Toshio Hayashi

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint A HMG-CoA reductase inhibitor possesses a potent anti-atherosclerotic effect other than serum lipid lowering effects--the relevance of endothelial nitric oxide synthase and superoxide anion scavenging action
    D Sumi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan
    Atherosclerosis 155:347-57. 2001
  2. pmc Metabolic predictors of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: difference in risk by age
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    Cardiovasc Diabetol 12:10. 2013
  3. ncbi request reprint High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: implications for atherosclerosis
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 466 8550 Nagoya, Japan
    Biochim Biophys Acta 1772:364-72. 2007
  4. ncbi request reprint Sarpogrelate HCl, a selective 5-HT2A antagonist, retards the progression of atherosclerosis through a novel mechanism
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Japan
    Atherosclerosis 168:23-31. 2003
  5. ncbi request reprint Nitric oxide metabolites are associated with survival in older patients
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya City, Japan
    J Am Geriatr Soc 55:1398-403. 2007
  6. pmc Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes Care 32:1221-3. 2009
  7. doi request reprint Nitric oxide and endothelial cellular senescence
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Pharmacol Ther 120:333-9. 2008
  8. ncbi request reprint A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa ku Nagoya City 466 8550, Japan
    Atherosclerosis 176:255-63. 2004
  9. ncbi request reprint NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction
    T Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes Obes Metab 7:334-43. 2005
  10. ncbi request reprint Importance of lipid levels in elderly diabetic individuals: baseline characteristics and 1-year survey of cardiovascular events
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Circ J 72:218-25. 2008

Collaborators

Detail Information

Publications69

  1. ncbi request reprint A HMG-CoA reductase inhibitor possesses a potent anti-atherosclerotic effect other than serum lipid lowering effects--the relevance of endothelial nitric oxide synthase and superoxide anion scavenging action
    D Sumi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan
    Atherosclerosis 155:347-57. 2001
    ....
  2. pmc Metabolic predictors of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: difference in risk by age
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    Cardiovasc Diabetol 12:10. 2013
    ..The aim of this study was to identify factors that predict IHD and cerebrovascular attack (CVA) in the elderly and to investigate their differences by age...
  3. ncbi request reprint High glucose downregulates the number of caveolae in monocytes through oxidative stress from NADPH oxidase: implications for atherosclerosis
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 466 8550 Nagoya, Japan
    Biochim Biophys Acta 1772:364-72. 2007
    ..Furthermore, the apoptosis of macrophages might occur with high glucose concentrations, leading to the spreading of lipids from macrophages into intracellular spaces in the vessel wall...
  4. ncbi request reprint Sarpogrelate HCl, a selective 5-HT2A antagonist, retards the progression of atherosclerosis through a novel mechanism
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Japan
    Atherosclerosis 168:23-31. 2003
    ....
  5. ncbi request reprint Nitric oxide metabolites are associated with survival in older patients
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya City, Japan
    J Am Geriatr Soc 55:1398-403. 2007
    ..To assess the efficacy of various vascular endocrinological substances, such as plasma nitric oxide metabolites (NOx), as surrogate markers of survival in older patients...
  6. pmc Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals: changes in the risk for atherosclerotic diseases at various ages
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes Care 32:1221-3. 2009
    ..To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals...
  7. doi request reprint Nitric oxide and endothelial cellular senescence
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Pharmacol Ther 120:333-9. 2008
    ..Further understanding of the mechanisms underlying the anti-senescence effect of NO in endothelial cells will provide insights into the potential of eNOS-based anti-senescence therapy for age-associated vascular disorders...
  8. ncbi request reprint A new HMG-CoA reductase inhibitor, pitavastatin remarkably retards the progression of high cholesterol induced atherosclerosis in rabbits
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa ku Nagoya City 466 8550, Japan
    Atherosclerosis 176:255-63. 2004
    ..The remarkable anti-atherosclerotic effects of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor have not been demonstrated in diet induced severe hyperlipidemia in rabbit model...
  9. ncbi request reprint NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction
    T Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes Obes Metab 7:334-43. 2005
    ....
  10. ncbi request reprint Importance of lipid levels in elderly diabetic individuals: baseline characteristics and 1-year survey of cardiovascular events
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Circ J 72:218-25. 2008
    ..Complications of dyslipidemia increase the risk, but direct evidence is limited, so a cohort prospective study (Japan-CDM) was conducted...
  11. ncbi request reprint Pitavastatin: efficacy and safety in intensive lipid lowering
    Toshio Hayashi
    Nagoya University Graduate School of Medicine, Department of Geriatrics, 65 Tsuruma cho, Showa Ku, Nagoya City, 466 8550, Japan
    Expert Opin Pharmacother 8:2315-27. 2007
    ..Due to the promising results observed in clinical trials, it has the potential to be an excellent addition to the worldwide lipid management market...
  12. ncbi request reprint The treadmill exercise-tolerance test is useful for the prediction and prevention of ischemic coronary events in elderly diabetics
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    J Diabetes Complications 19:264-8. 2005
    ..Approximately 80% of cases of ischemic heart disease (IHD) occur in patients with nonstenotic coronary arteries, and few studies have systematically assessed exercise testing (TMT) as a predictor of risk in the elderly...
  13. ncbi request reprint Selective iNOS inhibitor, ONO1714 successfully retards the development of high-cholesterol diet induced atherosclerosis by novel mechanism
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduated School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Atherosclerosis 187:316-24. 2006
    ..However, the role of iNOS in the development of atherosclerosis is not well known. We therefore investigated the relevance of iNOS inhibition...
  14. pmc Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Proc Natl Acad Sci U S A 103:10485-90. 2006
    ....
  15. pmc Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Tsuruma cho 65, Showa Ku, Nagoya 466 8550, Japan
    Proc Natl Acad Sci U S A 103:17018-23. 2006
    ..We suggest that the delay in endothelial senescence through NO and/or eNOS activation may have clinical utility in the treatment of atherosclerosis in the elderly...
  16. ncbi request reprint beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Tsuruma cho, Showa Ku, Nagoya, Japan 466 8550
    Life Sci 80:592-9. 2007
    ..The serum TNFalpha levels did not increase in DM-c rats compared with those of the DM or DM-a groups, and were comparable with those of group C...
  17. ncbi request reprint Gene transfer of endothelial NO synthase, but not eNOS plus inducible NOS, regressed atherosclerosis in rabbits
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa, Nagoya 466 8550, Japan
    Cardiovasc Res 61:339-51. 2004
    ..The relations among NO, O2-, and peroxynitrite may be critical, and lipid resorption from the lesions may be responsible for the regression...
  18. doi request reprint Possibility of the regression of atherosclerosis through the prevention of endothelial senescence by the regulation of nitric oxide and free radical scavengers
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Geriatr Gerontol Int 10:115-30. 2010
    ..Taken together, regression of atherosclerosis can be achieved by not only regulation of various risk factors but regulation of the cross-talk of NO and free radicals...
  19. pmc Age, gender, insulin and blood glucose control status alter the risk of ischemic heart disease and stroke among elderly diabetic patients
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cardiovasc Diabetol 10:86. 2011
    ..We analyzed the effects of insulin therapy, age and gender on the risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) according to glycemic control...
  20. doi request reprint The effects of selective estrogen receptor modulator treatment following hormone replacement therapy on elderly postmenopausal women with osteoporosis
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nitric Oxide 24:199-203. 2011
    ..A comparison between the atheroprotective and osteoprotective effects of the selective estrogen receptor modulator (SERM) raloxifene and those of hormone replacement therapy (HRT) has not been made in elderly women...
  21. ncbi request reprint Physiological concentration of 17beta-estradiol retards the progression of severe atherosclerosis induced by a high-cholesterol diet plus balloon catheter injury: role of NO
    T Hayashi
    Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan
    Arterioscler Thromb Vasc Biol 20:1613-21. 2000
    ..The retardation may be partially mediated by endothelial NO function in vessels treated with E(2)...
  22. ncbi request reprint Estriol (E3) replacement improves endothelial function and bone mineral density in very elderly women
    T Hayashi
    Department of Geriatrics, Nagoya University School of Medicine, Japan
    J Gerontol A Biol Sci Med Sci 55:B183-90; discussion B191-3. 2000
    ..E3 significantly improved BMD by inhibiting bone resorption. Endothelial function was improved in line with the antiatherosclerotic effects. E3 might be effective for use in HRT in elderly patients...
  23. doi request reprint Place of death for the elderly in need of end-of-life home care: a study in Japan
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Arch Gerontol Geriatr 53:242-4. 2011
    ..In conclusion, the nature of the patient's disease and the presence of visiting nurses influenced the decision regarding the patient's place of death. More study is necessary to better understand the end stages of death at home...
  24. pmc l-Citrulline and l-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Proc Natl Acad Sci U S A 102:13681-6. 2005
    ..This approach may have clinical utility in the treatment of atherosclerosis in humans...
  25. ncbi request reprint Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen: the possible role of nitric oxide
    T Hayashi
    Department of Geriatrics, Nagoya University School of Medicine, Nagoya, Japan
    Arterioscler Thromb Vasc Biol 20:782-92. 2000
    ..We conclude that approximately 50% of the total antiatherosclerotic effect of DHEA was achieved through the conversion of DHEA to estrogen. NO may also play a role in the antiatherosclerotic effect of DHEA and 17beta-estradiol...
  26. ncbi request reprint Endothelium-dependent relaxation of rabbit atherosclerotic aorta was not restored by control of hyperlipidemia: the possible role of peroxynitrite (ONOO(-))
    T Hayashi
    Department of Geriatrics, Nagoya University School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    Atherosclerosis 147:349-63. 1999
    ..Conclusively, ONOO(-) can play a role in impairment of NO-mediated vascular response during the regression of dietary cholesterol-induced atherosclerosis, not in the initiation of atherosclerosis...
  27. ncbi request reprint Anti-atherosclerotic effect of beta-blocker with nitric oxide-releasing action on the severe atherosclerosis
    Navin Kumar Thakur
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Cardiovasc Pharmacol 39:298-309. 2002
    ....
  28. ncbi request reprint Combined effect of testosterone and apocynin on nitric oxide and superoxide production in PMA-differentiated THP-1 cells
    Packiasamy A R Juliet
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Biochim Biophys Acta 1693:185-91. 2004
    ..Even though apocynin does not have any role on NO production, addition of apocynin together with testosterone is effective in suppressing iNOS activity...
  29. doi request reprint Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxide
    Hisako Matsui-Hirai
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Pharmacol Exp Ther 337:591-9. 2011
    ..Conclusively, the regulatory effects of insulin on endothelial senescence were modulated by the glucose environment. These data may help explain insulin's complicated roles in atherosclerosis in the elderly...
  30. ncbi request reprint Estriol retards and stabilizes atherosclerosis through an NO-mediated system
    Hatsuyo Kano
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Life Sci 71:31-42. 2002
    ..E3 strongly activates NO-mediated systems, and could play a role in retarding the progression of atherosclerosis and in stabilizing atheroma...
  31. ncbi request reprint 17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease
    Asaka Miyazaki-Akita
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    J Pharmacol Exp Ther 320:591-8. 2007
    ..Therefore, estrogen deficiency may result in an exaggeration of hyperglycemia-induced endothelial dysfunction, leading to the development of cardiovascular disease in postmenopausal diabetic women...
  32. ncbi request reprint The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase
    Qun Fang Ding
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Shawa ku, Nagoya, 466 8550, Japan Department of Geriatrics, The First University Hospital of West China University of Medical Sciences, Chengdu, China
    Life Sci 75:3185-94. 2004
    ..Conclusively, high glucose leads to eNOS dysfunction by inhibiting BH4 synthesis and atorvastatin stimulate BH4 synthesis directly, and it may work as atherogenic process...
  33. ncbi request reprint Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance: prevention of NO donor-induced endothelial cell abnormalities
    Akiko Fukatsu
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Physiol Heart Circ Physiol 293:H790-7. 2007
    ..We suggest that inhibition of NADPH oxidase, by preventing NO donor-induced endothelial dysfunction, may represent a potential therapeutic strategy that confers protection from nitrate tolerance development...
  34. ncbi request reprint Concomitant production of nitric oxide and superoxide in human macrophages
    Packiasamy A R Juliet
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550 Nagoya, Japan
    Biochem Biophys Res Commun 310:367-70. 2003
    ..It suggests that addition of iNOS inhibitor together with apocynin may be more effective in case of therapeutic application in disease conditions like atherosclerosis...
  35. doi request reprint Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Proc Natl Acad Sci U S A 111:1168-73. 2014
    ....
  36. doi request reprint Depression, quality of life (QoL) and will to live of community-dwelling postmenopausal women in three Asian countries: Korea, China and Japan
    Koichiro Ina
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Tsuruma cho 65, Showa Ku, Nagoya 466 8550, Japan
    Arch Gerontol Geriatr 53:8-12. 2011
    ..These results suggest that clinicians should pay more attention to depression in community-dwelling postmenopausal women...
  37. doi request reprint Clinical factors such as B-type natriuretic peptide link to factor VII, endothelial NO synthase and estrogen receptor alpha polymorphism in elderly women
    Jun Funami
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Tsuruma cho 65, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Life Sci 85:316-21. 2009
    ..This study evaluated the presence of genetic mutations in relation to thrombosis or atherosclerosis in elderly women...
  38. ncbi request reprint [Diabetic macroangiopathy and NO]
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Rinsho 62:548-54. 2004
  39. doi request reprint The role of insulin growth factor on atherosclerosis and endothelial function: the effect on hyperlipidemia and aging
    Hisako Hirai
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Life Sci 88:425-31. 2011
    ..Insulin/insulin-like growth factor (IGF-1) signaling is important for a variety of age-related processes. However, whether or not it affects atherosclerosis is unknown...
  40. ncbi request reprint Plasma adiponectin plays an important role in improving insulin resistance with glimepiride in elderly type 2 diabetic subjects
    Taku Tsunekawa
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Japan
    Diabetes Care 26:285-9. 2003
    ....
  41. ncbi request reprint Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin
    Masako Osawa
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya City 466 8550, Japan
    Nitric Oxide 16:157-63. 2007
    ..For elderly patients, the consideration of prognostic factors is very important, but there have been few reports about the potential use of vasoactive substances as prognostic markers in the elderly...
  42. ncbi request reprint HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basal NO and decreasing superoxide
    N K Thakur
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan
    Am J Physiol Heart Circ Physiol 281:H75-83. 2001
    ..Taken together, upregulation of eNOS and decrease of O treatment were observed in vivo in the process of the sufficient stabilization of atheroma following simvastatin...
  43. ncbi request reprint Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly postmenopausal women
    Qun Fang Ding
    Department of Geriatrics, Medicine in Growth and Aging, Program in Health and Community Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Diabetes Complications 21:315-9. 2007
    ..The IDF definition for MetS is the most sensitive one with regard to metabolic disorders, whereas JPN and CDS definitions correlate better with CHD and changes of adipocytokines among the four criteria studied...
  44. ncbi request reprint 17beta-estradiol inhibits NADPH oxidase activity through the regulation of p47phox mRNA and protein expression in THP-1 cells
    Daigo Sumi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, 65, Tsuruma cho, Showa Ku, Nagoya 466 8550, Japan
    Biochim Biophys Acta 1640:113-8. 2003
    ..Our results implicate that 17beta-estradiol has an anti-atherosclerotic effects through the improvement of nitric oxide (NO) bioavailability caused by the regulation of superoxide (O(2)(-)) production...
  45. ncbi request reprint Cerivastatin, a hydroxymethylglutaryl coenzyme a reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days
    T Tsunekawa
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Circulation 104:376-9. 2001
    ..Cerivastatin improved impaired endothelial function in the short-term without affecting lipid profiles in elderly diabetic patients. This effect may be partly due to upregulation of endothelial nitric oxide synthase...
  46. doi request reprint eNOS-dependent antisenscence effect of a calcium channel blocker in human endothelial cells
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 9:e88391. 2014
    ..These results demonstrate that nifedipine can prevent endothelial cell senescence in an eNOS-dependent manner. The anti-senescence action of nifedipine may represent a novel mechanism by which it protects against atherosclerosis. ..
  47. ncbi request reprint Temporal effects of 17beta-estradiol on caveolin-1 mRNA and protein in bovine aortic endothelial cells
    M Jayachandran
    Department of Geriatrics, Nagoya University School of Medicine, Nagoya 466-8550, Japan
    Am J Physiol Heart Circ Physiol 281:H1327-33. 2001
    ..The results further suggest that estrogen may indirectly regulate NO(x) through caveolin-1 expression, which inhibits eNOS catalytic activity...
  48. doi request reprint Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly
    Hiroyuki Umegaki
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Geriatr Gerontol Int 13:28-34. 2013
    ..Exercise is a helpful non-pharmacological therapy. Considering the progressive aging of the worldwide population, more research to investigate the best way to manage this population is important...
  49. ncbi request reprint [Hormone replacement Up-to-date. The effect of estrogen on vascular function and atherosclerosis]
    Toshio Hayashi
    Nagoya University Graduate School of Medicine, Department of Geriatrics, Japan
    Clin Calcium 17:1355-63. 2007
    ..We would like to explain and discuss these biphasic effects of estrogen on atherosclerotic diseases including their risk factors such as hyperlipidemia, diabetes mellitus and hypertension...
  50. ncbi request reprint Estrogen prevents destabilization of endothelial nitric oxide synthase mRNA induced by tumor necrosis factor alpha through estrogen receptor mediated system
    D Sumi
    Department of Geriatrics, Nagoya University Graduate School of Medicine, Japan
    Life Sci 69:1651-60. 2001
    ..This is the first finding that 17beta-estradiol stabilizes eNOS mRNA destabilized by TNF-alpha through estrogen receptor mediated mechanism...
  51. ncbi request reprint Seaweed prevents breast cancer?
    H Funahashi
    Department of Surgery II, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Cancer Res 92:483-7. 2001
    ..Furthermore, no apoptosis induction was observed in normal human mammary cells. In Japan, mekabu is widely consumed as a safe, inexpensive food. Our results suggest that mekabu has potential for chemoprevention of human breast cancer...
  52. ncbi request reprint [Macrovascular diseases-based on the data of Japanese cohort study (JCDM) including 1,016 very elderly diabetic individuals older than 75 years old]
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Rinsho 71:1999-2004. 2013
    ..HDL-C was correlated with CVA in patients > or = 75 years old. These age-dependent differences in risk are important for developing individualized strategies to prevent atherosclerotic disease...
  53. ncbi request reprint [Quality of life in elderly with atherosclerotic diseases]
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 39:404-8. 2002
    ..These examinations are expectable for future treatment of elderly patients...
  54. ncbi request reprint [Estrogen, SERM]
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Rinsho 69:1270-4. 2011
    ..Raloxifene decreases the incidence of vertebral fractures by 30-50% in postmenopausal women with osteoporosis. We also studied its effect on postmenopausal elderly women with osteoporosis...
  55. ncbi request reprint [Anti-thrombotic effect of nitric oxide]
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Rinsho 62:505-9. 2004
  56. ncbi request reprint [From the standpoint in department of geriatrics in university hospital]
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Ronen Igakkai Zasshi 41:294-7. 2004
    ..Finally, I would like to propose future research plan between departments of geriatrics in Japanese Universities and the National Institute for Longevity Sciences, which will open next March...
  57. ncbi request reprint [Pathophysiology and treatment strategy for post-menopausal hyperlipidemia]
    Toshio Hayashi
    Department of Geriatrics, Nagoya University Graduate School of Medicine
    Nihon Rinsho 65:522-6. 2007
  58. pmc In vivo tumouricidal effects of LAD-1 monoclonal antibody on murine RL-male-1 lymphoma mediated by enhanced phagocytosis
    M Ito
    Molecular Biology and Retroviral Genetics Group, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Clin Exp Immunol 141:54-61. 2005
    ..Thus, LAD-1-induced phagocytosis of lymphoma cells by hepatic macrophages in mice may, at least in part, be responsible for the prolonged survival of the mice...
  59. ncbi request reprint Expression of inducible nitric oxide synthase and Fas/Fas ligand correlates with the incidence of apoptotic cell death in atheromatous plaques of human coronary arteries
    T Esaki
    Department of Geriatrics, Nagoya University School of Medicine, 65 Turuma cho, Showa Ku, Nagoya 466, Japan
    Nitric Oxide 4:561-71. 2000
    ..These results suggest an important role of iNOS in mediating both regressive changes and progressive change in atheromatous plaques...
  60. ncbi request reprint A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression
    Tomofumi Takaya
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 27:1632-7. 2007
    ..In this study, we addressed the specific importance of uncoupled eNOS in atherosclerosis, and the potential mechanistic role for specific versus nonspecific antioxidant strategies in restoring eNOS coupling...
  61. pmc Endothelium-dependent hyperpolarization and relaxation in mesenteric arteries of middle-aged rats: influence of oestrogen
    Ichiro Sakuma
    Department of Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Br J Pharmacol 135:48-54. 2002
    ....
  62. ncbi request reprint Standardization of plasma brain natriuretic peptide concentrations in older Japanese-relationship to latent renal dysfunction and ischemic heart disease
    Hideki Nomura
    Department of Internal Medicine, Chubu Hospital, Obu, Aichi, Japan
    J Am Geriatr Soc 50:1504-9. 2002
    ..To investigate the relationship between cyclic guanosine monophosphate (cGMP) and BNP in older people with and without ischemic heart disease (IHD)...
  63. ncbi request reprint A potential mechanism for the impairment of nitric oxide formation caused by prolonged oral exposure to arsenate in rabbits
    Jingbo Pi
    Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Free Radic Biol Med 35:102-13. 2003
    ..produced from endothelial NOS, such that enhanced free radicals are produced at the expense of NO...
  64. ncbi request reprint Nitric oxide: inhibitory effects on endothelial cell calcium signaling, prostaglandin I2 production and nitric oxide synthase expression
    Kazuhiko Takeuchi
    Department of Internal Medicine III, Hamamatsu University School of Medicine, Handayama, Hamamatsu 431 3192, Japan
    Cardiovasc Res 62:194-201. 2004
    ..The aim of this study was to investigate the role of NO on the regulation of endothelial cell Ca2+ signaling and endothelial cell function...
  65. doi request reprint Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus
    Naoto Sasaki
    Department of General Medicine, Nakatsu Saiseikai Hospital, 2 10 39 Shibata, Kita ku, Osaka 530 0012, Japan
    Arterioscler Thromb Vasc Biol 28:1068-76. 2008
    ..Without enough BH4, eNOS is uncoupled to L-arginine and produces superoxide rather than NO. We examined the role of uncoupled eNOS in vascular remodeling in diabetes...
  66. ncbi request reprint 2,4,6-Trinitrotoluene inhibits endothelial nitric oxide synthase activity and elevates blood pressure in rats
    Yang Sun
    Doctoral Programs in Medicine Sciences, Graduate School of Comprehensive Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Arch Toxicol 79:705-10. 2005
    ..These results suggest that TNT is an environmental chemical that acts as an uncoupler of constitutive NOS isozymes, resulting in decreased nitric oxide formation associated with hypertension in rats...
  67. ncbi request reprint Effects of overtime work on blood pressure and body mass index in Japanese male workers
    Koji Wada
    Department of Occupational Health, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan
    Occup Med (Lond) 56:578-80. 2006
    ..Effects of overtime work on health is a controversial issue...
  68. ncbi request reprint Proposed guidelines for hypertriglyceridemia in Japan with non-HDL cholesterol as the second target
    Hitoshi Shimano
    The Research Committee for Primary Hyperlipidemia, Research on Measures for Intractable Diseases by the Ministry for Health, Labor, and Welfare in Japan
    J Atheroscler Thromb 15:116-21. 2008
    ....
  69. ncbi request reprint The long-term effect of estriol on endothelial function and bone mineral density in octogenarian women
    Toshio Hayashi
    J Am Geriatr Soc 50:777-8. 2002