Eiji Kawasaki

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. ncbi request reprint Novel enzyme-linked immunosorbent assay for bivalent ZnT8 autoantibodies
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Acta Diabetol 51:429-34. 2014
  2. pmc Type 1 diabetes and interferon therapy: a nationwide survey in Japan
    Kan Nakamura
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki, Japan
    Diabetes Care 34:2084-9. 2011
  3. ncbi request reprint ZnT8 and type 1 diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki 852 8501, Japan
    Endocr J 59:531-7. 2012
  4. doi request reprint Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Endocrinol Metab 95:707-13. 2010
  5. doi request reprint Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes
    Eiji Kawasaki
    Department of Metabolism, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Ann N Y Acad Sci 1150:248-51. 2008
  6. pmc Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients
    Eiji Kawasaki
    Department of Metabolism, Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Diabetes Care 31:1608-10. 2008
  7. ncbi request reprint Genetics of fulminant type 1 diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Ann N Y Acad Sci 1079:24-30. 2006
  8. doi request reprint Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki, Japan
    Clin Immunol 138:146-53. 2011
  9. doi request reprint Zinc transporter 8 autoantibodies in fulminant, acute-onset, and slow-onset patients with type 1 diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, and Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Diabetes Metab Res Rev 27:895-8. 2011
  10. ncbi request reprint Current aspects on the clinical immunology and genetics of autoimmune diabetes in Japan
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Diabetes Res Clin Pract 77:S104-9. 2007

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Novel enzyme-linked immunosorbent assay for bivalent ZnT8 autoantibodies
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Acta Diabetol 51:429-34. 2014
    ..Moreover, these results suggest that the humoral autoimmunity against ZnT8 is related to a high risk of faster development of type 1 diabetes and the ZnT8A levels are associated with the known aa325 variants. ..
  2. pmc Type 1 diabetes and interferon therapy: a nationwide survey in Japan
    Kan Nakamura
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki, Japan
    Diabetes Care 34:2084-9. 2011
    ..To assess the clinical, immunologic, and genetic characteristics of type 1 diabetes induced by interferon therapy, we conducted a nationwide cross-sectional survey...
  3. ncbi request reprint ZnT8 and type 1 diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki 852 8501, Japan
    Endocr J 59:531-7. 2012
    ..The humoral autoreactivity to ZnT8 depends on the clinical phenotype, which may provide clues to understand the role of this protein in the pathogenesis of type 1 diabetes...
  4. doi request reprint Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Endocrinol Metab 95:707-13. 2010
    ....
  5. doi request reprint Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes
    Eiji Kawasaki
    Department of Metabolism, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Ann N Y Acad Sci 1150:248-51. 2008
    ..These results emphasize the heterogeneity of humoral autoimmunity to protein tyrosine phosphatase-like molecules, but not to GAD, in patients with type 1 diabetes...
  6. pmc Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patients
    Eiji Kawasaki
    Department of Metabolism, Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Diabetes Care 31:1608-10. 2008
    ..To examine the contribution of the CTLA4 gene in the susceptibility to fulminant type 1 diabetes and compare it with classic type 1A diabetes...
  7. ncbi request reprint Genetics of fulminant type 1 diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Ann N Y Acad Sci 1079:24-30. 2006
    ..In this article we will summarize the current findings on the genetics of Japanese patients with fulminant type 1 diabetes...
  8. doi request reprint Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki, Japan
    Clin Immunol 138:146-53. 2011
    ..05). These results suggest differences in the humoral autoreactivity to ZnT8 depending on the clinical phenotype, which should provide strategy for autoantibody measurement in subjects to allow early diagnosis of autoimmune T1D...
  9. doi request reprint Zinc transporter 8 autoantibodies in fulminant, acute-onset, and slow-onset patients with type 1 diabetes
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, and Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Diabetes Metab Res Rev 27:895-8. 2011
    ..The aim of this study was to determine the prevalence and role of autoantibodies to zinc transporter 8 (ZnT8A) in three forms (fulminant, acute-onset, and slow-onset) of Japanese patients with type 1 diabetes...
  10. ncbi request reprint Current aspects on the clinical immunology and genetics of autoimmune diabetes in Japan
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Diabetes Res Clin Pract 77:S104-9. 2007
    ..Thus, accurate predictive strategies of future insulin deficiency in LADA patients using autoantibody epitope analysis, genetic determination, or T cell assay are needed for the effective immune intervention...
  11. doi request reprint Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes
    E Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Diabetologia 51:2299-302. 2008
    ..We analysed the association between humoral autoreactivity to zinc transporter-8 (ZnT8) and the SLC30A8 rs13266634 polymorphism (Arg325Trp), which is located at the most distal loop in the ZnT8 protein...
  12. doi request reprint Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Endocrinol Metab 94:947-52. 2009
    ..Our objective was to determine whether variants in the IL2RA gene are associated with type 1 diabetes in the Japanese population...
  13. ncbi request reprint Epitope analysis of GAD65 autoantibodies in Japanese patients with autoimmune diabetes
    Eiji Kawasaki
    Unit of Metabolism Diabetes and Clinical Nutrition, Nagasaki University School of Medicine, Nagasaki, Japan
    Ann N Y Acad Sci 1005:440-8. 2003
    ..In conclusion, Japanese patients with type 1 diabetes are clinically heterogeneous and the determination of immunological features are helpful to clarify the characteristics of the Japanese type 1 diabetic syndrome...
  14. ncbi request reprint Stromal cell-derived factor-1 chemokine gene variant in patients with type 1 diabetes and autoimmune thyroid disease
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Ann N Y Acad Sci 1037:79-83. 2004
    ..These results suggest that the SDF1-3'A variant is not associated with genetic susceptibility to type 1 diabetic patients and AITD...
  15. ncbi request reprint Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes
    Akane Ide
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Autoimmun 22:73-8. 2004
    ..These results suggest that the IL-18 gene polymorphism is associated with a type 1 diabetes susceptibility, and there might be a gene-gene interaction between IL-18 gene with susceptible CTLA-4 gene...
  16. ncbi request reprint Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population
    Masako Tsurumaru
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Endocrinol Metab 91:3138-43. 2006
    ..Recently, an association of a single nucleotide polymorphism, 163A>G encoding M55V, in the gene SUMO4, which has been shown to be a negative feedback regulator for nuclear factor kappaB, has been reported in type 1 diabetes...
  17. ncbi request reprint Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Am J Med Genet A 140:586-93. 2006
    ..In conclusion, the type 1 diabetes association with PTPN22 is confirmed, but it cannot be attributed solely to the +1858C > T variant. The promoter -1123G > C SNP is a more likely causative variant in PTPN22...
  18. doi request reprint Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese population
    Ichiro Horie
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Clin Endocrinol Metab 97:E1043-50. 2012
    ..We aimed to clarify the differences in the clinical and genetic characteristics of APS3v patients and T1D patients without AITD [T1D/AITD(-)] in the Japanese population...
  19. ncbi request reprint Association of interleukin-18 gene promoter polymorphisms in type 1 diabetes and autoimmune thyroid disease
    Akane Ide
    First Department of Internal Medicine, Graduate School of Biochemical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
    Ann N Y Acad Sci 1005:436-9. 2003
    ..These results suggest that polymorphisms of the IL-18 gene are not associated with a susceptibility to AITD and type 1 diabetes coexistent with AITD in Japanese population...
  20. ncbi request reprint Stromal-cell derived factor-1 chemokine gene variant is associated with type 1 diabetes age at onset in Japanese population
    Akane Ide
    First Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Hum Immunol 64:973-8. 2003
    ..008). These results suggest that the SDF-1 gene polymorphism is associated with the age-at-onset of type 1 diabetes in Japanese population...
  21. ncbi request reprint Is Type 1 diabetes in the Japanese population the same as among Caucasians?
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Ann N Y Acad Sci 1037:96-103. 2004
    ..Japanese patients with type 1 diabetes are clinically heterogeneous, and further investigations are required to clarify the underlying pathogenesis for each subgroup of type 1 diabetes...
  22. ncbi request reprint Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes
    Masakazu Kobayashi
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Immunol 179:2082-8. 2007
    ..The A16,19 altered peptide ligand, but not other native insulin peptides, suppresses insulin autoantibodies associated with protection from and remission of diabetes...
  23. ncbi request reprint Trajectories of anti-islet autoantibodies before development of type 1 diabetes in interferon-treated hepatitis C patients. Case reports and a literature review
    Kan Nakamura
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki, Japan
    Endocr J 57:947-51. 2010
    ..These clinical courses suggest that IFN-α therapy provoked acute islet autoimmunity and onset of type 1 diabetes. Therefore, during IFN-α therapy, patients should be closely monitored for the occurrence of type 1 diabetes...
  24. ncbi request reprint Interleukin-10 gene promoter region polymorphisms in patients with type 1 diabetes and autoimmune thyroid disease
    Akane Ide
    First Department of Internal Medicine, Graduate School of Biochemical Sciences, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan
    Ann N Y Acad Sci 1005:344-7. 2003
    ..These results suggest that IL-10 gene promoter region polymorphisms are not associated with genetic susceptibility to type 1 diabetes and AITD...
  25. doi request reprint Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice
    Keiko Fukushima
    Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan
    Biochem Biophys Res Commun 367:719-24. 2008
    ..These results indicate that poly I:C combined with B:9-23 peptide promotes infiltration of both pathogenic T cells and predominantly Tregs into the islets, thereby inhibiting progression from insulitis to overt diabetes in NOD mice...
  26. ncbi request reprint Distinct IA-2 autoantibody epitope recognition between childhood-onset and adult-onset type 1 diabetes
    Eiji Kawasaki
    The First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Ann N Y Acad Sci 958:235-40. 2002
    ..05). These results demonstrate that autoantibody recognition of the IA-2 epitope is distinct in childhood-onset and adult-onset type 1 diabetes...
  27. ncbi request reprint Emergence of anti-islet autoantibodies in Japanese patients with type 1 diabetes
    Ichiro Horie
    First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Endocr J 57:623-8. 2010
    ..The autoantibody profile and the mode of diabetes onset in the two cases were remarkably different. These cases imply that anti-islet autoantibodies do not always precede the onset of T1D...
  28. ncbi request reprint Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation
    Akie Moriuchi
    Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University, and Hospital of Medicine and Dentistry, Nagasaki, Japan
    Biochem Biophys Res Commun 356:1024-30. 2007
    ..This study indicates that telmisartan may stimulate adiponectin transcription independent of PPAR-gamma...
  29. ncbi request reprint Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset
    Akane Ide
    From the First Department of Internal Medicine, Nagasaki, Japan
    Hum Immunol 63:690-5. 2002
    ..004). These results suggest that the IL-10 gene promoter polymorphisms are associated with the age-at-onset in Japanese patients with type 1 diabetes...
  30. ncbi request reprint In vivo expression of B:9-23 peptide/I-A(g7) complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD mice
    Norio Abiru
    Unit of Metabolism Diabetes and Clinical Nutrition, Nagasaki University School of Medicine, Nagasaki, Japan
    Ann N Y Acad Sci 1005:218-21. 2003
    ....
  31. ncbi request reprint A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI
    Fumi Murata
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Japan
    Endocr J 59:669-76. 2012
    ....
  32. ncbi request reprint [Protein tyrosine phosphatase (ICA512/IA-2) antibody]
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry
    Nihon Rinsho 63:551-4. 2005
  33. ncbi request reprint Recent advancement of understanding pathogenesis of type 1 diabetes and potential relevance to diabetic nephropathy
    Kunihiro Ichinose
    Unit of Translational Medicine, Department of Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Am J Nephrol 27:554-64. 2007
    ....
  34. ncbi request reprint Prevention of type 1 diabetes: from the view point of beta cell damage
    Eiji Kawasaki
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Diabetes Res Clin Pract 66:S27-32. 2004
    ..Blockage of multiple pathways, rather than a single pathway, of beta cell-death may, therefore be necessary to fully protect beta cells from destruction and thereby prevent type 1 diabetes...
  35. ncbi request reprint Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay
    Eiji Kawasaki
    The First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Ann N Y Acad Sci 958:241-6. 2002
    ..0001). We concluded that this liquid-phase ELISA is suitable for detecting IA-2 autoantibodies in patients with type 1 diabetes with a similar sensitivity and specificity to those of conventional radioligand binding assay...
  36. ncbi request reprint Apoptosis and its pathway in early post-implantation embryos of diabetic rats
    Fuyan Sun
    Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
    Diabetes Res Clin Pract 67:110-8. 2005
    ..These results suggest that a Bax-regulated mitochondrial cytochrome c-mediated caspase-3 activation pathway might be involved in the diabetic embryopathy...
  37. ncbi request reprint A cross-talk between RNA splicing and signaling pathway alters Fas gene expression at post-transcriptional level: alternative splicing of Fas mRNA in the leukemic U937 cells
    Kouichiro Aratake
    First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Lab Clin Med 146:184-91. 2005
    ....
  38. ncbi request reprint Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes
    Takuya Awata
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
    J Clin Endocrinol Metab 92:1791-5. 2007
    ..It is suggested that insulin autoimmunity plays an important role in the development of type 1 diabetes in humans. However, the association between insulin gene (INS) region (IDDM2) and type 1 diabetes has been uncertain in Asians...
  39. ncbi request reprint Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study)
    Haruyo Takeda
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime, Japan
    Diabetes Care 25:995-1001. 2002
    ..To characterize the clinical, autoimmune, and genetic features in Japanese adult-onset diabetic patients with GAD autoantibodies...
  40. ncbi request reprint The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan
    Hiroshi Ikegami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 91:1087-92. 2006
    ..The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia...
  41. ncbi request reprint Current knowledge of Japanese type 1 diabetic syndrome
    Norio Abiru
    Unit of Metabolism Diabetes and Clinical Nutrition, Nagasaki University School of Medicine, 1 7 1 Sakamoto Nagasaki 852 8501, Japan
    Diabetes Metab Res Rev 18:357-66. 2002
    ..For accurate predictive strategies of future insulin deficiency, combinational multiple autoantibodies analysis or genetic determination should be considered for effective immune intervention...
  42. ncbi request reprint Fulminant type 1 diabetes: a nationwide survey in Japan
    Akihisa Imagawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Diabetes Care 26:2345-52. 2003
    ..To describe the clinical and immunologic characteristics of fulminant type 1 diabetes, a novel subtype of type 1 diabetes, we conducted a nationwide survey...
  43. ncbi request reprint Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes
    Shinsuke Noso
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Diabetes 54:3582-6. 2005
    ..These data indicate that the MAP3K7IP2/SUMO4 locus in the IDDM5 interval is associated with type 1 diabetes in Asian populations...
  44. doi request reprint Nationwide survey to compare the prevalence of transient elevation of liver transaminase during treatment of diabetic ketosis or ketoacidosis in new-onset acute and fulminant type 1 diabetes mellitus
    Hiroko Takaike
    Diabetes Center, Tokyo Women s Medical University, Japan
    Ann Med 40:395-400. 2008
    ..The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ketosis or ketoacidosis...
  45. ncbi request reprint Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients
    Satoshi Murao
    Matsuyama Shimin Hospital, Ehime, Japan
    Diabetes 53:2684-90. 2004
    ....
  46. ncbi request reprint Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese
    Akira Shimada
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Autoimmun 30:207-11. 2008
    ..Based upon these results, we propose that it may be worthwhile to focus on subjects with the BB genotype of this gene polymorphism as having high risk for type 1 diabetes...
  47. ncbi request reprint Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients
    Yongsoo Park
    Department of Internal Medicine, Hanyang University Hospital, 249 1 Kyomun dong, Kuri, Kyunggi Do, 471 020, Korea
    Ann N Y Acad Sci 1037:104-9. 2004
    ..Design of the antigen-specific immunointervention trials should take into account such HLA DR and DQ association...
  48. doi request reprint Pancreas histology and a longitudinal study of insulin secretion in a Japanese patient with latent autoimmune diabetes in adults
    Satoshi Murao
    Diabetes Care 31:e69. 2008
  49. ncbi request reprint Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations
    Shinsuke Noso
    Department of Endocrinology, Diabetes and Metabolism, Kinki University School of Medicine, 377 2 Ohno Higashi, Sayama shi, Osaka 589 8511, Japan
    Ann N Y Acad Sci 1079:41-6. 2006
    ..0 x 10(-6)), but indicated significant heterogeneity in the genetic effect of the SUMO4 gene on type 1 diabetes among diverse ethnic groups. These observations indicated the association of SUMO4 with type 1 diabetes in Asian populations...
  50. ncbi request reprint Insulin administration may trigger pancreatic beta-cell destruction in patients with type 2 diabetes
    Mai Nakamura
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon shi, Ehime 791 0295, Japan
    Diabetes Res Clin Pract 79:220-9. 2008
    ..The above findings suggest that insulin administration may have triggered pancreatic beta-cell destruction in these patients...
  51. ncbi request reprint Intermittent and recurrent hepatomegaly due to glycogen storage in a patient with type 1 diabetes: genetic analysis of the liver glycogen phosphorylase gene (PYGL)
    Masako Tomihira
    Division of Endocrinology and Metabolism, St Mary s Hospital, 422 Tsubukuhonmachi, Kurume, Fukuoka, Japan
    Diabetes Res Clin Pract 65:175-82. 2004
    ..Further studies including genetic analysis on the promoter region of the gene are necessary to clarify the etiology of susceptibility to excessive liver glycogen storage in patients with type 1 diabetes...