Toshiyuki Arai

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. ncbi request reprint Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis
    Takashi Hiromatsu
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Infect Dis 187:1442-51. 2003
  2. ncbi request reprint NK T cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice
    Takashi Hiromatsu
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Eur J Immunol 33:2511-9. 2003
  3. ncbi request reprint Hepatectomy for colorectal liver metastases with macroscopic intrabiliary tumor growth
    Teiichi Sugiura
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    World J Surg 30:1902-8. 2006
  4. pmc Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and long-term follow-up
    Masato Nagino
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 243:364-72. 2006
  5. ncbi request reprint A study of the subvesical bile duct (duct of Luschka) in resected liver specimens
    Kenju Ko
    Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya, 466 8550, Japan
    World J Surg 30:1316-20. 2006
  6. ncbi request reprint Treatment of colorectal liver metastasis with biliary and portal vein tumor thrombi by hepatopancreatoduodenectomy
    Teiichi Sugiura
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    J Hepatobiliary Pancreat Surg 13:256-9. 2006
  7. ncbi request reprint Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice
    Tetsuya Abe
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Hepatology 40:414-23. 2004
  8. ncbi request reprint Portal and mesenteric vein thrombosis after portal vein embolization in a patient with protein S deficiency
    Masayuki Ohkubo
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    J Hepatobiliary Pancreat Surg 11:338-41. 2004
  9. ncbi request reprint Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer
    Tatsuharu Yamada
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Langenbecks Arch Surg 390:421-9. 2005
  10. ncbi request reprint Intense PET signal in the degenerative necrosis superimposed on chronic pancreatitis
    Yukihiro Yokoyama
    Division of Surgical Oncology, Department of Surgery, University of Nagoya Graduate School of Medicine, Nagoya, Japan
    Pancreas 31:192-4. 2005

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Overexpression of interleukin-15 protects against Escherichia coli-induced shock accompanied by inhibition of tumor necrosis factor-alpha-induced apoptosis
    Takashi Hiromatsu
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    J Infect Dis 187:1442-51. 2003
    ..coli challenge. These results suggest that IL-15 overexpression can prevent TNF-alpha-induced apoptosis and protect against E. coli-induced shock, indicating a possible therapeutic application of IL-15 for septic shock...
  2. ncbi request reprint NK T cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice
    Takashi Hiromatsu
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Eur J Immunol 33:2511-9. 2003
    ..In conclusion, it is suggested that induction of Fas L on NK T cells in response to bacterial components such as lipoproteins plays an important role in pathogenesis of E. coli-induced liver injury in mice...
  3. ncbi request reprint Hepatectomy for colorectal liver metastases with macroscopic intrabiliary tumor growth
    Teiichi Sugiura
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    World J Surg 30:1902-8. 2006
    ..We set out to clarify the clinicopathologic characteristics of colorectal liver metastases with macroscopic intrabiliary tumor growth and to determine optimal surgical management...
  4. pmc Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and long-term follow-up
    Masato Nagino
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 243:364-72. 2006
    ..To assess clinical benefit of portal vein embolization (PVE) before extended, complex hepatectomy for biliary cancer...
  5. ncbi request reprint A study of the subvesical bile duct (duct of Luschka) in resected liver specimens
    Kenju Ko
    Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya, 466 8550, Japan
    World J Surg 30:1316-20. 2006
    ..Injury to the duct of Luschka is associated with biliary fistula from the gallbladder bed after cholecystectomy. However, few studies have reported on the detailed anatomy. We elucidated the anatomy and frequency of the duct of Luschka..
  6. ncbi request reprint Treatment of colorectal liver metastasis with biliary and portal vein tumor thrombi by hepatopancreatoduodenectomy
    Teiichi Sugiura
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    J Hepatobiliary Pancreat Surg 13:256-9. 2006
    ..The inferior vena cava, right kidney, and renal vein could be detached from the tumor. The patient has enjoyed an active life without recurrence for 2 years since the operation...
  7. ncbi request reprint Kupffer cell-derived interleukin 10 is responsible for impaired bacterial clearance in bile duct-ligated mice
    Tetsuya Abe
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Hepatology 40:414-23. 2004
    ..Fas-mediated hepatocyte apoptosis in cholestasis may be involved in the predominant IL-10 production by Kupffer cells...
  8. ncbi request reprint Portal and mesenteric vein thrombosis after portal vein embolization in a patient with protein S deficiency
    Masayuki Ohkubo
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    J Hepatobiliary Pancreat Surg 11:338-41. 2004
    ..It may be better to determine the concentrations of such coagulation regulators prior to portal vein embolization...
  9. ncbi request reprint Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer
    Tatsuharu Yamada
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Langenbecks Arch Surg 390:421-9. 2005
    ..However, little is known about the effect of chronic obstruction by malignancy on the MRP2 expression in patients or the association of MRP2 expression with posthepatectomy hyperbilirubinemia...
  10. ncbi request reprint Intense PET signal in the degenerative necrosis superimposed on chronic pancreatitis
    Yukihiro Yokoyama
    Division of Surgical Oncology, Department of Surgery, University of Nagoya Graduate School of Medicine, Nagoya, Japan
    Pancreas 31:192-4. 2005
    ..Repetitive PET examination is recommended for the accurate diagnosis...
  11. pmc "Anatomic" right hepatic trisectionectomy (extended right hepatectomy) with caudate lobectomy for hilar cholangiocarcinoma
    Masato Nagino
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 243:28-32. 2006
    ..The techniques of right hepatic trisectionectomy are now standardized in patients with hepatocellular or metastatic carcinoma, but not in those with hilar cholangiocarcinoma...
  12. pmc Immunohistochemically demonstrated lymph node micrometastasis and prognosis in patients with gallbladder carcinoma
    Eiji Sasaki
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 244:99-105. 2006
    ..To investigate whether immunohistochemically demonstrated lymph node micrometastasis has a survival impact in patients with advanced gallbladder carcinoma (pT2-4 tumors)...
  13. ncbi request reprint Epidermoid cyst in an intrapancreatic accessory spleen: a case report
    Hidetoshi Kanazawa
    Division of Surgical Oncology, Department of Surgery, Nagoya University, Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    J Hepatobiliary Pancreat Surg 11:61-3. 2004
    ..Consequently, it is not possible to make a definite preoperative diagnosis in most cases. Epidermoid cyst in intrapancreatic splenic tissue is another lesion to be considered in the differential diagnosis of pancreatic tail tumors...
  14. ncbi request reprint [Benefit of percutaneous transhepatic portal vein embolization for extended hepatectomy]
    Satoshi Kobayashi
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nihon Geka Gakkai Zasshi 105:354-8. 2004
    ..3% to 23.8% and from 21.9% to 9.5%, respectively. The technique of PTPE has contributed to an improved survival rate for patients with severely advanced biliary cancer...
  15. ncbi request reprint Changes in splenic volume during liver regeneration
    Hideya Ando
    Department of Surgery, Division of Surgical Oncology, Nagoya University Graduate School of Medicine, 466 8550, Nagoya, Japan
    World J Surg 28:977-81. 2004
    ..64, p = 0.0006). These data indicate that the spleen is enlarged during liver regeneration, suggesting that the liver and spleen share certain common growth regulatory mechanisms...
  16. ncbi request reprint [Hepatic failure following resection of cholestatic liver]
    Toshiyuki Arai
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nihon Geka Gakkai Zasshi 105:664-8. 2004
    ....
  17. ncbi request reprint Hepaticojejunostomy using a Roux-en-Y jejunal limb via the retrocolic-retrogastric route
    Masato Nagino
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466, Japan
    Langenbecks Arch Surg 387:188-9. 2002
    ..However, in morbidly obese patients difficulty arises from the thickened, foreshortened mesentery of the jejunum and from limited mobility due to intra-abdominal fat deposition...
  18. ncbi request reprint One hundred consecutive hepatobiliary resections for biliary hilar malignancy: preoperative blood donation, blood loss, transfusion, and outcome
    Masato Nagino
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Surgery 137:148-55. 2005
    ..The aim of this study was to review our experience with blood loss and perioperative blood requirements in 100 consecutive hepatectomies for biliary hilar malignancy...
  19. ncbi request reprint Free oxygen radicals reduce bile flow in rats via an intracellular cyclic AMP-dependent mechanism
    Satoru Kawai
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol Hepatol 22:429-35. 2007
    ..The aim of this study was to determine whether oxygen radicals reduce bile flow by mechanisms involving intrahepatocyte cAMP levels...
  20. ncbi request reprint Left hepatic trisegmentectomy with right hepatic vein resection after right hepatic vein embolization
    Masato Nagino
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Surgery 133:580-2. 2003
  21. ncbi request reprint Risk factors for incisional surgical site infections in elective surgery for colorectal cancer: focus on intraoperative meticulous wound management
    Keita Itatsu
    The Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Surg Today 44:1242-52. 2014
    ..The purpose of this study was to assess the impact of the methods used for intraoperative wound management on the incidence of I-SSI following elective surgery for colorectal cancer...
  22. ncbi request reprint [Biliary bacterial infection in liver surgery]
    Toshiyuki Arai
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nihon Geka Gakkai Zasshi 103:869-72. 2002
    ..As septic complications and liver failure are profoundly associated with each other, it is important to take all measures before surgery to enhance liver function and to prevent postoperative septic complications...
  23. pmc Surgical anatomy of the bile ducts at the hepatic hilum as applied to living donor liver transplantation
    Masayuki Ohkubo
    Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Surg 239:82-6. 2004
    ..To evaluate anatomic variations of the biliary tree as applied to living donor liver transplantation...
  24. ncbi request reprint [Surgical treatment for advanced gallbladder cancer: indications and limitations]
    Katsuhiko Uesaka
    Division of Surgical Oncology, Department of Surgery, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Nihon Geka Gakkai Zasshi 103:538-42. 2002
    ..Elucidation of the clinical and molecular characteristics leading to potential long-term survival and development of new strategies for the treatment of recurrent tumors are also important issues...
  25. ncbi request reprint [Current status and perspective in surgical treatment of biliary cancer]
    Tomoki Ebata
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine
    Nihon Rinsho 64:451-7. 2006
  26. ncbi request reprint [Surgical treatment for hilar cholangiocarcinoma]
    Toshiyuki Arai
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine
    Nihon Rinsho 64:476-8. 2006
  27. ncbi request reprint Right hepatopancreatoduodenectomy: improvements over 23 years to attain acceptability
    Tomoki Ebata
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Hepatobiliary Pancreat Surg 14:131-5. 2007
    ..We retrospectively analyzed our progress over 23 years in making this operation safer...
  28. ncbi request reprint TNM classification for perihilar cholangiocarcinoma: comparison between 5th and 6th editions of the AJCC/UICC staging system
    Hideki Nishio
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Langenbecks Arch Surg 390:319-27. 2005
    ..The new sixth edition of the American Joint Committee on Cancer (AJCC)/Internal Union Against Cancer (UICC) staging system focuses on vascular invasion and regional lymph node metastasis...
  29. ncbi request reprint Hepatic killing but not clearance of systemically circulating bacteria is dependent upon peripheral leukocytes via Mac-1 (CD11b/CD18)
    Mathew L Brengman
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Shock 19:263-7. 2003
    ..The role of leukocytes in killing systemically circulating bacteria is an integral component of hepatic RES function. This capability of the leukocyte appears to be dependent, in part, on the adhesion molecule, Mac-1...
  30. ncbi request reprint [Percutaneous transhepatic cholangiography (PTC) for diagnosis of biliary tract neoplasms]
    Hideki Nishio
    Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine
    Nihon Rinsho 64:411-4. 2006
  31. ncbi request reprint Gene expression in enhanced apoptosis of human lymphoma U937 cells treated with the combination of different free radical generators and hyperthermia
    Shigehito Wada
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Toyama, Toyama, 930 0194, Japan
    Free Radic Res 41:73-81. 2007
    ..The present results will provide a basis for further understanding the molecular mechanisms in enhancement of heat-induced apoptosis by different intracellular oxidative stress...
  32. ncbi request reprint An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-gamma
    Keiji Aizu
    Division of Host Defense, Research Center of Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Eur J Immunol 36:3060-70. 2006
    ..These results suggest that Tyk2 signaling is also important for DC function in the induction of MHC class Ia- and class Ib-restricted CD8+ Tc1 cells following L. monocytogenes infection...
  33. ncbi request reprint Enhancement of radiation-induced apoptosis by 6-formylpterin
    Zheng Guo Cui
    Department of Radiological Sciences, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Free Radic Res 38:363-73. 2004
    ..These results indicate that intracellular H2O2 generated by 6-FP enhances radiation-induced apoptosis via the mitochondria-mediated caspase-dependent pathway, with the active involvement of PKC delta...
  34. ncbi request reprint LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cells
    Hiroko Yamada
    Department of Hematology and Oncology, Kyoto University Hospital, Kyoto 606 8507, Japan
    Life Sci 78:926-33. 2006
    ....
  35. ncbi request reprint Effects of intracellular reactive oxygen species generated by 6-formylpterin on T cell functions
    Toshiyuki Arai
    Department of Anesthesia, Kyoto University Hospital, Kyoto 606 8507, Japan
    Biochem Pharmacol 67:1185-93. 2004
    ....
  36. ncbi request reprint Protective effects of intracellular reactive oxygen species generated by 6-formylpterin on tumor necrosis factor-alpha-induced apoptotic cell injury in cultured rat hepatocytes
    Hisanari Ishii
    Department of Anesthesia, Kyoto University Hospital, Kyoto 606 8507, Japan
    Life Sci 77:858-68. 2005
    ..Therefore, our findings suggest that intracellular ROS generated by 6-formylpterin decline the intracellular redox state to an oxidant state, which suppresses the caspase activity and prevents the apoptotic cell injury of hepatocytes...