Yuki Hamajima

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. pmc Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene
    N Hamajima
    Department of Pediatrics, Nagoya City University Medical School, Nagoya City Higashi General Hospital, Nagoya, Japan
    Am J Hum Genet 63:717-26. 1998
  2. ncbi request reprint Expression of Syk is associated with nasal polyp in patients with allergic rhinitis
    Yuki Hamajima
    Department of Otorhinolaryngology, Nagoya City University, 1, Kawasumi, Mizuho ku, Nagoya 467 8601, Aichi, Japan
    Auris Nasus Larynx 34:49-56. 2007
  3. ncbi request reprint A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution
    N Hamajima
    Department of Pediatrics, Nagoya City University Medical School, Japan
    Gene 180:157-63. 1996
  4. ncbi request reprint Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene
    K Kitamura
    Department of Biochemistry, Nagoya City University Medical School, Nagoya, Japan
    DNA Res 6:291-7. 1999
  5. doi request reprint Impaired olfactory function in mice with allergic rhinitis
    Shinya Ozaki
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical Science, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, 467 8602, Japan
    Auris Nasus Larynx 37:575-83. 2010
  6. ncbi request reprint Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Histochem Cell Biol 113:37-41. 2000
  7. ncbi request reprint Comparison of lifestyle and risk factors among Japanese with and without gastric cancer family history
    X E Huang
    Department of Public Health, Nagoya City University Medical School, Nagoya City, Aichi Prefecture, Japan
    Int J Cancer 86:421-4. 2000
  8. ncbi request reprint Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity
    M Kouwaki
    Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan
    Clin Cancer Res 4:2999-3004. 1998
  9. ncbi request reprint Influence of habitual smoking on gastric cancer by histologic subtype
    M Inoue
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 81:39-43. 1999
  10. pmc Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer
    X E Huang
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Breast Cancer Res 3:264-9. 2001

Collaborators

Detail Information

Publications27

  1. pmc Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene
    N Hamajima
    Department of Pediatrics, Nagoya City University Medical School, Nagoya City Higashi General Hospital, Nagoya, Japan
    Am J Hum Genet 63:717-26. 1998
    ..There was no significant difference, in residual activity, between mutations observed in the symptomatic and those observed in the asymptomatic individuals...
  2. ncbi request reprint Expression of Syk is associated with nasal polyp in patients with allergic rhinitis
    Yuki Hamajima
    Department of Otorhinolaryngology, Nagoya City University, 1, Kawasumi, Mizuho ku, Nagoya 467 8601, Aichi, Japan
    Auris Nasus Larynx 34:49-56. 2007
    ..It has been hypothesized that Syk expression in allergic nasal mucosa and polyps with allergy is different from non-allergic mucosa, and that changes in Syk expression contribute to the activation of allergic reactions...
  3. ncbi request reprint A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution
    N Hamajima
    Department of Pediatrics, Nagoya City University Medical School, Japan
    Gene 180:157-63. 1996
    ..e., human DHPase, in liver and kidney; human DRP-1, in brain; human DRP-2, ubiquitously expressed except for liver; human DRP-3, mainly in heart and skeletal muscle...
  4. ncbi request reprint Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene
    K Kitamura
    Department of Biochemistry, Nagoya City University Medical School, Nagoya, Japan
    DNA Res 6:291-7. 1999
    ....
  5. doi request reprint Impaired olfactory function in mice with allergic rhinitis
    Shinya Ozaki
    Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medical Science, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, 467 8602, Japan
    Auris Nasus Larynx 37:575-83. 2010
    ..The purpose of this study was to study olfactory function and changes in olfactory mucosa using allergic rhinitis mice...
  6. ncbi request reprint Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system
    H Inagaki
    Department of Pathology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Histochem Cell Biol 113:37-41. 2000
    ..Northern blot analysis showed that DRPs were differentially expressed in the mouse and human intestines, supporting the results of ISH. These data suggest that DRPs play a role not only in the CNS but also in the ENS...
  7. ncbi request reprint Comparison of lifestyle and risk factors among Japanese with and without gastric cancer family history
    X E Huang
    Department of Public Health, Nagoya City University Medical School, Nagoya City, Aichi Prefecture, Japan
    Int J Cancer 86:421-4. 2000
    ..39, 95% CI 1.28-4.45). No statistically significant interaction was found between GCFH and selected lifestyle items. In conclusion, our results suggest a limited influence of GCFH on risk factors for GC...
  8. ncbi request reprint Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity
    M Kouwaki
    Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan
    Clin Cancer Res 4:2999-3004. 1998
    ..The present data represent the first molecular genetic analysis of DPD deficiency accompanied by severe 5-FU toxicity in a Japanese patient...
  9. ncbi request reprint Influence of habitual smoking on gastric cancer by histologic subtype
    M Inoue
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 81:39-43. 1999
    ..Risk patterns were less clear in females. Our results suggest that habitual smoking is associated more likely with the differentiated type of gastric cancer, particularly in younger cases...
  10. pmc Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer
    X E Huang
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Breast Cancer Res 3:264-9. 2001
    ....
  11. ncbi request reprint Possible risk reduction in esophageal cancer associated with MPO -463 A allele
    K Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan
    J Epidemiol 11:109-14. 2001
    ..Although there are limitations for interpretation of this study because of prevalent case-control study and partial statistical significance, these results suggest that MPO -463 A allele reduce the risk of esophageal cancer...
  12. ncbi request reprint Effect of body size on breast-cancer risk among Japanese women
    K Hirose
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 80:349-55. 1999
    ..These findings suggest that avoidance of marked weight gain during adult life, especially after natural menopause and/or after age 60, may reduce the risk of breast cancer...
  13. ncbi request reprint ALDH2 polymorphisms and bone mineral density in an elderly Japanese population
    J Yamaguchi
    Department of Orthopaedic Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 4668550, Aichi, Japan
    Osteoporos Int 17:908-13. 2006
    ..Osteoporosis is a multifactorial genetic disease which greatly increases the risk of bone fracture in elderly persons...
  14. ncbi request reprint The interaction of host genetic factors and Helicobacter pylori infection
    T Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, 466 8550, Japan
    Inflammopharmacology 15:10-4. 2007
    ..Prevention of gastric cancer requires the development of better screening strategies for determining eradication candidates and further improvement of treatments of Helicobacter pylori infection...
  15. ncbi request reprint Adjustment of prognostic effects in prevalent case-control studies on genotype
    N Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 11:204-10. 2001
    ..An actual prevalent case-control study on breast cancer is used to demonstrate the three approaches. They are useful to compensate the disadvantage of prevalent case-control studies...
  16. ncbi request reprint Risk and prognostic factors for Japanese patients with chronic graft-versus-host disease after bone marrow transplantation
    Y Atsuta
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Tsurumai cho, Showa Ku, Nagoya, Japan
    Bone Marrow Transplant 37:289-96. 2006
    ..Our patients could not be accurately classified when the proposed prognostic models from Western countries were used, thus indicating the need for a different model to identify high-risk patients...
  17. pmc Aldose reductase gene is associated with diabetic macroangiopathy in Japanese Type 2 diabetic patients
    A Watarai
    Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabet Med 23:894-9. 2006
    ..Therefore, the present study was conducted to determine whether genetic variations of AR may determine susceptibility to diabetic macroangiopathy...
  18. pmc Interleukin 1B proinflammatory genotypes protect against gastro-oesophageal reflux disease through induction of corpus atrophy
    T Ando
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Gut 55:158-64. 2006
    ..We examined the association between proinflammatory cytokine gene polymorphisms, presence of gastric atrophy, and risk of GORD in H pylori positive and negative subjects in Japan...
  19. ncbi request reprint Tacrolimus instead of cyclosporine used for prophylaxis against graft-versus-host disease improves outcome after hematopoietic stem cell transplantation from unrelated donors, but not from HLA-identical sibling donors: a nationwide survey conducted in Jap
    M Yanada
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Bone Marrow Transplant 34:331-7. 2004
    ..62, 95% CI: 1.23-2.14, P=0.0007 for OS). This superiority of FK506 was not observed in SIB-HSCT cases. These findings indicate that the use of FK506 instead of CSP for GVHD prophylaxis is beneficial for patients undergoing UD-HSCT...
  20. ncbi request reprint Different susceptibility of each L-myc genotype to esophageal cancer risk factors
    H Kumimoto
    Central Laboratory and Radiation Biology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Jpn J Cancer Res 92:735-9. 2001
    ..40, respectively. The age-sex-adjusted ORs for both factors combined were 12.77, 18.45 and 1.44, respectively. These results suggested that the L-myc polymorphism might modify the effects of lifestyle factors on esophageal cancer risk...
  21. pmc Dietary factors and lung cancer risk in Japanese: with special reference to fish consumption and adenocarcinomas
    T Takezaki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, 464 8681, Nagoya, Japan
    Br J Cancer 84:1199-206. 2001
    ..This study suggests cooked/raw fish consumption lowers the risk of adenocarcinoma of the lung in Japanese...
  22. ncbi request reprint Association between the dopamine D2 receptor A2/A2 genotype and smoking behavior in the Japanese
    K Yoshida
    Department of Pulmonary Medicine, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 10:403-5. 2001
    ....
  23. ncbi request reprint Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis
    T Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Clin Cancer Res 6:4055-63. 2000
    ..Whether p53 alteration also provides information that can alter treatment decisions should be asked in clinical trials...
  24. ncbi request reprint SEREX analysis of gastric cancer antigens
    Y Obata
    Aichi Cancer Center, Research Institute and Department of Genetics and Pathology, Aichi Cancer Center Hospital, Nagoya, Japan
    Cancer Chemother Pharmacol 46:S37-42. 2000
    ..To evaluate the clinical usefulness of these antigens we are now examining their expression in normal and malignant tissues...
  25. ncbi request reprint Detection of gene-environment interaction by case-only studies
    N Hamajima
    Division of Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Jpn J Clin Oncol 29:490-3. 1999
    ..The newly introduced case-only study was compared with traditional case-control study in terms of statistical power to detect significant gene-environment interaction...
  26. ncbi request reprint Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer
    K Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Carcinogenesis 22:913-6. 2001
    ..Taking the observed high risk of esophageal cancer in association with the ALDH2 Lys487 allele into consideration, reducing alcohol intake may be most protective among Lys487 allele carriers of this polymorphism...
  27. pmc Identification of Id1 in acquired middle ear cholesteatoma
    Quan An Zhang
    Department of Otolaryngology, Xi an Jiao University, Xi an, People s Republic of China
    Arch Otolaryngol Head Neck Surg 134:306-10. 2008
    ..To determine (1) the relationship between chronic inflammatory changes in the ossicular chain area (OCA) and the formation of cholesteatoma and (2) the correlates between aberrant gene expression and abnormal proliferation of cholesteatoma...