Yoshinao Kubo


Affiliation: Nagasaki University
Country: Japan


  1. Kubo Y, Ishimoto A, Amanuma H. N-Linked glycosylation is required for XC cell-specific syncytium formation by the R peptide-containing envelope protein of ecotropic murine leukemia viruses. J Virol. 2003;77:7510-6 pubmed
    ..This suggests that N glycosylation of a molecule(s) other than the receptor is required for the induction of XC cell syncytia by the R(+) Env protein. ..
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    Kubo Y, Amanuma H. Mutational analysis of the R peptide cleavage site of Moloney murine leukaemia virus envelope protein. J Gen Virol. 2003;84:2253-7 pubmed
    ..This result strongly supports that R peptide cleavage is required for virus entry. ..
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    Kubo Y, Ishimoto A, Ono T, Yoshii H, Tominaga C, Mitani C, et al. Determinant for the inhibition of ecotropic murine leukemia virus infection by N-linked glycosylation of the rat receptor. Virology. 2004;330:82-91 pubmed
    ..These results indicate that the extra amino acids in the rCAT1 (as compared to the mCAT1) are associated with inhibition of ecotropic MLV infection by the rCAT1 glycosylation. ..
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    Kubo Y, Tominaga C, Yoshii H, Kamiyama H, Mitani C, Amanuma H, et al. Characterization of R peptide of murine leukemia virus envelope glycoproteins in syncytium formation and entry. Arch Virol. 2007;152:2169-82 pubmed
    ..These results provide valuable information for construction of efficient MLV vectors and for understanding the retroviral entry mechanism...
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    Kubo Y, Ishimoto A, Amanuma H. Genistein, a protein tyrosine kinase inhibitor, suppresses the fusogenicity of Moloney murine leukemia virus envelope protein in XC cells. Arch Virol. 2003;148:1899-914 pubmed
    ..This result indicates that protein tyrosine kinase activity is associated with the high sensitivity of XC cells to ecotropic Env-induced syncytium formation. ..
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    Kubo Y, Yokoyama M, Yoshii H, Mitani C, Tominaga C, Tanaka Y, et al. Inhibitory role of CXCR4 glycan in CD4-independent X4-tropic human immunodeficiency virus type 1 infection and its abrogation in CD4-dependent infection. J Gen Virol. 2007;88:3139-44 pubmed
    ..These findings indicate that it will be advantageous for X4 HIV-1 to remain CD4-dependent. A structural model that explains the glycan-mediated inhibition is discussed. ..
  7. Kubo Y, Yoshii H, Kamiyama H, Tominaga C, Tanaka Y, Sato H, et al. Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection. Virology. 2008;375:130-40 pubmed publisher