Atsushi Kawakami

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. doi A fatal case of acute exacerbation of interstitial lung disease in a patient with rheumatoid arthritis during treatment with tocilizumab
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatol Int 32:4023-6. 2012
  2. ncbi Clopidogrel-associated acute arthritis
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatol Int 32:449-50. 2012
  3. doi Effects of the anti-interleukin-6 receptor antibody, tocilizumab, on serum lipid levels in patients with rheumatoid arthritis
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatol Int 31:451-6. 2011
  4. doi Monitoring of therapeutic efficacy in a patient with RS₃PE syndrome by serologic variables and radiographic methods
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Rheumatol Int 30:1677-80. 2010
  5. doi Prediction of DAS28-CRP remission in patients with rheumatoid arthritis treated with tacrolimus at 6 months by baseline variables
    Toshiyuki Aramaki
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 19:652-6. 2009
  6. ncbi Prediction of DAS28-ESR remission at 6 months by baseline variables in patients with rheumatoid arthritis treated with etanercept in Japanese population
    Naoki Iwamoto
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 19:488-92. 2009
  7. doi Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drugs shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors
    Junko Kita
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 22:195-201. 2012
  8. doi Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 20:40-5. 2010
  9. doi Cutaneous vasculitis induced by TNF inhibitors: a report of three cases
    Keita Fujikawa
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 20:86-9. 2010
  10. doi Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach
    Junko Kita
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 23:254-9. 2013

Detail Information

Publications93

  1. doi A fatal case of acute exacerbation of interstitial lung disease in a patient with rheumatoid arthritis during treatment with tocilizumab
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatol Int 32:4023-6. 2012
    ..He died despite receiving steroid pulse therapy and antibiotic therapy on a respirator. This is the first case report to describe the exacerbation of ILD during treatment with tocilizumab in the postmarketing surveillance (PMS) period...
  2. ncbi Clopidogrel-associated acute arthritis
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatol Int 32:449-50. 2012
    ..According to the above manifestations, he was diagnosed as suffering from clopidogrel-associated acute arthritis...
  3. doi Effects of the anti-interleukin-6 receptor antibody, tocilizumab, on serum lipid levels in patients with rheumatoid arthritis
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatol Int 31:451-6. 2011
    ..All of the markers did not change during 3 months in control group. These data may raise an important issue to evaluate the impact of these alternations in lipid metabolism for longer periods in RA patients treated with TCZ...
  4. doi Monitoring of therapeutic efficacy in a patient with RS₃PE syndrome by serologic variables and radiographic methods
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Rheumatol Int 30:1677-80. 2010
    ..IL-6 (and VEGF), probably produced from the synovial tissues, are considered to be essential factors in the development of RS(3)PE syndrome...
  5. doi Prediction of DAS28-CRP remission in patients with rheumatoid arthritis treated with tacrolimus at 6 months by baseline variables
    Toshiyuki Aramaki
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 19:652-6. 2009
    ..That is clinically valuable for daily practice in the choice of disease-modifying antirheumatic drugs (DMARDs), especially tacrolimus...
  6. ncbi Prediction of DAS28-ESR remission at 6 months by baseline variables in patients with rheumatoid arthritis treated with etanercept in Japanese population
    Naoki Iwamoto
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 19:488-92. 2009
    ..Non-MTX nonbiologic DMARDs may be an alternative in RA patients administrated etanercept who are intolerant to MTX...
  7. doi Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drugs shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors
    Junko Kita
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 22:195-201. 2012
    ..Radiographic damage had not progressed in these patients. Delayed treatment with TNF inhibitors is effective and tolerable for patients with very early RA with poor prognosis factors...
  8. doi Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 20:40-5. 2010
    ..05). One patient discontinued TCZ because of tuberculous peritonitis. Although physicians need to watch for infectious adverse events, these data indicate that TCZ is effective for treating RA patients refractory to TNF antagonists...
  9. doi Cutaneous vasculitis induced by TNF inhibitors: a report of three cases
    Keita Fujikawa
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 20:86-9. 2010
    ..One patient spontaneously improved after cessation of the TNF inhibitor. Two patients required oral corticosteroid, the efficacy of which was observed to be excellent and rapid...
  10. doi Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach
    Junko Kita
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 23:254-9. 2013
    ..To identify the value of magnetic resonance imaging (MRI)-proven bone edema in patients with very early rheumatoid arthritis (RA)...
  11. doi Magnetic resonance imaging (MRI) detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis: comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaacetic acid-enhance
    Mami Tamai
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 22:654-8. 2012
    ....
  12. doi Comparative study of the detection of joint injury in early-stage rheumatoid arthritis by magnetic resonance imaging of the wrist and finger joints and physical examination
    Mami Tamai
    Nagasaki University, Japan
    Arthritis Care Res (Hoboken) 63:436-9. 2011
    ..To verify whether magnetic resonance imaging (MRI)-proven joint injury is sensitive as compared with joint injury determined by physical examination...
  13. doi Proinflammatory cytokines synergistically enhance the production of chemokine ligand 20 (CCL20) from rheumatoid fibroblast-like synovial cells in vitro and serum CCL20 is reduced in vivo by biologic disease-modifying antirheumatic drugs
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan
    J Rheumatol 36:2397-402. 2009
    ..Chemokine ligand 20 (CCL20) is a selective ligand for chemokine receptor 6 (CCR6). We investigated, both in vitro and in vivo, whether CCL20 is critically involved in the disease process of rheumatoid arthritis (RA)...
  14. doi High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion
    Keita Fujikawa
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Rheumatol 36:1126-9. 2009
    ....
  15. doi A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis
    Toshiyuki Aramaki
    First Department of Internal Medicine, Nagasaki University Hospital of Medicine and Dentistry, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan
    Mod Rheumatol 19:245-52. 2009
    ..These data suggest that a low NK activity on a per-cell basis might therefore contribute to an impaired NK activity in the patients with RA...
  16. pmc Anti-centromere antibody-seropositive Sjögren's syndrome differs from conventional subgroup in clinical and pathological study
    Hideki Nakamura
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Nagasaki, Japan
    BMC Musculoskelet Disord 11:140. 2010
    ..To clarify the clinicopathological characteristics of primary Sjögren's syndrome (pSS) with anti-centromere antibody (ACA)...
  17. ncbi Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy: histologic and MRI study
    Hideki Nakamura
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki City, Nagasaki, 852 8501, Japan
    Rheumatol Int 30:1381-3. 2010
    ..Diagnosis was made by rheumatoid vasculitis found in crural muscles. Intravenous cyclophosphamide with oral tacrolimus effectively improved dysesthesia with reduction of inflammatory response...
  18. doi Serum amyloid A (SAA) induces pentraxin 3 (PTX3) production in rheumatoid synoviocytes
    Kenshi Satomura
    Department of Rheumatology, Nagasaki Medical Center, Omura, Nagasaki, 856 8562, Japan
    Mod Rheumatol 23:28-35. 2013
    ..In the present study, we evaluated the relationship between PTX3 and serum amyloid A (SAA), another acute-phase reactant, in rheumatoid synoviocytes...
  19. doi Early diagnosis and treatment for remission of clinically amyopathic dermatomyositis complicated by rapid progress interstitial lung disease: a report of two cases
    Yoshiro Horai
    Unit of Translational Medicine, Department of Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 23:190-4. 2013
    ..Measurement of anti-CADM-140/MDA5 antibody was useful for obtaining a definitive diagnosis of CADM in these cases...
  20. doi Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration
    Junko Kita
    Unit of Translational Medicine, Department of Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 22:346-52. 2012
    ..Although this was a small clinical trial, we have shown-for the first time-that true remission of very early RA with poor prognosis factors can be achieved by treatment with synthetic DMARDs...
  21. ncbi Post-transcriptional regulation of IL-6 production by Zc3h12a in fibroblast-like synovial cells
    Tomohiro Koga
    Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Clin Exp Rheumatol 29:906-12. 2011
    ..We investigate the effect of Zc3h12a on IL-6 production in fibroblast-like synovial cells (FLS) from rheumatoid arthritis (RA) patients...
  22. doi Determination of the subset of Sjogren's syndrome with articular manifestations by anticyclic citrullinated peptide antibodies
    Naoki Iwamoto
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Rheumatol 36:113-5. 2009
    ..To investigate whether anticyclic citrullinated peptide antibodies (anti-CCP) predict the subset of Japanese patients with Sjögren's syndrome (SS) with articular manifestations...
  23. doi The power Doppler ultrasonography score from 24 synovial sites or 6 simplified synovial sites, including the metacarpophalangeal joints, reflects the clinical disease activity and level of serum biomarkers in patients with rheumatoid arthritis
    Shin Ya Kawashiri
    Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatology (Oxford) 50:962-5. 2011
    ..We evaluated the significance of the power Doppler ultrasonography (PDUS) score by comparing it with serum biomarkers and clinical disease activity...
  24. ncbi Type B insulin resistance complicated with systemic lupus erythematosus
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
    Intern Med 49:487-90. 2010
    ..This is a rare and important case report showing a clear correlation between anti-insulin receptor autoantibodies of type B insulin resistance and SLE disease activity...
  25. ncbi IFN-gamma/JAK/STAT pathway-induced inhibition of DR4 and DR5 expression on endothelial cells is cancelled by cycloheximide-sensitive mechanism: novel finding of cycloheximide-regulating death receptor expression
    Fumiko Tanaka
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8501, Japan
    Int J Mol Med 15:833-9. 2005
    ..We have not yet clarified precise mechanism, however, the present data provide a novel finding that IFN-gamma/JAK/STAT pathway elicits inhibition of TRAIL-mediated endothelial cell apoptosis through CHX-sensitive suppression of DR4/DR5...
  26. doi Decrement of serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis (RA) patients achieving remission after 6 months of etanercept treatment: comparison with CRP, IgM-RF, MMP-3 and anti-CCP Ab
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8501, Japan
    Joint Bone Spine 77:418-20. 2010
    ..The aim of this study was to evaluate whether serum COMP can estimate the therapeutic response of RA after 6 months of treatment with etanercept...
  27. ncbi Nitric oxide acts on the mitochondria and protects human endothelial cells from apoptosis
    Ayumi Hida
    First Department of Internal Medicine, Nagasaki School of Medicine and Sasebo Chuo Hospital, Nagasaki, Japan
    J Lab Clin Med 144:148-55. 2004
    ..These results suggest that NO promotes endothelial-cell proliferation and angiogenesis in the synovial tissues of patients with rheumatoid arthritis and that NO may be a therapeutic target for rheumatoid arthritis...
  28. doi High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome
    Tomoki Origuchi
    Department of Rehabilitation Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8520, Japan
    Mod Rheumatol 22:584-8. 2012
    ..7 ng/ml) (p < 0.05). We found that high serum MMP-3 is characteristic of patients with paraneoplastic RS3PE syndrome...
  29. ncbi A cross-talk between RNA splicing and signaling pathway alters Fas gene expression at post-transcriptional level: alternative splicing of Fas mRNA in the leukemic U937 cells
    Kouichiro Aratake
    First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Lab Clin Med 146:184-91. 2005
    ....
  30. ncbi Bone edema determined by magnetic resonance imaging reflects severe disease status in patients with early-stage rheumatoid arthritis
    Mami Tamai
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, School of Health Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, Japan
    J Rheumatol 34:2154-7. 2007
    ..To determine the significance of bone edema, detected by magnetic resonance imaging (MRI), in early-stage rheumatoid arthritis (RA)...
  31. ncbi Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-gamma through JAK/STAT pathway by translational regulation
    Mami Tamai
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Lab Clin Med 147:182-90. 2006
    ....
  32. ncbi Soluble urokinase plasminogen activator receptor as a useful biomarker to predict the response to adalimumab in patients with rheumatoid arthritis in a Japanese population
    Tomohiro Koga
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Clin Exp Rheumatol 29:811-5. 2011
    ..To determine whether soluble urokinase plasminogen activator receptor is a useful biomarker to predict the response to adalimumab (ADA) in Japanese patients with rheumatoid arthritis...
  33. doi Contribution of an adenine to guanine single nucleotide polymorphism of the matrix metalloproteinase-13 (MMP-13) -77 promoter region to the production of anticyclic citrullinated peptide antibodies in patients with HLA-DRB1*shared epitope-negative rheumat
    Naoki Iwamoto
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 21:240-3. 2011
    ..Our data suggest that SNP of the -77 MMP-13 promoter region acts as a surrogate marker of anti-CCP antibody production in HLA-DRB1*SE allele-negative RA patients, which may reflect RA severity...
  34. ncbi Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion
    Shin Ya Kawashiri
    Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatology (Oxford) 53:562-9. 2014
    ..The aim of this study was to investigate the characteristics of power Doppler (PD) subclinical synovitis in patients with RA who achieve clinical remission free from physical synovitis...
  35. doi The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM
    Tomohiro Koga
    Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto 1 7 1, Nagasaki 852 8501, Japan
    Rheumatology (Oxford) 51:1278-84. 2012
    ..We investigated the association of anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab) with clinical characteristics and mortality in Japanese patients with DM...
  36. ncbi Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells
    Taiichiro Miyashita
    The First Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Biochem Biophys Res Commun 312:397-404. 2003
    ....
  37. ncbi Disease activity score 28 may overestimate the remission induction of rheumatoid arthritis patients treated with tocilizumab: comparison with the remission by the clinical disease activity index
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 21:365-9. 2011
    ..CDAI is suggested to be an important alternate of composite measure in these cases...
  38. doi A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies
    Mami Tamai
    Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Arthritis Rheum 61:772-8. 2009
    ....
  39. ncbi Efficacy and safety of mizoribine by one single dose administration for patients with rheumatoid arthritis
    Kunihiro Ichinose
    Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    Intern Med 49:2211-8. 2010
    ..We evaluated the efficacy and safety of one single dose per day for patients with rheumatoid arthritis (RA)...
  40. ncbi In rheumatoid arthritis patients treated with tocilizumab, the rate of clinical disease activity index (CDAI) remission at 24 weeks is superior in those with higher titers of IgM-rheumatoid factor at baseline
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 21:370-4. 2011
    ..This is a new finding, and may be specific to tocilizumab as compared with previous observations in anti-TNF therapy...
  41. ncbi A case of cutaneous polyarteritis nodosa with elevated serum interleukin-6 levels complicated by leg arterial stenosis and destructive arthropathy of the left ankle
    Yoshiro Horai
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 24:206-11. 2014
    ..This is the first Japanese case of severe CPN complicated by destructive arthropathy. Quantification of serum IL-6 might be useful in diagnosis and evaluation of CPN...
  42. ncbi Characterization of peripheral natural killer cells in primary Sjögren's syndrome: impaired NK cell activity and low NK cell number
    Yasumori Izumi
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Lab Clin Med 147:242-9. 2006
    ..These data suggest that reduced NK cell numbers, probably a result of apoptotic death, may contribute to impaired NK cell activity in patients with primary SS...
  43. ncbi [Role of apoptosis in the pathogenesis of rheumatoid arthritis]
    Atsushi Kawakami
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    Nihon Rinsho 63:100-5. 2005
  44. ncbi Toll-like receptor in salivary glands from patients with Sjögren's syndrome: functional analysis by human salivary gland cell line
    Atsushi Kawakami
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Rheumatol 34:1019-26. 2007
    ..We investigated expression of toll-like receptor (TLR) in labial salivary glands of patients with Sjögren's syndrome (SS) and functional TLR expression in the cultured salivary gland cell line...
  45. ncbi Infliximab is effective for Takayasu arteritis refractory to glucocorticoid and methotrexate
    Fumiko Tanaka
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto
    Intern Med 45:313-6. 2006
    ..This is the first case presentation of TA in Japan successfully treated with infliximab...
  46. ncbi Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro-apoptotic stimuli
    Nozomi Iwanaga
    First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan
    J Lab Clin Med 145:105-10. 2005
    ....
  47. doi Clinical, serologic and magnetic resonance imaging of 3 cases of inflammatory myopathy with abundant macrophages in the Japanese population
    Shintaro Hara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Rheumatol Int 33:1059-64. 2013
    ..Severe illness, namely macrophage activation syndrome and acute respiratory distress syndrome, occurred in case 1 but was resolved with intensive combination therapy. The other 2 cases also required glucocorticoids to achieve remission...
  48. doi TLR3-mediated apoptosis and activation of phosphorylated Akt in the salivary gland epithelial cells of primary Sjögren's syndrome patients
    Hideki Nakamura
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki City, Nagasaki 852 8501, Japan
    Rheumatol Int 33:441-50. 2013
    ..Similar results were obtained using SGECs obtained from a normal subject. The results demonstrated for the first time that TLR3 induces the apoptotic cell death of SGECs via the PI3K-Akt signaling pathway...
  49. doi Musculoskeletal ultrasonography assists the diagnostic performance of the 2010 classification criteria for rheumatoid arthritis
    Shin Ya Kawashiri
    Department of Immunology and Rheumatology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 23:36-43. 2013
    ..We investigated whether musculoskeletal ultrasonography (MSKUS) assists the diagnostic performance of the 2010 rheumatoid arthritis (RA) classification criteria...
  50. doi A patient with systemic lupus erythematosus who developed massive small intestinal hemorrhaging during treatment for chronic lupus peritonitis
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 22:312-5. 2012
    ..Abdominal angiography detected multiple bleeding sites from the jejunal and ileal arteries. After transarterial embolization treatment, the melena disappeared. The pathology of this case appeared to be lupus mesenteric vasculitis...
  51. doi CD4+CD25(high)CD127(low/-) Treg cell frequency from peripheral blood correlates with disease activity in patients with rheumatoid arthritis
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 38:2517-21. 2011
    ..To investigate whether the frequency of peripheral blood (PB) regulatory T cells (Treg) correlates with the clinical disease activity of rheumatoid arthritis (RA)...
  52. doi Reduction in serum levels of substance P in patients with rheumatoid arthritis by etanercept, a tumor necrosis factor inhibitor
    Tomoki Origuchi
    Department of Rehabilitation Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8520, Japan
    Mod Rheumatol 21:244-50. 2011
    ..In the CGRP and GRP analyses, these average levels dropped from 1.57 and 0.51 ng/ml to 0.44 and 0.04 ng/ml, respectively. Etanercept appears to decrease substance P levels with an improvement in disease activities...
  53. ncbi A single centre retrospective analysis of AECG classification criteria for primary Sjogren's syndrome based on 112 minor salivary gland biopsies in a Japanese population
    Hideki Nakamura
    Department of Immunology and Rheumatology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki City, Nagasaki 852 8501, Japan
    Rheumatology (Oxford) 49:1290-3. 2010
    ..To assess the usefulness and performance of the American European Consensus Group (AECG) criteria based on minor salivary gland biopsy (MSGB) in Japanese patients with primary SS...
  54. doi Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine
    Satoru Akazawa
    Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Mod Rheumatol 20:606-10. 2010
    ..Subsequently, she was treated with prednisolone and the immunosuppressive agent mizoribine (MZR), and her cardiac function improved. We describe for the first time treatment with MZR for chronic cardiac involvement of SLE...
  55. ncbi [A case of microscopic polyangiitis relapsed with diffuse alveolar hemorrhage and rapidly progressive glomerulonephritis]
    Shinya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
    Nihon Rinsho Meneki Gakkai Kaishi 32:189-94. 2009
    ..Combination therapy with steroid pulse therapy and plasma exchange re-induced remission. Mizoribine was administrated as maintenance therapy with oral prednisolone...
  56. ncbi Membraneous glomerulonephritis and non-Hodgkin's lymphoma in a patient with primary Sjögren's syndrome
    Nozomi Iwanaga
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki, University, Nagasaki, Japan
    Intern Med 46:191-4. 2007
    ..Steroid pulse therapy was not effective. Three months later she was diagnosed with non-Hodgkin's lymphoma of the tongue, and she was given CHOP therapy and radiation. Both the lymphoma and membraneous glomerulonephritis were resolved...
  57. doi HTLV-I virological and histopathological analysis in two cases of anti-centromere-antibody-seropositive Sjögren's syndrome
    Hideki Nakamura
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Nagasaki, 852 8501, Japan
    Mod Rheumatol 23:133-9. 2013
    ..The aim of this study was to show the clinical and pathological characteristics of anti-centromere-antibody (ACA)-seropositive Sjögren's syndrome (SS) in two anti-human T-cell leukemia virus type I (HTLV-I)-seropositive patients...
  58. ncbi Long-term follow-up of adalimumab monotherapy for rheumatoid arthritis in Japanese patients: a report of six cases
    Kunihiro Ichinose
    Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatol Int 32:483-7. 2012
    ..89 ± 0.75. Two patients withdrew because of lack of efficacy, and one patient withdrew because of adverse events (non-Hodgkin lymphoma). Adalimumab resulted in a sustained clinical response in RA patients during 220-week follow-up...
  59. ncbi Twenty-four-week follow-up examination of a leukocytapheresis therapy in rheumatoid arthritis
    Yasumori Izumi
    First Department of Internal Medicine, Graduate School of Biochemical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 16:20-3. 2006
    ....
  60. ncbi Serum amyloid A is a useful marker to evaluate the disease activity of Takayasu's arteritis
    Tomohiro Koga
    Department of General Internal Medicine, NHO National Nagasaki Medical Center, Kubara 2 1001 1, Omura, Nagasaki, Japan
    Rheumatol Int 30:561-3. 2010
    ..The present case suggests that monitoring serum levels of SAA and [(18)F]-FDG-PET could help clinicians to make adequate treatment adjustments in TA patients...
  61. doi Rapid and significant induction of TRAIL-mediated type II cells in apoptosis of primary salivary epithelial cells in primary Sjögren's syndrome
    Hideki Nakamura
    Department of Immunology and Rheumatology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Apoptosis 13:1322-30. 2008
    ..Our results suggest that death receptor-dependent apoptosis in primary cultured SGEC is regulated by the engagement of type II cells in pSS...
  62. ncbi Activation of protein phosphatase causes alternative splicing of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): potential effect on immune surveillance
    Makoto Kamachi
    Department of Internal Medicine, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Biochem Biophys Res Commun 360:280-5. 2007
    ..We demonstrated that TRAIL alters gene expression through mRNA splicing and may change proapoptotic potential in response to cytokine stimulation...
  63. ncbi Examination of IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide antibody (anti-CCP Ab) in Japanese patients with palindromic rheumatism
    Mami Tamai
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Sakamoto, Nagasaki
    Intern Med 45:795-7. 2006
    ..Although follow-up is necessary, the present study may suggest the importance of serological examination, especially anti-CCP Ab, in patients with palindromic rheumatism...
  64. ncbi [A case of chronic tophaceous with a continuous polyarthritis and joint deformity caused by uncontrolled hyperuricemia]
    Shinya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 31:190-4. 2008
    ..m. and cholchine, and did not experience acute attack for 5 months. We suggest that prophylactic administration of cholchine is beneficial in refractory chronic gout patient...
  65. ncbi Case of Sjögren's syndrome presenting as trigeminal nerve palsy
    Yoshiro Horai
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan
    Nihon Rinsho Meneki Gakkai Kaishi 35:199-202. 2012
    ..SS should be considerd as a possible cause of trigeminal nerve disturbances. In addition, parotid gland changes related to SS should be aware in examination of cranial nerve disturbances with MRI...
  66. doi A case of Sjögren syndrome with pulmonary amyloidosis complicating microscopic polyangiitis
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 21:646-50. 2011
    ..Nerve conduction velocity findings showed mononeuropathy multiplex. Livedo vasculitis was observed on bilateral lower legs, and skin biopsy showed leukoclastic vasculitis. We diagnosed the patient as having microscopic polyangiitis...
  67. doi Successful treatment of a patient with IgG4-related disease with a paravertebral mass lesion
    Hideki Nakamura
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Nagasaki, 852 8501, Japan
    Mod Rheumatol 21:524-7. 2011
    ..Nine months after the initiation of prednisolone, serum IgG4 was reduced to 31.4 mg/dl, and there was norecurrence...
  68. ncbi Tacrolimus as a reinforcement therapy for a patient with MPO-ANCA-associated diffuse alveolar hemorrhage
    Satoko Kawasaki
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki City, Nagasaki 852 8501, Japan
    Clin Rheumatol 26:1211-4. 2007
    ..Tacrolimus was employed for the maintenance therapy, and the oral prednisolone dosage could successfully be tapered without recurrence, along with the decrement of the titer of MPO-ANCA...
  69. ncbi La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity
    Mingguo Huang
    Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Life Sci 81:1461-6. 2007
    ..These results suggest that La protein is cleaved by granzyme B and N-terminal La fragment (27 kD) translocated to the cytoplasm, thus leading to a novel autoantibody production during granzyme B-mediated cytotoxicity...
  70. doi Long-term efficacy of intravenously administered immunoglobulin in a case of polymyositis with limited application of steroid therapy
    Hideki Nakamura
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Nagasaki 852 8501, Japan
    Mod Rheumatol 20:496-9. 2010
    ..Two weeks after the IVIG therapy, muscle test scores, activities of daily living, and muscle enzymes were drastically improved. Twenty months after IVIG, no relapse of PM was observed...
  71. ncbi Adipogenesis of the mesenchymal stromal cells and bone oedema in rheumatoid arthritis
    A Okada
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Clin Exp Rheumatol 30:332-7. 2012
    ..Here, we demonstrate the possible roles of mesenchymal stromal cells (MSCs) in bone oedema formation and the pathogenic potential of the cells in RA...
  72. pmc Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome
    Kazuhiko Arima
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8501, Japan
    Proc Natl Acad Sci U S A 108:14914-9. 2011
    ..These results show that a mutation within a proteasome subunit is the direct cause of a human disease and suggest that decreased proteasome activity can cause inflammation...
  73. ncbi Successful treatment of a patient with primary Sjögren's syndrome complicated with pericarditis during pregnancy
    Kazuo Mutsukura
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    Intern Med 46:1143-7. 2007
    ..The patient's condition improved rapidly, and she delivered a healthy baby. This is the first case to support the beneficial effect of prednisolone in pericarditis with pSS, and illustrates its safety during pregnancy...
  74. doi Regulation of disease susceptibility and mononuclear cell infiltration into the labial salivary glands of Sjögren's syndrome by monocyte chemotactic protein-1
    Naoki Iwamoto
    Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Rheumatology (Oxford) 49:1472-8. 2010
    ..To investigate how monocyte chemotactic protein-1 (MCP-1) is involved in the pathological process of primary SS (pSS)...
  75. pmc Different expression levels of TNF receptors on the rheumatoid synovial macrophages derived from surgery and a synovectomy as detected by a new flow cytometric analysis
    Hiroaki Ida
    First Department of Internal Medicine, Nagasaki University Hospital, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Cytotechnology 60:161-4. 2009
    ..Using this system, we detected a higher population of macrophages and a greater TNF receptor expression on the synovial macrophages derived from a synovectomy in comparison to the findings obtained from knee joint replacement surgery...
  76. doi Successful treatment of sepsis-induced disseminated intravascular coagulation in a patient with idiopathic thrombocytopenic purpura using recombinant human soluble thrombomodulin
    Tomohiro Koga
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto 1 7 1, Nagasaki 852 8501, Japan
    Rheumatol Int 31:1657-9. 2011
    ..We suggest that rTM provides a new therapeutic strategy for DIC patients with high hemorrhagic risk...
  77. ncbi EGF activates PI3K-Akt and NF-kappaB via distinct pathways in salivary epithelial cells in Sjögren's syndrome
    Hideki Nakamura
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Nagasaki, Japan
    Rheumatol Int 28:127-36. 2007
    ..Our data suggest that EGF stimulates both the PI3K-Akt pathway and NF-kappaB via distinct mechanisms, promoting tropic effects in SS salivary epithelial cells...
  78. ncbi Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death
    Hiroaki Ida
    First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Eur J Immunol 33:3284-92. 2003
    ..We suggest that granzyme B leakage-induced cell death is an important determinant of activation-induced NK cell death and that this process may be important for the fate of NK cells which encounter malignant or virus-infected cells...
  79. ncbi Interleukin-18 induces serum amyloid A (SAA) protein production from rheumatoid synovial fibroblasts
    Fumiko Tanaka
    First Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto 1 7 1, Nagasaki, Japan
    Life Sci 74:1671-9. 2004
    ..These results indicate a novel role for IL-18 in rheumatoid inflammation through the synovial SAA production...
  80. doi Multiple bone fracture due to Fanconi's syndrome in primary Sjögren's syndrome complicated with organizing pneumonia
    Hideki Nakamura
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki City, Nagasaki, 852 8501, Japan
    Rheumatol Int 30:265-7. 2009
    ..A rare complication of Fanconi’s syndrome with OP in SS is described...
  81. ncbi Efficacy of probenecid for a patient with juvenile dermatomyositis complicated with calcinosis
    Hideki Nakamura
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Japan
    J Rheumatol 33:1691-3. 2006
    ..We suggest that probenecid is useful for the treatment of calcinosis of JDM...
  82. ncbi A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica
    Hideki Nakamura
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki, Nagasaki 852 8501, Japan
    Mod Rheumatol 19:427-30. 2009
    ..A skin biopsy from his toe revealed microthromboembolism without vasculitis, resulting in the diagnosis of cold agglutinin disease (CAD). This is a first case report of CAD complicated with PMR...
  83. ncbi Activation of MKK4 (SEK1), JNK, and c-Jun in labial salivary infiltrating T cells in patients with Sjögren's syndrome
    Kazutaka Soejima
    The First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki City, Nagasaki, 852 8501, Japan
    Rheumatol Int 27:329-33. 2007
    ..The results of this study suggest that the JNK cascade is activated in salivary infiltrating CD4+ T cells and CD8+ T cells in SS patients, which appears to contribute to the inflammatory salivary microenvironment of SS...
  84. ncbi A case of mixed connective tissue disease complicated with hypertrophic obstructive cardiomyopathy
    Hideki Nakamura
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki City, Nagasaki 852 8501, Japan
    Rheumatol Int 28:1273-5. 2008
    ..She was treated with prednisolone, resulting in improvement of swollen hand, elevated muscle enzymes and interstitial pneumonia. A rare complication of HOCM with MCTD was described...
  85. doi Isoniazid-triggered pure red cell aplasia in systemic lupus erythematosus complicated with myasthenia gravis
    Hideki Nakamura
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki City, Nagasaki, 852 8501, Japan
    Rheumatol Int 30:1643-5. 2010
    ..Finally, cyclosporine A successfully improved PRCA. Although both SLE and MG have the potential complication of PRCA, we report here a case of isoniazid-triggered PRCA...
  86. ncbi Clinical differences between interstitial lung disease associated with clinically amyopathic dermatomyositis and classic dermatomyositis
    Hiroshi Mukae
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Chest 136:1341-7. 2009
    ..The aim of the present study was to clarify the differences in clinical characteristics and prognosis of patients with ILD associated with CADM (CADM-ILD) and classic dermatomyositis associated with ILD (DM-ILD)...
  87. ncbi Involvement of apoptotic cell death in autoimmune diseases
    Atsushi Kawakami
    The First Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Med Electron Microsc 35:1-8. 2002
    ..These data indicate that the correction of apoptotic cell death in each cell type will become a new therapeutic strategy for treatment of human autoimmune diseases...
  88. doi A CLCN1 mutation in dominant myotonia congenita impairs the increment of chloride conductance during repetitive depolarization
    Akira Tsujino
    First Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Neurosci Lett 494:155-60. 2011
    ..This pathophysiology may explain the clinical features of myotonia congenita...
  89. ncbi Modulation of the expression of membrane-bound CD54 (mCD54) and soluble form of CD54 (sCD54) in endothelial cells by glucosyl transferase inhibitor: possible role of ceramide for the shedding of mCD54
    Atsushi Kawakami
    The First Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, 852 8501, Nagasaki, Japan
    Biochem Biophys Res Commun 296:26-31. 2002
    ..These data provide the possibility that the shedding of mCD54 into sCD54 by metalloproteinase-like enzyme is inhibited by PDMP, in which PDMP-induced accumulation of ceramide may act as a second messenger...
  90. ncbi Interferon-alpha sensitizes human hepatoma cells to TRAIL-induced apoptosis through DR5 upregulation and NF-kappa B inactivation
    Masaya Shigeno
    First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Oncogene 22:1653-62. 2003
    ..Our results suggest that IFN-alpha could sensitize certain human hepatoma cells to TRAIL-induced apoptosis by stimulating its death signaling and by repressing the survival function in these cells...
  91. ncbi Regulation of apoptotic cell death by cytokines in a human salivary gland cell line: distinct and synergistic mechanisms in apoptosis induced by tumor necrosis factor alpha and interferon gamma
    Makoto Kamachi
    First Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    J Lab Clin Med 139:13-9. 2002
    ....
  92. ncbi [Etanercept: recombinant human soluble tumor necrosis factor receptor fusion protein]
    Keita Fujikawa
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
    Nihon Rinsho 65:1211-7. 2007
    ..Recent investigations have revealed successful clinical efficacy of biologics in RA including etanercept. We reviewed here the structure and efficacy of etanercept in RA according to the published evidence...
  93. ncbi [Classification of early arthritis patients and how to determine disease severity]
    Atsushi Kawakami
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    Nihon Rinsho Meneki Gakkai Kaishi 30:37-40. 2007
    ..In addition, we are going to classify the pathologic status (disease severity) of early arthritis patients by serologic variables, radiographic findings and genetic analysis...