Yoshiki Hirooka

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. doi request reprint Contrast-enhanced endoscopic ultrasonography in digestive diseases
    Yoshiki Hirooka
    Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma cho, Showa Ku, Nagoya City, Japan
    J Gastroenterol 47:1063-72. 2012
  2. ncbi request reprint Recent advances in US diagnosis of pancreatic cancer
    Y Hirooka
    Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Hepatogastroenterology 48:916-22. 2001
  3. doi request reprint Diagnosis of pancreatic disorders using contrast-enhanced endoscopic ultrasonography and endoscopic elastography
    Yoshiki Hirooka
    Department of Endoscopy, Nagoya University Hospital, Nagoya City, Aichi Prefecture, Japan
    Clin Gastroenterol Hepatol 7:S63-7. 2009
  4. doi request reprint A combination therapy of gemcitabine with immunotherapy for patients with inoperable locally advanced pancreatic cancer
    Yoshiki Hirooka
    Department of Endoscopy, Nagoya University, Nagoya City, Japan
    Pancreas 38:e69-74. 2009
  5. doi request reprint Association of interleukin 28B and mutations in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Liver Int 31:1359-65. 2011
  6. doi request reprint Prevalence and clinical characterization of patients with acute hepatitis B induced by lamivudine-resistant strains
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 25:745-9. 2010
  7. doi request reprint Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C
    Yoshihiko Tachi
    Department of Gastroenterology, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    Liver Int 30:554-9. 2010
  8. doi request reprint Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Med Virol 84:438-44. 2012
  9. doi request reprint Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C
    Takashi Honda
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Liver Int 30:527-37. 2010
  10. doi request reprint Small-bowel obstruction: diagnostic comparison between double-balloon endoscopy and fluoroscopic enteroclysis, and the outcome of enteroscopic treatment
    Naoki Ohmiya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Gastrointest Endosc 69:84-93. 2009

Detail Information

Publications88

  1. doi request reprint Contrast-enhanced endoscopic ultrasonography in digestive diseases
    Yoshiki Hirooka
    Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma cho, Showa Ku, Nagoya City, Japan
    J Gastroenterol 47:1063-72. 2012
    ..Studies of CE-EUS in diseases in many other organs will increase in the near future...
  2. ncbi request reprint Recent advances in US diagnosis of pancreatic cancer
    Y Hirooka
    Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Hepatogastroenterology 48:916-22. 2001
    ..In this report, we describe the present situation and the prospective outlook for these new diagnostic modalities mainly on the basis of our own experiences...
  3. doi request reprint Diagnosis of pancreatic disorders using contrast-enhanced endoscopic ultrasonography and endoscopic elastography
    Yoshiki Hirooka
    Department of Endoscopy, Nagoya University Hospital, Nagoya City, Aichi Prefecture, Japan
    Clin Gastroenterol Hepatol 7:S63-7. 2009
    ..The evolving modalities of CE-EUS and EUS-elastography might provide clinical utility in the diagnosis of pancreatic disorders...
  4. doi request reprint A combination therapy of gemcitabine with immunotherapy for patients with inoperable locally advanced pancreatic cancer
    Yoshiki Hirooka
    Department of Endoscopy, Nagoya University, Nagoya City, Japan
    Pancreas 38:e69-74. 2009
    ....
  5. doi request reprint Association of interleukin 28B and mutations in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Liver Int 31:1359-65. 2011
    ..The aim of this study was to investigate whether the SNP of IL28B (rs8099917) and amino acid substitutions in the core and NS5A region affect the response to IFN therapy...
  6. doi request reprint Prevalence and clinical characterization of patients with acute hepatitis B induced by lamivudine-resistant strains
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 25:745-9. 2010
    ..The aim of this study was to investigate the molecular and clinical characteristics of patients with acute hepatitis B caused by LMV-resistant strains...
  7. doi request reprint Impact of amino acid substitutions in the hepatitis C virus genotype 1b core region on liver steatosis and hepatic oxidative stress in patients with chronic hepatitis C
    Yoshihiko Tachi
    Department of Gastroenterology, Nagoya University School of Medicine, Nagoya, Aichi, Japan
    Liver Int 30:554-9. 2010
    ..Hepatitis C virus (HCV) genotype 1 core protein induces hepatic steatosis and reactive oxygen species production in transgenic mice. The amino acid substitutions in the HCV core region appear to be related to hepatocarcinogenesis...
  8. doi request reprint Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Med Virol 84:438-44. 2012
    ..In conclusion, HCV genotype 1a is rare in Japan. The presence of IL28B genotype TT, and more than two mutations, in the ISDR are associated with a good response to IFN therapy in patients with HCV genotype 1a...
  9. doi request reprint Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C
    Takashi Honda
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Liver Int 30:527-37. 2010
    ..The aim of this study was to evaluate the efficacy and indication of combination therapy with ribavirin plus peginterferon-alpha-2b in chronic hepatitis C virus (HCV) patients aged 65 years and older...
  10. doi request reprint Small-bowel obstruction: diagnostic comparison between double-balloon endoscopy and fluoroscopic enteroclysis, and the outcome of enteroscopic treatment
    Naoki Ohmiya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Gastrointest Endosc 69:84-93. 2009
    ..Small-bowel obstruction (SBO) sometimes remains undiagnosed and untreatable without surgery...
  11. doi request reprint Intraductal papillary mucinous neoplasms of the pancreas: differentiation of malignant and benign tumors by endoscopic ultrasound findings of mural nodules
    Eizaburo Ohno
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 249:628-34. 2009
    ..The aim of this study was to identify predictors of malignancy using contrast-enhanced endoscopic ultrasound (CE-EUS)...
  12. doi request reprint Confocal endomicroscopy for phenotypic diagnosis of gastric cancer
    Kakunori Banno
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 25:712-8. 2010
    ..Relationships between mucin phenotype and malignant potential in gastric cancers have attracted attention. We attempted to assess the possibility of obtaining phenotypic diagnoses by confocal endomicroscopy...
  13. doi request reprint Malignant transformation of branch duct-type intraductal papillary mucinous neoplasms of the pancreas based on contrast-enhanced endoscopic ultrasonography morphological changes: focus on malignant transformation of intraductal papillary mucinous neoplasm
    Eizaburo Ohno
    Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan
    Pancreas 41:855-62. 2012
    ..We conducted a retrospective long-term follow-up study for malignant transformation (MT) of BD-IPMNs focusing on morphological changes...
  14. doi request reprint Dynamic quantitative evaluation of contrast-enhanced endoscopic ultrasonography in the diagnosis of pancreatic diseases
    Hiroshi Matsubara
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, and Department of Endoscopy, Nagoya University Hospital, Nagoya City, Japan
    Pancreas 40:1073-9. 2011
    ..This study aimed to investigate the usefulness of contrast-enhanced endoscopic ultrasonography (EUS) with time-intensity curve (TIC) in differentiating pancreatic diseases...
  15. ncbi request reprint Interleukin-8 gene polymorphism associated with susceptibility to non-cardia gastric carcinoma with microsatellite instability
    Kennosuke Shirai
    Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 21:1129-35. 2006
    ..Recently, cytokine polymorphisms have been reported to affect the development of non-cardia GC. The objective of this study was to elucidate the relationship between cytokine polymorphisms and MSI phenotypes...
  16. ncbi request reprint MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis
    Naoki Ohmiya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan 466 8550
    J Clin Oncol 24:4434-40. 2006
    ..The aim of this study was to determine whether SNP309 is associated with susceptibility to gastric carcinoma and its prognosis...
  17. ncbi request reprint P53, p21, and p73 gene polymorphisms in gastric carcinoma
    Osamu Shirai
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    Hepatogastroenterology 57:1595-601. 2010
    ..The aim of this study was to evaluate the association of genetic polymorphisms of p53, p21, and p73 genes with susceptibility to gastric carcinoma (GC), its clinicopathologic features, and prognosis...
  18. doi request reprint Mutations in the interferon sensitivity-determining region of hepatitis C virus genotype 2a correlate with response to pegylated-interferon-alpha 2a monotherapy
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    J Med Virol 81:459-66. 2009
    ..Rapid virologic response and the ISDR sequence variations are significantly associated with response to pegylated-IFN-alpha 2a monotherapy in Japanese patients with HCV genotype 2a...
  19. ncbi request reprint Usefulness of contrast-enhanced endoscopic ultrasonography in the differentiation between malignant and benign lymphadenopathy
    Akira Kanamori
    Department of Gastroenterology, Nagoya University School of Medicine, Nagoya, Japan
    Am J Gastroenterol 101:45-51. 2006
    ..In this study, we report the usefulness of contrast-enhanced EUS (CE-EUS) in the evaluation of benign lymph nodes (BLN) or malignant lymph nodes (MLN) based on blood flow patterns...
  20. doi request reprint Pilot study on confocal endomicroscopy for determination of the depth of squamous cell esophageal cancer in vivo
    Youichi Iguchi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 24:1733-9. 2009
    ..We planned a pilot study of the diagnosis of the depth of esophageal cancer using confocal endomicroscopy for treatment strategies...
  21. pmc A preliminary result of three-dimensional microarray technology to gene analysis with endoscopic ultrasound-guided fine-needle aspiration specimens and pancreatic juices
    Koji Nonogaki
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 4668550, Japan
    J Exp Clin Cancer Res 29:36. 2010
    ....
  22. doi request reprint Usefulness of EUS combined with contrast-enhancement in the differential diagnosis of malignant versus benign and preoperative localization of pancreatic endocrine tumors
    Takuya Ishikawa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gastrointest Endosc 71:951-9. 2010
    ..Pancreatic endocrine tumors (PETs) develop in relatively few patients, but they are often difficult to diagnose because of their small size and various clinical symptoms...
  23. doi request reprint Geranylgeranylacetone protects against diclofenac-induced gastric and small intestinal mucosal injuries in healthy subjects: a prospective randomized placebo-controlled double-blind cross-over study
    Yasumasa Niwa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Digestion 80:260-6. 2009
    ..We planned a pilot study to investigate the protective effects of geranylgeranylacetone (GGA) against NSAID-induced small intestinal injuries using video capsule endoscopy (VCE)...
  24. ncbi request reprint Are symptomatic changes in irritable bowel syndrome correlated with the capsule endoscopy transit time? A pilot study using the 5-HT4 receptor agonist mosapride
    Masanao Nakamura
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hepatogastroenterology 58:453-8. 2011
    ....
  25. doi request reprint Route selection for double-balloon endoscopy, based on capsule transit time, in obscure gastrointestinal bleeding
    Masanao Nakamura
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, and Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma cho, Showa Ku, Nagoya, 466 8550, Japan
    J Gastroenterol 45:592-9. 2010
    ..The aim of this retrospective study was to clarify the accuracy of the transit time of video capsule endoscopy (VCE) to the lesion as a predictive indicator for the decision on the initial DBE route...
  26. doi request reprint Comparison of the efficacy of ribavirin plus peginterferon alfa-2b for chronic hepatitis C infection in patients with and without coagulation disorders
    Takashi Honda
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 85:228-34. 2013
    ..In conclusion, combination therapy for chronic hepatitis C was comparably effective between patients with and without coagulation disorders and did not result in adverse bleeding...
  27. doi request reprint Real-time viewing of video capsule endoscopy for on-going mid GI bleeding
    Masanao Nakamura
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hepatogastroenterology 59:2533-35. 2012
    ..In the middle of the ileum, active bleeding from Dieulafoy's lesion was found and we treated it successfully. It was suggested the effectiveness of VCE in reference to the determination of RT for on-going mid GI bleeding...
  28. doi request reprint Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C
    Yoji Ishizu
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 27:1112-6. 2012
    ..HH shows ethnicity-based differences and little is known about the effects of HH mutations on CHC in the Japanese. Thus, the aim of this study was to clarify the clinical influence of HFE mutations in Japanese CHC patients...
  29. ncbi request reprint Rugal hyperplastic gastritis increases the risk of gastric carcinoma, especially diffuse and p53-independent subtypes
    Akihiko Oguri
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Gastroenterol Hepatol 19:561-6. 2007
    ..The objective of this study was to determine the association between hyperrugosity and gastric carcinogenesis, including p53 mutations...
  30. ncbi request reprint Diagnosis and treatment of obscure GI bleeding at double balloon endoscopy
    Naoki Ohmiya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Japan
    Gastrointest Endosc 66:S72-7. 2007
    ..Double balloon endoscopy (DBE) and videocapsule endoscopy (VCE) have been useful in managing obscure GI bleeding (OGIB)...
  31. doi request reprint Association of hepatitis B virus subgenotypes and basal core promoter/precore region variants with the clinical features of patients with acute hepatitis
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Gastroenterol 43:558-64. 2008
    ..The aim of this study was to investigate the distributions of subgenotypes and BCP/PC variants to identify clinical differences in acute hepatitis B patients...
  32. doi request reprint Prevalence of hepatitis B virus subgenotypes and basal core promoter, precore variants in patients with acute hepatitis B in central Vietnam
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Intervirology 52:22-8. 2009
    ....
  33. ncbi request reprint Comparison of image quality between electronic and mechanical radial scanning echoendoscopes in pancreatic diseases
    Katsushi Niwa
    Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 19:454-9. 2004
    ..In 2000, a newly designed echoendoscope, the electronic radial scanning echoendoscope (ER-ES), appeared. The aim of the present study was to compare B-mode image quality between the ER-ES and the MR-ES in pancreatic diseases...
  34. doi request reprint Prospective multicenter study to investigate the introduction rate of second-line S-1 in gemcitabine-refractory unresectable pancreatic cancer
    Hiroki Kawashima
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Chemother Pharmacol 68:677-83. 2011
    ..Therefore, we conducted a prospective multicenter study in which chemo-naïve patients were enrolled and had two levels of S-1 dose...
  35. doi request reprint Enteroscopic and radiologic diagnoses, treatment, and prognoses of small-bowel tumors
    Wataru Honda
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gastrointest Endosc 76:344-54. 2012
    ..Small-bowel tumors (SBTs) represent a diagnostic challenge...
  36. doi request reprint Mutations in two PKR-binding domains in chronic hepatitis C of genotype 3a and correlation with viral loads and interferon responsiveness
    Shouichi Yokozaki
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 83:1727-32. 2011
    ..The findings from this study suggest that the ISDR plays an important role in regulating viral replication in patients infected with HCV genotype 3a...
  37. ncbi request reprint Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan
    Ayumu Taguchi
    Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, 466 8550 Japan
    Cancer Epidemiol Biomarkers Prev 14:2487-93. 2005
    ..In conclusion, we showed that the IL-8 -251 T > A polymorphism is associated with higher expression of IL-8 protein, more severe neutrophil infiltration, and increased risk of atrophic gastritis and gastric cancer...
  38. doi request reprint Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease
    Masao Doisaki
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Japan
    Biochem Biophys Res Commun 393:303-7. 2010
    ..These results suggest that insulin regulates BCAA catabolism in type 2 diabetic rats by modulating the hepatic BDK activity...
  39. ncbi request reprint Progress of endoscopic ultrasonography and intraductal ultrasonography in the diagnosis of malignant biliary diseases
    Hiroki Kawashima
    Department of Gastroenterology, Nagoya University School of Medicine, Nagoya, Japan
    J Hepatobiliary Pancreat Surg 13:69-74. 2006
    ..Reconstruction of 3D images enables us to diagnose more objectively. Here we describe the roles of these new ultrasound technologies in the diagnosis of biliary malignancies...
  40. ncbi request reprint Usefulness of contrast-enhanced transabdominal ultrasonography in the diagnosis of intraductal papillary mucinous tumors of the pancreas
    Terutomo Itoh
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Am J Gastroenterol 100:144-52. 2005
    ..We evaluated the qualitative and quantitative diagnostic ability of contrast-enhanced transabdominal ultrasonography (CE-US), mainly in differentiating benign from malignant tumors in patients with IPMT...
  41. ncbi request reprint Gastric GIST malignancy evaluated by 18FDG-PET as compared with EUS-FNA and endoscopic biopsy
    Masahiro Yamada
    Department of Gastroenterology, Nagoya Graduate School of Medicine, and Department of Endoscopy, Nagoya University Hospital, Japan
    Scand J Gastroenterol 42:633-41. 2007
    ....
  42. doi request reprint Preoperative endoscopic nasobiliary drainage in 164 consecutive patients with suspected perihilar cholangiocarcinoma: a retrospective study of efficacy and risk factors related to complications
    Hiroki Kawashima
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 257:121-7. 2013
    ..To assess the clinical benefits of preoperative endoscopic nasobiliary drainage (ENBD) in patients with perihilar cholangiocarcinoma...
  43. pmc Endoscopic ultrasound-guided fine needle aspiration in the differentiation of type 1 and type 2 autoimmune pancreatitis
    Takuya Ishikawa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    World J Gastroenterol 18:3883-8. 2012
    ..To investigate the usefulness of endoscopic ultra-sound-guided fine needle aspiration (EUS-FNA) in the differentiation of autoimmune pancreatitis (AIP)...
  44. doi request reprint Endoscopic and imaging findings in protein-losing enteropathy
    Hiroyuki Takenaka
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Clin Gastroenterol 46:575-80. 2012
    ....
  45. doi request reprint Feasibility of tissue elastography using transcutaneous ultrasonography for the diagnosis of pancreatic diseases
    Hiroki Uchida
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya City, Japan
    Pancreas 38:17-22. 2009
    ..We investigated the feasibility of using real-time tissue elastography (EG) with transcutaneous ultrasonography (EG-US) for pancreatic diseases...
  46. ncbi request reprint Association with 5'-untranslated region and response to interferon in chronic hepatitis C
    Yoshiaki Katano
    Department of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hepatogastroenterology 54:854-7. 2007
    ..The objective of the present study was to evaluate possible associations of 5'UTR mutations with responsiveness to interferon (IFN) therapy in chronic hepatitis C patients...
  47. ncbi request reprint Characteristics of gastric and intestinal mucin phenotypes of gastric carcinoma
    Nobuyuki Mabuchi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hepatogastroenterology 55:2277-81. 2008
    ..To better understand the carcinogenesis pathway in gastric cancer, we investigated the relationship between mucin phenotype and clinicopathologic features...
  48. ncbi request reprint Use of color Doppler ultrasonography in the diagnosis of anomalous connection in pancreatobiliary disease
    Hiroki Kawashima
    Department of Endoscopy, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    World J Gastroenterol 11:1018-22. 2005
    ..To estimate the detectability of anomalous connection in pancreatobiliary disease (ACPBD) cases, measuring gallbladder wall blood flow (GWBF)...
  49. ncbi request reprint Severity of atrophic gastritis related to antiparietal cell antibody and gastric carcinogenesis, including p53 mutations
    Ayumu Taguchi
    Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 21:545-51. 2006
    ..This study was aimed to clarify the role of APCA in the progression of atrophic gastritis and gastric carcinogenesis, and to determine the relationship of the severity of atrophic gastritis to gastric carcinoma and to p53 mutations...
  50. ncbi request reprint Efficacy of antiviral therapy with lamivudine after initial treatment for hepatitis B virus-related hepatocellular carcinoma
    Teiji Kuzuya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    J Gastroenterol Hepatol 22:1929-35. 2007
    ..The aim of this study was to determine whether antiviral therapy with lamivudine is beneficial in patients after initial treatment for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC)...
  51. doi request reprint Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma
    Hiroki Kawashima
    Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Hepatobiliary Pancreat Sci 20:441-7. 2013
    ..The objective of this study is to clarify the diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy (TBFB) samples...
  52. doi request reprint Peripancreatic vascular involvements of autoimmune pancreatitis
    Takuya Ishikawa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 27:1790-5. 2012
    ..We aimed to investigate the peripancreatic vascular involvements associated with AIP...
  53. doi request reprint Usefulness of flexible spectral imaging color enhancement (FICE) for the detection of angiodysplasia in the preview of capsule endoscopy
    Masanao Nakamura
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hepatogastroenterology 59:1474-7. 2012
    ..The aim of this study is to evaluate the preview of angiodysplasia by FICE in comparison with the conventional preview...
  54. ncbi request reprint Comparison of hepatitis B virus subgenotypes in patients with acute and chronic hepatitis B and absence of lamivudine-resistant strains in acute hepatitis B in Japan
    Kazuhiko Hayashi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Tsuruma cho, Showa Ku, Nagoya, Japan
    J Med Virol 79:366-73. 2007
    ..In conclusion, the prevalence of uncommon Japanese HBV subgenotypes is expected to increase, although lamivudine-resistant strains have not yet been found in patients with acute hepatitis B...
  55. ncbi request reprint Prevalence and prognosis of gastric cancer detected by screening in a large Japanese population: data from a single institute over 30 years
    Ryoji Miyahara
    Department of Gastroenterology, Nagoya Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 22:1435-42. 2007
    ..The aim of this study was to examine the usefulness of direct radiology as a general health screening technique and the historical changes of gastric cancer in Japan...
  56. ncbi request reprint [A case of gallbladder adenoma with wide base]
    Koji Nonogaki
    Department of Gastroenterology, Nagoya University Graduate School of Medicine
    Nihon Shokakibyo Gakkai Zasshi 105:74-80. 2008
    ..Cholecystectomy was performed and the tumor was diagnosed as tubular adenoma of the gallbladder. The p53 immumostaining was negative. A gallbladder adenoma with wide base is rare, here we report this case with the several considerations...
  57. ncbi request reprint A comparison of image quality between tissue harmonic imaging and fundamental imaging with an electronic radial scanning echoendoscope in the diagnosis of pancreatic diseases
    Hideki Ishikawa
    Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Gastrointest Endosc 57:931-6. 2003
    ..This study compares the quality of US images acquired by tissue harmonic imaging during electronic radial scanning EUS to those acquired by fundamental imaging...
  58. doi request reprint Diagnosis of the invasion depth of gastric cancer using MDCT with virtual gastroscopy: comparison with staging with endoscopic ultrasound
    Kazuhiro Furukawa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    AJR Am J Roentgenol 197:867-75. 2011
    ....
  59. ncbi request reprint Efficacy of STI571 for a patient with metastatic gastrointestinal stromal tumor
    Yoji Sasaki
    Division of Therapeutic Medicine, Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Hepatogastroenterology 52:1764-7. 2005
    ..STI571 was effective medicine for the metastatic gastrointestinal stromal tumor for six months in this case...
  60. pmc Clinical oncology for pancreatic and biliary cancers: Advances and current limitations
    Yoshiki Hirooka
    Yoshiki Hirooka, Yosuke Nakamura, Ryoji Miyahara, Hidemi Goto, Department of Endoscopy, Nagoya University Hospital, 65, Tsuruma cho, Showa Ku, Nagoya City, Aichi Prefecture 81 466 8550, Japan
    World J Clin Oncol 2:217-24. 2011
    ..Diagnostic EUS-FNA of pancreatic cystic lesions has marginal utility mainly due to low sensitivity. Therefore, in particular, endoscopists should keep this limitation in mind...
  61. doi request reprint Management of small-bowel polyps in Peutz-Jeghers syndrome by using enteroclysis, double-balloon enteroscopy, and videocapsule endoscopy
    Naoki Ohmiya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Gastrointest Endosc 72:1209-16. 2010
    ..Management of small-bowel polyps in Peutz-Jeghers syndrome (PJS) by using fluoroscopic enteroclysis (FE), double-balloon enteroscopy (DBE), and videocapsule enteroscopy (VCE) remains incompletely determined...
  62. doi request reprint Efficacy of rebamipide for diclofenac-induced small-intestinal mucosal injuries in healthy subjects: a prospective, randomized, double-blinded, placebo-controlled, cross-over study
    Yasumasa Niwa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    J Gastroenterol 43:270-6. 2008
    ..The aim of this study was to compare prevention by rebamipide and placebo of NSAID-induced smallintestinal injury in healthy subjects...
  63. doi request reprint Outcome after enteroscopy for patients with obscure GI bleeding: diagnostic comparison between double-balloon endoscopy and videocapsule endoscopy
    Daigo Arakawa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gastrointest Endosc 69:866-74. 2009
    ..Double-balloon endoscopy (DBE) and videocapsule endoscopy (VCE) have been useful in managing obscure GI bleeding (OGIB)...
  64. pmc Images of colonic real-time tissue sonoelastography correlate with those of colonoscopy and may predict response to therapy in patients with ulcerative colitis
    Daisuke Ishikawa
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    BMC Gastroenterol 11:29. 2011
    ..We evaluated the usefulness of EG in patients with ulcerative colitis (UC) by investigating the association between EG and colonoscopic findings and disease activity...
  65. ncbi request reprint Small bowel tuberculosis diagnosed by the combination of video capsule endoscopy and double balloon enteroscopy
    Masanao Nakamura
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Gastroenterol Hepatol 19:595-8. 2007
    ....
  66. ncbi request reprint Cholecystocolonic fistula preoperatively diagnosed by endoscopic ultrasound of the colon
    Naoto Okada
    Department of Gastroenterology, Nagoya University School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 20:1621-4. 2005
    ..Barium enema and endoscopic retrograde cholangiopancreatography did not reveal fistula. Curved-linear array EUS of the colon showed fistula...
  67. doi request reprint An esophageal SCC case which could be distinguished from non-neoplasia using magnifying endoscopy with NBI imaging
    Ryoji Miyahara
    Department of Endoscopy, Nagoya University Hospital Department of Gastroenterology, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Dig Endosc 23:72-4. 2011
    ..Endoscopic submucosal dissection was carried out...
  68. doi request reprint Recovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP α1/SHP-2 signaling system
    Kazuo Hara
    Department of Gastroenterology and Division of Cancer Biology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, 466 8550, Japan
    Cancer Res 71:1229-34. 2011
    ..Taken together, our findings define SHP-2 as an essential component of tumor suppression and anoikis mediated by SIRPα1 in human breast carcinoma cells as well as in v-Src-transformed cells...
  69. ncbi request reprint Diagnosis of the depth of invasion of esophageal carcinoma using digital radiography
    Bunichi Ito
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Eur J Radiol 54:377-82. 2005
    ..The purpose of our investigation was to determine the usefulness of digital radiography (DR) for diagnosing the depth of invasion of esophageal carcinoma...
  70. pmc Endoscopic papillectomy of minor papillar adenoma associated with pancreas divisum
    Akira Kanamori
    Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki 503 8502, Japan
    World J Gastroenterol 15:1138-40. 2009
    ..The patient has been asymptomatic without recurrence of tumor or stenosis of the Santorini orifice upon endoscopic examination for the past 2 years...
  71. doi request reprint Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus
    Teiji Kuzuya
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 373:94-8. 2008
    ..These results suggest that BCAA catabolism in type 2 diabetes is downregulated and enhanced by BCAA supplementation...
  72. ncbi request reprint Heterotopic pancreas in the esophagus diagnosed by EUS-guided FNA
    Jun Goto
    Division of Therapeutic Medicine, Department of Internal Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gastrointest Endosc 62:812-4. 2005
  73. doi request reprint Prevalence of pancreatic cystic lesions including intraductal papillary mucinous neoplasms in patients with end-stage renal disease on hemodialysis
    Takuya Ishikawa
    Department of Gastroenterology, Nagoya Kyoritsu Hospital, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Pancreas 38:175-9. 2009
    ..Reports on PC lesions in hemodialysis (HD) patients are remarkably limited. The aim of this study was to clarify the prevalence and characteristics of PC lesions in HD patients...
  74. doi request reprint New objective evaluation method for functional bowel disorder using video capsule endoscopy
    Masanao Nakamura
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Dig Endosc 21:29-33. 2009
    ..The aim of the present study was to use video capsule endoscopy (VCE) to objectively evaluate bowel movements in patients with irritable bowel syndrome (IBS) compared with healthy volunteers...
  75. ncbi request reprint [Advances of trans-abdominal ultrasonography and endoscopic ultrasonography in the diagnosis of pancreatic cancer]
    Yoshiki Hirooka
    Department of Endoscopy, Nagoya University Hospital
    Nihon Rinsho 64:107-13. 2006
  76. ncbi request reprint Risk factors of recipient receiving living donor liver transplantation in the comprehensive era of indication and perioperative managements
    Masatoshi Ishigami
    Department of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Nagoya J Med Sci 72:119-27. 2010
    ..33 times risk in the recent era with comprehensive indication and preoperative management for LDLT. Indication must be cautious for elderly patients, and prevention of rejection is crucial for the improvement of results for LDLT...
  77. doi request reprint Anti-hepatitis B surface immunoglobulin reduction in early postoperative period after liver transplantation in hepatitis B virus-positive patients
    Masatoshi Ishigami
    Departments of Gastroenterology Transplant Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hepatol Res 41:1189-98. 2011
    ....
  78. ncbi request reprint Preclinical study of endoscopic ultrasonography with electronic radial scanning echoendoscope
    Katsushi Niwa
    Second Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 18:828-35. 2003
    ..To evaluate the imaging possibility of a newly designed electronic radial scanning echoendoscope (ER-ES)...
  79. ncbi request reprint Changes in circulating cytokine levels and lymphocyte subsets in healthy liver donors after partial hepatectomy
    Sayori Nakashima
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hepatol Res 37:878-84. 2007
    ..Conclusion: These findings suggest that immune suppression after partial hepatectomy involves decreases in CD4(+) helper T cells, particularly Th1 cells...
  80. doi request reprint Transpapillary biliary forceps biopsy to distinguish benign biliary stricture from malignancy: how many tissue samples should be obtained?
    Hiroki Kawashima
    Department of Gastroenterology, Nagoya University Graduate School of Medicine Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan
    Dig Endosc 24:22-7. 2012
    ..Therefore, there are false negatives in more than 20% of patients, which makes it difficult to diagnose benign biliary stricture as benignancy in a clinical setting...
  81. doi request reprint A case of lymphomatoid gastropathy: An indolent CD56-positive atypical gastric lymphoid proliferation, mimicking aggressive NK/T cell lymphomas
    Tsutomu Tanaka
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pathol Res Pract 207:786-9. 2011
    ..The recurrence of lymphomatoid gastropathy is very rare and should be diagnosed carefully to distinguish it from the aggressive lymphoma...
  82. doi request reprint Impact of early elevation of serum bilirubin during treatment with pegylated interferon and ribavirin in patients with chronic hepatitis C
    Masatoshi Ishigami
    Department of Gastroenterology, Nagoya University School of Medicine, Nagoya, Japan
    Hepatol Res 40:963-70. 2010
    ..0321). Conclusion:  Early elevation of serum bilirubin level was found to be a possible predictive marker of both a severe drop of Hb in the early phase of treatment and dose reduction of ribavirin...
  83. doi request reprint Prospective clinical study of EUS-guided choledochoduodenostomy for malignant lower biliary tract obstruction
    Kazuo Hara
    Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Gastroenterol 106:1239-45. 2011
    ..However, prospective studies of EUS-CDS have not yet been performed. We conducted a prospective study to evaluate the safety, feasibility, and efficacy of EUS-CDS in patients with malignant lower biliary tract obstruction...
  84. ncbi request reprint Retroperitoneal neurilemoma diagnosed by EUS-guided FNA
    Naoto Okada
    The Second Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Gastrointest Endosc 57:790-2. 2003
  85. doi request reprint Retrospective analysis of primary gastric diffuse large B cell lymphoma in the rituximab era: a multicenter study of 95 patients in Japan
    Tsutomu Tanaka
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Tsuruma cho, Showa Ku, Nagoya, Japan
    Ann Hematol 91:383-90. 2012
    ..Clinical outcomes of PG-DLBCL were extremely favorable for localized-stage patients in the rituximab era, although these might be poor for advanced-stage patients even in the rituximab era. Further prospective analyses are warranted...
  86. ncbi request reprint A mutation in the interferon sensitivity-determining region is associated with responsiveness to interferon-ribavirin combination therapy in chronic hepatitis patients infected with a Japan-specific subtype of hepatitis C virus genotype 1B
    Mutsumi Murayama
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Virol 79:35-40. 2007
    ..The ISDR is a useful predictive marker for response to IFN-ribavirin combination therapy in J-type HCV...
  87. ncbi request reprint Endoscopic resection of Peutz-Jeghers polyps throughout the small intestine at double-balloon enteroscopy without laparotomy
    Naoki Ohmiya
    Division of Gastroenterology, Department of Therapeutic Medicine, Nagoya, Japan
    Gastrointest Endosc 61:140-7. 2005
    ..Small-bowel enteroscopy with the double-balloon method was developed to improve access to the small intestine. This study evaluated the usefulness of this method for the resection of small-intestinal Peutz-Jeghers polyps...
  88. doi request reprint Is nasobiliary drainage unnecessary for drainage of acute suppurative cholangitis? Our experience
    Hiroki Kawashima
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Dig Endosc 22:S118-22. 2010
    ..ENBD was mainly selected for the patients with multiple biliary strictures, hemorrhage tendency and excessive purulent bile. Even though internal drainage is suitable in many ASC patients, ENBD is necessary in selected patients...