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Genomes and GenesSpecies | K TsukasakiSummaryAffiliation: Nagasaki University Country: Japan Publications
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Publications
Adult T-cell leukemia-lymphomaKunihiro Tsukasaki
Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
Hematology 17:S32-5. 2012..So far, no agent has been found to be effective for the latter. Further investigation on the pathogenesis of ATL is crucial for the prevention and treatment of this refractory leukemia-lymphoma...- Lymphoma study group of JCOGKunihiro Tsukasaki
Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Sakamoto, Nagasaki, Japan
Jpn J Clin Oncol 42:85-95. 2012..The multicenter trials by the JCOG-LSG combining new modalities such as molecular-targeting agents will contribute to further improvements in the treatment of lymphoid malignancies... 
Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarraysKunihiro Tsukasaki
Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, CA, USA
Int J Cancer 109:875-81. 2004..These results demonstrated that distinct sets of genes that are known to be critical in cellular transformation and/or activation are up- or down-regulated during the transition to the acute phase of ATL...- VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801Kunihiro Tsukasaki
Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
J Clin Oncol 25:5458-64. 2007..To test the superiority of VCAP-AMP-VECP over biweekly cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), we conducted a randomized controlled trial exclusively for ATLL... 
Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meetingKunihiro Tsukasaki
Department of Molecular Medicine and Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
J Clin Oncol 27:453-9. 2009....- Comparative genomic hybridization analysis of Japanese B-cell chronic lymphocytic leukemia: correlation with clinical courseKunihiro Tsukasaki
Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
Leuk Lymphoma 47:261-6. 2006.... - Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical courseK Tsukasaki
Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
Blood 97:3875-81. 2001..In summary, clonal diversity is common during progression of ATL, and CGH alterations are associated with clinical course. (Blood. 2001;97:3875-3881).. - Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriersK Tsukasaki
Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, 90024, USA
Cancer Res 61:3770-4. 2001.... - Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemiasW K Hofmann
Division of Hematology Oncology, Cedars Sinai Research Institute, UCLA School of Medicine, 8700 Beverly Boulevard, Suite B213, Los Angeles, CA 90048, USA
Leuk Res 25:333-8. 2001..The presence of a CHK2 mutation in MDS highlights the importance of alterations of cell cycle checkpoint genes in this disease... - LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathwayH Hasegawa
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
Leukemia 25:575-87. 2011..In conclusion, we showed that LBH589 is a strong inducer of apoptosis in ATLL cells and uncovered a novel apoptotic pathway initiated by activation of RAIDD... - Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cellsH Hasegawa
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Leukemia 23:2090-101. 2009..We also found synergism with a combination of Nutlin-3a and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), suggesting the application of Nutlin-3a-based therapy to be broader than expected... - Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarrayW K Hofmann
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Road, Los Angeles, CA 90048, USA
Blood 98:787-94. 2001..The suggestion is made that in addition to the known overexpression of cyclin D1, which drives entry into the cell cycle, disturbances of pathways associated with apoptosis contribute to the development of MCL. (Blood. 2001;98:787-794).. - Fas gene mutation in the progression of adult T cell leukemiaT Maeda
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Aichi 464 0221, Japan
J Exp Med 189:1063-71. 1999..Mutation of the Fas gene may be one of the mechanisms underlying the progression of ATL... - Analysis of the CHK2 gene in lymphoid malignanciesS Tavor
Division of Hematology Oncology, Cedars Sinai Research Institute, UCLA School of Medicine, 8700 Beverly Blvd, D 5068, Los Angeles, CA 90048, USA
Leuk Lymphoma 42:517-20. 2001..Another point mutation in the non-coding region was identified in one of adult T-cell leukemias (ATL) samples. This result suggests that mutation of the CHK2 gene may rarely be involved in the development of selected lymphomas... - Proviral status of HTLV-1 integrated into the host genomic DNA of adult T-cell leukemia cellsS Kamihira
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki City, Japan 852 8501
Clin Lab Haematol 27:235-41. 2005..These results suggest that analysis of the proviral status provides useful diagnostic and virologic-oncological information about ATL and HTLV-1 pathology, especially the important role of pX gene in tumorigenesis... - Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutationsShimeru Kamihira
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Eur J Haematol 82:301-7. 2009..This clarification of the unique associations in cell lines useful for bio-medical studies will contribute to a better understanding of p53-associated carcinogenesis... - Adhesion-dependent growth of primary adult T cell leukemia cells with down-regulation of HTLV-I p40Tax protein: a novel in vitro model of the growth of acute ATL cellsKazuhiro Nagai
Transfusion Service, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
Int J Hematol 88:551-64. 2008..In conclusion, our co-culture system allows for the first time the growth of primary ATL cells in vitro, and might be useful as an in vitro assay for biological and clinical studies to develop molecular targeting drugs against ATL... - Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 provirus-positive cellsTetsuya Usui
Department of Laboratory Medicine Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan
Retrovirology 5:34. 2008..HBZs consisting of non-spliced and spliced isoforms (HBZ-SI) are thought to be implicated in viral replication and T-cell proliferation but there is little evidence on the HBZ expression profile on a large scale... - Prevalence of monoclonal gammopathy of undetermined significance: study of 52,802 persons in Nagasaki City, JapanMasako Iwanaga
Department of Hematology and Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
Mayo Clin Proc 82:1474-9. 2007..To assess the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in a large Japanese population... - Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapyDaisuke Sasaki
Department of Laboratory Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
Haematologica 96:712-9. 2011..This complex plays vital roles in the regulation of development-specific gene expression... - Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivorsMasako Iwanaga
Department of Hematology and Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Blood 113:1639-50. 2009..There was no clear association between radiation exposure and the malignant progression of MGUS. Further detailed analysis is needed... - Multiple immune abnormalities in a patient with idiopathic CD4+ T-lymphocytopeniaYasuaki Yamada
Department of Laboratory Medicine, Nagasaki University Hospital, Nagasaki
Intern Med 48:1967-71. 2009..This is probably the first childhood-onset ICL case in which the trigger event for the development was known together with the patient's autoimmune background... - Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in JapanMasako Iwanaga
Department of Hematology and Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
Blood 116:1211-9. 2010.... - Deoxycoformycin-containing combination chemotherapy for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study (JCOG9109)Kunihiro Tsukasaki
Nagasaki University, Nagasaki, Japan
Int J Hematol 77:164-70. 2003..We conclude that DCF-containing combination chemotherapy is not a promising regimen against aggressive ATL... - Mutations in the mitotic check point gene, MAD1L1, in human cancersK Tsukasaki
Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California, CA 90048, USA
Oncogene 20:3301-5. 2001..Our results suggest a pathogenic role of MAD1L1 mutations in various types of human cancer... - High human T cell leukemia virus type-1(HTLV-1) provirus load in patients with HTLV-1 carriers complicated with HTLV-1-unrelated disordersDaisuke Sasaki
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Virol J 7:81. 2010.... - Methylation analysis of cell cycle control genes in adult T-cell leukemia/lymphomaW K Hofmann
Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
Leuk Lymphoma 42:1107-9. 2001..The RB gene was not found to be methylated in any of the ATL samples. The data indicate that inactivation of these cell cycle regulatory genes by hypermethylation is important in the development of ATL... - Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cellsMasaki Abe
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Eur J Haematol 81:209-17. 2008.... - Long-term efficacy of imatinib in a practical setting is correlated with imatinib trough concentration that is influenced by body size: a report by the Nagasaki CML Study GroupMari Sakai
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Int J Hematol 89:319-25. 2009.... - Imatinib provides durable molecular and cytogenetic responses in a practical setting for both newly diagnosed and previously treated chronic myelogenous leukemia: a study in nagasaki prefecture, JapanEmi Matsuo
Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Int J Hematol 85:132-9. 2007.... - Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-MetY Onimaru
Department of Hematology and Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
Int J Oncol 33:697-703. 2008..Autocrine and/or paracrine growth caused by HGF and c-Met was suggested in aggressive ATLL cells secreting HGF and/or IL-6, respectively... - Small number of HTLV-1-positive cells frequently remains during complete remission after allogeneic hematopoietic stem cell transplantation that are heterogeneous in origin among cases with adult T-cell leukemia/lymphomaR Yamasaki
Molecular Medicine Unit and Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Leukemia 21:1212-7. 2007..These results demonstrated that after allo-HSCT the small amount of residual HTLV-1-positive cells were heterogeneous in origin and that long-term disease control for ATLL could be obtained without the complete elimination of HTLV-1... - Rapid and high-resolution detection of IgH gene rearrangements using PCR and melting curve analysisA Uemura
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan
Int J Lab Hematol 29:200-7. 2007..2% and 100%, respectively. This indicates that the new protocol of PCR-MCA is acceptable for clinical testing; especially, PCR-MCA is relevant in terms of the rapid and sensitive detection of IgH clonality within amplicons... - An ATL cell line with an IgH pseudo-rearranged band pattern by southern blotting: a pitfall of genetic diagnosisAkiko Uemura
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Lab Hematol 11:8-13. 2005..The SO4 cells, in the hematology laboratory, will provide a lesson about the pitfalls of genetic tests for mature T-cell neoplasms and contribute to the genetic elucidation of leukomogenesis as an in vitro model... - Primary T-cell lymphoma of the thyroid gland with chemokine receptors of Th1 phenotype complicating autoimmune thyroiditisSatoshi Koida
Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki 852 8523 Japan
Haematologica 92:e37-40. 2007.... - Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphomaHitomi Harasawa
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Leuk Lymphoma 47:2163-73. 2006..Collectively, the frequent co-expression of CCR4 and CCR10, the known pair of skin-homing chemokine receptors, may play an important role in ATLL invasion into the skin... - The echocardiographic Tei-index reflects early myocardial damage induced by anthracyclines in patients with hematological malignanciesNorihiko Senju
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
Heart Vessels 22:393-7. 2007..These results suggested that the DeltaTei-index is a more sensitive indicator of early cardiotoxicity induced by anthracyclines than LVEF regardless of its value before treatment... - Durable remission by sobuzoxane in an HIV-seronegative patient with human herpesvirus 8-negative primary effusion lymphomaYoriko Inoue
Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4, Sakamoto, Nagasaki 852-8523, Japan
Int J Hematol 79:271-5. 2004..At the time of this report the patient had been free from PEL for more than 18 months without chemotherapy... - A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 productionHiroo Hasegawa
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Blood 110:1664-74. 2007..These results indicate that 15d-PGJ(2) sensitizes TRAIL-resistant cells to TRAIL in a PPAR gamma-independent manner and that the use of 15d-PGJ(2) or its inducers, such as FCB, is a new strategy for cancer therapy... - Impact of p53 aberration on the progression of Adult T-cell Leukemia/LymphomaMasayuki Tawara
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
Cancer Lett 234:249-55. 2006..More than half of the patients had one of the two aberrations, and both aberrations emerged as significant markers for a poor prognosis... - Methylenetetrahydrofolate reductase genotype does not play a role in adult T-cell leukemia/lymphoma pathogenesis among human T-lymphotrophic virus type 1 carriersSeisho Takeuchi
Department of Medicine, Kochi Medical School, Kochi University, Kochi, Japan
Leuk Res 28:1039-41. 2004..No statistically significant associations were found between MTHFR genotype and development of ATL. These data suggest that genetic polymorphisms in the MTHFR locus do not play a role in ATL pathogenesis among HTLV-1 carriers... - Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemiaSeisho Takeuchi
Division of Hematology Oncology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, USA
Br J Haematol 119:985-7. 2002..These data suggest that genetic polymorphisms in the TNF locus have a limited effect on the outcome of childhood ALL... - Chromosomal aberrations in follicular non-Hodgkin lymphomas of Japanese patients, detected with comparative genomic hybridization and polymerase chain reaction analysisKunihiro Tsukasaki
Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, D-69120 Heidelberg, Germany
Cancer Genet Cytogenet 162:107-14. 2005..Despite the extended primer set used, the frequency of PCR-detected t(14;18) remained low. Additional studies are required to assess the reasons for geographic variation in FL... - Natural course of HTLV-1 carriers with monoclonal proliferation of T lymphocytes ("pre-ATL") in a 20-year follow-up studyYoshitaka Imaizumi
Blood 105:903-4. 2005 - Expression of CCR9 in HTLV-1+ T cells and ATL cells expressing TaxDaisuke Nagakubo
Department of Microbiology and SORST, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
Int J Cancer 120:1591-7. 2007..Collectively, CCR9 is inducible in ATL cells expressing Tax and may play a role in the gastrointestinal involvement of ATL... - Mutations in the retinoblastoma-related gene RB2/p130 in adult T-cell leukaemia/lymphomaSeisho Takeuchi
Department of Internal Medicine, Kochi Medical School, Okohcho, Nankoku, Kochi 783 8505, Japan
Leuk Lymphoma 44:699-701. 2003..This is the first report describing mutation of the RB2/p130 gene in ATL, suggesting that RB2/p130 may be involved in the development of ATL, and may behave as a tumor suppressor gene in T lymphocytes... - Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cellsNaoki Mori
Department of Preventive Medicine and AIDS Research, Institute of Tropical Medicine, Nagasaki University, Japan
Blood 100:1828-34. 2002..Our results indicate that NF-kappaB plays a crucial role in the pathogenesis and survival of HTLV-I-infected leukemic cells and that it is a suitable target for the prevention and treatment of ATL... - Apoptosis induced by the histone deacetylase inhibitor FR901228 in human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cellsNaoki Mori
Division of Molecular Virology and Oncology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa 903 0215, Japan
J Virol 78:4582-90. 2004..Our results indicated that FR901228 could induce apoptosis of these cells and suppress the expression of NF-kappaB and AP-1 and suggest that FR901228 could be therapeutically effective in ATL... - [Treatment of adult T-cell leukemia/lymphoma: progresses in the chemotherapy and stem cell transplantation]Kunihiro Tsukasaki
Rinsho Ketsueki 45:195-201. 2004 - Methylation analysis of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphomaYang Yang
Department of Medicine, Kochi Medical School, Okohcho, Nankoku, Kochi 783-8505, Japan
Leuk Res 29:47-51. 2005..Demethylation with 5-azacytidine treatment restored APC expression in the ST1 cell line. Our data show that hypermethylation of the APC gene is involved in the pathogenesis of ATL... - A novel plasmacytoid dendritic cell line, CAL-1, established from a patient with blastic natural killer cell lymphomaTakahiro Maeda
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Int J Hematol 81:148-54. 2005..We describe the first novel pDC cell line of CAL-1. This cell line should open the opportunity for study not only of CD4+CD56+ tumor cells but also of pDCs in vitro... - P53 codon 72 polymorphism is associated with disease progression in adult T-cell leukaemia/lymphomaSeisho Takeuchi
Br J Haematol 131:552-3. 2005 - Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cellsHiroo Hasegawa
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, 852-8501, Japan
Blood 107:679-88. 2006..More interestingly, similar effects were observed in other leukemia cell lines by exactly the same mechanisms. These results suggest that combined treatment with BB-1 and TRAIL may be a new strategy for cancer therapy... - Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavirM Zahidunnabi Dewan
Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Blood 107:716-24. 2006..These results would provide a new concept and novel platform for new drug development of leukemia and solid cancer as well... - Methylation of the MLH1 gene in hematological malignanciesMasahide Matsushita
Department of Medicine, Kochi Medical School, Okohcho, Nankoku, Kochi 783 8505, Japan
Oncol Rep 14:191-4. 2005..Methylation of the MSH2 gene was not found in any of the samples. Our data show that hypermethylation of the MLH1 gene is occasionally involved in the pathogenesis of hematological malignancies, but is not always associated with MSI...