Mineyoshi Aoyama

Summary

Affiliation: Nagoya City University
Country: Japan

Publications

  1. ncbi request reprint Human neuroblastomas with unfavorable biologies express high levels of brain-derived neurotrophic factor mRNA and a variety of its variants
    M Aoyama
    Department of Pediatrics, Nagoya City University Medical School, Mizuho ku, 467 8601, Nagoya, Japan
    Cancer Lett 164:51-60. 2001
  2. ncbi request reprint Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells
    Mineyoshi Aoyama
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Int J Oncol 37:1011-6. 2010
  3. doi request reprint Region-specific expression of a water channel protein, aquaporin 4, on brain astrocytes
    M Aoyama
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Neurosci Res 90:2272-80. 2012
  4. ncbi request reprint Expression of glia maturation factor beta after cryogenic brain injury
    Naokazu Hotta
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Brain Res Mol Brain Res 133:71-7. 2005
  5. ncbi request reprint Expression of myelencephalon-specific protease after cryogenic lesioning of the rat parietal cortex
    Yuichi Oka
    Department of Neurosurgery and Restorative Neuroscience, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Muzuho ku, Nagoya 467 8601, Japan
    J Neurotrauma 22:501-10. 2005
  6. ncbi request reprint ERas enhances resistance to CPT-11 in gastric cancer
    Eiji Kubota
    Department of Gastroenterology and Metabolism, Nagoya City University, Graduate School of Medical Sciences 1 Kawasumi, Mizuho, Nagoya 467 8601, Japan
    Anticancer Res 31:3353-60. 2011
  7. doi request reprint Subventricular zone-derived oligodendrogenesis in injured neonatal white matter in mice enhanced by a nonerythropoietic erythropoietin derivative
    Eisuke Kako
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Stem Cells 30:2234-47. 2012
  8. doi request reprint Diclofenac enhances proinflammatory cytokine-induced phagocytosis of cultured microglia via nitric oxide production
    Hiroki Kakita
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Toxicol Appl Pharmacol 268:99-105. 2013
  9. ncbi request reprint Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury
    Shin Kato
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    J Neurosci Res 89:1566-74. 2011
  10. pmc The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes
    Kenji Ikuta
    Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, MuzuhoMizuho ku, Nagoya, 467 8601, Japan
    Arthritis Res Ther 14:R87. 2012

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Human neuroblastomas with unfavorable biologies express high levels of brain-derived neurotrophic factor mRNA and a variety of its variants
    M Aoyama
    Department of Pediatrics, Nagoya City University Medical School, Mizuho ku, 467 8601, Nagoya, Japan
    Cancer Lett 164:51-60. 2001
    ..These results suggest that an autocrine and/or paracrine mechanism involving BDNF may stimulate signal transduction via TRKB receptors rich in neuroblastomas with unfavorable biologies, resulting in an aberrant survival of tumor cells...
  2. ncbi request reprint Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells
    Mineyoshi Aoyama
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Int J Oncol 37:1011-6. 2010
    ..These results show that the ERas/PI3K pathway may provide resistance to chemotherapy and promote transforming activity in neuroblastoma...
  3. doi request reprint Region-specific expression of a water channel protein, aquaporin 4, on brain astrocytes
    M Aoyama
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Neurosci Res 90:2272-80. 2012
    ..Further examination of the heterogeneous astrocyte populations within each region will lend additional support to the regional specificity of neuronal functions and neuronal-glial interactions...
  4. ncbi request reprint Expression of glia maturation factor beta after cryogenic brain injury
    Naokazu Hotta
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Brain Res Mol Brain Res 133:71-7. 2005
    ..These findings may provide new insight into GMFB function in pathological conditions following brain injury...
  5. ncbi request reprint Expression of myelencephalon-specific protease after cryogenic lesioning of the rat parietal cortex
    Yuichi Oka
    Department of Neurosurgery and Restorative Neuroscience, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Muzuho ku, Nagoya 467 8601, Japan
    J Neurotrauma 22:501-10. 2005
    ..The regulation of active MSP may be important in the physiological or pathological changes involved in remyelination or demyelination...
  6. ncbi request reprint ERas enhances resistance to CPT-11 in gastric cancer
    Eiji Kubota
    Department of Gastroenterology and Metabolism, Nagoya City University, Graduate School of Medical Sciences 1 Kawasumi, Mizuho, Nagoya 467 8601, Japan
    Anticancer Res 31:3353-60. 2011
    ..We have reported that embryonic stem cell-expressed Ras (ERas) is expressed in human gastric cancer and is associated with its tumorigenicity. Here, we asked whether ERas plays a role in resistance to chemotherapy in gastric cancer...
  7. doi request reprint Subventricular zone-derived oligodendrogenesis in injured neonatal white matter in mice enhanced by a nonerythropoietic erythropoietin derivative
    Eisuke Kako
    Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan
    Stem Cells 30:2234-47. 2012
    ..These results demonstrate the limitation and potential of endogenous OPCs in the pSVZ as a therapeutic target for treating neonatal white-matter injury...
  8. doi request reprint Diclofenac enhances proinflammatory cytokine-induced phagocytosis of cultured microglia via nitric oxide production
    Hiroki Kakita
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Toxicol Appl Pharmacol 268:99-105. 2013
    ..These findings, together with previous observations regarding astrocytes, may explain the significant increase in mortality of IAE patients treated with DCF...
  9. ncbi request reprint Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury
    Shin Kato
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    J Neurosci Res 89:1566-74. 2011
    ..Our present finding of an interaction between astrocytes and OPCs may lead to a new therapeutic approach to OPCs for use against cellular stress and injury...
  10. pmc The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes
    Kenji Ikuta
    Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, MuzuhoMizuho ku, Nagoya, 467 8601, Japan
    Arthritis Res Ther 14:R87. 2012
    ..Here we examined whether Sp1 is necessary for GLS production in RA. We also studied the effects of the Sp1 inhibitor mithramycin on GLS production in RA fibroblast-like synoviocytes (FLSs)...
  11. ncbi request reprint Gliostatin/thymidine phosphorylase-regulated vascular endothelial growth-factor production in human fibroblast-like synoviocytes
    Tomohiro Tanikawa
    Department of Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho chou, Mizuho ku, Nagoya, 467 8601, Japan
    Rheumatol Int 27:553-9. 2007
    ..These findings indicate that GLS/TP and VEGF have synergistic effects on angiogenesis in rheumatoid synovitis, and that GLS/TP has a role in regulating VEGF...
  12. doi request reprint FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytes
    Takaya Yamagami
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, 467 8601, Japan
    Rheumatol Int 31:903-9. 2011
    ..GLS levels in TNF-α-stimulated FLSs were reduced by FK506 treatment. Our data show a novel mechanism for the action of physiological concentrations of FK506 in RA that regulates the production of GLS in FLSs...
  13. doi request reprint Tumor necrosis factor stimulates osteoclastogenesis from human bone marrow cells under hypoxic conditions
    Takayuki Nomura
    Department of Orthodontics, School of Dentistry, Aichi Gakuin University, Chikusa ku, Nagoya 464 8651, Japan Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya 467 8601, Japan
    Exp Cell Res 321:167-77. 2014
    ..The TNFR1 antibody was observed to significantly suppress OC formation. These results suggest that hypoxic exposure plays an important role in TNF-induced osteoclastogenesis from human BMCs. ..
  14. doi request reprint Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes
    Tetsuro Morishima
    Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    Neurosci Res 61:18-26. 2008
    ..The increase in AQP4 expression level on the cell membrane of astrocytes induced by lactic acid may be a new regulation mechanism of AQP4 in the brain...
  15. doi request reprint Diclofenac enhances proinflammatory cytokine-induced aquaporin-4 expression in cultured astrocyte
    Hayato Asai
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
    Cell Mol Neurobiol 33:393-400. 2013
    ..This effect is mediated via NF-κB signaling. The enhancement of AQP4 production by DCF may explain the significantly increased mortality rates in IAE patients treated with DCF...
  16. doi request reprint TNF-alpha-induced aquaporin 9 in synoviocytes from patients with OA and RA
    Masashizu Nagahara
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Rheumatology (Oxford) 49:898-906. 2010
    ..To determine whether aquaporins (AQPs) are expressed in the synovial tissues of patients with OA and RA, and to examine the patterns of expression in patients with and without hydrarthrosis...
  17. doi request reprint Diclofenac enhances proinflammatory cytokine-induced nitric oxide production through NF-kappaB signaling in cultured astrocytes
    Hiroki Kakita
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Toxicol Appl Pharmacol 238:56-63. 2009
    ..The enhancement of DCF on NO production may explain the significant increase in the mortality rate of influenza-associated encephalopathy in patients treated with DCF...
  18. pmc Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancer
    Eiji Kubota
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Am J Pathol 177:955-63. 2010
    ..These data suggest that ERas is activated in a significant population of gastric cancer, where it may play a crucial role in gastric cancer cell survival and metastases to liver via down-regulation of E-cadherin...
  19. ncbi request reprint Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes
    Kentaro Ohara
    Department of Molecular Neurobiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Neurosci Lett 462:109-12. 2009
    ..These results indicate that the deregulation of glutamate release from astrocytes may contribute to the dysfunction of glutamatergic neurons in patients with acute liver failure (ALF)...
  20. ncbi request reprint Expression of myelencephalon-specific protease in transient middle cerebral artery occlusion model of rat brain
    Atsushi Uchida
    Department of Neurosurgery and Restorative Neuroscience, Nagoya City University Graduate School of Medical Sciences, Mizuho, Nagoya 467 8601, Japan
    Brain Res Mol Brain Res 126:129-36. 2004
    ..The activation of MSP may play a role in remodeling processes such as neurite outgrowth and remyelination...
  21. ncbi request reprint ACTH(1-24) down-regulates expression of ciliary neurotrophic factor mRNA in cultured rat astrocyte
    Minoru Kokubo
    Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Pediatr Res 52:950-7. 2002
    ..These results suggest that ACTH(1-24) administrated in West syndrome may influence the expression of neurotrophic factors in astrocytes in vivo...
  22. ncbi request reprint Sensitive immunoassays for human and rat GMFB and GMFG, tissue distribution and age-related changes
    Masaaki Inagaki
    Department of Molecular Neurobiology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho, Nagoya 467 8601, Japan
    Biochim Biophys Acta 1670:208-16. 2004
    ..No significant sex differences in the serum levels of GMFs were observed in human and rat. The present EIA systems are sufficiently sensitive for studying GMFs in human and rat organs...
  23. ncbi request reprint The inhibitory effect of disease-modifying anti-rheumatic drugs and steroids on gliostatin/platelet-derived endothelial cell growth factor production in human fibroblast-like synoviocytes
    Takuma Kusabe
    Department of Musculoskeletal Medicine, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, 467 8601, Japan
    Rheumatol Int 25:625-30. 2005
    ..These findings indicate that AuTG and DEX have anti-rheumatic activity, which is mediated via the suppression of GLS production. Neither methotrexate (MTX) nor sulfasalazine (SSZ) had a significant influence on GLS levels in our study...
  24. ncbi request reprint Severity of virilization of external genitalia in Japanese patients with salt-wasting 21-hydroxylase deficiency
    Yukari Sugiyama
    Department of Pediatrics, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan
    Tohoku J Exp Med 215:341-8. 2008
    ..The degree of the impairment of 21-hydroxylase activity does not correlate with the severity of virilization of the external genitalia in female patients with the SW type of 21OHD...
  25. ncbi request reprint Prognostic impact of microRNA-145 down-regulation in adult T-cell leukemia/lymphoma
    Hongjing Xia
    Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Hum Pathol 45:1192-8. 2014
    ..Hence, miR-145 may be a useful prognostic marker and a potential therapeutic target for ATL. ..