Moreover, the nature of our results support that two-stage analysis with large sample size is appropriate to examine the susceptibility genes for common diseases...
  55. doi request reprint Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence
    Kyohei Otani
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Shikata cho 2 5 1, Okayama 700 8558, Japan
    Neurosci Lett 434:88-92. 2008
    ..0212), with an odds ratio of 0.62 (95% confidence interval: 0.51-0.76). The present study demonstrated that reduced CYP2D6 activity was a negative risk factor for methamphetamine dependence...
  56. ncbi request reprint A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 32:1727-37. 2007
    ..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations...
  57. ncbi request reprint [Genetic studies on substance dependence]
    Hiroshi Ujiie
    Seishin Shinkeigaku Zasshi 106:1598-603. 2004
  58. ncbi request reprint Positive association of AKT1 haplotype to Japanese methamphetamine use disorder
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Int J Neuropsychopharmacol 9:77-81. 2006
    ..Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition...
  59. ncbi request reprint The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Japan
    Neurosci Lett 383:194-8. 2005
    ..Because the polymorphism is located in the promoter region of the XBP-1 gene and affects transcription activity of the gene, it is unlikely that dysfunction of XBP-1 may induces susceptibility to methamphetamine dependence...
  60. ncbi request reprint Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations
    Kazuhiko Nakamura
    Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Hum Genet 120:243-52. 2006
    ..014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis...
  61. ncbi request reprint Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis
    Hideaki Kobayashi
    Department of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Med Genet B Neuropsychiatr Genet 141:482-6. 2006
    ..These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis...
  62. ncbi request reprint Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence
    Akira Nomura
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Neurosci Lett 400:158-62. 2006
    ..83, 95% ci=1.24-2.68)...
  63. pmc Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    Tadao Arinami
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki Ken, 305 8577, Japan
    Am J Hum Genet 77:937-44. 2005
    ....
  64. ncbi request reprint A nonsynonymous polymorphism in the human fatty acid amide hydrolase gene did not associate with either methamphetamine dependence or schizophrenia
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Lett 376:182-7. 2005
    ..Because the Pro129Thr polymorphism reduces enzyme instability, it is unlikely that dysfunction of FAAH and enhanced endocannabinoid system induce susceptibility to either methamphetamine dependence/psychosis or schizophrenia...
  65. ncbi request reprint Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population
    Minori Koga
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Neurosci Lett 417:326-9. 2007
    ..79, respectively). We concluded that the missense mutation Asp123Glu of the FEZ1 gene is unlikely to play a substantial role in the genetic susceptibility to schizophrenia...
  66. ncbi request reprint Study of association between alpha-synuclein gene polymorphism and methamphetamine psychosis/dependence
    Hideaki Kobayashi
    Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Ann N Y Acad Sci 1025:325-34. 2004
    ..Further analyses are necessary to clarify the gender difference, by using a larger sample size and/or different ethnic groups, as well as functional variations in the alpha-synuclein gene...
  67. ncbi request reprint Association of AKT1 with schizophrenia confirmed in a Japanese population
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Biol Psychiatry 56:698-700. 2004
    ..Recent evidence supporting this hypothesis showed decreased AKT1 protein levels in patients with schizophrenia and significant association of AKT1 haplotypes according to the transmission disequilibrium test...
  68. ncbi request reprint Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder
    Akira Yoshimi
    Division of Clinical Science and Neuropsychopharmacology, Graduate School of Pharmacy, Meijo University, Aichi, 468 8503, Japan
    Schizophr Res 100:334-41. 2008
    ..Our findings suggest that PPP1R1B SNPs are unlikely to be related to the development of schizophrenia and bipolar disorder in the Japanese population...
  69. ncbi request reprint Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population
    Talal Albalushi
    Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:392-6. 2008
    ..Our data indicate that SNPs previously reported to be associated with schizophrenia do not contribute to genetic susceptibility to schizophrenia...
  70. ncbi request reprint No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Schizophr Res 91:22-6. 2007
    ..Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population...
  71. ncbi request reprint Gene polymorphisms of the mu opioid receptor in methamphetamine abusers
    Soichiro Ide
    Department of Molecular Psychiatry, Tokyo Institute of Psychiatry, Japan
    Ann N Y Acad Sci 1025:316-24. 2004
    ..Further analysis should be capable of identifying associations between the OPRM variations and MAP dependence/psychosis...
  72. ncbi request reprint The glycine transporter 1 gene (GLYT1) is associated with methamphetamine-use disorder
    Yukitaka Morita
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences 2 5 1 Shikata cho, Okayama, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:54-8. 2008
    ..000039, odds ratio: 2.04). The present findings indicate that genetic variation of the GLYT1 gene may contribute to individual vulnerability to methamphetamine dependence and psychosis...
  73. ncbi request reprint The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis
    Makiko Kishimoto
    Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Biol Psychiatry 63:191-6. 2008
    ..DTNBP1 may confer susceptibility to psychotic symptoms in various psychiatric disorders besides schizophrenia...
  74. ncbi request reprint Association analysis of chromosome 5 GABAA receptor cluster in Japanese schizophrenia patients
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Biol Psychiatry 58:440-5. 2005
    ..A GABA(A) receptor gene cluster on 5q31-35 (beta2 [GABRB2], alpha6 [GABRA6], alpha1 [GABRA1], and gamma2 [GABRG2] subunit genes) is one of the most attractive candidate regions for schizophrenia susceptibility...
  75. ncbi request reprint Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers
    Hiroki Koizumi
    Department of Psychiatry, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Am J Med Genet B Neuropsychiatr Genet 126:43-5. 2004
    ..007, odds ratio: 2.77, 95% CI 1.30-5.89) higher than that of male abusers with deletion alleles. These findings suggest that GSTM1 gene deletion may contribute to a vulnerability to MAP abuse in female subjects, but not in male subjects...
  76. ncbi request reprint 'Awakenings' in demented patients
    Koji Hori
    Psychiatry Clin Neurosci 57:237. 2003