A Kinoshita

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. ncbi Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease
    A Kinoshita
    Department of Human Genetics, Nagasaki University School of Medicine, Nagasaki, Japan
    Nat Genet 26:19-20. 2000
  2. ncbi Phase I and pharmacokinetic study of paclitaxel and irinotecan for patients with advanced non-small cell lung cancer
    T Kasai
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Eur J Cancer 38:1871-8. 2002
  3. pmc Phase II study of irinotecan combined with carboplatin in previously untreated small-cell lung cancer
    A Kinoshita
    National Nagasaki Medical Center, Nagasaki, Japan
    Br J Cancer 94:1267-71. 2006
  4. ncbi Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes
    K Ikeda
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Int J Cancer 82:599-604. 1999
  5. ncbi Phase I study of irinotecan and cisplatin with concurrent split-course radiotherapy in limited-disease small-cell lung cancer
    M Oka
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Japan
    Eur J Cancer 38:1998-2004. 2002
  6. ncbi Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus
    A Kinoshita
    Alzheimer Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurochem 82:839-47. 2002
  7. pmc Identification of eight novel NSD1 mutations in Sotos syndrome
    J Kamimura
    Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Med Genet 40:e126. 2003
  8. pmc Isolated congenital anosmia locus maps to 18p11.23-q12.2
    M Ghadami
    J Med Genet 41:299-303. 2004
  9. pmc A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family
    A Okubo
    Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Med Genet 41:e97. 2004
  10. ncbi Cloning of the gene and cDNA for human heart chymase
    H Urata
    Department of Heart and Hypertension Research, Cleveland Clinic Foundation, Ohio 44195 5069
    J Biol Chem 266:17173-9. 1991

Collaborators

Detail Information

Publications17

  1. ncbi Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease
    A Kinoshita
    Department of Human Genetics, Nagasaki University School of Medicine, Nagasaki, Japan
    Nat Genet 26:19-20. 2000
    ..1-q13.3, which two other groups confirmed. As the human transforming growth factor-1 gene (TGFB1) is located within this interval, we considered it a candidate gene for CED...
  2. ncbi Phase I and pharmacokinetic study of paclitaxel and irinotecan for patients with advanced non-small cell lung cancer
    T Kasai
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Eur J Cancer 38:1871-8. 2002
    ..However, the toxicity was tolerable. Paclitaxel 180 mg/m(2) and CPT-11 50 mg/m(2) were the recommended doses for further phase II study of this combination...
  3. pmc Phase II study of irinotecan combined with carboplatin in previously untreated small-cell lung cancer
    A Kinoshita
    National Nagasaki Medical Center, Nagasaki, Japan
    Br J Cancer 94:1267-71. 2006
    ..In conclusion, the combination of irinotecan and carboplatin is an active and well-tolerated regimen in cases of SCLC...
  4. ncbi Adult T-cell leukemia cells over-express the multidrug-resistance-protein (MRP) and lung-resistance-protein (LRP) genes
    K Ikeda
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Int J Cancer 82:599-604. 1999
    ..Our findings suggest that the MRP and LRP genes in ATL are often activated by HTLV-I infection and may confer MDR of ATL cells in vivo. Combined chemotherapy with inhibitors of these MDR genes may be promising in the treatment of ATL...
  5. ncbi Phase I study of irinotecan and cisplatin with concurrent split-course radiotherapy in limited-disease small-cell lung cancer
    M Oka
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Japan
    Eur J Cancer 38:1998-2004. 2002
    ..8% (95% confidence interval: (CI) 71.7-98.9%). This combined modality is tolerable, and CPT-11/cisplatin of 40/60 mg/m(2) in this modality is recommended for phase II study...
  6. ncbi Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus
    A Kinoshita
    Alzheimer Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurochem 82:839-47. 2002
    ..Visualization of the APP-CT-Fe65 complex in the nucleus may serve as a readout for processes that modify gamma secretase release of APP-CT...
  7. pmc Identification of eight novel NSD1 mutations in Sotos syndrome
    J Kamimura
    Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Med Genet 40:e126. 2003
  8. pmc Isolated congenital anosmia locus maps to 18p11.23-q12.2
    M Ghadami
    J Med Genet 41:299-303. 2004
  9. pmc A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family
    A Okubo
    Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Med Genet 41:e97. 2004
  10. ncbi Cloning of the gene and cDNA for human heart chymase
    H Urata
    Department of Heart and Hypertension Research, Cleveland Clinic Foundation, Ohio 44195 5069
    J Biol Chem 266:17173-9. 1991
    ..These contrasting features of the human heart chymase gene and cDNA, and the potential determinants of its primary structure that underlie its unique functional characteristics are considered...
  11. ncbi Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65
    A Kinoshita
    Alzheimer s Disease Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 21:8354-61. 2001
    ..These findings demonstrate that LRP interaction with APP occurs via both extracellular and intracellular protein interaction domains...
  12. pmc Effects of renal function on pharmacokinetics of recombinant human granulocyte colony-stimulating factor in lung cancer patients
    M Fukuda
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
    Antimicrob Agents Chemother 45:1947-51. 2001
    ..001). Our findings suggest that renal function and neutrophil counts correlate with CL(G-CSF) and that the role of renal function in eliminating rhG-CSF is important in lung cancer patients with neutropenia...
  13. ncbi Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta 1
    T Saito
    Department of Biochemistry, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    J Biol Chem 276:11469-72. 2001
    ..These data suggest that the domain-specific mutations of beta1-LAP result in a more facile activation of TGF-beta1, thus causing CED...
  14. ncbi ESR dosimetry of 89Sr and 153Sm in bone
    A Kinoshita
    , FFCLRP, , Ribeirao Preto, Brazil
    Appl Radiat Isot 54:269-74. 2001
    ..For 153Sm-EDTMP, the bone doses in three rabbits were (4 +/- 2), (5 +/- 1) and (5 +/- 2) cGy kg/MBq. For 89SrCl2, a dose of (2 +/- 1) cGy kg/MBq was found in one rabbit...
  15. ncbi Abnormalities of extracellular matrices and transforming growth factor beta1 localization in the kidney of the hereditary nephrotic mice (ICGN strain)
    K Uchio
    Department of Animal Sciences, Kyoto University, Japan
    J Vet Med Sci 61:769-76. 1999
    ..The present findings may contribute to elucidation of the pathogenic mechanisms of hereditary nephrotic syndrome in ICGN mice and, in future, human idiopathic nephrotic syndrome...
  16. ncbi Genetic analysis of the epithelial sodium channel in Liddle's syndrome
    Y Uehara
    Department of Internal Medicine, Fukuoka University, School of Medicine, Japan
    J Hypertens 16:1131-5. 1998
    ..Liddle's syndrome is an autosomal inheritable disorder that causes hypertension due to excess function of sodium channel...
  17. ncbi Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor
    K Uemura
    Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan 606 8507
    Neuroscience 145:5-10. 2007
    ..Since both N-cadherin and beta-catenin are essential for synaptic plasticity, impairment of N-cadherin cleavage caused by Abeta may underlie the synapse toxicity involved in AD pathogenesis...