Akihiro Abe

Summary

Affiliation: Nagoya University
Country: Japan

Publications

  1. pmc Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy
    Akihiro Abe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 88:471-5. 2008
  2. ncbi request reprint Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector
    Akihiro Abe
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 320:920-6. 2004
  3. ncbi request reprint Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication
    Akihiro Abe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 84:328-36. 2006
  4. doi request reprint BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4
    Momoko Suzuki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Eur J Haematol 84:229-38. 2010
  5. doi request reprint CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737
    Kazuyuki Shimada
    Institute for Advanced Research, Nagoya University, Nagoya, Japan
    Exp Hematol 40:724-737.e2. 2012
  6. ncbi request reprint LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22)
    Shizuka Imagama
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 79:25-31. 2007
  7. pmc Injectable bone tissue engineering using expanded mesenchymal stem cells
    Yoichi Yamada
    Center for Genetic and Regenerative Medicine, Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Stem Cells 31:572-80. 2013
  8. doi request reprint Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment
    Yosuke Minami
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Hematol 92:664-6. 2010
  9. ncbi request reprint Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD/SCID/IL-2Rgammac-/- mice
    Ryohei Tanizaki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 101:631-8. 2010
  10. pmc Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice
    Kiyoko Yamamoto
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 8:e74864. 2013

Collaborators

Detail Information

Publications24

  1. pmc Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy
    Akihiro Abe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 88:471-5. 2008
    ..Our results implicate that the sorted and purified stem cells are useful for more sensitive quantification of BCR-ABL-positive minimal residual disease...
  2. ncbi request reprint Expression cloning of oligomerization-activated genes with cell-proliferating potency by pseudotype retrovirus vector
    Akihiro Abe
    Department of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 320:920-6. 2004
    ..These fusions may be a useful model for clarifying the downstream signal transduction of constitutive active kinase and this expression cloning method may provide a new tool with which to study cell proliferation signalling...
  3. ncbi request reprint Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication
    Akihiro Abe
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 84:328-36. 2006
    ..FLT3 kinase inhibitor AG1296 specifically inhibited cell growth. NAMO-2 provides a useful tool to analyze adherence-dependent survival signaling of leukemia with FLT3/ITD and a model for the screening of FLT3 kinase inhibitors...
  4. doi request reprint BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4
    Momoko Suzuki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Eur J Haematol 84:229-38. 2010
    ..We investigated the mechanism responsible for imatinib (IM) resistance in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(+) ALL) cell lines...
  5. doi request reprint CML cells expressing the TEL/MDS1/EVI1 fusion are resistant to imatinib-induced apoptosis through inhibition of BAD, but are resensitized with ABT-737
    Kazuyuki Shimada
    Institute for Advanced Research, Nagoya University, Nagoya, Japan
    Exp Hematol 40:724-737.e2. 2012
    ..These findings indicate a novel pathway of TKI resistance regulated by EVI1 proteins and provide a promising means for overcoming resistance in chronic myeloid leukemia and other hematological malignancies displaying EVI1 overexpression...
  6. ncbi request reprint LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22)
    Shizuka Imagama
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 79:25-31. 2007
    ..We describe here a previously unreported rearrangement, t(11;21)(q13;q22), that disrupts the RUNX1 gene in a patient with acute leukemia and the molecular analysis of the fusion gene...
  7. pmc Injectable bone tissue engineering using expanded mesenchymal stem cells
    Yoichi Yamada
    Center for Genetic and Regenerative Medicine, Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Stem Cells 31:572-80. 2013
    ..No significant bone resorption occurred during long-term follow-up. Injectable TEB restored masticatory function in patients. This novel clinical approach represents an effective therapeutic utilization of bone tissue engineering...
  8. doi request reprint Expanded distribution of the T315I mutation among hematopoietic stem cells and progenitors in a chronic myeloid leukemia patient during imatinib treatment
    Yosuke Minami
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Int J Hematol 92:664-6. 2010
    ..These results suggest that the monitoring of gene mutations in HSC and progenitors at diagnosis might be helpful for the early detection of TKI-resistant CML patients and facilitate appropriate therapeutic decision...
  9. ncbi request reprint Irrespective of CD34 expression, lineage-committed cell fraction reconstitutes and re-establishes transformed Philadelphia chromosome-positive leukemia in NOD/SCID/IL-2Rgammac-/- mice
    Ryohei Tanizaki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Sci 101:631-8. 2010
    ..These findings suggest that leukemia-repopulating cells in transformed Ph(+) leukemia are included in a lineage-committed but multilayered fraction, and that CD34(+) leukemia cells potentially emerge from CD34(-) populations...
  10. pmc Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice
    Kiyoko Yamamoto
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 8:e74864. 2013
    ..AML1s induced the emergence of blast-like cells. The overall findings suggest the roles of altered functions of AML1 imposed by some, but not all, mutants, and the elevated expression of wt.AML1 for the disease progression of CML. ..
  11. doi request reprint A novel RUNX1-C11orf41 fusion gene in a case of acute myeloid leukemia with a t(11;21)(p14;q22)
    Akihiro Abe
    Department of Hematology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Cancer Genet 205:608-11. 2012
    ..This suggested that the RUNX1 breakpoint was in intron 6 and had generated alternative fusion splice variants. A reciprocal C11orf41-RUNX1 fusion was not detected. Thus, we identified C11orf41 as a novel fusion partner of RUNX1 in AML...
  12. doi request reprint Prognostic implication and biological roles of RhoH in acute myeloid leukaemia
    Toshihiro Iwasaki
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur J Haematol 81:454-60. 2008
    ..e. high GTP-Rac) contributes to chemotherapy resistance in leukaemia cells. Our result suggests that inhibition of Rac and its signalling components might provide a useful anti-leukaemic strategy...
  13. ncbi request reprint Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cells
    Kengo Maeda
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Biochem Biophys Res Commun 323:345-54. 2004
    ..These findings demonstrated that coupling of Gab1 to PI3K is important for biological responses in RET-expressing cells...
  14. ncbi request reprint Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene
    Manabu Ninomiya
    Department of Hematology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cancer Genet Cytogenet 169:1-11. 2006
    ..These results suggest that TRL-01 is a useful cell line for studying not only the leukemia-related biology of MLL-ENL but also the intercellular association between leukemia and stroma...
  15. pmc Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome
    Jinglan Xu
    Department of Haematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 140:394-401. 2008
    ..These findings suggest that in situ detection of nuclear NPBC by immunohistochemistry could provide new insights into the pathogenesis and prognosis of AML and MDS...
  16. doi request reprint Escape of leukemia blasts from HLA-specific CTL pressure in a recipient of HLA one locus-mismatched bone marrow transplantation
    Tomonori Kato
    Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Cell Immunol 276:75-82. 2012
    ..These data suggest that immune escape of leukemia blasts from CTL pressure toward a certain HLA molecule can lead to clinical relapse after bone marrow transplantation...
  17. pmc Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis
    Fumihiko Hayakawa
    Department of Hematology and Oncology, Nagoya University, Graduate School of Medicine, Nagoya 466 8550, Japan
    J Biol Chem 283:24420-5. 2008
    ..Our work provides new insights into PML regulation by post-translational modification and new information about the therapeutic mechanism of HDAC inhibitors...
  18. doi request reprint N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin
    Eiko Yamamoto
    Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Endocrinology 150:990-9. 2009
    ..These results suggest that GnT-V is expressed in human EVT and is involved in regulating trophoblast invasion through modifications of the oligosaccharide chains of alpha5beta1 integrin...
  19. ncbi request reprint Clarifying the impact of polycomb complex component disruption in human cancers
    Yukiya Yamamoto
    Department of Hematology, Fujita Health University, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Mol Cancer Res 12:479-84. 2014
    ..Mol Cancer Res; 12(4); 479-84. ©2014 AACR. ..
  20. doi request reprint Isolation of human mAbs that directly modulate FMS-related tyrosine kinase 3 signaling
    Yukiya Yamamoto
    Department of Hematology, School of Medicine, Fujita Health University, Aichi, Japan
    Cancer Sci 103:350-9. 2012
    ..In addition, 3E6 might be a potential scaffold for novel dendritic cell-based immunotherapies...
  21. ncbi request reprint Self-assembling peptide nanofiber scaffolds, platelet-rich plasma, and mesenchymal stem cells for injectable bone regeneration with tissue engineering
    Ryoko Yoshimi
    Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Japan
    J Craniofac Surg 20:1523-30. 2009
    ..Taken together, it is suggested that PM might be useful as a scaffold of bone regeneration in cell therapy, and these results might lead to an effective treatment method for bone defects...
  22. ncbi request reprint DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand
    Eiki Kanbe
    First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, Japan
    Exp Hematol 31:300-8. 2003
    ..The nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) ligands may enhance the etoposide-induced apoptosis by modulating the topoisomerase (Topo) IIalpha expression through binding to direct repeat 1 (DR1)-like element...
  23. pmc Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells
    Thomas Wossning
    Institute of Biology III, Albert Ludwigs University of Freiburg, 79104 Freiburg, and Department of Pediatric Hematology and Oncology, Children s Hospital, Munich, Germany
    J Exp Med 203:2829-40. 2006
    ..Collectively, our data suggest that Syk is a protooncogene involved in the transformation of lymphocytes, thus making Syk a potential target for the treatment of leukemia...
  24. ncbi request reprint Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation
    Kouichi Watamoto
    Department of Molecular Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466 8550, Japan
    Oncogene 22:9176-84. 2003
    ..These observations support the suggestion that control of the HDAC5 nucleocytoplasmic distribution might be associated with MEL cell differentiation, possibly through regulated GATA-1 transactivation...