Masahiro Nakashima

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. ncbi request reprint Foci formation of P53-binding protein 1 in thyroid tumors: activation of genomic instability during thyroid carcinogenesis
    Masahiro Nakashima
    Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Cancer 122:1082-8. 2008
  2. ncbi request reprint Incidence of multiple primary cancers in Nagasaki atomic bomb survivors: association with radiation exposure
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Medicine, Nagasaki 851 8523, Japan
    Cancer Sci 99:87-92. 2008
  3. ncbi request reprint RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Hum Pathol 38:621-8. 2007
  4. pmc Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature
    Radan Dzodic
    Institute for Oncology and Radiology of Serbia, 14 Pasterova, Belgrade 11000, Serbia
    Diagn Pathol 5:17. 2010
  5. ncbi request reprint Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant beta-catenin expression
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Pathol 202:446-55. 2004
  6. ncbi request reprint Correlation of cytoplasmic beta-catenin and cyclin D1 overexpression during thyroid carcinogenesis around Semipalatinsk nuclear test site
    Serik Meirmanov
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    Thyroid 13:537-45. 2003
  7. doi request reprint Significance of HER2 and C-MYC oncogene amplifications in breast cancer in atomic bomb survivors: associations with radiation exposure and histologic grade
    Shiro Miura
    Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Cancer 112:2143-51. 2008
  8. ncbi request reprint Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing
    Chun Yang Wen
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Gastroenterol 38:431-5. 2003
  9. ncbi request reprint The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpression
    Alexander Abrosimov
    Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
    Endocr Pathol 18:68-75. 2007
  10. doi request reprint Alteration of p53-binding protein 1 expression during skin carcinogenesis: association with genomic instability
    Yuki Naruke
    Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki Unviersity Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Sci 99:946-51. 2008

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Foci formation of P53-binding protein 1 in thyroid tumors: activation of genomic instability during thyroid carcinogenesis
    Masahiro Nakashima
    Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Cancer 122:1082-8. 2008
    ..We propose that immunofluorescence analysis of 53BP1 expression can be a useful tool to estimate the level of GIN and, simultaneously, the malignant potency of human thyroid tumors...
  2. ncbi request reprint Incidence of multiple primary cancers in Nagasaki atomic bomb survivors: association with radiation exposure
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Medicine, Nagasaki 851 8523, Japan
    Cancer Sci 99:87-92. 2008
    ..These results on the incidence of MPC in the tumor-bearing survivors and its correlations with the atomic bombing of 62 years ago are described for the first time in this report...
  3. ncbi request reprint RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Hum Pathol 38:621-8. 2007
    ..RET amplification might be induced by a high level of genomic instability in connection with progression of thyroid carcinogenesis and, subsequently, be associated with radiation-induced and/or high-grade malignant cases...
  4. pmc Intraductal papilloma of ectopic breast tissue in axillary lymph node of a patient with a previous intraductal papilloma of ipsilateral breast: a case report and review of the literature
    Radan Dzodic
    Institute for Oncology and Radiology of Serbia, 14 Pasterova, Belgrade 11000, Serbia
    Diagn Pathol 5:17. 2010
    ..This case shows that even though benign proliferative change in ectopic breast tissue is an extremely rare phenomenon, this possibility should be taken into account for correct diagnosis...
  5. ncbi request reprint Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant beta-catenin expression
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    J Pathol 202:446-55. 2004
    ..Pin1 may be an important factor in regulating cyclin D1 and beta-catenin expression during thyroid carcinogenesis...
  6. ncbi request reprint Correlation of cytoplasmic beta-catenin and cyclin D1 overexpression during thyroid carcinogenesis around Semipalatinsk nuclear test site
    Serik Meirmanov
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan
    Thyroid 13:537-45. 2003
    ..The analysis of the alteration of the Wnt signaling-related molecules in thyroid cancer around the SNTS may be important to gain an insight into radiation-induced thyroid tumorigenesis...
  7. doi request reprint Significance of HER2 and C-MYC oncogene amplifications in breast cancer in atomic bomb survivors: associations with radiation exposure and histologic grade
    Shiro Miura
    Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Cancer 112:2143-51. 2008
    ..The objective of this study was to clarify the association of oncogene amplification in breast cancer in A-bomb survivors with radiation exposure...
  8. ncbi request reprint Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing
    Chun Yang Wen
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Gastroenterol 38:431-5. 2003
    ..The purpose of this study was to evaluate the expression of Tie-2 and Ang-1 and -2 in an acetic acid-induced gastric ulcer healing process in rats...
  9. ncbi request reprint The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpression
    Alexander Abrosimov
    Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
    Endocr Pathol 18:68-75. 2007
    ..In general, it does not prove to be a prognosticator of PTC aggressiveness. A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human PTCs and PMCs...
  10. doi request reprint Alteration of p53-binding protein 1 expression during skin carcinogenesis: association with genomic instability
    Yuki Naruke
    Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki Unviersity Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Sci 99:946-51. 2008
    ..The detection of 53BP1 expression by immunofluorescence can be a useful histological marker to estimate the malignant potential of human skin tumors...
  11. doi request reprint Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells
    Shu Takakura
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Sci 99:1147-54. 2008
    ..In conclusion, these findings suggest that the miR-17-92 cluster plays an important role in certain types of ATCs and could be a novel target for ATC treatment...
  12. doi request reprint Immunohistochemical analyses of beta-catenin and cyclin D1 expression in giant cell tumor of bone (GCTB): a possible role of Wnt pathway in GCTB tumorigenesis
    Shohei Matsubayashi
    Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Pathol Res Pract 205:626-33. 2009
    ..Importantly, it was suggested that the nuclear beta-catenin staining level might be associated with tumor recurrence in GCTB...
  13. doi request reprint Genomic instability in the epidermis induced by atomic bomb (A-bomb) radiation: a long-lasting health effect in A-bomb survivors
    Yuki Naruke
    Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Cancer 115:3782-90. 2009
    ..In this study, the authors evaluated the presence of GIN in the epidermis of survivors as a late effect of A-bomb radiation...
  14. doi request reprint Interweaving microRNAs and proinflammatory cytokines in gastric mucosa with reference to H. pylori infection
    Hajime Isomoto
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Immunol 32:290-9. 2012
    ..pylori-negative gastric mucosa. Underscoring the causal association between miRNAs and proinflammatory cytokines may provide insights into the pathogenesis of H. pylori-associated gastritis linking to gastric carcinogenesis...
  15. doi request reprint Expression of apoptotic epithelial cells within lamina propria beneath the basement membrane triggers dextran sulfate sodium-induced colitis
    Kazuko Shichijo
    Division of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, Japan
    Dig Dis Sci 53:2443-51. 2008
    ..Our results suggest that interventions directed toward the apoptotic process may be beneficial in the treatment of ulcerative colitis...
  16. ncbi request reprint Altered expression of beta-catenin during radiation-induced colonic carcinogenesis
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Pathol Res Pract 198:717-24. 2002
    ..Because translocation of beta-catenin was found in irradiated-colonic mucosa as well as colon cancer, disruption of beta-catenin expression might be one of the early events in radiation-induced colonic carcinogenesis...
  17. ncbi request reprint The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma
    Ilya Sedliarou
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Int J Oncol 25:1729-35. 2004
    ..020). The results indicate the BRAFT1796A mutation is prevalent in PMCs, and thus these tumors may have a spectrum of genetic events partly overlapping with that of PTCs...
  18. ncbi request reprint Expression of apoptotic epithelial cells in biopsy specimens of patients with colitis
    Kazuko Shichijo
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Dig Dis Sci 52:2037-43. 2007
    ..Our results suggest that interventions directed toward the apoptotic process may be beneficial in the treatment of colitis...
  19. ncbi request reprint Small cell carcinoma of the endometrium: report of a case with analysis of Wnt/beta-catenin pathway
    Serik Meirmanov
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Pathol Res Pract 199:551-8. 2003
    ....
  20. ncbi request reprint Diagnostic usefulness of PCR profiling of the differentially expressed marker genes in thyroid papillary carcinomas
    Aiko Hamada
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Lett 224:289-301. 2005
    ....
  21. pmc Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis
    Katsuya Matsuda
    Department of Tumour and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Histopathology 59:441-51. 2011
    ..Our aim was to analyse the presence of DSBs by immunofluorescence for 53BP1 expression in a series of cervical lesions, to evaluate the significance of GIN during carcinogenesis...
  22. ncbi request reprint Novel tumorigenic rearrangement, Delta rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient
    Vladimir Saenko
    Department of International Health and Radiation Research, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Mutat Res 527:81-90. 2003
    ..Thus, the Delta rfp/ret rearrangement may be involved in a causative manner in cancerogenesis and provides additional evidence of the role of activated ret oncogene in the development of a subset of papillary thyroid carcinoma...
  23. doi request reprint Basic fibroblast growth factor suppresses radiation-induced apoptosis and TP53 pathway in rat small intestine
    Mutsumi Matsuu-Matsuyama
    Division of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Radiat Res 174:52-61. 2010
    ..The inhibition of apoptosis thus might be related to suppression of the TP53 pathway...
  24. ncbi request reprint Sucralfate protects intestinal epithelial cells from radiation-induced apoptosis in rats
    Mutsumi Matsuu-Matsuyama
    Department of Molecular Pathology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Radiat Res 47:1-8. 2006
    ..The protective effects of sucralfate against ARC may be partially due to the suppression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region...
  25. ncbi request reprint Sympathetic hyperfunction causes increased sensitivity of the autonomic nervous system to whole-body X irradiation
    Mutsumi Matsuu
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Radiat Res 163:137-43. 2005
    ..Sympathetic hyperfunction may be associated with a higher sensitivity to radiation, including radiation injury and radiation sickness...
  26. ncbi request reprint Epstein-Barr virus-associated gastric carcinoma in Kazakhstan
    Gabit Alipov
    Division of Scientific Data Regsitry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    World J Gastroenterol 11:27-30. 2005
    ....
  27. ncbi request reprint Protection by polaprezinc against radiation-induced apoptosis in rat jejunal crypt cells
    Mutsumi Matsuu-Matsuyama
    Division of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoro, Nagasaki, Japan
    J Radiat Res 49:341-7. 2008
    ..Polaprezinc treatment resulted in decreases of p53 accumulation, p21(WAF1/CIP1) and Bax expression after irradiation. Polaprezinc has a protective effect against ionizing radiation induced apoptosis in rat jejunal crypt cells...
  28. ncbi request reprint Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
    Hiroyuki Namba
    Department of Molecular Medicine, Tissue and Histopathology Section, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Sakamoto, Japan
    J Clin Endocrinol Metab 88:4393-7. 2003
    ..033) and clinical stage (P = 0.049). Our results indicate that activating mutation of BRAF gene could be a potentially useful marker of prognosis of patients with advanced thyroid cancers...
  29. doi request reprint Pelvic pain in women with ovarian endometrioma is mostly associated with coexisting peritoneal lesions
    Khaleque Newaz Khan
    Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Hum Reprod 28:109-18. 2013
    ..Is the occurrence of pelvic pain in women with ovarian endometrioma associated with coexisting peritoneal lesions (PLs)?..
  30. pmc MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells
    Kayoko Matsushima
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    J Transl Med 9:30. 2011
    ..Accumulating evidence indicates that deregulation of miR is associated with human malignancies including ESCC. The aim of this study was to identify miR that could be specifically expressed and exert distinct biological actions in ESCC...
  31. pmc Significance of genomic instability in breast cancer in atomic bomb survivors: analysis of microarray-comparative genomic hybridization
    Masahiro Oikawa
    Department of Human Genetics, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Radiat Oncol 6:168. 2011
    ....
  32. ncbi request reprint Correlation of donor-derived keratinocytes and severity of graft-versus-host disease (GVHD) in epidermis
    Daisuke Niino
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Pathol Res Pract 200:775-81. 2005
    ..We hypothesize that donor-derived stem cells may play a role in the regeneration of damaged keratinocytes in GVHD...
  33. ncbi request reprint The protective effect of fermented milk kefir on radiation-induced apoptosis in colonic crypt cells of rats
    Mutsumi Matsuu
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, Nagasaki 852 8523, Japan
    J Radiat Res 44:111-5. 2003
    ..The antiapoptotic effect of fermented milk kefir was due to the inhibition of caspase-3 activation...
  34. doi request reprint Cell proliferation effect of GnRH agonist on pathological lesions of women with endometriosis, adenomyosis and uterine myoma
    Khaleque Newaz Khan
    Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan
    Hum Reprod 25:2878-90. 2010
    ..Here, we investigated expression of GnRH receptors (GnRHRs) and effect of GnRHa on the proliferation of cells derived from endometria and pathological lesions of women with these reproductive diseases...
  35. ncbi request reprint Norepinephrine enhances radiosensitivity in rat ileal epithelial cells
    Mutsumi Matsuu-Matsuyama
    Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Sciences
    J Radiat Res 52:369-73. 2011
    ..These results showing enhanced radiosensitivity of rat ileal epithelial cells by NE suggest that NE may be one of the factors which aggravate acute radiation injury in the intestine...
  36. ncbi request reprint Expression of parathyroid hormone (PTH)-related peptide (PthrP) and PTH/PTHrP receptor in osteoclast-like giant cells
    Masahiro Nakashima
    Tissue and Histopathology Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan
    Pathol Res Pract 199:85-92. 2003
    ..Thus, although PTHrP expression was commonly observed in various types of multinucleated giant cells, their immunohistochemical profiles for PPR were distinct. We conclude that PPR might play a role during OCGC formation in GCTB and ATC...
  37. doi request reprint One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formation
    Rodrigo Hamuy
    Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Wound Repair Regen 21:141-54. 2013
    ....
  38. ncbi request reprint Antibody to eosinophil cationic protein suppresses dextran sulfate sodium-induced colitis in rats
    Kazuko Shichijo
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    World J Gastroenterol 11:4505-10. 2005
    ..To produce an antibody against rat eosinophil cationic protein (ECP) and to examine the effects of the antibody in rats with dextran sulfate sodium (DSS)-induced colitis...
  39. ncbi request reprint Expression of pituitary tumor transforming gene in human gastric carcinoma
    Chun Yang Wen
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    World J Gastroenterol 10:481-3. 2004
    ..However, there is little information on its expression in gastric carcinoma. We sought to investigate the expression of PTTG1 in gastric carcinoma and to explore the relationship between its expression and clinicopathological factors...
  40. doi request reprint A Predictive Factor of the Quality of Microarray Comparative Genomic Hybridization Analysis for Formalin-fixed Paraffin-embedded Archival Tissue
    Kenjiro Nakao
    Departments of Surgical Oncology Tumor and Diagnostic Pathology Biostatistics Section, Division of Scientific Data Registry Department of Human Genetics, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences Center for Industry, University and Government Cooperation, Nagasaki University Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan
    Diagn Mol Pathol 22:174-80. 2013
    ..The double-stranded DNA ratio can be used to predict the performance of aCGH analysis for DNA from FFPE samples. Using this quality metric, valuable FFPE archival tissue samples can be utilized for aCGH analysis. ..
  41. doi request reprint The usefulness of basic fibroblast growth factor for radiation-exposed tissue
    Naoshi Kinoshita
    Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Wound Repair Regen 20:91-102. 2012
    ..Thus, bFGF improved and maintained the tissue viability after immediate irradiation in the skin and soft tissue...
  42. ncbi request reprint Intimal sarcoma of the pulmonary artery: report of an autopsy case
    Shiro Miura
    Department of Molecular Pathology, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Pathol Res Pract 201:469-74. 2005
    ....
  43. ncbi request reprint Loss of heterozygosity on chromosome 9q22.3 in microdissected basal cell carcinomas around the Semipalatinsk Nuclear Testing Site, Kazakhstan
    Kenji Iwata
    Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Hum Pathol 35:460-4. 2004
    ..03). The higher incidence of LOH on 9q22.3 in BCC from around SNTS suggests involvement of chronic low-dose irradiation by fallout from the test site as a factor in the cancers...
  44. ncbi request reprint Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer
    Katsu Ishigaki
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Clin Endocrinol Metab 87:3433-40. 2002
    ..Our results suggest that aberrant activation of Wnt/beta-catenin signaling is strongly involved in thyroid tumorigenesis...
  45. ncbi request reprint Autocrine/paracrine role of the angiopoietin-1 and -2/Tie2 system in cell proliferation and chemotaxis of cultured fibroblastic synoviocytes in rheumatoid arthritis
    Kazuhiro Takahara
    Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Japan
    Hum Pathol 35:150-8. 2004
    ..Our results suggest that the autocrine/paracrine signaling of the Ang/Tie2 system is important for the up-regulated angiogenesis in the RA synovium, as well as for synoviocyte behavior, by regulating chemotactic cell movement...
  46. ncbi request reprint IL-11 up-regulates Tie-2 expression during the healing of gastric ulcers in rats
    Chun Yang Wen
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    World J Gastroenterol 9:788-90. 2003
    ..To investigate Tie-2 expression during the repair of acetic acid-induced gastric ulcers in rats treated with recombinant human IL-11 (rhIL-11) and in untreated control animals...
  47. doi request reprint DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts
    Sachio Makino
    Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Dermatol Sci 51:171-80. 2008
    ..Activation of the NF-kappaB pathway is thought to be closely linked to abnormal cell proliferation and ECM production in keloid fibroblasts...
  48. ncbi request reprint The selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cells
    Alexei Podtcheko
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    J Clin Endocrinol Metab 88:1889-96. 2003
    ..Taken together, these results suggest that selective suppression of c-ABL activity by STI571 may represent a potential anticancer strategy for p53-mutated undifferentiated thyroid carcinomas...
  49. doi request reprint Dynamics of ionizing radiation-induced DNA damage response in reconstituted three-dimensional human skin tissue
    Keiji Suzuki
    Atomic Bomb Disease Institute, Course of Life Sciences and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Radiat Res 174:415-23. 2010
    ..These results confirmed a dynamic DNA damage response in three-dimensional tissue, which provides a practical model for studying DNA damage response in vivo...
  50. pmc Patterns of FOXE1 expression in papillary thyroid carcinoma by immunohistochemistry
    Andrey Bychkov
    Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Thyroid 23:817-28. 2013
    ..Its role in thyroid carcinogenesis, however, remains unknown. The purpose of the present study was to assess the relationship between the FOXE1 immunohistochemical features and the clinical and genetic characteristics of PTC...
  51. doi request reprint Toll-like receptor system and endometriosis
    Khaleque Newaz Khan
    Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Obstet Gynaecol Res 39:1281-92. 2013
    ..In the first part of this review article, the fundamentals of innate immune system, functional characteristics of TLR and signaling pathways of TLR4 are discussed for easy understanding by the readers. ..
  52. ncbi request reprint Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia
    Boban Stanojevic
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Endocr J 58:381-93. 2011
    ..However, it has a potential to contribute to patients stratification into high- and low-risk groups...
  53. ncbi request reprint Mechanism of the antiulcerogenic effect of IL-11 on acetic acid-induced gastric ulcer in rats
    Chun Yang Wen
    Department of Molecular Pathology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, 1 12 4, Sakamoto, Nagasaki, 852 8523, Japan
    Life Sci 70:2997-3005. 2002
    ..IL-11alpha receptor expression was observed in the mucosal neck cells of the rhIL-11-treated rats and control rats. These findings suggest that IL-11 accelerates ulcer healing by inducing the proliferation of mucosal and muscular cells...
  54. pmc Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study
    Yoshiki Yoshihara
    Division of Orthopaedic Pathomechanism, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Arthritis Res Ther 6:R347-54. 2004
    ..Longitudinal studies are required to assess the association between HTLV-I infection and OA...
  55. ncbi request reprint Genetic profile and determinants of homocysteine levels in Kazakhstan patients with breast cancer
    Ainur Akilzhanova
    Professor and Chairman, Department of Global Health, Medicine and Welfare, Atomic Bomb Disease Institute, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Anticancer Res 33:4049-59. 2013
    ..Aim: To analyze associations between homocysteine level, MTHFR and FTO rs1477196 polymorphisms and folate status in patients with breast cancer (BC) in order to clarify determinants of hyperhomocysteinemia...
  56. ncbi request reprint Relationship between period of survival and clinicopathological characteristics in patients with hepatocellular carcinoma who underwent hepatectomy
    Atsushi Nanashima
    Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Hepatogastroenterology 57:540-6. 2010
    ..We examined the relationship between clinicopathological parameters' and survival periods in 234 HCC patients who underwent hepatectomy...
  57. ncbi request reprint Living-donor liver transplantation from second generation children for atomic bomb survivors
    Susumu Eguchi
    Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Hepatol Res 39:1150-2. 2009
    ..Post transplant course was uneventful without any systemic disorders under regular immunosuppression schema during 3-year follow-up. The detailed results are herein reported for the first time in the literature...
  58. doi request reprint Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis
    Khaleque Newaz Khan
    Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Fertil Steril 94:2860-3.e1-3. 2010
    ....