Toshihisa Komori

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. pmc Functions of the osteocyte network in the regulation of bone mass
    Toshihisa Komori
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852 8588, Japan
    Cell Tissue Res 352:191-8. 2013
  2. ncbi request reprint Regulation of bone development and maintenance by Runx2
    Toshihisa Komori
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    Front Biosci 13:898-903. 2008
  3. doi request reprint Regulation of bone development and extracellular matrix protein genes by RUNX2
    Toshihisa Komori
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Cell Tissue Res 339:189-95. 2010
  4. doi request reprint Regulation of osteoblast differentiation by Runx2
    Toshihisa Komori
    Unit of BasicMedical Sciences, Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Adv Exp Med Biol 658:43-9. 2010
  5. doi request reprint Signaling networks in RUNX2-dependent bone development
    Toshihisa Komori
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    J Cell Biochem 112:750-5. 2011
  6. pmc SP7 inhibits osteoblast differentiation at a late stage in mice
    Carolina A Yoshida
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    PLoS ONE 7:e32364. 2012
  7. pmc Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading
    Takeshi Moriishi
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    PLoS ONE 7:e40143. 2012
  8. pmc Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis
    Takeshi Moriishi
    Department of Cell Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    PLoS ONE 6:e27487. 2011
  9. doi request reprint Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects
    Takafumi Maeno
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    Bone 49:673-82. 2011
  10. ncbi request reprint Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency
    Zenjiro Maruyama
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Dev Dyn 236:1876-90. 2007

Collaborators

Detail Information

Publications59

  1. pmc Functions of the osteocyte network in the regulation of bone mass
    Toshihisa Komori
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852 8588, Japan
    Cell Tissue Res 352:191-8. 2013
    ..In this condition, Rankl upregulation in osteoblasts and Sost upregulation in osteocytes are, at least in part, responsible for enhanced bone resorption and suppressed bone formation, respectively...
  2. ncbi request reprint Regulation of bone development and maintenance by Runx2
    Toshihisa Komori
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    Front Biosci 13:898-903. 2008
    ..Runx2 is also involved in the catabolic effect of PTH through the induction of Tnfsf11. Thus, Runx2 regulates bone development, bone maturation, and bone maintenance through the regulation of osteoblast differentiation and function...
  3. doi request reprint Regulation of bone development and extracellular matrix protein genes by RUNX2
    Toshihisa Komori
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Cell Tissue Res 339:189-95. 2010
    ..During dentinogenesis, Runx2 expression is downregulated, and RUNX2 inhibits the terminal differentiation of odontoblasts...
  4. doi request reprint Regulation of osteoblast differentiation by Runx2
    Toshihisa Komori
    Unit of BasicMedical Sciences, Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Adv Exp Med Biol 658:43-9. 2010
    ..Furthermore, Runx2 triggers the expression of major bone matrix genes during the early stages of osteoblast differentiation, but Runx2 is not essential for the maintenance of these gene expressions in mature osteoblasts...
  5. doi request reprint Signaling networks in RUNX2-dependent bone development
    Toshihisa Komori
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    J Cell Biochem 112:750-5. 2011
    ..Thus, RUNX2 regulates osteoblast differentiation and chondrocyte maturation through the network with SP7 and with FGF, Wnt, and IHH signaling pathways during skeletal development...
  6. pmc SP7 inhibits osteoblast differentiation at a late stage in mice
    Carolina A Yoshida
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    PLoS ONE 7:e32364. 2012
    ..These findings suggest that SP7 and RUNX2 inhibit osteoblast differentiation at a late stage in a manner independent of RUNX2 and SP7, respectively, and SP7 positively regulates its own promoter...
  7. pmc Osteocyte network; a negative regulatory system for bone mass augmented by the induction of Rankl in osteoblasts and Sost in osteocytes at unloading
    Takeshi Moriishi
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    PLoS ONE 7:e40143. 2012
    ....
  8. pmc Overexpression of Bcl2 in osteoblasts inhibits osteoblast differentiation and induces osteocyte apoptosis
    Takeshi Moriishi
    Department of Cell Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    PLoS ONE 6:e27487. 2011
    ..These findings indicate that overexpression of BCL2 in osteoblasts inhibits osteoblast differentiation, reduces osteocyte processes, and causes osteocyte apoptosis...
  9. doi request reprint Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects
    Takafumi Maeno
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    Bone 49:673-82. 2011
    ....
  10. ncbi request reprint Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency
    Zenjiro Maruyama
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Dev Dyn 236:1876-90. 2007
    ....
  11. doi request reprint Akt regulates skeletal development through GSK3, mTOR, and FoxOs
    Satoshi Rokutanda
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Dev Biol 328:78-93. 2009
    ....
  12. doi request reprint Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis
    Yuying Wang
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    Bone 50:409-19. 2012
    ..These findings indicate that Pdk4 plays an important role in bone loss at unloading by promoting osteoclastogenesis...
  13. doi request reprint Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation
    Masaki Mikasa
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    J Bone Miner Metab 29:291-9. 2011
    ..These findings indicate that Runx2 regulates chondrocyte maturation and proliferation at least partly through the induction of Tcf7...
  14. ncbi request reprint Inhibition of the terminal differentiation of odontoblasts and their transdifferentiation into osteoblasts in Runx2 transgenic mice
    Toshihiro Miyazaki
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Arch Histol Cytol 71:131-46. 2008
    ..Thus, Runx2 expression has to be down-regulated during odontoblast differentiation to acquire full odontoblast differentiation for dentinogenesis...
  15. doi request reprint Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass
    Ritsuko Masuyama
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Bone Miner Res 27:1708-21. 2012
    ..These results indicate that TRPV4 activation reciprocally regulates Ca(2+)/calmodulin signaling, which involves an association of TRPV4 with myosin IIa, and promotes sufficient osteoclast function...
  16. doi request reprint Galnt3 deficiency disrupts acrosome formation and leads to oligoasthenoteratozoospermia
    Toshihiro Miyazaki
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Histochem Cell Biol 139:339-54. 2013
    ....
  17. ncbi request reprint [Molecular mechanisms of the regulation of osteoblast and chondrocyte differentiation and bone formation]
    Toshihisa Komori
    Division of Cell Biology, Department of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Seikagaku 78:501-8. 2006
  18. doi request reprint [Regulation of bone mass by osteocyte network]
    Takeshi Moriishi
    Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Clin Calcium 22:705-12. 2012
    ....
  19. ncbi request reprint Regulation of skeletal development by the Runx family of transcription factors
    Toshihisa Komori
    Department of Developmental and Reconstructive Medicine, Division of Oral Cytology and Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    J Cell Biochem 95:445-53. 2005
    ..Therefore, elucidation of the signaling pathways through Runx2 and Runx3 will unravel the complex mechanism of skeletal development...
  20. ncbi request reprint Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development
    Naoko Kanatani
    Department of Developmental and Reconstructive Medicine, Division of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Dev Biol 296:48-61. 2006
    ..These findings demonstrate that Runx2 isoforms exert their functions through at least partly different mechanisms and Cbfbeta regulates bone development by regulating Runx2 function isoform-dependently...
  21. ncbi request reprint Regulation of osteoblast differentiation by transcription factors
    Toshihisa Komori
    Department of Developmental and Reconstructive Medicine, Division of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    J Cell Biochem 99:1233-9. 2006
    ..To gain an understanding of bone development, it is important to position these transcription factors to the right places in the processes of osteoblast differentiation...
  22. ncbi request reprint Role of Runx proteins in chondrogenesis
    Carolina A Yoshida
    Divisionof Oral Cytology Cell Biology, Departmentof Developmental Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Crit Rev Eukaryot Gene Expr 15:243-54. 2005
    ..It also highlights how Runx proteins regulate transcription of target genes and how Runx proteins are regulated in the cartilaginous skeleton...
  23. doi request reprint [Clinical aspect of recent progress in phosphate metabolism. The functions of osteocytes]
    Toshihisa Komori
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences
    Clin Calcium 19:837-43. 2009
    ..Further, osteocytes play an important role in phosphate metabolism, because osteocytes are important producers of FGF23, and FGF23 is upregulated in the osteocytes of Hyp mice and DMP1 knockout mice...
  24. ncbi request reprint Evaluation of 9.4-T MR microimaging in assessing normal and defective fetal bone development: comparison of MR imaging and histological findings
    Yoko Ichikawa
    Department of Radiology and Cancer Biology, Nagasaki University School of Dentistry, Nagasaki, Japan
    Bone 34:619-28. 2004
    ..We concluded that MR microimaging is useful in assessing the bone development...
  25. doi request reprint Immobilization-induced cartilage degeneration mediated through expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and chondromodulin-I
    Junya Sakamoto
    Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Connect Tissue Res 50:37-45. 2009
    ..Our results showed that immobilization induces thinning of the articular cartilage and appearance of vascular channel, in areas with balanced expression of HIF-1alpha/VEGF and ChM-1...
  26. pmc Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis
    Masahiro Iwamoto
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Dev Biol 305:40-51. 2007
    ..The results suggest that ERG is part of molecular mechanisms leading chondrocytes into a permanent developmental path and become joint forming cells, and may do so by acting downstream of GDF-5...
  27. ncbi request reprint BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines
    Tingjiao Liu
    Section of Oral Pathology, Department of Oral Restitution, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 211:728-35. 2007
    ....
  28. ncbi request reprint Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene
    Hirayuki Enomoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 278:23971-7. 2003
    ....
  29. pmc Bone morphogenetic protein rescues the lack of secondary cartilage in Runx2-deficient mice
    Hiroki Fukuoka
    Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Graduate School, Tokyo Medical and Dental University, Japan
    J Anat 211:8-15. 2007
    ....
  30. ncbi request reprint [Function of Osterix in osteoblasts]
    Zenjiro Maruyama
    Department of Rehabilitation, Tokyo Metropolitan Fuchu Hospital
    Nihon Rinsho 65:81-3. 2007
  31. ncbi request reprint [Cbfa1/Runx2, an essential transcription factor for the regulation of osteoblast differentiation]
    Toshihisa Komori
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan Science and Technology Corporation
    Nihon Rinsho 60:91-7. 2002
  32. ncbi request reprint [Multifunctional roles of Runx2/Cbfa1 in skeletal development]
    Tatsuya Furuichi
    Department of Molecular Medicine, Osaka University Graduate School of Medicine
    Nihon Rinsho 62:57-61. 2004
  33. ncbi request reprint Runx2 deficiency in chondrocytes causes adipogenic changes in vitro
    Hirayuki Enomoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Cell Sci 117:417-25. 2004
    ..Our findings suggest that these Runx2-dependent functions are mediated, at least in part, by interleukin-11...
  34. pmc Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    Carolina A Yoshida
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Genes Dev 18:952-63. 2004
    ..These findings demonstrate that Runx2 and Runx3 are essential for chondrocyte maturation and that Runx2 regulates limb growth by organizing chondrocyte maturation and proliferation through the induction of Ihh expression...
  35. ncbi request reprint Requisite roles of Runx2 and Cbfb in skeletal development
    Toshihisa Komori
    Department of Molecular Medicine, Osaka University Medical School, 2 2 Yamada oka, Suita 565 0871, Japan
    J Bone Miner Metab 21:193-7. 2003
    ..Core binding factor beta (Cbfb) is a cotranscription factor which forms a heterodimer with Runx proteins. Cbfb is required for the functions of Runx1 and Runx2. Thus, Runx2/Cbfb heterodimers play essential roles in skeletal development...
  36. ncbi request reprint Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
    Hideaki Sowa
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
    J Biol Chem 279:40267-75. 2004
    ..In osteoblasts the interaction of menin and the transforming growth factor-beta/Smad3 pathway negatively regulates the BMP-2/Smad1/5- and Runx2-induced transcriptional activities leading to inhibition of late-stage differentiation...
  37. ncbi request reprint Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation
    Fumitaka Ichida
    Department of Biochemistry and Fixed Prothodontics, Graduate School of Dentistry, Osaka University, Suita, Osaka, 565 0871 Japan
    J Biol Chem 279:34015-22. 2004
    ..These data indicate that Msx2 promotes osteoblast differentiation independently of Runx2 and negatively regulates adipocyte differentiation through inhibition of PPARgamma and the C/EBP family...
  38. pmc Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
    Takashi Fujita
    Department of Pharmacology, Setsunan University, Hirakata, Japan
    J Cell Biol 166:85-95. 2004
    ..These findings demonstrate that Runx2 and PI3K-Akt signaling are mutually dependent on each other in the regulation of osteoblast and chondrocyte differentiation and their migration...
  39. ncbi request reprint Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 111:621-33. 2002
    ..Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes...
  40. ncbi request reprint Core-binding factor beta interacts with Runx2 and is required for skeletal development
    Carolina A Yoshida
    Department of Molecular Medicine, Osaka University Medical School, 2 2 Yamada Oka Suita, Osaka 565 0871, Japan
    Nat Genet 32:633-8. 2002
    ..These findings indicate that Cbfbeta is required for the function of Runx2 in skeletal development...
  41. ncbi request reprint Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2
    Takashi Fujita
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, 573 0101, Japan
    J Cell Biochem 93:374-83. 2004
    ....
  42. pmc Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1
    Kyoichi Isono
    Developmental Genetics Group, RIKEN Research Center for Allergy and Immunology, Tsurumi ku, Yokohama 230 0045, Japan
    Genes Dev 19:536-41. 2005
    ..Importantly, the levels of Sf3b1 in PcG complexes were decreased in Sf3b1-heterozygous embryos. These findings suggest that Sf3b1-PcG protein interaction is essential for true PcG-mediated repression of Hox genes...
  43. ncbi request reprint The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis
    Motomi Enomoto-Iwamoto
    Department of Molecular, Cell and Tumor Biology, Osaka University Faculty of Dentistry, Suita, Osaka 565 0871, Japan
    Dev Biol 251:142-56. 2002
    ..Phases of skeletogenesis, such as terminal chondrocyte maturation and joint formation, appear to be particularly dependent on Wnt signaling and thus very sensitive to Frzb-1 antagonistic action...
  44. ncbi request reprint Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development
    Kang Young Choi
    Department of Biochemistry, School of Dentistry and Skeletal Diseases Genome Research Center, Kyungpook National University, 101 Dong In dong, Jung Gu, Daegu, 700 422, Korea
    Dev Dyn 233:115-21. 2005
    ..These results indicate that Runx2 is an important mediator of the expression of Bmp2 in response to FGF stimulation in cranial bone development...
  45. ncbi request reprint Runx2, a multifunctional transcription factor in skeletal development
    Toshihisa Komori
    Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Cell Biochem 87:1-8. 2002
    ..Therefore, the determination of Runx2 function and the investigation of the cascades of Runx2-dependent gene regulation are important in the elucidation of skeletal biology...
  46. ncbi request reprint Impaired vascular invasion of Cbfa1-deficient cartilage engrafted in the spleen
    Miki Himeno
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Japan
    J Bone Miner Res 17:1297-305. 2002
    ....
  47. ncbi request reprint Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts
    Zhong Jian Shen
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 3 10 Kanda Sunugadai 2 Chome Chiyoda ku, Tokyo, 101 Japan
    J Biol Chem 277:29840-6. 2002
    ..Finally, CIZ overexpression suppressed the formation of mineralized nodules in osteoblastic cell cultures. These data indicate that CIZ is a novel type inhibitor of BMP/Smad signaling...
  48. ncbi request reprint Runx2 is a target of mechanical unloading to alter osteoblastic activity and bone formation in vivo
    Ruchanee Salingcarnboriboon
    Department of Molecular Pharmacology, Tokyo Medical and Dental University, Japan
    Endocrinology 147:2296-305. 2006
    ..Finally, we propose Runx2 as a critical target gene in unloading to alter osteoblastic activity and bone formation in vivo...
  49. ncbi request reprint Impairment of bone healing by insulin receptor substrate-1 deficiency
    Takashi Shimoaka
    Departments of Orthopaedic Surgery, Tissue Engineering, and Metabolic Diseases, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo, Tokyo 113 8655, Japan
    J Biol Chem 279:15314-22. 2004
    ....
  50. ncbi request reprint Statins inhibit osteoblast migration by inhibiting Rac-Akt signaling
    Ryo Fukuyama
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata 573 0101, Japan
    Biochem Biophys Res Commun 315:636-42. 2004
    ....
  51. ncbi request reprint [Functions of BMPs, Runx2, and osterix in the development of bone and cartilage]
    Toshihisa Komori
    Division of Oral Cytology and Cell Biology, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences
    Nihon Rinsho 63:1671-7. 2005
    ....
  52. ncbi request reprint Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5
    Toru Moro
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Cell Physiol 204:927-33. 2005
    ..These results indicate that Cdk6 may be a regulator of chondrocyte differentiation and that its p38-mediated downregulation is involved in the efficient differentiation...
  53. pmc Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo
    Tomomasa Yokomizo
    Institute of Basic Medical Sciences and Center for TARA, University of Tsukuba, Tsukuba, Japan
    EMBO J 26:184-96. 2007
    ..These results provide evidence of the presence of GATA-1(+) hemangioblastic cells in the extra-embryonic region and also their functional contribution to hematopoiesis in the embryo...
  54. ncbi request reprint Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification
    Yoshihiro Tamamura
    Department of Orthopaedic Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:19185-95. 2005
    ....
  55. ncbi request reprint Aged mice require full transcription factor, Runx2/Cbfa1, gene dosage for cancellous bone regeneration after bone marrow ablation
    Kunikazu Tsuji
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    J Bone Miner Res 19:1481-9. 2004
    ..This indicates that full Runx2 dosage is needed for the maintenance of osteoblastic activity in adult mice...
  56. pmc Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells
    Toru Tanaka
    Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi, Gunma 371 8511, Japan
    Mol Cell Biol 28:1147-60. 2008
    ..We propose that Runx2 plays a pivotal role in osteogenic conversion tightly coupled with repression of the SMC phenotype in atherosclerotic lesions...
  57. ncbi request reprint Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice
    Choo ryung J Chung
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Dent Sci 51:105-13. 2004
    ..However, while rotational movement between the first and third week was increased in WT, it was not altered in Runx2(+/-) mice. These data indicate that Runx2 plays a role in cranium and the tooth development in adulthood...
  58. ncbi request reprint Delayed tooth eruption and suppressed osteoclast number in the eruption pathway of heterozygous Runx2/Cbfa1 knockout mice
    Shuichi Yoda
    Maxillofacial Orthognathics, Department of Maxillofacial Reconstruction and Function, Division of Maxillofacial Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Arch Oral Biol 49:435-42. 2004
    ..These results also suggest the possibility that impaired recruitment of osteoclasts is one of the cellular mechanisms of delayed tooth eruption in CCD patients...
  59. ncbi request reprint [Mechanism of transcriptional regulation by Runx2 in osteoblasts]
    Toshihisa Komori
    Nagasaki University Graduate School of Biomedical Sciences, Department of Developmental and Reconstructive Medicine, Division of Cell Biology
    Clin Calcium 16:801-7. 2006
    ..Therefore, Runx2 and PI3K-Akt signaling are mutually dependent each other in the regulation of osteoblast and chondrocyte differentiation and their migration...