Hikaru Hashitani


Affiliation: Nagoya City University
Country: Japan


  1. Hashitani H, Takano H, Fujita K, Mitsui R, Suzuki H. Functional properties of suburothelial microvessels in the rat bladder. J Urol. 2011;185:2382-91 pubmed publisher
    ..In contrast, sympathetic nerve released noradrenaline acts on ?(1A)-adrenoceptors to constrict suburothelial arterioles. ..
  2. Shimizu Y, Mochizuki S, Mitsui R, Hashitani H. Neurohumoral regulation of spontaneous constrictions in suburothelial venules of the rat urinary bladder. Vascul Pharmacol. 2014;60:84-94 pubmed publisher
    ..In addition, suburothelial venular constrictions appear to be modulated by several bioactive substances that could be released from urothelium or suburothelial sensory nerves. ..
  3. Hashitani H. Interaction between interstitial cells and smooth muscles in the lower urinary tract and penis. J Physiol. 2006;576:707-14 pubmed
    ..However, overall contractility of urethral smooth muscles does not necessarily rely on pacemaking of ICs, and thus some population of smooth muscles may also have their own excitability. ..
  4. Hashitani H, Suzuki H. Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ. J Physiol. 2007;583:505-19 pubmed
    ..ICC-LCs may not act as a coordinated pacemaker electrical network as do ICC in the gastrointestinal (GI) tract. Rather they may randomly increase excitability of USMCs to maintain the tone of urethral smooth muscles. ..
  5. Hashitani H, Brading A, Suzuki H. Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol. 2004;141:183-93 pubmed
  6. Hashitani H, Mitsui R, Masaki S, van Helden D. Pacemaker role of pericytes in generating synchronized spontaneous Ca2+ transients in the myenteric microvasculature of the guinea-pig gastric antrum. Cell Calcium. 2015;58:442-56 pubmed publisher
    ..Pericyte Ca(2+) transients arise from Ca(2+) release from the sarco-endoplasmic reticulum and the opening of T-type Ca(2+) VDCCs is required for their synchrony and propagation to arteriolar SMCs. ..
  7. Hashitani H, Mitsui R, Shimizu Y, Higashi R, Nakamura K. Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder. Br J Pharmacol. 2012;167:1723-36 pubmed publisher
    ..The pericytes in mouse bladder can generate spontaneous Ca(2+) transients and contractions, and thus have a fundamental role in promoting spontaneous constrictions of suburothelial venules. ..
  8. Takagi H, Hashitani H. Effects of K(+) channel openers on spontaneous action potentials in detrusor smooth muscle of the guinea-pig urinary bladder. Eur J Pharmacol. 2016;789:179-186 pubmed publisher
    ..Spare SK channels could be pharmacologically activated to suppress DSM excitability. BK channels appear to be involved in the cyclic AMP-induced inhibition of action potentials but not the membrane hyperpolarization. ..
  9. Isogai A, Lee K, Mitsui R, Hashitani H. Functional coupling of TRPV4 channels and BK channels in regulating spontaneous contractions of the guinea pig urinary bladder. Pflugers Arch. 2016;468:1573-85 pubmed publisher
    ..Despite the membrane hyperpolarization in GSK, Ca(2+) entry mainly through TRPV4 develops the tonic contraction. ..

More Information


  1. Hashitani H, Hashiatni H, Lang R, Suzuki H. Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra. Br J Pharmacol. 2010;161:680-94 pubmed publisher