Toshiya Endo

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria
    Yasushi Tamura
    Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    J Cell Biol 174:631-7. 2006
  2. pmc Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly
    Daigo Ishikawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Cell Biol 166:621-7. 2004
  3. pmc Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import
    Yasushi Tamura
    Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya, Japan
    J Cell Biol 184:129-41. 2009
  4. pmc Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation
    S I Nishikawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Cell Biol 153:1061-70. 2001
  5. doi request reprint Structural insight into the mitochondrial protein import system
    Toshiya Endo
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Biochim Biophys Acta 1808:955-70. 2011
  6. doi request reprint Structural basis for the disulfide relay system in the mitochondrial intermembrane space
    Toshiya Endo
    Department of Chemistry, Nagoya University, Japan
    Antioxid Redox Signal 13:1359-73. 2010
  7. ncbi request reprint Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles
    Toshiya Endo
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Cell Sci 116:3259-67. 2003
  8. ncbi request reprint [Protein traffic (in eukaryotic cells): mechanism of operation of the protein-traffic control system in the cell]
    Toshiya Endo
    Tanpakushitsu Kakusan Koso 49:877-88. 2004
  9. ncbi request reprint Multiple pathways for mitochondrial protein traffic
    Toshiya Endo
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Biol Chem 390:723-30. 2009
  10. ncbi request reprint Functions of outer membrane receptors in mitochondrial protein import
    Toshiya Endo
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, 464 8602, Japan
    Biochim Biophys Acta 1592:3-14. 2002

Collaborators

Detail Information

Publications59

  1. pmc Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria
    Yasushi Tamura
    Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    J Cell Biol 174:631-7. 2006
    ..These results suggest that Tam41 facilitates mitochondrial protein import by maintaining the functional integrity of the TIM23 protein translocator complex from the matrix side of the inner membrane...
  2. pmc Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly
    Daigo Ishikawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Cell Biol 166:621-7. 2004
    ..Depletion of Tom13 or Tom38/Sam35 affects assembly pathways of the beta-barrel proteins differently, suggesting that they mediate different steps of the complex assembly processes of beta-barrel proteins in the outer membrane...
  3. pmc Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import
    Yasushi Tamura
    Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya, Japan
    J Cell Biol 184:129-41. 2009
    ..Therefore, the Tim23-Tim50 pair coordinates the actions of the TOM40 and TIM23 complexes together with motor proteins for mitochondrial protein import...
  4. pmc Molecular chaperones in the yeast endoplasmic reticulum maintain the solubility of proteins for retrotranslocation and degradation
    S I Nishikawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Cell Biol 153:1061-70. 2001
    ..These results suggest that one role of the BiP, Jem1p, and Scj1p chaperones is to maintain lumenal ERAD substrates in a retrotranslocation-competent state...
  5. doi request reprint Structural insight into the mitochondrial protein import system
    Toshiya Endo
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Biochim Biophys Acta 1808:955-70. 2011
    ..This article is part of a Special Issue entitled Protein translocation across or insertion into membranes...
  6. doi request reprint Structural basis for the disulfide relay system in the mitochondrial intermembrane space
    Toshiya Endo
    Department of Chemistry, Nagoya University, Japan
    Antioxid Redox Signal 13:1359-73. 2010
    ..Here we review the recent advancement of the knowledge on the mechanism of the disulfide relay system in the mitochondrial IMS, especially shedding light on the structural aspects of its components...
  7. ncbi request reprint Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles
    Toshiya Endo
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Cell Sci 116:3259-67. 2003
    ..The TOM complex can be disconnected from the TIM systems and their energy sources (ATP and DeltaPsi), however, using alternative mechanisms to achieve vectorial protein translocation across the outer membrane..
  8. ncbi request reprint [Protein traffic (in eukaryotic cells): mechanism of operation of the protein-traffic control system in the cell]
    Toshiya Endo
    Tanpakushitsu Kakusan Koso 49:877-88. 2004
  9. ncbi request reprint Multiple pathways for mitochondrial protein traffic
    Toshiya Endo
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Biol Chem 390:723-30. 2009
    ..Here, we summarize the expanding knowledge on the roles of translocators, chaperones, and related components in the multiple pathways for mitochondrial protein trafficking...
  10. ncbi request reprint Functions of outer membrane receptors in mitochondrial protein import
    Toshiya Endo
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, 464 8602, Japan
    Biochim Biophys Acta 1592:3-14. 2002
    ..This leads to a new model that different features associated with the mitochondrial targeting sequence of the precursor protein can be recognized by the mitochondrial protein import system in different steps during the import...
  11. ncbi request reprint Transport of proteins across or into the mitochondrial outer membrane
    Toshiya Endo
    Department of Chemistry, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Biochim Biophys Acta 1803:706-14. 2010
    ..Here we review the current view on a remarkable variety of mechanisms of protein transport taking place at the mitochondrial outer membrane...
  12. ncbi request reprint The phosphate carrier has an ability to be sorted to either the TIM22 pathway or the TIM23 pathway for its import into yeast mitochondria
    Koji Yamano
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 280:10011-7. 2005
    ..PiC thus appears to have a latent signal for sorting to the TIM23 pathway, which is exposed by reduced interactions with the Tim9-Tim10 complex and maintenance of the import competence...
  13. doi request reprint Identification and characterization of a Jem1p ortholog of Candida albicans: dissection of Jem1p functions in karyogamy and protein quality control in Saccharomyces cerevisiae
    Tadashi Makio
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Genes Cells 13:1015-26. 2008
    ..Since the interaction of CaJem1p with Nep98p is weaker than that of ScJem1p, the Nep98p-ScJem1p interaction is likely important for promoting karyogamy in S. cerevisiae...
  14. pmc Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40
    Koji Yamano
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 285:41222-31. 2010
    ..These results collectively show that Tom7 recruits Mdm10, enhancing its association with the MMM1 complex, to regulate timing of the release of Tom40 from the TOB complex for subsequent assembly into the TOM40 complex...
  15. pmc Structural basis for unfolding pathway-dependent stability of proteins: vectorial unfolding versus global unfolding
    Keisuke Yagawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Protein Sci 19:693-702. 2010
    ..On the other hand, the Y9P mutation causes a bend in the backbone structure, which leads to the formation of a more stable N-terminal structure probably through enhanced hydrophobic interactions...
  16. pmc Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria
    Hayashi Yamamoto
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 108:91-6. 2011
    ..Therefore Tom20 has a dual role in protein import into mitochondria: recognition of the targeting signal in the presequence and tethering the presequence to the TOM40 complex to increase import efficiency...
  17. ncbi request reprint Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes
    Hayashi Yamamoto
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, 464 8602, Nagoya, Japan
    Cell 111:519-28. 2002
    ..A translocation intermediate accumulated at the TOM complex is crosslinked to Tim50. We suggest that Tim50, in cooperation with Tim23, facilitates transfer of the translocating protein from the TOM complex to the TIM23 complex..
  18. pmc Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space
    Shin Kawano
    Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 106:14403-7. 2009
    ..These results are consistent with the growth phenotypes of Mia40 mutant cells containing Ser replacement of the conserved cysteine residues...
  19. pmc In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work
    Takuya Shiota
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 108:15179-83. 2011
    ....
  20. pmc Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
    Yasushi Tamura
    Institute for Advanced Research, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Cell Metab 17:709-18. 2013
    ..The present findings unveil the missing step of the cardiolipin synthesis pathway in mitochondria as well as the flexibile regulation of phospholipid biosynthesis to respond to compromised CDP-DAG synthesis in mitochondria...
  21. ncbi request reprint Tom40 protein import channel binds to non-native proteins and prevents their aggregation
    Masatoshi Esaki
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Nat Struct Biol 10:988-94. 2003
    ..These results indicate that, in contrast to the nonstick tunnel of the ribosome for polypeptide exit, the Tom40 channel offers an optimized environment to translocating non-native precursor proteins by preventing their aggregation...
  22. pmc Structural basis of functional cooperation of Tim15/Zim17 with yeast mitochondrial Hsp70
    Takaki Momose
    Department of Chemistry, Graduate School of Science, Nagoya University, Japan
    EMBO Rep 8:664-70. 2007
    ..Therefore, the function of Tim15 in yeast cell growth is well correlated with its ability to suppress mtHsp70 aggregation, although it is still unknown whether inhibition of mtHsp70 aggregation is the primary function of Tim15...
  23. pmc Roles of Tom70 in import of presequence-containing mitochondrial proteins
    Hayashi Yamamoto
    Department of Chemistry, Graduate School of Science, Japan Science and Technology Agency, Research Centre for Material Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 284:31635-46. 2009
    ..Therefore Tom70 plays the role of a docking site for not only cytosolic chaperones but also aggregate-prone substrates to maintain their solubility for efficient transfer to downstream components of the mitochondrial import machineries...
  24. pmc Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40
    Koji Yamano
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, Aichi Ken, Japan
    EMBO Rep 11:187-93. 2010
    ..These results show that Mdm10 regulates the timing of release of unassembled Tom40 from the TOB complex, to facilitate its coordinated assembly into the TOM40 complex...
  25. doi request reprint Roles of dom34:hbs1 in nonstop protein clearance from translocators for normal organelle protein influx
    Toshiaki Izawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, Japan
    Cell Rep 2:447-53. 2012
    ..Clearance of stuck nonstop proteins from organellar translocator channels is crucial for normal protein influx into organelles and for normal cell growth, especially when nonstop mRNA decay does not function efficiently...
  26. ncbi request reprint Cytoplasmic splicing of tRNA in Saccharomyces cerevisiae
    Tohru Yoshihisa
    Research Center for Materials Science, Nagoya University, Japan
    Genes Cells 12:285-97. 2007
    ..These and other results indicate that, in S. cerevisiae, pre-tRNAs in the cytoplasm are genuine substrates for splicing, and that the splicing is indeed carried out in the cytoplasm...
  27. ncbi request reprint Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone proteins that facilitates protein translocation across the inner membrane
    Hayashi Yamamoto
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    FEBS Lett 579:507-11. 2005
    ..Tim15/Zim17 therefore cooperates with mtHsp70 to facilitate import of presequence-containing proteins into the matrix...
  28. ncbi request reprint Nep98p is a component of the yeast spindle pole body and essential for nuclear division and fusion
    Shuh ichi Nishikawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 278:9938-43. 2003
    ..Because Jem1p is not required for nuclear division, Nep98p probably has dual functions in Jem1p-dependent karyogamy and in Jem1p-independent nuclear division...
  29. ncbi request reprint Mitochondrial protein import. Requirement of presequence elements and tom components for precursor binding to the TOM complex
    Masatoshi Esaki
    Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya, Japan
    J Biol Chem 279:45701-7. 2004
    ..Tom7 constitutes or is close to the trans site and has overlapping functions with the C-terminal intermembrane space domain of Tom22 in the mitochondrial protein import...
  30. ncbi request reprint Identification of Tim40 that mediates protein sorting to the mitochondrial intermembrane space
    Mari Naoé
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 279:47815-21. 2004
    ..These results suggest the essential role of Tim40 in sorting/assembly of small Tim proteins...
  31. pmc The Tom40 assembly process probed using the attachment of different intramitochondrial sorting signals
    Takuya Shiota
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Mol Biol Cell 23:3936-47. 2012
    ..These results provide insight into the mechanism responsible for the precise delivery of β-barrel proteins to the outer mitochondrial membrane...
  32. ncbi request reprint Nuclear inner membrane fusion facilitated by yeast Jem1p is required for spindle pole body fusion but not for the first mitotic nuclear division during yeast mating
    Shuh ichi Nishikawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Genes Cells 13:1185-95. 2008
    ..This observation suggests that nuclear inner-membrane fusion is required for SPB fusion, but not for SPB duplication in the first mitotic cell division...
  33. doi request reprint NMR analyses on the interactions of the yeast Tim50 C-terminal region with the presequence and Tim50 core domain
    Bytul Rahman
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    FEBS Lett 588:678-84. 2014
    ..sPBD can also bind to the core domain of Tim50 through the presequence binding region, which could promote transfer of the presequence from sPBD to the core domain in Tim50. ..
  34. doi request reprint Step-size analyses of the mitochondrial Hsp70 import motor reveal the Brownian ratchet in operation
    Koji Yamano
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 283:27325-32. 2008
    ..These results suggest that the mtHsp70 import motor functions at least as a molecular Brownian ratchet to unfold mitochondrial precursor proteins...
  35. ncbi request reprint Tom20 and Tom22 share the common signal recognition pathway in mitochondrial protein import
    Koji Yamano
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 283:3799-807. 2008
    ..Therefore Tom20 and Tom22 are apparently involved in the same step or sequential steps along the same pathway of targeting signal recognition in import...
  36. pmc Yos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation
    Toshiaki Izawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, Japan
    Mol Biol Cell 23:1283-93. 2012
    ..These results collectively indicate that Yos9p and Hrd1p mediate ER retention of misfolded proteins in the early stage of ERAD, which constitutes a process separable from the later degradation step...
  37. ncbi request reprint Reinvestigation of the requirement of cytosolic ATP for mitochondrial protein import
    Takeyoshi Asai
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 279:19464-70. 2004
    ..In contrast, the ADP/ATP carrier requires external ATP for efficient import into mitochondria even after binding to mitochondria, a situation that is only partly attributed to cytosolic Hsp70...
  38. doi request reprint Structural stabilities of different regions of the titin I27 domain contribute differently to unfolding upon mitochondrial protein import
    Takaomi Oguro
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Mol Biol 385:811-9. 2009
    ..In other words, the rate-limiting step of the global unfolding upon import into mitochondria switches, depending on the balance between the stability of the N-terminal structure and the stability of the core region of the I27 domain...
  39. doi request reprint Identification of yeast Art5 as a multicopy suppressor for the mitochondrial translocator maintenance protein Tam41
    Yoshihiro Harada
    Department of Chemistry, Graduate School of Science, Nagoya University, and Chikusa ku, Nagoya 464 8602, Japan
    Biochem Biophys Res Commun 392:228-33. 2010
    ..Art5 as a functional partner for Tam41 will provide a starting point to reveal the precise function of Tam41 in the maintenance of the TIM23 complex...
  40. pmc Roles of protein-disulfide isomerase-mediated disulfide bond formation of yeast Mnl1p in endoplasmic reticulum-associated degradation
    Machiko Sakoh-Nakatogawa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 284:11815-25. 2009
    ..Close interdependence between Mnl1p and PDI suggests that these two proteins form a functional unit in the ERAD pathway...
  41. pmc Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria
    Tohru Yoshihisa
    Research Center for Materials Science, Nagoya University, Nagoya, 464 8602, Japan
    Mol Biol Cell 14:3266-79. 2003
    ..It is difficult to explain these results from the view of tRNA splicing in the nucleus. We rather propose a new possibility that tRNA splicing occurs on the mitochondrial surface in yeast...
  42. pmc Dual functions of yeast tRNA ligase in the unfolded protein response: unconventional cytoplasmic splicing of HAC1 pre-mRNA is not sufficient to release translational attenuation
    Takao Mori
    Department of Chemistry and Division of Biological Science, Graduate School of Science, and Research Center for Materials Science, Nagoya University, Nagoya 464 8602, Japan
    Mol Biol Cell 21:3722-34. 2010
    ..These results indicate that the splicing and the release of translational attenuation of HAC1 mRNA are separable steps and that Rlg1p has pivotal roles in both of these steps...
  43. pmc BiP-mediated polar nuclei fusion is essential for the regulation of endosperm nuclei proliferation in Arabidopsis thaliana
    Daisuke Maruyama
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Proc Natl Acad Sci U S A 107:1684-9. 2010
    ..This is experimental evidence for the importance of fusion of the polar nuclei in the proliferation of endosperm nuclei...
  44. doi request reprint A vacuolar carboxypeptidase mutant of Arabidopsis thaliana is degraded by the ERAD pathway independently of its N-glycan
    Masaya Yamamoto
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Biochem Biophys Res Commun 393:384-9. 2010
    ..Therefore, AtCPY*-GFP can be used as a marker protein to analyze the ERAD pathway, likely for nonglycosylated substrates, in plant cells...
  45. ncbi request reprint tRNA actively shuttles between the nucleus and cytosol in yeast
    Akira Takano
    Department of Chemistry, Graduate School of Science, Japan Science and Technology Corporation, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Science 309:140-2. 2005
    ..Several export mutants accumulate mature tRNAs in the nucleus even in the absence of transcription. Import requires energy but not the Ran cycle. These results indicate that tRNAs shuttle between the nucleus and cytosol...
  46. doi request reprint Analyses of protein-protein interactions by in vivo photocrosslinking in budding yeast
    Takuya Shiota
    Department of Chemistry, Nagoya University, Nagoya, Japan
    Methods Mol Biol 1033:207-17. 2013
    ..Since photocrosslinking can be performed for pBpa-incorporated proteins that are properly assembled into a protein complex in living cells, this method will allow us to reveal protein-protein interactions of the target proteins at work. ..
  47. ncbi request reprint Roles of O-mannosylation of aberrant proteins in reduction of the load for endoplasmic reticulum chaperones in yeast
    Kunio Nakatsukasa
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    J Biol Chem 279:49762-72. 2004
    ..O-Mannosylation may therefore function as a fail-safe mechanism for the ERAD by solubilizing the aberrant proteins that overflowed from the ERAD pathway and reducing the load for ER chaperones...
  48. pmc Comparison of the protein-unfolding pathways between mitochondrial protein import and atomic-force microscopy measurements
    Takehiro Sato
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Japan
    Proc Natl Acad Sci U S A 102:17999-8004. 2005
    ..We propose that the mitochondrial-import system can catalyze precursor-unfolding by reducing the stability of unfolding intermediates...
  49. pmc The intron of tRNA-TrpCCA is dispensable for growth and translation of Saccharomyces cerevisiae
    Shunsuke Mori
    Department of Chemistry, Graduate School of Science, Nagoya University, Nagoya, 464 8602, Japan
    RNA 17:1760-9. 2011
    ..This raises the possibility that some mechanism other than selective pressure from translational efficiency maintains the tRNA intron on the yeast genome...
  50. ncbi request reprint [What is the physiological role of nuclear tRNA?]
    Tohru Yoshihisa
    Tanpakushitsu Kakusan Koso 51:2232-4. 2006
  51. doi request reprint Arabidopsis thaliana has a set of J proteins in the endoplasmic reticulum that are conserved from yeast to animals and plants
    Masaya Yamamoto
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, 464 8602 Japan
    Plant Cell Physiol 49:1547-62. 2008
    ..These results suggest that A. thaliana has a set of ER J proteins structurally and functionally conserved from yeast to plants...
  52. ncbi request reprint A novel import route for an N-anchor mitochondrial outer membrane protein aided by the TIM23 complex
    Jiyao Song
    Department of Chemistry, Graduate School of Science Nagoya University, Chikusa ku Nagoya, Japan
    EMBO Rep 15:670-7. 2014
    ..Therefore, Om45 is anchored to the OM via the IMS by a novel import pathway involving the TIM23 complex. ..
  53. ncbi request reprint Multiple BiP genes of Arabidopsis thaliana are required for male gametogenesis and pollen competitiveness
    Daisuke Maruyama
    Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, 464 8602 Japan
    Plant Cell Physiol 55:801-10. 2014
    ....
  54. ncbi request reprint [Morphology of mitochondria]
    Akemi Kawai
    Graduate School of Science, Nagoya University
    Nihon Rinsho 60:9-13. 2002
  55. ncbi request reprint Peptide library approach with a disulfide tether to refine the Tom20 recognition motif in mitochondrial presequences
    Takayuki Obita
    Department of Structural Biology, Biomolecular Engineering Research Institute, Suita, Osaka 565 0874, Japan
    J Mol Biol 328:495-504. 2003
    ..We successfully deduced a refined, common motif for the recognition by Tom20, and found that the segment consisting of residues 14-20 of the ALDH presequence was locally optimized in the sequence space, with respect to Tom20 binding...
  56. pmc Crystallization and preliminary X-ray analysis of mitochondrial presequence receptor Tom20 in complexes with a presequence from aldehyde dehydrogenase
    Mayumi Igura
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:514-7. 2005
    ..1 and 1.9 A. Crystal dehydration and subsequent annealing was essential to obtain good diffraction data for the 2.1 A crystal form...
  57. pmc Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states
    Takashi Saitoh
    Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    EMBO J 26:4777-87. 2007
    ..We suggest that the dynamic, multiple-mode interaction is the molecular mechanism facilitating the broadly selective specificity of the Tom20 receptor toward diverse mitochondrial presequences...
  58. doi request reprint Alcohol preference in mice lacking the Avpr1a vasopressin receptor
    Atsushi Sanbe
    Department of Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan
    Am J Physiol Regul Integr Comp Physiol 294:R1482-90. 2008
    ....
  59. doi request reprint Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions
    Akari Kato
    Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Exp Cell Res 314:2661-73. 2008
    ..Our results indicate that the hypoxia-induced activation of the XB-S promoter is regulated through dissociation of HDAC1 from an Sp1-binding HRE site...