Hiroyuki Namba

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. ncbi request reprint Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
    Hiroyuki Namba
    Department of Molecular Medicine, Tissue and Histopathology Section, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Sakamoto, Japan
    J Clin Endocrinol Metab 88:4393-7. 2003
  2. doi request reprint Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells
    Shu Takakura
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Sci 99:1147-54. 2008
  3. ncbi request reprint BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kappaB activation
    Iryna Palona
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki University Hospital, 852 8523, Japan
    Endocrinology 147:5699-707. 2006
  4. ncbi request reprint Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant beta-catenin expression
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Pathol 202:446-55. 2004
  5. ncbi request reprint Overexpression of wild-type THRbeta1 suppresses the growth and invasiveness of human papillary thyroid cancer cells
    Ilya Sedliarou
    Departments of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Anticancer Res 27:3999-4009. 2007
  6. ncbi request reprint Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation
    Atsushi Kumagai
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8523, Japan
    Oncol Rep 16:123-6. 2006
  7. ncbi request reprint No evidence of ARAF, CRAF and MET mutations in BRAFT1799A negative human papillary thyroid carcinoma
    Atsushi Kumagai
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagaski, Japan
    Endocr J 53:615-20. 2006
  8. ncbi request reprint Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas
    Atsushi Kumagai
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Clin Endocrinol Metab 89:4280-4. 2004
  9. ncbi request reprint The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpression
    Alexander Abrosimov
    Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
    Endocr Pathol 18:68-75. 2007
  10. ncbi request reprint Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusively
    Norisato Mitsutake
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, and Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital of Medicine and Dentistry, Japan
    Endocrinology 148:1797-803. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
    Hiroyuki Namba
    Department of Molecular Medicine, Tissue and Histopathology Section, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Sakamoto, Japan
    J Clin Endocrinol Metab 88:4393-7. 2003
    ..033) and clinical stage (P = 0.049). Our results indicate that activating mutation of BRAF gene could be a potentially useful marker of prognosis of patients with advanced thyroid cancers...
  2. doi request reprint Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells
    Shu Takakura
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Sci 99:1147-54. 2008
    ..In conclusion, these findings suggest that the miR-17-92 cluster plays an important role in certain types of ATCs and could be a novel target for ATC treatment...
  3. ncbi request reprint BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kappaB activation
    Iryna Palona
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki University Hospital, 852 8523, Japan
    Endocrinology 147:5699-707. 2006
    ..Inactivation of NF-kappaB may provide a new therapeutic modality for thyroid cancers with BRAFV600E...
  4. ncbi request reprint Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant beta-catenin expression
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Pathol 202:446-55. 2004
    ..Pin1 may be an important factor in regulating cyclin D1 and beta-catenin expression during thyroid carcinogenesis...
  5. ncbi request reprint Overexpression of wild-type THRbeta1 suppresses the growth and invasiveness of human papillary thyroid cancer cells
    Ilya Sedliarou
    Departments of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Anticancer Res 27:3999-4009. 2007
    ..Thyroid hormone receptors (THRs) are transcription factors which regulate cell growth and differentiation. The compromised function of THRs has been reported in several human malignancies, suggesting their implication in carcinogenesis...
  6. ncbi request reprint Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation
    Atsushi Kumagai
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8523, Japan
    Oncol Rep 16:123-6. 2006
    ..These findings strongly suggest that this case is a poorly differentiated carcinoma that arose from PTC and implies a possible association of BRAF mutation with dedifferentiated phenotype of PTCs...
  7. ncbi request reprint No evidence of ARAF, CRAF and MET mutations in BRAFT1799A negative human papillary thyroid carcinoma
    Atsushi Kumagai
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagaski, Japan
    Endocr J 53:615-20. 2006
    ....
  8. ncbi request reprint Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas
    Atsushi Kumagai
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Clin Endocrinol Metab 89:4280-4. 2004
    ..The differences in the prevalence of BRAF(T1796A) mutations between childhood and adult cases of PTC may well reflect inherent differences in the clinical features of these cancers between the two age groups...
  9. ncbi request reprint The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpression
    Alexander Abrosimov
    Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
    Endocr Pathol 18:68-75. 2007
    ..In general, it does not prove to be a prognosticator of PTC aggressiveness. A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human PTCs and PMCs...
  10. ncbi request reprint Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusively
    Norisato Mitsutake
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, and Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital of Medicine and Dentistry, Japan
    Endocrinology 148:1797-803. 2007
    ..These results suggest that cancer stem-like cells are partly, but not exclusively, enriched in SP population. Clarifying the key tumorigenic population might contribute to the establishment of a novel therapy for thyroid cancer...
  11. ncbi request reprint RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Hum Pathol 38:621-8. 2007
    ..RET amplification might be induced by a high level of genomic instability in connection with progression of thyroid carcinogenesis and, subsequently, be associated with radiation-induced and/or high-grade malignant cases...
  12. ncbi request reprint Clinical implications of pre-operative rapid BRAF analysis for papillary thyroid cancer
    Atsushi Kumagai
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Endocr J 54:399-405. 2007
    ..In summary, our PCR-RFLP method for BRAF(T1799A) detection using FNAB samples is useful not only for preoperative diagnosis of PTC but also as a complementary diagnostic tool for accurate pathological diagnosis, even after surgery...
  13. ncbi request reprint Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest
    Dmitry Bulgin
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Thyroid 16:217-24. 2006
    ..It has been shown that c-Jun NH(2)-terminal kinase (JNK) activation is one of the manifestations of radiation response in ATC cells...
  14. ncbi request reprint The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma
    Ilya Sedliarou
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Int J Oncol 25:1729-35. 2004
    ..020). The results indicate the BRAFT1796A mutation is prevalent in PMCs, and thus these tumors may have a spectrum of genetic events partly overlapping with that of PTCs...
  15. ncbi request reprint Diagnostic usefulness of PCR profiling of the differentially expressed marker genes in thyroid papillary carcinomas
    Aiko Hamada
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Lett 224:289-301. 2005
    ....
  16. ncbi request reprint Nuclear factor-kB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer
    Hiroyuki Namba
    Department of Molecular Medicine, Nagasaki University, Graduate School of Biomedical Sciences, Japan
    Arq Bras Endocrinol Metabol 51:843-51. 2007
    ....
  17. ncbi request reprint Different structural components of conventional papillary thyroid carcinoma display mostly identical BRAF status
    Alexander Abrosimov
    Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Cancer 120:196-200. 2007
    ....
  18. ncbi request reprint A novel role for thyroid hormone receptor beta in cellular radiosensitivity
    Michiko Matsuse
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Radiat Res 49:17-27. 2008
    ..Mutant THRB produced a radioprotective effect, attenuated radiation-induced growth inhibition and cellular senescence. The results suggest that THRB may modulate cellular radiosensitivity and stress-induced senescence...
  19. ncbi request reprint [Gene abnormalities in thyroid cancer]
    Hiroyuki Namba
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science
    Nihon Rinsho 65:1967-72. 2007
    ..In this article, we review the genetic diagnostic methods and phenotype-genotype relationship of human thyroid cancers...
  20. ncbi request reprint Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer
    Katsu Ishigaki
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Clin Endocrinol Metab 87:3433-40. 2002
    ..Our results suggest that aberrant activation of Wnt/beta-catenin signaling is strongly involved in thyroid tumorigenesis...
  21. ncbi request reprint Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, dehydroxymethylepoxyquinomicin
    Dmitriy V Starenki
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Clin Cancer Res 10:6821-9. 2004
    ....
  22. ncbi request reprint Vitamin D3 treatment for locally advanced thyroid cancer: a case report
    Mariko Morishita
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Endocr J 52:613-6. 2005
    ..Therefore, this case report provides important evidence for the effectiveness of vitamin D3 therapy against advanced thyroid cancers...
  23. ncbi request reprint Large deletions in mitochondrial DNA in radiation-associated human thyroid tumors
    Tatiana I Rogounovitch
    Department of Molecular Medicine, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Res 62:7031-41. 2002
    ..Thus, simultaneous determination of the number of large-scale mtDNA deletions and relative mtDNA content may be useful to elucidate molecular distinctive features of radiation-associated thyroid tumors...
  24. ncbi request reprint A histone deacetylase inhibitor enhances killing of undifferentiated thyroid carcinoma cells by p53 gene therapy
    Ryo Imanishi
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8523, Japan
    J Clin Endocrinol Metab 87:4821-4. 2002
    ..Our findings indicate that HDAC-1 enhances apoptotic killing by p53 transfer, and suggest that this combination strategy may be useful in treating undifferentiated thyroid carcinomas...
  25. ncbi request reprint Inhibition of nuclear factor-kappaB cascade potentiates the effect of a combination treatment of anaplastic thyroid cancer cells
    Dmitriy Starenki
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    J Clin Endocrinol Metab 89:410-8. 2004
    ..We therefore suggest that inhibition of NF-kappaB could be an effective modality for radiation therapy of advanced human thyroid cancers...
  26. ncbi request reprint Radiation-induced senescence-like terminal growth arrest in thyroid cells
    Alexei Podtcheko
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Thyroid 15:306-13. 2005
    ..We, therefore, conclude that induction of SLP with terminal growth arrest contribute to the elimination of clonogenic populations after IR...
  27. ncbi request reprint Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient
    Vladimir Saenko
    Department of International Health and Radiation Research, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Mutat Res 527:81-90. 2003
    ..Thus, the Delta rfp/ret rearrangement may be involved in a causative manner in cancerogenesis and provides additional evidence of the role of activated ret oncogene in the development of a subset of papillary thyroid carcinoma...
  28. ncbi request reprint Pediatric CT scan usage in Japan: results of a hospital survey
    Nader Ghotbi
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Radiat Med 24:560-7. 2006
    ....
  29. ncbi request reprint Functional domains of paired-like homeoprotein Cart1 and the relationship between dimerization and transcription activity
    Keizo Furukawa
    Department of Orthopaedic Surgery, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Genes Cells 7:1135-47. 2002
    ..However, its transactivation mechanism is still poorly understood, including the target gene. Here, we report biochemical dissections of Cart1 functional domains and a relationship between dimerization and transcription activity...
  30. ncbi request reprint [Familial thyroid cancer]
    Hiroyuki Namba
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science
    Nihon Rinsho . 2006
  31. ncbi request reprint Distinctive gene expression of receptor-type tyrosine kinase families during rat hepatocarcinogenesis
    Hiroaki Kuroda
    Department of Surgery II, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Int J Mol Med 9:473-80. 2002
    ..Distinctive gene expression of RTK may contribute to epigenic implication of hepatoma formation...
  32. ncbi request reprint TP53 codon 72 polymorphism in radiation-associated human papillary thyroid cancer
    Tatiana I Rogounovitch
    Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Oncol Rep 15:949-56. 2006
    ..The findings suggest TP53 allele combinations other than Arg/Arg may contribute to the risk of development of PTC in individuals exposed to radiation during their late childhood, adolescence or in young adulthood...
  33. ncbi request reprint Epstein-Barr virus-based vector improves the tumor cell killing effect of pituitary tumor in HVJ-liposome-mediated transcriptional targeting suicide gene therapy
    Tsuyoshi Izumo
    Department of Neurosurgery, Nagasaki University, Graduate School of Biomedical Science, Nagasaki, Japan
    Int J Oncol 31:379-87. 2007
    ....
  34. ncbi request reprint A rapid and simple detection method for the BRAF(T1796A) mutation in fine-needle aspirated thyroid carcinoma cells
    Naomi Hayashida
    Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Thyroid 14:910-5. 2004
    ..Our results indicate that the preoperative determination of the presence of a BRAF(T1796A) mutation by conventional PCR-RFLP may be potentially useful in the diagnosis of the most common thyroid malignancies...