Gaku Ichihara

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat
    Jie Chang
    Graduate School of Regional Innovation Studies, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Nutr Metab (Lond) 9:87. 2012
  2. pmc Carbon Nanotubes in historical and future perspective Summary of an Extended Session at Carbon 2008 in Nagano (JP)
    Morinobu Endo
    Electrical and Electronic Engineering, Faculty of Engineering, Shinshu University, Nagano, Japan
    Part Fibre Toxicol 5:21. 2008
  3. ncbi request reprint [Investigation of toxicity through human cases and animal experiments--study of bromopropanes]
    Gaku Ichihara
    Department of Occupational and Environmental Health, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Nihon Eiseigaku Zasshi 60:405-10. 2005
  4. pmc Neurologic abnormalities in workers of a 1-bromopropane factory
    Gaku Ichihara
    Field of Social Life Science, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Environ Health Perspect 112:1319-25. 2004
  5. ncbi request reprint A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane
    Gaku Ichihara
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Ind Med 45:63-75. 2004
  6. ncbi request reprint Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane
    Gaku Ichihara
    Occupational and Environmental Health, Social Life Science, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Int Arch Occup Environ Health 78:79-96. 2005
  7. ncbi request reprint 1-Bromopropane, an alternative to ozone layer depleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure
    G Ichihara
    Department of Occupational and Environmental Health, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Toxicol Sci 55:116-23. 2000
  8. ncbi request reprint Reproductive toxicity of 1-bromopropane, a newly introduced alternative to ozone layer depleting solvents, in male rats
    G Ichihara
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Japan
    Toxicol Sci 54:416-23. 2000
  9. ncbi request reprint Dose-dependent biochemical changes in rat central nervous system after 12-week exposure to 1-bromopropane
    Hailan Wang
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurotoxicology 24:199-206. 2003
  10. ncbi request reprint Effects of exposure of rat dams to 1-bromopropane during pregnancy and lactation on growth and sexual maturation of their offspring
    Koichi Furuhashi
    Department of Occupational and Environmental Health, Field of Social Life Science, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Toxicology 224:219-28. 2006

Collaborators

Detail Information

Publications37

  1. pmc Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat
    Jie Chang
    Graduate School of Regional Innovation Studies, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Nutr Metab (Lond) 9:87. 2012
    ..abstract:..
  2. pmc Carbon Nanotubes in historical and future perspective Summary of an Extended Session at Carbon 2008 in Nagano (JP)
    Morinobu Endo
    Electrical and Electronic Engineering, Faculty of Engineering, Shinshu University, Nagano, Japan
    Part Fibre Toxicol 5:21. 2008
    ..The paper of Poland et al was presented and detailed by Dr. Duffin, a senior researcher at the ELEGI-COLT lab at Edinburgh University (UK). Dr. Takagi and his team did not share our discussion although they were invited to do so...
  3. ncbi request reprint [Investigation of toxicity through human cases and animal experiments--study of bromopropanes]
    Gaku Ichihara
    Department of Occupational and Environmental Health, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya 466 8550, Japan
    Nihon Eiseigaku Zasshi 60:405-10. 2005
    ..Further studies should focus more on the differences and commonality between animals and humans in response to toxic agents...
  4. pmc Neurologic abnormalities in workers of a 1-bromopropane factory
    Gaku Ichihara
    Field of Social Life Science, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Environ Health Perspect 112:1319-25. 2004
    ..Time-weighted average exposure levels in the workers were 0.34-49.19 ppm. Exposure to 1-BP could adversely affect peripheral nerves or/and the central nervous system...
  5. ncbi request reprint A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane
    Gaku Ichihara
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Ind Med 45:63-75. 2004
    ..The aim of this study was to evaluate the health effects of exposure mainly to 1-bromopropane, which is an alternative to ozone-depleting solvents, and to establish biomarkers for assessing 1-bromopropane exposure...
  6. ncbi request reprint Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane
    Gaku Ichihara
    Occupational and Environmental Health, Social Life Science, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Int Arch Occup Environ Health 78:79-96. 2005
    ..The dose-response of bromopropanes in humans and mechanism(s) underlying the differences in the toxic effects of the two bromopropanes remain to be determined...
  7. ncbi request reprint 1-Bromopropane, an alternative to ozone layer depleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure
    G Ichihara
    Department of Occupational and Environmental Health, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Toxicol Sci 55:116-23. 2000
    ..1-Bromopropane may be seriously neurotoxic to humans and should thus be used carefully in the workplace...
  8. ncbi request reprint Reproductive toxicity of 1-bromopropane, a newly introduced alternative to ozone layer depleting solvents, in male rats
    G Ichihara
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Japan
    Toxicol Sci 54:416-23. 2000
    ..Its reproductive toxicity is different from that of 2-bromopropane, which specifically impairs spermatogonia. Thus, this solvent may have serious reproductive toxic effects in men, and should be used very cautiously in the workplace...
  9. ncbi request reprint Dose-dependent biochemical changes in rat central nervous system after 12-week exposure to 1-bromopropane
    Hailan Wang
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neurotoxicology 24:199-206. 2003
    ..The biochemical changes in the cerebrum indicate that long-term exposure to 1-bromopropane has effects on the CNS...
  10. ncbi request reprint Effects of exposure of rat dams to 1-bromopropane during pregnancy and lactation on growth and sexual maturation of their offspring
    Koichi Furuhashi
    Department of Occupational and Environmental Health, Field of Social Life Science, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Toxicology 224:219-28. 2006
    ..Moreover, exposure during lactation is associated with reduced early survival of third generation (F2) rats...
  11. doi request reprint Comparative study on susceptibility to 1-bromopropane in three mice strains
    Fang Liu
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Toxicol Sci 112:100-10. 2009
    ..Comparison with previous studies in rats indicates that mice are far more susceptible than rats to 1BP regarding hepatotoxicity and reproductive toxicity...
  12. ncbi request reprint A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats
    Ai Okamura
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Toxicology 213:129-37. 2005
    ..This conclusion was also supported by an estimate of the decrease in human sperm motility based on the urinary DMP concentrations observed in actual occupational settings...
  13. doi request reprint Proteomic identification of carbonylated proteins in F344 rat hippocampus after 1-bromopropane exposure
    Zhenlie Huang
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Toxicol Appl Pharmacol 263:44-52. 2012
    ..001; r = 0.71). In conclusion, 1-BP-induced neurotoxicity in the rat hippocampus seems to involve oxidative damage of cellular proteins, decreased TPI activity, and elevated AGEs...
  14. ncbi request reprint Reversibility of the adverse effects of 1-bromopropane exposure in rats
    Shameema Banu
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Toxicol Sci 100:504-12. 2007
    ....
  15. doi request reprint Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity
    Fang Liu
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Toxicol Sci 115:596-606. 2010
    ..That oxidative stress plays a role in 1-BP hepatotoxicity is deduced from the low expression levels and activities of antioxidant enzymes and high MDA levels in Nrf2-null mice...
  16. ncbi request reprint A survey of semen indices in insecticide sprayers
    Michihiro Kamijima
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Occup Health 46:109-18. 2004
    ..Despite possible inherent differences between the groups, the above season-dependent differences suggested that the observed lower semen quality in the sprayers was associated with pesticide spraying work...
  17. doi request reprint Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats
    Lingyi Zhang
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Toxicology 304:76-82. 2013
    ..The present study tested the hypothesis that 1-BP suppresses neurogenesis in the dentate gyrus, which is involved in higher cerebral function, in adult rats...
  18. ncbi request reprint Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days
    Hailan Wang
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Toxicol Sci 67:114-20. 2002
    ..Glutathione depletion or modification to functional proteins containing a sulfhydryl base as a critical site might be the underlying mechanism of 1-bromopropane neurotoxicity...
  19. ncbi request reprint Di(2-ethylhexyl)phthalate induces hepatic tumorigenesis through a peroxisome proliferator-activated receptor alpha-independent pathway
    Yuki Ito
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Occup Health 49:172-82. 2007
    ..These results suggest that increases in oxidative stress induced by DEHP exposure may lead to the induction of inflammation and/or the expression of protooncogenes, resulting in a high incidence of tumorigenesis in Pparalpha-null mice...
  20. ncbi request reprint Effects of exposure to 1-bromopropane on astrocytes and oligodendrocytes in rat brain
    Sahabudeen Sheik Mohideen
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya University, Japan
    J Occup Health 55:29-38. 2013
    ..The present study investigated the effects of 1-BP on astrocytes and oligodendrocytes in the rat cerebellum and hippocampus to find sensitive markers of central nervous system toxicity...
  21. ncbi request reprint Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum
    Kaviarasan Subramanian
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showaku, Nagoya 466 8550, Japan
    Toxicology 302:18-24. 2012
    ..The results showed that exposure to 1-BP induced morphological change in the microglia and oxidative stress, suggesting that these effects are part of the underlying neurotoxic mechanism of 1-BP in the CNS...
  22. ncbi request reprint Exposure to 1-bromopropane causes ovarian dysfunction in rats
    Tetsuya Yamada
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Toxicol Sci 71:96-103. 2003
    ..Our results indicate that 1-bromopropane can induce a dose-dependent ovarian dysfunction in nonpregnant female rats associated with disruption in follicular growth process...
  23. doi request reprint Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1
    Doni Hikmat Ramdhan
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Japan
    Toxicol Appl Pharmacol 231:300-7. 2008
    ..Intermediate metabolite(s) from TRI to chloral hydrate produced by CYP2E1-mediated oxidation may be involved in the former, and TCA in the latter...
  24. ncbi request reprint Differential cardiovascular effects of endotoxin derived from Escherichia coli or Pseudomonas aeruginosa
    Aya Matsushita
    Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University, Japan
    Exp Anim 56:339-48. 2007
    ..These differential responses may be attributable in part to the difference in the associated increases in the plasma concentration of TNF-alpha. The cardiovascular effects of LPS thus depend on the causative organisms...
  25. doi request reprint Trends in asbestos and non-asbestos fibre concentrations in the lung tissues of Japanese patients with mesothelioma
    Kiyoshi Sakai
    Nagoya City Public Health Research Institute, 1 11 Hagiyama cho, Mizuho ku, Nagoya, Aichi 467 8615, Japan
    Ann Occup Hyg 58:103-20. 2014
    ..We aimed to elucidate changes in asbestos and non-asbestos fibre concentrations in the lung tissues of Japanese patients with mesothelioma over time...
  26. ncbi request reprint Pleural plaque profiles on the chest radiographs and CT scans of asbestos-exposed Japanese construction workers
    Momen Elshazley
    Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan
    Ind Health 49:626-33. 2011
    ....
  27. doi request reprint Changes in neurotransmitter receptor expression levels in rat brain after 4-week exposure to 1-bromopropane
    Sahabudeen Sheik Mohideen
    Department of Occupational and Environmental Health, Graduate School of Medicine, Nagoya University, 65 Tsurumai Cho, Showaku, Nagoya 466 8550, Japan
    Neurotoxicology 30:1078-83. 2009
    ..The results suggest that mRNA expression analysis is useful in identifying brain regions susceptible to 1-BP, as well as providing potential biomarkers for central nervous system toxicity...
  28. doi request reprint Proteomic analysis of hippocampal proteins of F344 rats exposed to 1-bromopropane
    Zhenlie Huang
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Toxicol Appl Pharmacol 257:93-101. 2011
    ..Overall, the results suggest that 1-BP-induced hippocampal damage involves oxidative stress, loss of ATP production, neurotransmitter dysfunction and inhibition of ubiquitination-proteasome system...
  29. ncbi request reprint Functional activation of peroxisome proliferator-activated receptor alpha (PPARalpha) by environmental chemicals in relation to their toxicities
    Tamie Nakajima
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa ka, Nagoya 466 8550, Japan
    Nagoya J Med Sci 65:85-94. 2002
    ..The effect of perfluorooctanoic acid on humans was evaluated from the aspect of lipid metabolism in one study, which concluded that there was no effect...
  30. ncbi request reprint Generalized skin reactions in relation to trichloroethylene exposure: a review from the viewpoint of drug-metabolizing enzymes
    Tamie Nakajima
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Japan
    J Occup Health 45:8-14. 2003
    ..This hypothesis may also be applicable to trichloroethylene because NAT is involved in the glutathione-mediated metabolism...
  31. doi request reprint Exposure to 1-bromopropane causes degeneration of noradrenergic axons in the rat brain
    Sahabudeen Sheik Mohideen
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Toxicology 285:67-71. 2011
    ..The results suggest that depressive symptoms in workers exposed to 1-BP are due, at least in part, to the degeneration of noradrenergic axons in the brain...
  32. ncbi request reprint Effect of inhalation exposure to 2-bromopropane on the nervous system in rats
    X Yu
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Japan
    Toxicology 135:87-93. 1999
    ..In 100-ppm exposed rats (n = 9), no significant changes were noted in body weight and the peripheral nerve. In conclusions, long-term exposure to 1000 ppm of 2-BP may result in peripheral neuropathy in rats...
  33. ncbi request reprint Chemopreventive effect of selenium-enriched Japanese radish sprout against breast cancer induced by 7,12-dimethylbenz[a]anthracene in rats
    Osamu Yamanoshita
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Japan
    Tohoku J Exp Med 212:191-8. 2007
    ..Thus, Se-enriched sprout may be a useful dietary ingredient for preventing breast cancer...
  34. ncbi request reprint Species differences in the metabolism of di(2-ethylhexyl) phthalate (DEHP) in several organs of mice, rats, and marmosets
    Yuki Ito
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 466 8550, Nagoya, Japan
    Arch Toxicol 79:147-54. 2005
    ....
  35. ncbi request reprint Dispersion method for safety research on manufactured nanomaterials
    Wenting Wu
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Japan
    Ind Health 52:54-65. 2014
    ..The cup-type sonicator might be a useful alternative to the traditional bath-type sonicator or probe-type sonicator based on its effective energy delivery and assurance of suspension purity. ..
  36. doi request reprint Methylation of dimethyltin in mice and rats
    Koichi Furuhashi
    Department of Occupational and Environmental Health, Field of Social Life Science, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Chem Res Toxicol 21:467-71. 2008
    ..Neither DMT nor TMT was detected in the samples collected at baseline. Our results indicate urinary excretion of TMT in mice and rats injected with DMTC, confirming the production of TMT in vivo, probably through methylation of DMT...
  37. ncbi request reprint Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure
    Sahoko Ichihara
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cardiovasc Res 69:726-35. 2006
    ..We have now investigated the role of MMPs and their tissue inhibitors (TIMPs) in the transition from compensated left ventricular (LV) hypertrophy to heart failure as well as the effects of pravastatin on this transition in a rat model...