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Genomes and Genes | Eiji KawasakiSummaryAffiliation: Nagasaki University Country: Japan Publications
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Publications
ZnT8 and type 1 diabetesEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki 852 8501, Japan
Endocr J 59:531-7. 2012..The humoral autoreactivity to ZnT8 depends on the clinical phenotype, which may provide clues to understand the role of this protein in the pathogenesis of type 1 diabetes...- Current aspects on the clinical immunology and genetics of autoimmune diabetes in JapanEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
Diabetes Res Clin Pract 77:S104-9. 2007..Thus, accurate predictive strategies of future insulin deficiency in LADA patients using autoantibody epitope analysis, genetic determination, or T cell assay are needed for the effective immune intervention... 
Differences in the contribution of the CTLA4 gene to susceptibility to fulminant and type 1A diabetes in Japanese patientsEiji Kawasaki
Department of Metabolism, Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
Diabetes Care 31:1608-10. 2008..To examine the contribution of the CTLA4 gene in the susceptibility to fulminant type 1 diabetes and compare it with classic type 1A diabetes...
Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetesE Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
Diabetologia 51:2299-302. 2008..We analysed the association between humoral autoreactivity to zinc transporter-8 (ZnT8) and the SLC30A8 rs13266634 polymorphism (Arg325Trp), which is located at the most distal loop in the ZnT8 protein...- Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese populationEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
J Clin Endocrinol Metab 94:947-52. 2009..Our objective was to determine whether variants in the IL2RA gene are associated with type 1 diabetes in the Japanese population... - Genetics of fulminant type 1 diabetesEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
Ann N Y Acad Sci 1079:24-30. 2006..In this article we will summarize the current findings on the genetics of Japanese patients with fulminant type 1 diabetes... - Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetesEiji Kawasaki
Department of Metabolism, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
Ann N Y Acad Sci 1150:248-51. 2008..These results emphasize the heterogeneity of humoral autoimmunity to protein tyrosine phosphatase-like molecules, but not to GAD, in patients with type 1 diabetes... - Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetesEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
J Clin Endocrinol Metab 95:707-13. 2010.... - Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patientsEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki, Japan
Clin Immunol 138:146-53. 2011..05). These results suggest differences in the humoral autoreactivity to ZnT8 depending on the clinical phenotype, which should provide strategy for autoantibody measurement in subjects to allow early diagnosis of autoimmune T1D... - Zinc transporter 8 autoantibodies in fulminant, acute-onset, and slow-onset patients with type 1 diabetesEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, and Department of Endocrinology and Metabolism, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Diabetes Metab Res Rev 27:895-8. 2011..The aim of this study was to determine the prevalence and role of autoantibodies to zinc transporter 8 (ZnT8A) in three forms (fulminant, acute-onset, and slow-onset) of Japanese patients with type 1 diabetes... - Epitope analysis of GAD65 autoantibodies in Japanese patients with autoimmune diabetesEiji Kawasaki
Unit of Metabolism Diabetes and Clinical Nutrition, Nagasaki University School of Medicine, Nagasaki, Japan
Ann N Y Acad Sci 1005:440-8. 2003..In conclusion, Japanese patients with type 1 diabetes are clinically heterogeneous and the determination of immunological features are helpful to clarify the characteristics of the Japanese type 1 diabetic syndrome... - Association between IL-18 gene promoter polymorphisms and CTLA-4 gene 49A/G polymorphism in Japanese patients with type 1 diabetesAkane Ide
The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
J Autoimmun 22:73-8. 2004..These results suggest that the IL-18 gene polymorphism is associated with a type 1 diabetes susceptibility, and there might be a gene-gene interaction between IL-18 gene with susceptible CTLA-4 gene... - Stromal cell-derived factor-1 chemokine gene variant in patients with type 1 diabetes and autoimmune thyroid diseaseEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
Ann N Y Acad Sci 1037:79-83. 2004..These results suggest that the SDF1-3'A variant is not associated with genetic susceptibility to type 1 diabetic patients and AITD... - Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populationsEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
Am J Med Genet A 140:586-93. 2006..In conclusion, the type 1 diabetes association with PTPN22 is confirmed, but it cannot be attributed solely to the +1858C > T variant. The promoter -1123G > C SNP is a more likely causative variant in PTPN22... - Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese populationMasako Tsurumaru
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
J Clin Endocrinol Metab 91:3138-43. 2006..Recently, an association of a single nucleotide polymorphism, 163A>G encoding M55V, in the gene SUMO4, which has been shown to be a negative feedback regulator for nuclear factor kappaB, has been reported in type 1 diabetes... - Association of interleukin-18 gene promoter polymorphisms in type 1 diabetes and autoimmune thyroid diseaseAkane Ide
First Department of Internal Medicine, Graduate School of Biochemical Sciences, Nagasaki University School of Medicine, Nagasaki, Japan
Ann N Y Acad Sci 1005:436-9. 2003..These results suggest that polymorphisms of the IL-18 gene are not associated with a susceptibility to AITD and type 1 diabetes coexistent with AITD in Japanese population... - Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese populationIchiro Horie
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
J Clin Endocrinol Metab 97:E1043-50. 2012..We aimed to clarify the differences in the clinical and genetic characteristics of APS3v patients and T1D patients without AITD [T1D/AITD(-)] in the Japanese population... - Stromal-cell derived factor-1 chemokine gene variant is associated with type 1 diabetes age at onset in Japanese populationAkane Ide
First Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Hum Immunol 64:973-8. 2003..008). These results suggest that the SDF-1 gene polymorphism is associated with the age-at-onset of type 1 diabetes in Japanese population... - Is Type 1 diabetes in the Japanese population the same as among Caucasians?Eiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
Ann N Y Acad Sci 1037:96-103. 2004..Japanese patients with type 1 diabetes are clinically heterogeneous, and further investigations are required to clarify the underlying pathogenesis for each subgroup of type 1 diabetes... - Trajectories of anti-islet autoantibodies before development of type 1 diabetes in interferon-treated hepatitis C patients. Case reports and a literature reviewKan Nakamura
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, 1 7 1 Sakamoto, Nagasaki, Japan
Endocr J 57:947-51. 2010..These clinical courses suggest that IFN-α therapy provoked acute islet autoimmunity and onset of type 1 diabetes. Therefore, during IFN-α therapy, patients should be closely monitored for the occurrence of type 1 diabetes... - Interleukin-10 gene promoter region polymorphisms in patients with type 1 diabetes and autoimmune thyroid diseaseAkane Ide
First Department of Internal Medicine, Graduate School of Biochemical Sciences, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan
Ann N Y Acad Sci 1005:344-7. 2003..These results suggest that IL-10 gene promoter region polymorphisms are not associated with genetic susceptibility to type 1 diabetes and AITD... - Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetesMasakazu Kobayashi
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
J Immunol 179:2082-8. 2007..The A16,19 altered peptide ligand, but not other native insulin peptides, suppresses insulin autoantibodies associated with protection from and remission of diabetes... - Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic miceKeiko Fukushima
Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan
Biochem Biophys Res Commun 367:719-24. 2008..These results indicate that poly I:C combined with B:9-23 peptide promotes infiltration of both pathogenic T cells and predominantly Tregs into the islets, thereby inhibiting progression from insulitis to overt diabetes in NOD mice... - Distinct IA-2 autoantibody epitope recognition between childhood-onset and adult-onset type 1 diabetesEiji Kawasaki
The First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
Ann N Y Acad Sci 958:235-40. 2002..05). These results demonstrate that autoantibody recognition of the IA-2 epitope is distinct in childhood-onset and adult-onset type 1 diabetes... - Type 1 diabetes and interferon therapy: a nationwide survey in JapanKan Nakamura
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki, Japan
Diabetes Care 34:2084-9. 2011..To assess the clinical, immunologic, and genetic characteristics of type 1 diabetes induced by interferon therapy, we conducted a nationwide cross-sectional survey... - Emergence of anti-islet autoantibodies in Japanese patients with type 1 diabetesIchiro Horie
First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
Endocr J 57:623-8. 2010..The autoantibody profile and the mode of diabetes onset in the two cases were remarkably different. These cases imply that anti-islet autoantibodies do not always precede the onset of T1D... - Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onsetAkane Ide
From the First Department of Internal Medicine, Nagasaki, Japan
Hum Immunol 63:690-5. 2002..004). These results suggest that the IL-10 gene promoter polymorphisms are associated with the age-at-onset in Japanese patients with type 1 diabetes... - Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activationAkie Moriuchi
Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University, and Hospital of Medicine and Dentistry, Nagasaki, Japan
Biochem Biophys Res Commun 356:1024-30. 2007..This study indicates that telmisartan may stimulate adiponectin transcription independent of PPAR-gamma... - In vivo expression of B:9-23 peptide/I-A(g7) complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD miceNorio Abiru
Unit of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University School of Medicine, Nagasaki, Japan
Ann N Y Acad Sci 1005:218-21. 2003.... - A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRIFumi Murata
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital, Japan
Endocr J 59:669-76. 2012.... - Recent advancement of understanding pathogenesis of type 1 diabetes and potential relevance to diabetic nephropathyKunihiro Ichinose
Unit of Translational Medicine, Department of Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Am J Nephrol 27:554-64. 2007.... - Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assayEiji Kawasaki
The First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
Ann N Y Acad Sci 958:241-6. 2002..0001). We concluded that this liquid-phase ELISA is suitable for detecting IA-2 autoantibodies in patients with type 1 diabetes with a similar sensitivity and specificity to those of conventional radioligand binding assay... - Prevention of type 1 diabetes: from the view point of beta cell damageEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
Diabetes Res Clin Pract 66:S27-32. 2004..Blockage of multiple pathways, rather than a single pathway, of beta cell-death may, therefore be necessary to fully protect beta cells from destruction and thereby prevent type 1 diabetes... - Apoptosis and its pathway in early post-implantation embryos of diabetic ratsFuyan Sun
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
Diabetes Res Clin Pract 67:110-8. 2005..These results suggest that a Bax-regulated mitochondrial cytochrome c-mediated caspase-3 activation pathway might be involved in the diabetic embryopathy... - Fulminant type 1 diabetes: a nationwide survey in JapanAkihisa Imagawa
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
Diabetes Care 26:2345-52. 2003..Flu-like symptoms are characteristic of disease onset. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes... - Current knowledge of Japanese type 1 diabetic syndromeNorio Abiru
Unit of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University School of Medicine, 1-7-1 Sakamoto Nagasaki 852-8501, Japan
Diabetes Metab Res Rev 18:357-66. 2002..For accurate predictive strategies of future insulin deficiency, combinational multiple autoantibodies analysis or genetic determination should be considered for effective immune intervention... - Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patientsSatoshi Murao
Matsuyama Shimin Hospital, Ehime, Japan
Diabetes 53:2684-90. 2004.... - Clinical, autoimmune, and genetic characteristics of adult-onset diabetic patients with GAD autoantibodies in Japan (Ehime Study)Haruyo Takeda
Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime, Japan
Diabetes Care 25:995-1001. 2002.... - Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetesTakuya Awata
Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
J Clin Endocrinol Metab 92:1791-5. 2007..It is suggested that insulin autoimmunity plays an important role in the development of type 1 diabetes in humans. However, the association between insulin gene (INS) region (IDDM2) and type 1 diabetes has been uncertain in Asians... - [Protein tyrosine phosphatase (ICA512/IA-2) antibody]Eiji Kawasaki
Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry
Nippon Rinsho 63:551-4. 2005 - Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patientsYongsoo Park
Department of Internal Medicine, Hanyang University Hospital, 249 1 Kyomun dong, Kuri, Kyunggi Do, 471 020, Korea
Ann N Y Acad Sci 1037:104-9. 2004..Design of the antigen-specific immunointervention trials should take into account such HLA DR and DQ association... - Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in JapaneseAkira Shimada
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Autoimmun 30:207-11. 2008..Based upon these results, we propose that it may be worthwhile to focus on subjects with the BB genotype of this gene polymorphism as having high risk for type 1 diabetes... - Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populationsShinsuke Noso
Department of Endocrinology, Diabetes and Metabolism, Kinki University School of Medicine, 377 2 Ohno Higashi, Sayama shi, Osaka 589 8511, Japan
Ann N Y Acad Sci 1079:41-6. 2006..0 x 10(-6)), but indicated significant heterogeneity in the genetic effect of the SUMO4 gene on type 1 diabetes among diverse ethnic groups. These observations indicated the association of SUMO4 with type 1 diabetes in Asian populations... - Nationwide survey to compare the prevalence of transient elevation of liver transaminase during treatment of diabetic ketosis or ketoacidosis in new-onset acute and fulminant type 1 diabetes mellitusHiroko Takaike
Diabetes Center, Tokyo Women s Medical University, Japan
Ann Med 40:395-400. 2008..The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ketosis or ketoacidosis... - The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in JapanHiroshi Ikegami
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565 0871, Japan
J Clin Endocrinol Metab 91:1087-92. 2006..The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia... - Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetesShinsuke Noso
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
Diabetes 54:3582-6. 2005..These data indicate that the MAP3K7IP2/SUMO4 locus in the IDDM5 interval is associated with type 1 diabetes in Asian populations... - Pancreas histology and a longitudinal study of insulin secretion in a Japanese patient with latent autoimmune diabetes in adultsSatoshi Murao
Diabetes Care 31:e69. 2008 - Intermittent and recurrent hepatomegaly due to glycogen storage in a patient with type 1 diabetes: genetic analysis of the liver glycogen phosphorylase gene (PYGL)Masako Tomihira
Division of Endocrinology and Metabolism, St Mary s Hospital, 422 Tsubukuhonmachi, Kurume, Fukuoka, Japan
Diabetes Res Clin Pract 65:175-82. 2004..Further studies including genetic analysis on the promoter region of the gene are necessary to clarify the etiology of susceptibility to excessive liver glycogen storage in patients with type 1 diabetes... - Insulin administration may trigger pancreatic beta-cell destruction in patients with type 2 diabetesMai Nakamura
Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon shi, Ehime 791 0295, Japan
Diabetes Res Clin Pract 79:220-9. 2008..The above findings suggest that insulin administration may have triggered pancreatic beta-cell destruction in these patients...