Masatoshi Ichihara

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint RET and neuroendocrine tumors
    Masatoshi Ichihara
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Lett 204:197-211. 2004
  2. ncbi request reprint Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase
    Mayumi Uchida
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 119:3067-77. 2006
  3. ncbi request reprint CD109 expression in squamous cell carcinoma of the uterine cervix
    Jing Min Zhang
    Department of Pathology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pathol Int 55:165-9. 2005
  4. ncbi request reprint Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties
    Yi Jin
    Department of Pathology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Cancer Sci 95:815-21. 2004
  5. ncbi request reprint Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells
    Kengo Maeda
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 323:345-54. 2004
  6. ncbi request reprint Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase
    Maki Ishida
    Department of Pathology, and Department of Mrfovs Technology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 98:815-21. 2007
  7. ncbi request reprint RET and neuroendocrine tumors
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Pituitary 9:179-92. 2006
  8. pmc GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region
    Takatoshi Morinaga
    Department of Pathology, Nagoya University Graduate School of Medicine 65 Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Nucleic Acids Res 33:4191-201. 2005
  9. ncbi request reprint A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1
    Chikage Suzuki
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8850, Japan
    Biochem Biophys Res Commun 366:226-32. 2008
  10. pmc A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia
    Mayumi Jijiwa
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Mol Cell Biol 24:8026-36. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint RET and neuroendocrine tumors
    Masatoshi Ichihara
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Lett 204:197-211. 2004
    ..In this review, we describe the current knowledge about the molecular mechanism of RET activation in human neuroendocrine tumors as well as the physiological roles and signal transduction of RET tyrosine kinase...
  2. ncbi request reprint Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase
    Mayumi Uchida
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Cell Sci 119:3067-77. 2006
    ..Together, our results suggest that Dok-4, through activation of the Rap1-ERK1/2 pathway, regulates GDNF-mediated neurite outgrowth during neuronal development...
  3. ncbi request reprint CD109 expression in squamous cell carcinoma of the uterine cervix
    Jing Min Zhang
    Department of Pathology, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pathol Int 55:165-9. 2005
    ..These findings suggest that CD109 may become a molecular target for the development of new therapeutics for squamous cell carcinoma of various tissue origins...
  4. ncbi request reprint Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties
    Yi Jin
    Department of Pathology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Cancer Sci 95:815-21. 2004
    ..These findings suggest that CKAP2 is a new MAP with microtubule-stabilizing properties and may represent a new molecular target for cancer chemotherapy...
  5. ncbi request reprint Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells
    Kengo Maeda
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 323:345-54. 2004
    ..These findings demonstrated that coupling of Gab1 to PI3K is important for biological responses in RET-expressing cells...
  6. ncbi request reprint Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase
    Maki Ishida
    Department of Pathology, and Department of Mrfovs Technology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 98:815-21. 2007
    ..Taken together, our results suggest that SPRY2 regulates GDNF-dependent proliferation and differentiation of TGW neuroblastoma cells mediated by RET tyrosine kinase...
  7. ncbi request reprint RET and neuroendocrine tumors
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Pituitary 9:179-92. 2006
    ..In this review, we summarize progress in the study of RET from bench to bedside, focusing on pathophysiology of neuroendocrine tumors...
  8. pmc GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region
    Takatoshi Morinaga
    Department of Pathology, Nagoya University Graduate School of Medicine 65 Tsurumai cho, Showa Ku, Nagoya 466 8550, Japan
    Nucleic Acids Res 33:4191-201. 2005
    ..These findings thus suggest that GZF1 may regulate the spatial and temporal expression of the HOXA10 gene which plays a role in morphogenesis...
  9. ncbi request reprint A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1
    Chikage Suzuki
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8850, Japan
    Biochem Biophys Res Commun 366:226-32. 2008
    ..Furthermore, siRNA-mediated silencing of BMZF3 inhibited cell proliferation. These findings suggest that BMZF3 is a transcriptional repressor induced by GDNF that plays a role in cell proliferation...
  10. pmc A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia
    Mayumi Jijiwa
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Mol Cell Biol 24:8026-36. 2004
    ..Thus, these findings demonstrated that the signal via tyrosine 1062 plays an important role in histogenesis of the enteric nervous system and nephrogenesis...
  11. ncbi request reprint Induction of CRMP-2 by GDNF and analysis of the CRMP-2 promoter region
    Yoshinori Kodama
    Department of Pathology, Nagoya University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 320:108-15. 2004
    ..However, neuritogenesis of TGW cells was mostly dependent on Src family kinase activity and not ERK activity, indicating that the increased expression of CRMP-2 alone was not sufficient for neuritogenesis...
  12. ncbi request reprint Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation
    Kumi Kawai
    Department of Molecular Pathology, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550
    Cancer Sci 94:992-7. 2003
    ..These results may reflect the profiles of the transcriptional changes associated with dedifferentiation or progression of mammary carcinomas developed in genetically engineered mice...
  13. doi request reprint Epidermal hyperplasia and appendage abnormalities in mice lacking CD109
    Shinji Mii
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Pathol 181:1180-9. 2012
    ..These results suggest that CD109 regulates differentiation of keratinocytes via a signaling pathway involving Stat3...
  14. ncbi request reprint The RET proto-oncogene: a molecular therapeutic target in thyroid cancer
    Yoshinori Kodama
    Department of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku Nagoya, 466 8550, Japan
    Cancer Sci 96:143-8. 2005
    ..RET and some signaling molecules that function downstream of RET could be potential targets for the development of selective cancer therapeutics...
  15. pmc Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice
    Hiroki Sakakura
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    PLoS ONE 9:e83385. 2014
    ..The half-life of tumor-secreted CD109 was about 5.86±0.17 h. These results indicate that CD109 is present in serum as a soluble form, and suggest its potential as a novel tumor marker in patients with cancers that express CD109. ..
  16. ncbi request reprint Expression of CD109 in human cancer
    Mizuo Hashimoto
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Oncogene 23:3716-20. 2004
    ..Thus, these results suggested that CD109 might be a useful molecular target for the development of new therapeutics for malignant tumors, such as squamous cell carcinoma...
  17. ncbi request reprint Analyses of ultraviolet-induced focus formation of hREV1 protein
    Yoshiki Murakumo
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Genes Cells 11:193-205. 2006
    ..Furthermore, it was found that the hREV1 focus formation after UV irradiation required a region near the C-terminal (826-1178)...
  18. pmc Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats
    Mikako Ito
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Med Gas Res 2:15. 2012
    ..abstract:..
  19. pmc Characterization of gene expression induced by RET with MEN2A or MEN2B mutation
    Tsuyoshi Watanabe
    Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Pathol 161:249-56. 2002
    ....
  20. pmc Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases
    Kinji Ohno
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Oxid Med Cell Longev 2012:353152. 2012
    ..Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease...
  21. ncbi request reprint Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis
    Naoyuki Fukuda
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Biol Chem 278:50386-92. 2003
    ....
  22. ncbi request reprint UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor α and interleukin 6
    Maiko Miyata
    Department of Life and Medical Sciences, Chubu University Faculty of Life and Health Sciences, Matsumoto, Kasugai 487 8501, Japan Department of Biochemistry II, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa Ku, Nagoya 466 0065, Japan
    Biochem Biophys Res Commun 445:504-10. 2014
    ....
  23. doi request reprint Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease
    Yuan Fu
    Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurosci Lett 453:81-5. 2009
    ..Our studies suggest that hydrogen water is likely able to retard the development and progression of Parkinson's disease...