Tamotsu Tsukahara


Affiliation: Nagasaki University
Country: Japan


  1. Tsukahara T, Tsukahara R, Haniu H, Matsuda Y, Murakami Murofushi K. Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma. Mol Cell Endocrinol. 2015;412:320-9 pubmed publisher
    ..These findings could be important for regulatory roles of PPARγ and VEGF in the vascular processes associated with diabetes and atherosclerosis. ..
  2. Tsukahara T, Matsuda Y, Haniu H. The role of autophagy as a mechanism of toxicity induced by multi-walled carbon nanotubes in human lung cells. Int J Mol Sci. 2014;16:40-8 pubmed publisher
    ..This review highlights the importance of autophagy as an emerging mechanism of CNT toxicity. ..
  3. Tsukahara T, Yamagishi S, Matsuda Y, Haniu H. Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARγ activation in human umbilical vein endothelial cells. Biomed Pharmacother. 2018;106:686-691 pubmed publisher
    ..These results suggest that an imbalance of the PPARγ agonist-antagonist equilibrium is involved in changes in cellular functions, including ROS generation and lipid peroxidation. ..
  4. Tsukahara T, Haniu H, Matsuda Y, Murakmi Murofushi K. Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels in ApoE-deficient mice. Biochem Biophys Res Commun. 2016;473:107-113 pubmed publisher
    ..Taken together, these results suggest that 2ccPA governs anti-atherogenic activities in the carotid arteries of apoE-deficient mice. ..
  5. Tsukahara R, Haniu H, Matsuda Y, Tsukahara T. The AGP-PPAR? axis promotes oxidative stress and diabetic endothelial cell dysfunction. Mol Cell Endocrinol. 2018;473:100-113 pubmed publisher
    ..These results suggested that AGP plays a significant role in the initiation/progression of diabetes-related atherosclerosis through PPAR? activation. ..
  6. Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, et al. The Dispersion State of Tangled Multi-Walled Carbon Nanotubes Affects Their Cytotoxicity. Nanomaterials (Basel). 2016;6: pubmed publisher
    ..We suggest that dispersion state should be accounted for when evaluating the cytotoxicity of MWCNTs. ..
  7. Tsukahara T, Yamagishi S, Matsuda Y, Haniu H. Lysophosphatidic acid signaling regulates the KLF9-PPAR? axis in human induced pluripotent stem cell-derived neurons. Biochem Biophys Res Commun. 2017;491:223-227 pubmed publisher
    ..We discuss the contribution of the LPA1-PPAR?-KLF9 axis to neurite outgrowth and proliferation in human iPSC-derived neurons. ..
  8. Tsukahara T, Matsuda Y, Haniu H. Lysophospholipid-Related Diseases and PPAR? Signaling Pathway. Int J Mol Sci. 2017;18: pubmed publisher
    ..The present review discusses the arbitrary aspects of the physiological and pathophysiological actions of lysophospholipids in vascular and nervous system biology. ..