Affiliation: Nagasaki University
Nishida K, Honda T, Nakashima M, Sasaki H, Nakamura J. Influence of liver disease on phenolsulfonphthalein absorption from liver surface to examine possibility of direct liver surface application for drug targeting. Biol Pharm Bull. 2003;26:988-93 pubmed
..Consequently, it is expected that there will be no marked decline in the absorption rate from the liver surface in a liver disease state, leading us to apply this administration method for liver targeting. ..
Nishida K, Fujiwara R, Kodama Y, Fumoto S, Mukai T, Nakashima M, et al
. Regional delivery of model compounds and 5-Fluorouracil to the liver by their application to the liver surface in rats: its implication for clinical use. Pharm Res. 2005;22:1331-7 pubmed
..These results demonstrate the possibility of regional delivery of drugs to the liver by application to the liver surface. ..
Nishida K, Kuma A, Fumoto S, Nakashima M, Sasaki H, Nakamura J. Absorption characteristics of model compounds from the small intestinal serosal surface and a comparison with other organ surfaces. J Pharm Pharmacol. 2005;57:1073-7 pubmed
..In addition, the small intestine is likely to contribute largely to hydrophilic compound absorption from the peritoneal cavity, judging from absorption clearance, CL(a), calculated using the peritoneal organ surface area. ..
Nishida K, Nose S, Kuma A, Mukai T, Nakashima M, Sasaki H, et al
. Absorption of phenolsulfonphthalein as a model across the mesenteric surface in rats to determine the drug absorption route after intraperitoneal administration. J Pharm Pharmacol. 2004;56:683-7 pubmed
Nishida K, Kamenosono M, Kuma A, Fumoto S, Mukai T, Nakashima M, et al
. Delivery advantage to the unilateral kidney by direct drug application to the kidney surface in rats and pharmacokinetic verification based on a physiological model. J Drug Target. 2005;13:215-23 pubmed
..Moreover, the delivery advantage of kidney surface application of PSP was verified by its comparison with other routes such as i.v. and i.a. administrations. ..