Hiroshi Ueda

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. ncbi Lysophosphatidic acid: Chemical signature of neuropathic pain
    Hiroshi Ueda
    Department of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan Electronic address
    Biochim Biophys Acta 1831:61-73. 2013
  2. ncbi Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain
    Yasutaka Kakiuchi
    Department of Biology, Faculty of Science, Ochanomizu University, 2 1 1 Ohtsuka, Bunkyo ku, Tokyo 112 8610, Japan
    Mol Pain 7:33. 2011
  3. ncbi Prothymosin alpha plays a key role in cell death mode-switch, a new concept for neuroprotective mechanisms in stroke
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki, 852 8521, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:315-23. 2008
  4. ncbi Prothymosin alpha as robustness molecule against ischemic stress to brain and retina
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Ann N Y Acad Sci 1194:20-6. 2010
  5. ncbi Prothymosin alpha and cell death mode switch, a novel target for the prevention of cerebral ischemia-induced damage
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Pharmacol Ther 123:323-33. 2009
  6. ncbi Lysophosphatidic acid as the initiator of neuropathic pain
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, Nagasaki University, Japan
    Biol Pharm Bull 34:1154-8. 2011
  7. ncbi [Novel sensory fiber-specific nociception test with the Neurometer]
    Hiroshi Ueda
    Nippon Yakurigaku Zasshi 131:367-71. 2008
  8. ncbi Identification of prothymosin-alpha1, the necrosis-apoptosis switch molecule in cortical neuronal cultures
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8521, Japan
    J Cell Biol 176:853-62. 2007
  9. ncbi Peripheral mechanisms of neuropathic pain - involvement of lysophosphatidic acid receptor-mediated demyelination
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 4:11. 2008
  10. ncbi Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain
    Lin Ma
    Nagasaki University Graduate School of Biomedical Sciences, Japan
    Mol Pain 5:64. 2009

Collaborators

Detail Information

Publications92

  1. ncbi Lysophosphatidic acid: Chemical signature of neuropathic pain
    Hiroshi Ueda
    Department of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan Electronic address
    Biochim Biophys Acta 1831:61-73. 2013
    ..Given these bodies of research evidence, LPA therefore presents as the chemical signature for the initiation of neuropathic pain. This article is part of a Special Issue entitled Advances in Lysophospholipid Research...
  2. ncbi Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain
    Yasutaka Kakiuchi
    Department of Biology, Faculty of Science, Ochanomizu University, 2 1 1 Ohtsuka, Bunkyo ku, Tokyo 112 8610, Japan
    Mol Pain 7:33. 2011
    ..We characterized the effects of cPA and 2-carba-cPA (2ccPA), a chemically stable cPA analog, on acute and chronic pain...
  3. ncbi Prothymosin alpha plays a key role in cell death mode-switch, a new concept for neuroprotective mechanisms in stroke
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki, 852 8521, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:315-23. 2008
    ..As ProTalpha almost entirely prevents the focal ischemia-induced motor dysfunction 4 h after the start of ischemia, this protein seems to have a promising potentiality for clinical use...
  4. ncbi Prothymosin alpha as robustness molecule against ischemic stress to brain and retina
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Ann N Y Acad Sci 1194:20-6. 2010
    ..From the experiment using anti-ProTalpha IgG or antisense oligonucleotide for ProTalpha, it was revealed that ProTalpha has a pathophysiological role in protecting neurons in stroke...
  5. ncbi Prothymosin alpha and cell death mode switch, a novel target for the prevention of cerebral ischemia-induced damage
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Pharmacol Ther 123:323-33. 2009
    ..Analyses in terms of the therapeutic time window and potency suggest that ProTalpha could be the prototypic compound to develop the medicine useful for treatment of stroke in clinics...
  6. ncbi Lysophosphatidic acid as the initiator of neuropathic pain
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, Nagasaki University, Japan
    Biol Pharm Bull 34:1154-8. 2011
    ..Thus, both the LPA(1) and LPA(3) receptors play key roles in the initiation step using a feed-forward system for neuropathic pain...
  7. ncbi [Novel sensory fiber-specific nociception test with the Neurometer]
    Hiroshi Ueda
    Nippon Yakurigaku Zasshi 131:367-71. 2008
  8. ncbi Identification of prothymosin-alpha1, the necrosis-apoptosis switch molecule in cortical neuronal cultures
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8521, Japan
    J Cell Biol 176:853-62. 2007
    ..Collectively, these results suggest that ProTalpha is an extracellular signal protein that acts as a cell death mode switch and could be a promising candidate for preventing brain strokes with the help of known apoptosis inhibitors...
  9. ncbi Peripheral mechanisms of neuropathic pain - involvement of lysophosphatidic acid receptor-mediated demyelination
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 4:11. 2008
    ..These results lead to further hypotheses of physical communication between innocuous Abeta- and noxious C- or Adelta-fibers to influence the molecular mechanisms of allodynia...
  10. ncbi Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain
    Lin Ma
    Nagasaki University Graduate School of Biomedical Sciences, Japan
    Mol Pain 5:64. 2009
    ..We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX)...
  11. ncbi Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Neurochem 107:1556-65. 2008
    ..These findings suggest that simultaneous intense stimulation of neurokinin 1 and NMDA receptors in the spinal dorsal horn triggers lysophosphatidic acid production from lysophosphatidylcholine through extracellular autotaxin...
  12. ncbi Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain
    Lin Ma
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Pharmacol Exp Ther 333:540-6. 2010
    ..These findings provide evidence that PLA2- and ATX-mediated de novo LPA production in the early phase is involved in nerve injury-induced neuropathic pain...
  13. ncbi Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine
    Jun Nagai
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 6:78. 2010
    ..Previously, we found that lysophosphatidic acid receptor (LPA1) signaling initiates sciatic nerve injury-induced neuropathic pain and demyelination...
  14. ncbi Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    Mol Pain 2:16. 2006
    ..These results also suggest that the EPF analysis is useful for the evaluation of plasticity in sensory functions in animal disease models...
  15. ncbi Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Neurochem 112:521-30. 2010
    ..Together these data suggest that activation of PTH2 receptors stimulates nociceptive A-fiber through G(s)-cAMP-dependent protein kinase signaling, and this pathway has elevated sensitization following nerve injury...
  16. ncbi Inhibition of paclitaxel-induced A-fiber hypersensitization by gabapentin
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    J Pharmacol Exp Ther 318:735-40. 2006
    ....
  17. ncbi Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 2:25. 2006
    ..All these results suggest that the loss of pain transmission through polymodal C-fiber neurons is also mediated by the LPA1 activation following nerve injury...
  18. ncbi Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain
    Weijiao Xie
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Neurochem 113:1002-11. 2010
    ..The present study provides strong evidence that LPA-induced calpain activation plays a crucial role in the manifestation of neuropathic pain through MAG down-regulation in the DR...
  19. ncbi Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid: ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia
    Hitoshi Uchida
    Nagasaki University Graduate School of Biomedical Sciences, Bunkyo Machi, Japan
    Neurochem Int 54:215-21. 2009
    ..These results suggest that ephrinB1 plays a crucial role in LPA-induced neuropathic pain. In addition, the present study may provide a new strategy to identify unique neuropathic pain-related genes...
  20. ncbi Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury
    Weijiao Xie
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    Mol Pain 4:46. 2008
    ..These results suggest that LPA(1) receptor-mediated signaling mechanisms also participate in functional cross-talk between Abeta- and C- or Adelta-fibers...
  21. ncbi The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Brain Res Bull 60:275-81. 2003
    ..Altogether, these findings indicate that the ANF test is a highly sensitive and less stressful technique to study in vivo mechanisms of pain at the peripheral nerve ending...
  22. ncbi Pharmacological switch in Abeta-fiber stimulation-induced spinal transmission in mice with partial sciatic nerve injury
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    Mol Pain 4:25. 2008
    ....
  23. ncbi Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 3:41. 2007
    ..However, the tonic cholinergic inhibition of pain remains to be well characterized...
  24. ncbi Microglial activation mediates de novo lysophosphatidic acid production in a model of neuropathic pain
    Lin Ma
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Bunkyo Machi, Nagasaki, Japan
    J Neurochem 115:643-53. 2010
    ..These findings suggest that the early phase of microglial activation is involved in de novo LPA production, and that this underlies the initial mechanisms of nerve injury-induced neuropathic pain...
  25. ncbi Curcumin blocks chronic morphine analgesic tolerance and brain-derived neurotrophic factor upregulation
    Yosuke Matsushita
    aDivision of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Neuroreport 20:63-8. 2009
    ..These results suggest that curcumin might be a promising adjuvant to reduce morphine analgesic tolerance, and that epigenetic control could be a new strategy useful for the control of this problem...
  26. ncbi Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain
    Hitoshi Uchida
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    J Neurosci 30:4806-14. 2010
    ..8-selective blocker-induced hypoesthesia. Together, these data suggest that NRSF causes pathological and pharmacological dysfunction of C-fibers, which underlies the negative symptoms in neuropathic pain...
  27. ncbi LPA-mediated demyelination in ex vivo culture of dorsal root
    Ryousuke Fujita
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Neurochem Int 50:351-5. 2007
    ..All these findings suggest that the demyelination observed in the neuropathic pain due to nerve injury occurs through a direct action of LPA on Schwann cells...
  28. ncbi Loss of peripheral morphine analgesia contributes to the reduced effectiveness of systemic morphine in neuropathic pain
    Md Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    J Pharmacol Exp Ther 309:380-7. 2004
    ....
  29. ncbi Neuron-specific non-classical release of prothymosin alpha: a novel neuroprotective damage-associated molecular patterns
    Sebok Kumar Halder
    Department of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Neurochem 123:262-75. 2012
    ..Taken together, these results suggest that only neurons have machineries to release ProTĪ± upon cerebral ischemic stress in vivo...
  30. ncbi Neuronal necrosis inhibition by insulin through protein kinase C activation
    Wakako Hamabe
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Pharmacol Exp Ther 307:205-12. 2003
    ..All of these findings suggest that insulin inhibited the neuronal necrosis resistant to known neurotrophic factors under the serum-free culture through PKC mechanisms...
  31. ncbi In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 305:495-501. 2003
    ..All these findings suggest that the N/OFQ-ergic neuron may play an in vivo inhibitory role on the second-order neurons for primary polymodal substance P-ergic fibers in the spinal cord...
  32. ncbi Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice
    M Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Pharmacol Exp Ther 306:709-17. 2003
    ..Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain...
  33. ncbi Novel type of Gq/11 protein-coupled neurosteroid receptor sensitive to endocrine disrupting chemicals in mast cell line (RBL-2H3)
    Kaori Mizota
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Br J Pharmacol 145:545-50. 2005
    ..6 Taken together, these results suggest that a G(q/11)-coupled neurosteroid receptor may regulate the neuroimmunological activity related to sensory stimulation and that some EDCs have antagonistic actions for this receptor...
  34. ncbi Mechanisms underlying morphine analgesic tolerance and dependence
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Front Biosci 14:5260-72. 2009
    ..This review also introduces a new approach using in vivo electroporation to identify the brain loci responsible for morphine tolerance and dependence...
  35. ncbi Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist
    Lin Ma
    Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Neurochem 109:603-10. 2009
    ..All of these results using Ki-16425 suggest that lysophosphatidic acid 1 receptor-mediated signaling which underlies the development of neuropathic pain works at an early stage of the critical period after nerve injury...
  36. ncbi The cognition-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo
    Mutsumi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 309:200-7. 2004
    ..All these findings suggest that nefiracetam inhibit necrosis and apoptosis occurred in the ischemic/hypoxic neuronal injury through an increase in Ca(2+) influx...
  37. ncbi Permanent relief from intermittent cold stress-induced fibromyalgia-like abnormal pain by repeated intrathecal administration of antidepressants
    Michiko Nishiyori
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 7:69. 2011
    ..Numerous clinical studies have demonstrated that antidepressants are effective in treating FM pain. We previously established a mouse model of FM-like pain, induced by intermittent cold stress (ICS)...
  38. ncbi Switching of bradykinin-mediated nociception following partial sciatic nerve injury in mice
    Md Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Pharmacol Exp Ther 308:1158-64. 2004
    ..Altogether, these findings confirm a switching of receptor and fiber subtype for BK nociception after peripheral nerve injury, which might contribute to the pathobiology of neuropathic pain...
  39. ncbi Endocrine disrupting chemicals bind to a novel receptor, microtubule-associated protein 2, and positively and negatively regulate dendritic outgrowth in hippocampal neurons
    Hayato Matsunaga
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Neurochem 114:1333-43. 2010
    ....
  40. ncbi Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University, Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki, 852 8521, Japan
    Nat Med 10:712-8. 2004
    ..Inhibitors of Rho and Rho kinase also prevented these signs of neuropathic pain. These results imply that receptor-mediated LPA signaling is crucial in the initiation of neuropathic pain...
  41. ncbi Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain
    Md Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Pharmacol Exp Ther 304:940-8. 2003
    ..Together, our results suggest that novel expression of capsaicin receptors in neuropathic condition contributes to the analgesic effects of the capsaicin cream...
  42. ncbi Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8521, Japan
    J Pharmacol Exp Ther 306:141-6. 2003
    ..t. injection with MK-801. These results suggest that nocistatin and C-peptide derived from prepro-N/OFQ stimulate distinct nociceptive fibers through different in vivo signaling mechanisms...
  43. ncbi Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia
    Ryousuke Fujita
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Bunkyo Machi, Nagasaki, Japan
    J Neurochem 107:152-60. 2008
    ....
  44. ncbi Synergistic Ca2+ and Cu2+ requirements of the FGF1-S100A13 interaction measured by quartz crystal microbalance: an initial step in amlexanox-reversible non-classical release of FGF1
    Hayato Matsunaga
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Neurochem Int 52:1076-85. 2008
    ..All of these findings suggest that synergistic effects of Ca2+ and Cu2+ play a key role in the interaction between FGF1 and S100A13, which is the initial step in non-classical release of FGF1...
  45. ncbi Single application of A2 NTX, a botulinum toxin A2 subunit, prevents chronic pain over long periods in both diabetic and spinal cord injury-induced neuropathic pain models
    Lin Ma
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Sci 119:282-6. 2012
    ..A2 NTX seems to be a long-lasting treatment for diabetic and spinal cord injury-induced neuropathic pain...
  46. ncbi Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes
    Naoko Takayama
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Peptides 26:2513-7. 2005
    ..The present findings suggest that astrocytes could play roles in the neuronal plasticity during morphine chronic treatments by enhancing gene expression of anti-opioid peptide, N/OFQ...
  47. ncbi Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University, Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 4:6. 2008
    ..Therefore, targeted inhibition of ATX-mediated LPA biosynthesis as well as LPA1 receptor and its downstream pathways may represent a novel way to prevent nerve injury-induced neuropathic pain...
  48. ncbi [Anti-opioid action of glutamate-NMDA receptor systems underlying morphine analgesic tolerance]
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523
    Masui 58:1136-42. 2009
    ..We also introduce a new approach using in vivo electroporation to identify the brain loci responsible for morphine tolerance and dependence...
  49. ncbi [Pain and QOL--morphine-tolerance and morphine-resistant neuropathic pain]
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University, Graduate School of Biomedical Sciences, Japan
    Nihon Yakurigaku Zasshi 122:192-200. 2003
    ..Here I overview the proposed mechanisms for morphine tolerance and neuropathic pain in relation to the availability of analgesic adjuvants...
  50. ncbi NSAID zaltoprofen possesses novel anti-nociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Neurosci Lett 397:249-53. 2006
    ..All these results suggest that NSAID zaltoprofen possesses novel anti-nociceptive mechanism, which inhibits B2-type BK receptor function in nerve endings...
  51. ncbi New approaches to study the development of morphine tolerance and dependence
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, 852 8521, Nagasaki, Japan
    Life Sci 74:313-20. 2003
    ....
  52. ncbi Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia
    Michiko Nishiyori
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Neurosci Lett 472:184-7. 2010
    ..Collectively, these results indicate that the loss of descending serotonergic activation seems to be a key mechanism underlying the absence of morphine-induced analgesia...
  53. ncbi Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task
    Jun Nagai
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Pharmacol Exp Ther 321:195-201. 2007
    ..In addition, this apparatus has an advantage that various physical and psychological parameters of movement activity affecting learning and memory behavior are also evaluated at the same time...
  54. ncbi Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia
    Naoko Takayama
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8521, Japan
    J Neurosci 25:430-5. 2005
    ....
  55. ncbi Regional distribution and cell type-specific subcellular localization of Prothymosin alpha in brain
    Sebok Kumar Halder
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki, 852 8521, Japan
    Cell Mol Neurobiol 32:59-66. 2012
    ..The present study would contribute toward better understanding of physiological and pathophysiological roles of ProTĪ± in the brain...
  56. ncbi Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia
    Michiko Nishiyori
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Mol Pain 4:52. 2008
    ..These results suggest that the ICS model is useful for the study of generalized pain syndrome...
  57. ncbi Pre-emptive morphine treatment abolishes nerve injury-induced lysophospholipid synthesis in mass spectrometrical analysis
    Jun Nagai
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Neurochem 118:256-65. 2011
    ..These results suggest that LPC (or LPA) is produced by injury-induced nociceptive signal, which is effectively and pre-emptively suppressed by central morphine, possibly through known descending anti-nociceptive pathways...
  58. ncbi N-terminus of MAP2C as a neurosteroid-binding site
    Kaori Mizota
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Neuroreport 19:1529-33. 2008
    ..These findings suggest that neurosteroids specifically bind to the N-terminus of rhMAP2 and regulate tubulin assembly...
  59. ncbi Anti-opioid systems in morphine tolerance and addiction--locus-specific involvement of nociceptin and the NMDA receptor
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Novartis Found Symp 261:155-62; discussion 162-6, 191-3. 2004
    ..All these results suggest that the enhanced anti-opioid system may contribute to the development of morphine tolerance and dependence, and their contribution could be brain locus specific...
  60. ncbi Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Pharmacol Ther 109:57-77. 2006
    ..This discovery may lead to the subsequent discovery of LPA-induced secondary genes, which would be therapeutic targets for neuropathic pain...
  61. ncbi [Cancer pain model and morphine analgesia]
    Mutsumi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences
    Nippon Rinsho 65:2-4. 2007
  62. ncbi Insulin receptor-protein kinase C-gamma signaling mediates inhibition of hypoxia-induced necrosis of cortical neurons
    Wakako Hamabe
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Pharmacol Exp Ther 313:1027-34. 2005
    ..Together, these results suggest that insulin mediates inhibition of neuronal necrosis through a novel mechanism involving PKC-gamma activation...
  63. ncbi Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism
    Md Haronur Rashid
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Brain Res 953:53-62. 2002
    ..These results also suggest that the neuropathy-specific analgesic action of intrathecal nicotinic agonists was due to stimulation of this cholinergic-GABAergic system whose inhibitory tone had been reduced due to injury...
  64. ncbi Molecular mechanism of neuropathic pain
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. -u.ac.jp
    Drug News Perspect 16:605-13. 2003
    ..Understanding the molecular mechanisms of neuropathic pain would certainly provide a hope for the future development of effective therapies for this intractable painful disease...
  65. ncbi Evidence for serum-deprivation-induced co-release of FGF-1 and S100A13 from astrocytes
    Hayato Matsunaga
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Neurochem Int 49:294-303. 2006
    ....
  66. ncbi Neurosteroid-induced hyperalgesia through a histamine release is inhibited by progesterone and p,p'-DDE, an endocrine disrupting chemical
    Hitoshi Uchida
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Japan
    Neurochem Int 42:401-7. 2003
    ..These results suggest that DHEAS has significant hyperalgesic and vasodilatory actions through histamine release, and these actions were reversible by PROG and an EDC...
  67. ncbi Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism
    Takeshi Ono
    Department of Anesthesiology, Nagasaki University School of Medicine, Nagasaki, Japan
    Neurochem Int 41:399-407. 2002
    ..These results suggest that extremely low doses of morphine can stimulate sensory nerve endings through activation of peripheral MOP-R and its downstream mechanisms include activation of PLC through a SP release from polymodal C fibers...
  68. ncbi Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    J Neurosci 23:6529-36. 2003
    ..These findings suggest that GluRepsilon1 has locus-specific roles in the development of morphine analgesic tolerance and physical dependence...
  69. ncbi Endocrine disrupting chemical atrazine causes degranulation through Gq/11 protein-coupled neurosteroid receptor in mast cells
    Kaori Mizota
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Toxicol Sci 90:362-8. 2006
    ..All these findings strongly suggest that herbicide atrazine exerts inflammatory activity through activation of putative G(q/11)-coupled neurosteroid receptor and phospholipase C...
  70. ncbi Nonopioid and neuropathy-specific analgesic action of the nootropic drug nefiracetam in mice
    Md Harunor Rashid
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Pharmacol Exp Ther 303:226-31. 2002
    ..We also demonstrate that nefiracetam-induced analgesic action was nonopioid in nature and was due to stimulation of nicotinic cholinergic system at spinal and supraspinal levels...
  71. ncbi [Neuronal death mode switch and neurogenesis as in vivo neuroprotection]
    Hiroshi Ueda
    Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, Nagasaki 852 8521, Japan
    Nihon Yakurigaku Zasshi 119:79-88. 2002
    ..As lysophosphatidic acid has various activities to drive neurogenesis, the neurogenesis could also be managed by other drugs to compensate for functions lost by neuronal death...
  72. ncbi Cell death mode switch from necrosis to apoptosis in brain
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Biol Pharm Bull 27:950-5. 2004
    ..The authors attempt to overview the current understanding of the molecular mechanisms of necrosis and apoptosis in relation to the ATP hypothesis, and also introduce novel mechanisms for an in vitro cell death mode switch...
  73. ncbi Voltage-dependent N-type Ca2+ channel activity regulates the interaction between FGF-1 and S100A13 for stress-induced non-vesicular release
    Hayato Matsunaga
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Cell Mol Neurobiol 26:237-46. 2006
    ..4. Thus, it is suggested that the interaction between FGF-1 and S100A13 responsible for stress-induced non-vesicular release is dependent of Ca(2+)-influx through N-type Ca(2+)-channels...
  74. ncbi Locus-specific involvement of anti-opioid systems in morphine tolerance and dependence
    Hiroshi Ueda
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    Ann N Y Acad Sci 1025:376-82. 2004
    ..All these results suggest that enhanced anti-opioid systems may contribute to the development of morphine tolerance and dependence, and their contributions could be brain locus specific...
  75. ncbi [Lysophosphatidic acid as initiator of neuropathic pain]
    Hiroshi Ueda
    Nippon Yakurigaku Zasshi 127:161-5. 2006
  76. ncbi Desensitization of the inhibitory effect of norepinephrine on insulin secretion from pancreatic islets of exercise-trained rats
    Yuriko Urano
    Department of Kinesiology, Graduate School of Sciene, Tokyo Metropolitan University, Tokyo 192-0397, Japan
    Metabolism 53:1424-32. 2004
    ....
  77. ncbi Downregulation of P2X3 receptor-dependent sensory functions in A/J inbred mouse strain
    Makoto Tsuda
    Section of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
    Eur J Neurosci 15:1444-50. 2002
    ..The present study suggests that the downregulation of sensory P2X3 could be one of the molecular predispositions to low sensitivity to tissue injury pain in the A/J inbred mouse strain...
  78. ncbi Involvement of Gq/11 in both integrin signal-dependent and -independent pathways regulating endothelin-induced neural progenitor proliferation
    Rika Morishita
    Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Kamiya cho, Kasugai, Aichi 480 0392, Japan
    Neurosci Res 59:205-14. 2007
    ..PKC appears to increase tyrosine phosphorylation of paxillin to enhance integrin signaling, which further increases DNA synthesis and proliferation...
  79. ncbi Expression of smooth muscle cell-specific proteins in neural progenitor cells induced by agonists of G protein-coupled receptors and transforming growth factor-beta
    Rika Morishita
    Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, Japan
    J Neurochem 101:1031-40. 2007
    ..These results suggest that separate signaling pathways of G protein and TGF-beta cooperatively promote the expression of SMC-specific proteins in neural progenitor cells...
  80. ncbi Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice
    Md Harunor Rashid
    Department of Integrative Physiology, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Pain 125:125-35. 2006
    ....
  81. ncbi Emerging functions for tuberoinfundibular peptide of 39 residues
    Ted B Usdin
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Building 36 Room 3D06, 36 Convent Drive, Bethesda, MD 20892 4094, USA
    Trends Endocrinol Metab 14:14-9. 2003
    ..Injection of TIP39, and sequestration of endogenous TIP39 by intrathecal injection of an antibody to TIP39, have provided evidence that it is involved in some aspects of pain sensitivity. Thus, TIP39 might be a new neuromodulator...
  82. ncbi Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception
    Arpad Dobolyi
    Laboratory of Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:1651-6. 2002
    ..Cells in these areas project to the superficial dorsal horn of the spinal cord. Our data suggest that TIP39 released from supraspinal fibers potentiates aspects of nociception within the spinal cord...
  83. ncbi Gi2 signaling enhances proliferation of neural progenitor cells in the developing brain
    Haruo Shinohara
    Department of Anatomy, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    J Biol Chem 279:41141-8. 2004
    ..These findings indicate that Gi2 mediates signaling from receptors such as the endothelin-B receptor to maintain mitogenic activity in the neural progenitor cells of developing brain...
  84. ncbi The cognition-enhancer nefiracetam is protective in BDNF-independent neuronal cell death under the serum-free condition
    Ryousuke Fujita
    Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Neurochem Int 40:139-43. 2002
    ..These results suggest that the reported anti-amnesic action of nefiracetam in ischemic animals may be partly attributed to the neuroprotective action...
  85. ncbi Effects of various mu- and delta-opioid ligands on food intake in the meat-type chick
    Takashi Bungo
    Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790 8566, Japan
    Physiol Behav 85:519-23. 2005
    ..These results suggest that the endogenous opioid peptides, which act on the mu- and/or delta-opioid receptor, have an important role in feeding behavior in the central nervous system of meat-type chicks...
  86. ncbi Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42
    Hiroshi Ueda
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    J Biol Chem 283:1946-53. 2008
    ..These results provide evidence for a signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018...
  87. ncbi Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus
    Ritsuko Katoh-Semba
    Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi 480 0392, Japan
    FASEB J 16:1328-30. 2002
    ..Our results suggest the basis for a new strategy for treatment of memory dysfunction...
  88. ncbi Reversal of antigen-dependent signaling by two mutations in antibody/receptor chimera: implication of inverse agonism in cytokine receptor superfamily
    Masahiro Kawahara
    Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Biochem Pharmacol 68:539-48. 2004
    ....
  89. ncbi Galphaq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells
    Hiroshi Ueda
    Department of Molecular Neurobiology, Institute for Developmental Research, Aichi Human Service Center, Kamiya-cho, Kasugai, 480-0392, Japan
    Exp Cell Res 298:207-17. 2004
    ..These results demonstrate that Gq/11 signaling induces apoptosis by reducing insulin-stimulated Akt phosphorylation through tyrosine dephosphorylation and activating RhoA in HeLa cells...
  90. ncbi Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake in layer-type, but not meat-type, chicks
    Takashi Bungo
    Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, 3 5 7 Tarumi, Matsuyama 790 8566, Japan
    Brain Res 993:235-8. 2003
    ..These results suggest that there are some differences in central GABAergic systems between these strains of chicks, but GABAergic systems have an important role in the regulation of food intake in neonatal chicks...
  91. ncbi Response of neuropeptide Y-induced feeding to mu-, delta- and kappa-opioid receptor antagonists in the neonatal chick
    Koh-Ichi Dodo
    Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Tarumi 3-5-7 Matsuyama, Ehime 790-8566, Japan
    Neurosci Lett 373:85-8. 2005
    ....
  92. ncbi Bypassing antibiotic selection: positive screening of genetically modified cells with an antigen-dependent proliferation switch
    Masahiro Kawahara
    Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Nucleic Acids Res 31:e32. 2003
    ..The AMEGA without antibiotic selection will not harm normal cells, which will be especially useful for increasing the efficacy for stem cell-based gene therapy...