H Fujisawa

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint [Overview: differentiation and migration of neuronal cells]
    Hajime Fujisawa
    Tanpakushitsu Kakusan Koso 49:226-7. 2004
  2. pmc Determination of cell adhesion sites of neuropilin-1
    M Shimizu
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, USA
    J Cell Biol 148:1283-93. 2000
  3. ncbi request reprint From the discovery of neuropilin to the determination of its adhesion sites
    Hajime Fujisawa
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Adv Exp Med Biol 515:1-12. 2002
  4. ncbi request reprint Receptors for collapsin/semaphorins
    H Fujisawa
    Group of Developmental Neurobiology, Nagoya University Graduate School of Science, Japan
    Curr Opin Neurobiol 8:587-92. 1998
  5. ncbi request reprint A requirement for neuropilin-1 in embryonic vessel formation
    T Kawasaki
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 126:4895-902. 1999
  6. ncbi request reprint Differential expression of plexin-A subfamily members in the mouse nervous system
    Y Murakami
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Nagoya, Japan
    Dev Dyn 220:246-58. 2001
  7. ncbi request reprint Identification of a neuronal cell surface molecule, plexin, in mice
    T Kameyama
    Laboratory of Development Biology, Nagoya University Graduate School of Science, Japan
    Biochem Biophys Res Commun 226:524-9. 1996
  8. ncbi request reprint Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice
    T Kitsukawa
    Division of Biological Science, Nagoya University Graduate School of Science, Japan
    Neuron 19:995-1005. 1997
  9. ncbi request reprint Neocortical origin and tangential migration of guidepost neurons in the lateral olfactory tract
    N Tomioka
    Division of Biological Science, Nagoya University Graduate School of Science, Japan
    J Neurosci 20:5802-12. 2000
  10. ncbi request reprint Roles of a neuronal cell-surface molecule, neuropilin, in nerve fiber fasciculation and guidance
    H Fujisawa
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 01, Japan
    Cell Tissue Res 290:465-70. 1997

Collaborators

Detail Information

Publications45

  1. ncbi request reprint [Overview: differentiation and migration of neuronal cells]
    Hajime Fujisawa
    Tanpakushitsu Kakusan Koso 49:226-7. 2004
  2. pmc Determination of cell adhesion sites of neuropilin-1
    M Shimizu
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, USA
    J Cell Biol 148:1283-93. 2000
    ..In addition, we demonstrated that the cell adhesion ligands for neuropilin-1 were proteins and distributed in embryonic mesenchymal cells but distinct from the class 3 semaphorins, VEGF, or plexins...
  3. ncbi request reprint From the discovery of neuropilin to the determination of its adhesion sites
    Hajime Fujisawa
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Adv Exp Med Biol 515:1-12. 2002
    ..Later, NRP was shown to bind semaphorins and vascular endothelial growth factor (VEGF). It was also shown that NRP makes receptor complexes with Plex to propagate semaphorin signals...
  4. ncbi request reprint Receptors for collapsin/semaphorins
    H Fujisawa
    Group of Developmental Neurobiology, Nagoya University Graduate School of Science, Japan
    Curr Opin Neurobiol 8:587-92. 1998
    ..In addition, characterization of the neuropilin protein has yielded new insights into the functions of this molecule in vascular formation and in axon guidance...
  5. ncbi request reprint A requirement for neuropilin-1 in embryonic vessel formation
    T Kawasaki
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 126:4895-902. 1999
    ..The vascular defects induced by neuropilin-1 deficiency in mouse embryos suggest that neuropilin-1 plays roles in embryonic vessel formation, as well as nerve fiber guidance...
  6. ncbi request reprint Differential expression of plexin-A subfamily members in the mouse nervous system
    Y Murakami
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Nagoya, Japan
    Dev Dyn 220:246-58. 2001
    ....
  7. ncbi request reprint Identification of a neuronal cell surface molecule, plexin, in mice
    T Kameyama
    Laboratory of Development Biology, Nagoya University Graduate School of Science, Japan
    Biochem Biophys Res Commun 226:524-9. 1996
    ..Northern blot analysis indicated that mouse plexin 1 was predominantly expressed in the brain...
  8. ncbi request reprint Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice
    T Kitsukawa
    Division of Biological Science, Nagoya University Graduate School of Science, Japan
    Neuron 19:995-1005. 1997
    ..Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents...
  9. ncbi request reprint Neocortical origin and tangential migration of guidepost neurons in the lateral olfactory tract
    N Tomioka
    Division of Biological Science, Nagoya University Graduate School of Science, Japan
    J Neurosci 20:5802-12. 2000
    ..These results reveal a new type of neuronal migration in the telencephalon and introduce an unexpected dramatic feature of the earliest regionalization of the telencephalon...
  10. ncbi request reprint Roles of a neuronal cell-surface molecule, neuropilin, in nerve fiber fasciculation and guidance
    H Fujisawa
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 01, Japan
    Cell Tissue Res 290:465-70. 1997
    ..These findings suggest that neuropilin serves in a variety of neuronal cell interactions by binding to a variety of molecules, and that it plays essential roles in nerve fiber fasciculation and guidance...
  11. ncbi request reprint Identification of plexin family molecules in mice
    T Kameyama
    Laboratory of Developmental Biology, Nagoya University Graduate School of Science, Japan
    Biochem Biophys Res Commun 226:396-402. 1996
    ..Also, Northern blot analysis showed molecular heterogeneity in mouse plexin 2 mRNAs. These findings indicate that in the mouse, plexins comprise a molecular family (the plexin family)...
  12. ncbi request reprint Requirement for early-generated neurons recognized by monoclonal antibody lot1 in the formation of lateral olfactory tract
    Y Sato
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    J Neurosci 18:7800-10. 1998
    ..Ablation of lot cells prevented LOT formation in organotypic culture. These results suggest that lot cells are "guidepost cells" for mitral cell axons...
  13. ncbi request reprint Distributions of PAX6 and PAX7 proteins suggest their involvement in both early and late phases of chick brain development
    A Kawakami
    Division of Biological Science, Graduate School of Science, Nagoya University, Japan
    Mech Dev 66:119-30. 1997
    ....
  14. ncbi request reprint [Semaphorins and their receptors, neuropilins and plexins, regulate neural circuits formation]
    Fumikazu Suto
    Tanpakushitsu Kakusan Koso 49:317-23. 2004
  15. ncbi request reprint Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development
    Hajime Fujisawa
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    J Neurobiol 59:24-33. 2004
    ....
  16. ncbi request reprint [Roles of semaphorins in neuron network formation]
    Hajime Fujisawa
    Group of Developmental Neurobiology and The 21 Century COE Program, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya, 464 8602 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 24:187-92. 2004
    ....
  17. pmc EAT-20, a novel transmembrane protein with EGF motifs, is required for efficient feeding in Caenorhabditis elegans
    Y Shibata
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Genetics 154:635-46. 2000
    ..However, electrical activity of eat-20 mutants appears normal by electropharyngeogram...
  18. pmc The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis
    Fumi Nakao
    Division of Biological Science, Nagoya University Graduate School of Science, Nagoya, Japan
    Genetics 176:1591-607. 2007
    ..EFN-4 and PLX-2 are coexpressed in the late embryonic epidermis where they play redundant roles in MAB-20-dependent cell sorting...
  19. ncbi request reprint Identification and characterization of a novel mouse plexin, plexin-A4
    Fumikazu Suto
    Group of Developmental Neurobiology, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Mech Dev 120:385-96. 2003
    ..These results suggest that plexin-A4 plays a role in the propagation of Sema3A activities...
  20. pmc Mutations affecting nerve attachment of Caenorhabditis elegans
    G Shioi
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Genetics 157:1611-22. 2001
    ..The pleiotropic nature of the defects indicates that ven and mua/mup genes are required generally for the maintenance of attachment of tissues to the body wall in C. elegans...
  21. pmc Roles of semaphorin-6B and plexin-A2 in lamina-restricted projection of hippocampal mossy fibers
    Hiroshi Tawarayama
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    J Neurosci 30:7049-60. 2010
    ..Based on these results, we propose that the balance between mossy fiber repulsion by Sema6A and Sema6B and attraction by PlxnA2 and unknown molecule(s) prescribes the areas permissive for mossy fibers to innervate...
  22. ncbi request reprint Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system
    Takahiko Kawasaki
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 129:671-80. 2002
    ....
  23. ncbi request reprint Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis
    Takashi Fujii
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 129:2053-63. 2002
    ....
  24. ncbi request reprint C. elegans PlexinA PLX-1 mediates a cell contact-dependent stop signal in vulval precursor cells
    Zhicen Liu
    Division of Biological Science, Nagoya University Graduate School of Science, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Dev Biol 282:138-51. 2005
    ..Analyses using cell fate-specific markers showed that the arrangement defects of VPCs also affect cell fate specification and cell lineages, but in a relatively small fraction of plx-1 mutants...
  25. pmc Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2alpha in Caenorhabditis elegans
    Akira Nukazuka
    Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Genes Dev 22:1025-36. 2008
    ..Thus, our results reveal a physiological significance for translation of mRNAs for cytoskeletal regulators, linking environmental cues to cytoskeletal rearrangement during cellular morphogenesis in vivo...
  26. doi request reprint Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells
    Julie Renaud
    Centre National de la Recherche Scientifique, UMR7102, 9 quai Saint Bernard, Paris F 75005, France
    Nat Neurosci 11:440-9. 2008
    ..This suggests that semaphorin-plexin signaling modulates cell migration by controlling centrosome positioning...
  27. ncbi request reprint The transmembrane semaphorin Sema6A controls cerebellar granule cell migration
    Geraldine Kerjan
    Centre National de la Recherche Scientifique UMR7102, Université de Paris 6, Case 12, 9 quai Saint Bernard, 75005 Paris, France
    Nat Neurosci 8:1516-24. 2005
    ..Finally, the analysis of mouse chimeras suggests that this function of Sema6A is primarily non-cell-autonomous...
  28. ncbi request reprint FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology
    Oumi Nakajima
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    Biochem Biophys Res Commun 346:140-9. 2006
    ..Furthermore, the neurons overexpressing FKBP133 became significantly resistant to Semaphorin-3A induced collapse response. These results suggest that FKBP133 modulates growth cone behavior with the WH1 domain...
  29. ncbi request reprint [Roles of neural repellents semaphorins and their receptors in morphogenesis]
    Hajime Fujisawa
    Tanpakushitsu Kakusan Koso 50:678-83. 2005
  30. doi request reprint Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells
    Toshihiko Toyofuku
    Department of Immunopathology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Biol 321:251-62. 2008
    ..We therefore conclude that the coordination of repulsive cues provided by Sema6A/Sema6B through Plexin-A2 paired with the attractive cue by Sema3C through Plexin-D1 is required for the precise navigation of migrating cardiac NCCs...
  31. pmc Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve
    Quenten Schwarz
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Genes Dev 18:2822-34. 2004
    ..These observations demonstrate, for the first time, that VEGF contributes to neuronal patterning in vivo, and that different compartments of one cell can be co-ordinately patterned by structurally distinct ligands for a shared receptor...
  32. ncbi request reprint Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers
    Fumikazu Suto
    Division of Developmental Genetics, National Institute of Genetics, Mishima 411 8540, Japan CREST, Japan Science and Technology Agency, Kawaguchi 332 0012, Japan
    Neuron 53:535-47. 2007
    ....
  33. ncbi request reprint Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system
    Holger Gerhardt
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    Dev Dyn 231:503-9. 2004
    ..These observations suggest that Nrp-1 plays an important role in allowing the endothelial tip cell filopodia to switch substrate and protrude in a new direction at a specific location in the developing brain...
  34. ncbi request reprint Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling
    Heike Beck
    Institute of Neurology Edinger Institute, JWG University, Frankfurt am Main, Germany
    J Neuropathol Exp Neurol 61:339-50. 2002
    ..Possibly, the loss of semaphorins facilitates binding of the competing ligands (VEGF/PLGF), thus inducing angiogenesis. In addition, the observed expression patterns further suggest a neurotrophic/neuroprotective role of VEGF/PLGF...
  35. pmc Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    Christiana Ruhrberg
    Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 16:2684-98. 2002
    ..We conclude that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern...
  36. ncbi request reprint Neuropilin-1 on hematopoietic cells as a source of vascular development
    Yoshihiro Yamada
    Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    Blood 101:1801-9. 2003
    ..In NP-1-/- embryos, vascular sprouting is impaired at the central nervous system (CNS) and pericardium where VEGF is not abundant, indicating that NP-1-expressing cells are required for normal vascular development...
  37. pmc Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis
    Seiji Takashima
    Department of Internal Medicine and Therapeutics, Department of Nutrition and Physiological Chemistry, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 99:3657-62. 2002
    ..Their abnormal vascular phenotype resembled those of VEGF and VEGFR-2 knockouts. These results suggest that NRPs are early genes in embryonic vessel development and that both NP1 and NP2 are required...
  38. ncbi request reprint [Present status and future aspects of studies on neuronal network formation (discussion)]
    Shigetada Nakanishi
    Tanpakushitsu Kakusan Koso 49:205-25. 2004
  39. pmc Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2
    Toshihiko Toyofuku
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Genes Dev 18:435-47. 2004
    ..Thus, the differential association of Plexin-A1 with additional receptor components entitles Sema6D to exert distinct biological activities at adjacent regions. This is crucial for complex cardiac morphogenesis...
  40. ncbi request reprint Mosaic development of the olfactory cortex with Pax6-dependent and -independent components
    Tatsumi Hirata
    Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Yata 1111, Mishima 411 8540, Japan
    Brain Res Dev Brain Res 136:17-26. 2002
    ....
  41. ncbi request reprint Developmental regulation of notochord-derived repulsion for dorsal root ganglion axons
    Tomoyuki Masuda
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Mol Cell Neurosci 25:217-27. 2004
    ..Thus, notochord-derived multiple axon repulsions act in a spatiotemporal-specific manner to shape the initial trajectories of DRG axons...
  42. ncbi request reprint Chronotopic organization of olfactory bulb axons in the lateral olfactory tract
    Hitoshi Yamatani
    Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Yata 1111, Mishima 411 8540, Japan
    J Comp Neurol 475:247-60. 2004
    ....
  43. ncbi request reprint Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance
    Fumikazu Suto
    Division of Developmental Genetics, National Institute of Genetics, Mishima 411 8540, Japan
    J Neurosci 25:3628-37. 2005
    ..Our results imply that plexin-A4 mediates multiple semaphorin signals and regulates axon guidance in vivo...
  44. ncbi request reprint Differential non-target-derived repulsive signals play a critical role in shaping initial axonal growth of dorsal root ganglion neurons
    Tomoyuki Masuda
    Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Dev Biol 254:289-302. 2003
    ..Thus, differential chemorepulsive signals help shape the initial trajectories of DRG axons and are critical for the proper wiring of the nervous system...
  45. ncbi request reprint Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme
    Paivi Kettunen
    Division of Anatomy and Cell Biology, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Development 132:323-34. 2005
    ..Moreover, our results suggest that the odontogenic epithelium possesses the instructive information to control the formation of tooth nerve supply...