Norisato Mitsutake

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. ncbi request reprint Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest
    Dmitry Bulgin
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Thyroid 16:217-24. 2006
  2. ncbi request reprint Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusively
    Norisato Mitsutake
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, and Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital of Medicine and Dentistry, Japan
    Endocrinology 148:1797-803. 2007
  3. doi request reprint Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells
    Shu Takakura
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Sci 99:1147-54. 2008
  4. pmc MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells
    Kayoko Matsushima
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    J Transl Med 9:30. 2011
  5. ncbi request reprint Overexpression of wild-type THRbeta1 suppresses the growth and invasiveness of human papillary thyroid cancer cells
    Ilya Sedliarou
    Departments of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Anticancer Res 27:3999-4009. 2007
  6. pmc Imatinib enhances docetaxel-induced apoptosis through inhibition of nuclear factor-κB activation in anaplastic thyroid carcinoma cells
    Eunsook Kim
    Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Thyroid 22:717-24. 2012
  7. doi request reprint Functional characterization of the novel BRAF complex mutation, BRAF(V600delinsYM) , identified in papillary thyroid carcinoma
    Michiko Matsuse
    Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Cancer 132:738-43. 2013
  8. pmc Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction
    Keiji Suzuki
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan
    PLoS ONE 6:e19354. 2011
  9. doi request reprint Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma
    Natallia M Akulevich
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Endocr Relat Cancer 16:491-503. 2009
  10. ncbi request reprint BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kappaB activation
    Iryna Palona
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki University Hospital, 852 8523, Japan
    Endocrinology 147:5699-707. 2006

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest
    Dmitry Bulgin
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Thyroid 16:217-24. 2006
    ..It has been shown that c-Jun NH(2)-terminal kinase (JNK) activation is one of the manifestations of radiation response in ATC cells...
  2. ncbi request reprint Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusively
    Norisato Mitsutake
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, and Takashi Nagai Memorial International Hibakusha Medical Center, Nagasaki University Hospital of Medicine and Dentistry, Japan
    Endocrinology 148:1797-803. 2007
    ..These results suggest that cancer stem-like cells are partly, but not exclusively, enriched in SP population. Clarifying the key tumorigenic population might contribute to the establishment of a novel therapy for thyroid cancer...
  3. doi request reprint Oncogenic role of miR-17-92 cluster in anaplastic thyroid cancer cells
    Shu Takakura
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Sci 99:1147-54. 2008
    ..In conclusion, these findings suggest that the miR-17-92 cluster plays an important role in certain types of ATCs and could be a novel target for ATC treatment...
  4. pmc MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells
    Kayoko Matsushima
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Sakamoto, Nagasaki, Japan
    J Transl Med 9:30. 2011
    ..Accumulating evidence indicates that deregulation of miR is associated with human malignancies including ESCC. The aim of this study was to identify miR that could be specifically expressed and exert distinct biological actions in ESCC...
  5. ncbi request reprint Overexpression of wild-type THRbeta1 suppresses the growth and invasiveness of human papillary thyroid cancer cells
    Ilya Sedliarou
    Departments of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Anticancer Res 27:3999-4009. 2007
    ..Thyroid hormone receptors (THRs) are transcription factors which regulate cell growth and differentiation. The compromised function of THRs has been reported in several human malignancies, suggesting their implication in carcinogenesis...
  6. pmc Imatinib enhances docetaxel-induced apoptosis through inhibition of nuclear factor-κB activation in anaplastic thyroid carcinoma cells
    Eunsook Kim
    Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Thyroid 22:717-24. 2012
    ..In this study, therefore, we investigated whether imatinib enhances the antitumor activity of docetaxel in ATC cells...
  7. doi request reprint Functional characterization of the novel BRAF complex mutation, BRAF(V600delinsYM) , identified in papillary thyroid carcinoma
    Michiko Matsuse
    Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Cancer 132:738-43. 2013
    ..These findings suggest that the novel BRAF mutation, BRAF(V600delinsYM) , is a gain-of-function mutation and plays an important role in PTC development...
  8. pmc Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction
    Keiji Suzuki
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan
    PLoS ONE 6:e19354. 2011
    ..The presently described culture system may be useful for regenerative medicine, but the primary importance will be as a tool to elucidate the mechanisms of thyroid diseases...
  9. doi request reprint Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma
    Natallia M Akulevich
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Endocr Relat Cancer 16:491-503. 2009
    ..32, 95% CI 1.57-6.99). The results indicate that polymorphisms of DNA damage response genes may be potential risk modifiers of ionizing radiation-induced or sporadic PTCs...
  10. ncbi request reprint BRAFV600E promotes invasiveness of thyroid cancer cells through nuclear factor kappaB activation
    Iryna Palona
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki University Hospital, 852 8523, Japan
    Endocrinology 147:5699-707. 2006
    ..Inactivation of NF-kappaB may provide a new therapeutic modality for thyroid cancers with BRAFV600E...
  11. ncbi request reprint Mutation analysis of RAP1 gene in papillary thyroid carcinomas
    Michiko Matsuse
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Endocr J 56:161-4. 2009
    ..No mutations in either RAP1A or RAP1B genes were found. These results suggest that RAP1 mutation does not play an important role in PTC pathogenesis...
  12. ncbi request reprint The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpression
    Alexander Abrosimov
    Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, 852 8523, Japan
    Endocr Pathol 18:68-75. 2007
    ..In general, it does not prove to be a prognosticator of PTC aggressiveness. A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human PTCs and PMCs...
  13. doi request reprint miR-196a downregulation increases the expression of type I and III collagens in keloid fibroblasts
    Kazuya Kashiyama
    Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Invest Dermatol 132:1597-604. 2012
    ..Downregulation of miR-196a may be one of the mechanisms by which collagens are highly deposited in keloid tissues. Our findings suggest that miR-196a could be a new therapeutic target for keloid lesions...
  14. doi request reprint miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells
    Kenta Ujifuku
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Cancer Lett 296:241-8. 2010
    ..In conclusion, our findings suggest that those miRNAs may play a role in acquired TMZ resistance and could be a novel target for recurrent GBM treatment...
  15. doi request reprint DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts
    Sachio Makino
    Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Dermatol Sci 51:171-80. 2008
    ..Activation of the NF-kappaB pathway is thought to be closely linked to abnormal cell proliferation and ECM production in keloid fibroblasts...
  16. ncbi request reprint Different structural components of conventional papillary thyroid carcinoma display mostly identical BRAF status
    Alexander Abrosimov
    Department of International Health and Radiation Research, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Cancer 120:196-200. 2007
    ....
  17. doi request reprint Reciprocal paracrine interactions between normal human epithelial and mesenchymal cells protect cellular DNA from radiation-induced damage
    Yuka Nakazawa
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Radiat Oncol Biol Phys 71:567-77. 2008
    ..To explore whether interactions between normal epithelial and mesenchymal cells can modulate the extent of radiation-induced DNA damage in one or both types of cells...
  18. doi request reprint The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population
    Michiko Matsuse
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Med Genet 48:645-8. 2011
    ..FOXE1 and NKX2-1 are two known genetic risk factors for the predisposition to sporadic papillary thyroid carcinoma (PTC) in Europeans, but their association in other ethnicities is still unknown...
  19. pmc Copy number alteration and uniparental disomy analysis categorizes Japanese papillary thyroid carcinomas into distinct groups
    Michiko Matsuse
    Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan
    PLoS ONE 7:e36063. 2012
    ..These data suggest that Japanese PTCs may be classified into three distinct groups: CNA(+), UPD(+), and no chromosomal aberrations. BRAF(V600E) mutational status did not correlate with any parameters of chromosomal defects...
  20. ncbi request reprint A novel role for thyroid hormone receptor beta in cellular radiosensitivity
    Michiko Matsuse
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Radiat Res 49:17-27. 2008
    ..Mutant THRB produced a radioprotective effect, attenuated radiation-induced growth inhibition and cellular senescence. The results suggest that THRB may modulate cellular radiosensitivity and stress-induced senescence...
  21. ncbi request reprint The selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cells
    Alexei Podtcheko
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    J Clin Endocrinol Metab 88:1889-96. 2003
    ..Taken together, these results suggest that selective suppression of c-ABL activity by STI571 may represent a potential anticancer strategy for p53-mutated undifferentiated thyroid carcinomas...
  22. doi request reprint Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma
    Mika Shimamura
    MD, Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523 Japan
    Endocrinology 154:4423-30. 2013
    ..These results suggest that BRAF(V600E) does not appear to induce PTC-like lesions when expressed in a fraction of thyroid cells postnatally under normal TSH concentrations. ..
  23. doi request reprint One-stage, simultaneous skin grafting with artificial dermis and basic fibroblast growth factor successfully improves elasticity with maturation of scar formation
    Rodrigo Hamuy
    Division of Plastic and Reconstructive Surgery, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Wound Repair Regen 21:141-54. 2013
    ....
  24. pmc Patterns of FOXE1 expression in papillary thyroid carcinoma by immunohistochemistry
    Andrey Bychkov
    Department of Radiation Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Thyroid 23:817-28. 2013
    ..Its role in thyroid carcinogenesis, however, remains unknown. The purpose of the present study was to assess the relationship between the FOXE1 immunohistochemical features and the clinical and genetic characteristics of PTC...
  25. ncbi request reprint Childhood thyroid carcinoma with BRAFT1799A mutation shows unique pathological features of poor differentiation
    Atsushi Kumagai
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8523, Japan
    Oncol Rep 16:123-6. 2006
    ..These findings strongly suggest that this case is a poorly differentiated carcinoma that arose from PTC and implies a possible association of BRAF mutation with dedifferentiated phenotype of PTCs...
  26. ncbi request reprint Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia
    Boban Stanojevic
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Endocr J 58:381-93. 2011
    ..However, it has a potential to contribute to patients stratification into high- and low-risk groups...
  27. ncbi request reprint [Molecular mechanism of thyroid carcinogenesis]
    Shunichi Yamashita
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences
    Nihon Rinsho 65:1959-65. 2007
    ..In this article, we mainly review thyroid carcinogenesis based on the evidence of radiation-induced cancer and cancer stem cell hypothesis...
  28. doi request reprint Radiation exposure does not significantly contribute to the risk of recurrence of Chernobyl thyroid cancer
    Pavel O Rumyantsev
    Department of Radiosurgery, Medical Radiological Research Center of Russian Academy of Medical Sciences, Obninsk 249036, Russian Federation
    J Clin Endocrinol Metab 96:385-93. 2011
    ..Long-term results of treatment are not well known, especially in comparison with sporadic PTC...
  29. doi request reprint Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout mice
    Mami Nakahara
    Department of Medical Gene Technology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Endocrinology 151:4047-54. 2010
    ..TSHR KO mice are, therefore, of value for future studies dissecting the autoimmune response to the mouse TSHR...
  30. ncbi request reprint Aberrant localization of beta-catenin correlates with overexpression of its target gene in human papillary thyroid cancer
    Katsu Ishigaki
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Clin Endocrinol Metab 87:3433-40. 2002
    ..Our results suggest that aberrant activation of Wnt/beta-catenin signaling is strongly involved in thyroid tumorigenesis...
  31. doi request reprint SNAIL induces epithelial-to-mesenchymal transition and cancer stem cell-like properties in aldehyde dehydroghenase-negative thyroid cancer cells
    Kazuaki Yasui
    Department of Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Thyroid 23:989-96. 2013
    ..It is not clear if there is a link between EMT and CSCs in thyroid cancers. We therefore investigated the CSC properties of thyroid cancers that underwent EMT...
  32. doi request reprint Fibroblast-mediated in vivo and in vitro growth promotion of tumorigenic rat thyroid carcinoma cells but not normal Fisher rat thyroid follicular cells
    Ohki Saitoh
    Department of Medical Gene Technology, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Thyroid 19:735-42. 2009
    ..The objective of this study was to determine if epithelial-stromal interaction influenced the growth of thyroid carcinoma cells in vivo and in vitro and to determine if radiation had added or interacting effects...
  33. ncbi request reprint Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells
    Norisato Mitsutake
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0547, USA
    Cancer Res 65:2465-73. 2005
    ..However, in contrast to RET/PTC, BRAF(V600E) may facilitate the acquisition of secondary genetic events through induction of genomic instability, which may account for its aggressive properties...
  34. ncbi request reprint Microsomal prostaglandin E2 synthase-1 is induced by conditional expression of RET/PTC in thyroid PCCL3 cells through the activation of the MEK-ERK pathway
    Efisio Puxeddu
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 278:52131-8. 2003
    ..As enzymes involved in prostanoid biosynthesis can be targeted with pharmacological inhibitors, these findings may have therapeutic implications...
  35. ncbi request reprint Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    Jeffrey A Knauf
    Division of Endocrinology and Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0547, USA
    Cancer Res 65:4238-45. 2005
    ..This closely recapitulates the phenotype of BRAF-positive PTCs in humans and supports a key role for this oncogene in its pathogenesis...
  36. ncbi request reprint Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling
    Cleo Mesa
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Cancer Res 66:6521-9. 2006
    ..The preferential induction of MMPs by BRAF could explain in part the more invasive behavior of thyroid cancers with BRAF mutations...
  37. ncbi request reprint BRAF mediates RET/PTC-induced mitogen-activated protein kinase activation in thyroid cells: functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis
    Norisato Mitsutake
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, Ohio 45267 0547, USA
    Endocrinology 147:1014-9. 2006
    ..These data indicate that BRAF is required for RET/PTC-induced MAPK activation in thyroid cells and support the notion that BRAF inactivation may be an attractive target for PTCs...