Research Topics
Genomes and Genes | Norisato MitsutakeSummaryAffiliation: Nagasaki University Country: Japan Publications
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Publications
Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrestDmitry Bulgin
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
Thyroid 16:217-24. 2006..Hence, pharmacological interference with JNK pathway in combination with radiotherapy may be a promising treatment of ATC...- Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusivelyNorisato Mitsutake
Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, and Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital of Medicine and Dentistry, Japan
Endocrinology 148:1797-803. 2007..These results suggest that cancer stem-like cells are partly, but not exclusively, enriched in SP population. Clarifying the key tumorigenic population might contribute to the establishment of a novel therapy for thyroid cancer... 
Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cellsShu Takakura
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
Cancer Sci 99:1147-54. 2008..In conclusion, these findings suggest that the miR-17-92 cluster plays an important role in certain types of ATCs and could be a novel target for ATC treatment...
MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cellsKayoko Matsushima
Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
J Transl Med 9:30. 2011..Accumulating evidence indicates that deregulation of miR is associated with human malignancies including ESCC. The aim of this study was to identify miR that could be specifically expressed and exert distinct biological actions in ESCC...- Overexpression of wild-type THRbeta1 suppresses the growth and invasiveness of human papillary thyroid cancer cellsIlya Sedliarou
Departments of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
Anticancer Res 27:3999-4009. 2007..Thyroid hormone receptors (THRs) are transcription factors which regulate cell growth and differentiation. The compromised function of THRs has been reported in several human malignancies, suggesting their implication in carcinogenesis... - Imatinib enhances docetaxel-induced apoptosis through inhibition of nuclear factor-κB activation in anaplastic thyroid carcinoma cellsEunsook Kim
Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Thyroid 22:717-24. 2012..In this study, therefore, we investigated whether imatinib enhances the antitumor activity of docetaxel in ATC cells... - Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinomaNatallia M Akulevich
Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
Endocr Relat Cancer 16:491-503. 2009..32, 95% CI 1.57-6.99). The results indicate that polymorphisms of DNA damage response genes may be potential risk modifiers of ionizing radiation-induced or sporadic PTCs... - Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introductionKeiji Suzuki
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan
PLoS ONE 6:e19354. 2011..The presently described culture system may be useful for regenerative medicine, but the primary importance will be as a tool to elucidate the mechanisms of thyroid diseases... - Functional characterization of the novel BRAF complex mutation, BRAF(V600delinsYM) , identified in papillary thyroid carcinomaMichiko Matsuse
Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Int J Cancer 132:738-43. 2013..These findings suggest that the novel BRAF mutation, BRAF(V600delinsYM) , is a gain-of-function mutation and plays an important role in PTC development... - The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpressionAlexander Abrosimov
Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
Endocr Pathol 18:68-75. 2007..In general, it does not prove to be a prognosticator of PTC aggressiveness. A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human PTCs and PMCs... - Mutation analysis of RAP1 gene in papillary thyroid carcinomasMichiko Matsuse
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
Endocr J 56:161-4. 2009..No mutations in either RAP1A or RAP1B genes were found. These results suggest that RAP1 mutation does not play an important role in PTC pathogenesis... - BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kappaB activationIryna Palona
Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki University Hospital, 852 8523, Japan
Endocrinology 147:5699-707. 2006..Inactivation of NF-kappaB may provide a new therapeutic modality for thyroid cancers with BRAFV600E... - miR-196a downregulation increases the expression of type I and III collagens in keloid fibroblastsKazuya Kashiyama
Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
J Invest Dermatol 132:1597-604. 2012..Downregulation of miR-196a may be one of the mechanisms by which collagens are highly deposited in keloid tissues. Our findings suggest that miR-196a could be a new therapeutic target for keloid lesions... - miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cellsKenta Ujifuku
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
Cancer Lett 296:241-8. 2010..In conclusion, our findings suggest that those miRNAs may play a role in acquired TMZ resistance and could be a novel target for recurrent GBM treatment... - Different structural components of conventional papillary thyroid carcinoma display mostly identical BRAF statusAlexander Abrosimov
Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Int J Cancer 120:196-200. 2007.... - Reciprocal paracrine interactions between normal human epithelial and mesenchymal cells protect cellular DNA from radiation-induced damageYuka Nakazawa
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Int J Radiat Oncol Biol Phys 71:567-77. 2008..To explore whether interactions between normal epithelial and mesenchymal cells can modulate the extent of radiation-induced DNA damage in one or both types of cells... - DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblastsSachio Makino
Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
J Dermatol Sci 51:171-80. 2008..Activation of the NF-kappaB pathway is thought to be closely linked to abnormal cell proliferation and ECM production in keloid fibroblasts... - Copy number alteration and uniparental disomy analysis categorizes Japanese papillary thyroid carcinomas into distinct groupsMichiko Matsuse
Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan
PLoS ONE 7:e36063. 2012..These data suggest that Japanese PTCs may be classified into three distinct groups: CNA(+), UPD(+), and no chromosomal aberrations. BRAF(V600E) mutational status did not correlate with any parameters of chromosomal defects... - The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese populationMichiko Matsuse
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
J Med Genet 48:645-8. 2011..FOXE1 and NKX2-1 are two known genetic risk factors for the predisposition to sporadic papillary thyroid carcinoma (PTC) in Europeans, but their association in other ethnicities is still unknown... - A novel role for thyroid hormone receptor beta in cellular radiosensitivityMichiko Matsuse
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
J Radiat Res 49:17-27. 2008..Mutant THRB produced a radioprotective effect, attenuated radiation-induced growth inhibition and cellular senescence. The results suggest that THRB may modulate cellular radiosensitivity and stress-induced senescence... - The selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cellsAlexei Podtcheko
Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
J Clin Endocrinol Metab 88:1889-96. 2003..Taken together, these results suggest that selective suppression of c-ABL activity by STI571 may represent a potential anticancer strategy for p53-mutated undifferentiated thyroid carcinomas... - Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiationAtsushi Kumagai
Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8523, Japan
Oncol Rep 16:123-6. 2006..These findings strongly suggest that this case is a poorly differentiated carcinoma that arose from PTC and implies a possible association of BRAF mutation with dedifferentiated phenotype of PTCs... - Mutational and clinico-pathological analysis of papillary thyroid carcinoma in SerbiaBoban Stanojevic
Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
Endocr J 58:381-93. 2011..However, it has a potential to contribute to patients stratification into high- and low-risk groups... - [Molecular mechanism of thyroid carcinogenesis]Shunichi Yamashita
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
Nihon Rinsho 65:1959-65. 2007..In this article, we mainly review thyroid carcinogenesis based on the evidence of radiation-induced cancer and cancer stem cell hypothesis... - Radiation exposure does not significantly contribute to the risk of recurrence of Chernobyl thyroid cancerPavel O Rumyantsev
Department of Radiosurgery, Medical Radiological Research Center of Russian Academy of Medical Sciences, Obninsk 249036, Russian Federation
J Clin Endocrinol Metab 96:385-93. 2011..Long-term results of treatment are not well known, especially in comparison with sporadic PTC... - One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formationRodrigo Hamuy
Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Wound Repair Regen 21:141-54. 2013.... - Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout miceMami Nakahara
Department of Medical Gene Technology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Endocrinology 151:4047-54. 2010..TSHR KO mice are, therefore, of value for future studies dissecting the autoimmune response to the mouse TSHR... - Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancerKatsu Ishigaki
Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
J Clin Endocrinol Metab 87:3433-40. 2002..Our results suggest that aberrant activation of Wnt/beta-catenin signaling is strongly involved in thyroid tumorigenesis... - Fibroblast-mediated in vivo and in vitro growth promotion of tumorigenic rat thyroid carcinoma cells but not normal Fisher rat thyroid follicular cellsOhki Saitoh
Department of Medical Gene Technology, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Thyroid 19:735-42. 2009..The objective of this study was to determine if epithelial-stromal interaction influenced the growth of thyroid carcinoma cells in vivo and in vitro and to determine if radiation had added or interacting effects... - Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodelingCleo Mesa
Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
Cancer Res 66:6521-9. 2006..The preferential induction of MMPs by BRAF could explain in part the more invasive behavior of thyroid cancers with BRAF mutations... - BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesisNorisato Mitsutake
Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Ohio 45267-0547, USA
Endocrinology 147:1014-9. 2006..These data indicate that BRAF is required for RET/PTC-induced MAPK activation in thyroid cells and support the notion that BRAF inactivation may be an attractive target for PTCs... - Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiationJeffrey A Knauf
Division of Endocrinology and Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0547, USA
Cancer Res 65:4238-45. 2005..This closely recapitulates the phenotype of BRAF-positive PTCs in humans and supports a key role for this oncogene in its pathogenesis... - Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cellsNorisato Mitsutake
Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0547, USA
Cancer Res 65:2465-73. 2005..However, in contrast to RET/PTC, BRAF(V600E) may facilitate the acquisition of secondary genetic events through induction of genomic instability, which may account for its aggressive properties... - Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathwayEfisio Puxeddu
Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Biol Chem 278:52131-8. 2003..As enzymes involved in prostanoid biosynthesis can be targeted with pharmacological inhibitors, these findings may have therapeutic implications...