Tomoyuki Kakugawa

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. doi request reprint Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Nagasaki 852 8501, Japan
    BMC Pulm Med 14:48. 2014
  2. ncbi request reprint Serum heat shock protein 47 levels in patients with drug-induced lung disease
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respir Res 14:133. 2013
  3. pmc Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Cell Stress Chaperones 18:581-90. 2013
  4. pmc Development of imatinibmesylate-induced interstitial lung disease 2 weeks after discontinuation of the treatment: a case report
    Shota Nakashima
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Multidiscip Respir Med 7:48. 2012
  5. doi request reprint Effects of doxycycline on production of growth factors and matrix metalloproteinases in pulmonary fibrosis
    Hanako Fujita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respiration 81:420-30. 2011
  6. ncbi request reprint Elevated levels of interferon gamma-inducible protein-10 and epithelial neutrophil-activating peptide-78 in patients with pulmonary sarcoidosis
    Kanako Sugiyama
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respirology 11:708-14. 2006
  7. doi request reprint Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells
    Misato Amenomori
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Exp Lung Res 36:411-9. 2010
  8. pmc Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells
    Keiko Hisatomi
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    BMC Pulm Med 12:24. 2012
  9. ncbi request reprint HSP47 in lung fibroblasts is a predictor of survival in fibrotic nonspecific interstitial pneumonia
    Misato Amenomori
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Respir Med 104:895-901. 2010
  10. ncbi request reprint Comparison of BALF concentrations of ENA-78 and IP10 in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
    Seiko Nakayama
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respir Med 99:1145-51. 2005

Collaborators

Detail Information

Publications46

  1. doi request reprint Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Nagasaki 852 8501, Japan
    BMC Pulm Med 14:48. 2014
    ..We hypothesized that HSP47 could be a useful marker for fibrotic lung disease. The aim of this study was to evaluate serum levels of HSP47 in patients with various idiopathic interstitial pneumonias (IIPs)...
  2. ncbi request reprint Serum heat shock protein 47 levels in patients with drug-induced lung disease
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respir Res 14:133. 2013
    ..The aim of this study was to evaluate serum HSP47 levels in patients with drug-induced lung disease (DILD)...
  3. pmc Serum heat shock protein 47 levels are elevated in acute exacerbation of idiopathic pulmonary fibrosis
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Cell Stress Chaperones 18:581-90. 2013
    ..Serum HSP47 was significantly higher in AE-IPF than in S-IPF patients, suggesting that underlying fibrogenic mechanisms involving HSP47 differ in the two conditions...
  4. pmc Development of imatinibmesylate-induced interstitial lung disease 2 weeks after discontinuation of the treatment: a case report
    Shota Nakashima
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Multidiscip Respir Med 7:48. 2012
    ..abstract:..
  5. doi request reprint Effects of doxycycline on production of growth factors and matrix metalloproteinases in pulmonary fibrosis
    Hanako Fujita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respiration 81:420-30. 2011
    ..Doxycycline hydrochloride (DOXY), an inhibitor of MMPs, attenuates pulmonary fibrosis in models and in patients with IPF; however, the mechanism of this action remains obscure...
  6. ncbi request reprint Elevated levels of interferon gamma-inducible protein-10 and epithelial neutrophil-activating peptide-78 in patients with pulmonary sarcoidosis
    Kanako Sugiyama
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respirology 11:708-14. 2006
    ..In sarcoidosis, the potential role of IP-10 to regulate the migration and activation of T-cells towards sites of sarcoid activity has been suggested...
  7. doi request reprint Differential effects of human neutrophil peptide-1 on growth factor and interleukin-8 production by human lung fibroblasts and epithelial cells
    Misato Amenomori
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Exp Lung Res 36:411-9. 2010
    ..These results suggest that alpha-defensins play different roles in the pathogenesis of IPF, CF, and DPB according to the location in the lung where the alpha-defensins are mainly produced...
  8. pmc Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells
    Keiko Hisatomi
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    BMC Pulm Med 12:24. 2012
    ..The present study evaluates the effects of pirfenidone on collagen type I and HSP47 expression in the human alveolar epithelial cell line, A549 cells in vitro...
  9. ncbi request reprint HSP47 in lung fibroblasts is a predictor of survival in fibrotic nonspecific interstitial pneumonia
    Misato Amenomori
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Respir Med 104:895-901. 2010
    ..Therefore, the association between lung fibroblast HSP47 expression and prognosis in fibrotic NSIP was evaluated...
  10. ncbi request reprint Comparison of BALF concentrations of ENA-78 and IP10 in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
    Seiko Nakayama
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respir Med 99:1145-51. 2005
    ..Therefore, the pathogenesis of NSIP seems to be different from that of IPF, but this remains unclear. The aim of the present study was to evaluate the contribution of ENA-78 and IP10 in the two diseases...
  11. ncbi request reprint Pirfenidone inhibits the expression of HSP47 in TGF-beta1-stimulated human lung fibroblasts
    Seiko Nakayama
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Life Sci 82:210-7. 2008
    ....
  12. doi request reprint Localization of HSP47 mRNA in murine bleomycin-induced pulmonary fibrosis
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Virchows Arch 456:309-15. 2010
    ..These results suggest that these cells may synthesize procollagen in the fibrotic process of bleomycin-treated lungs through upregulation of HSP47 mRNA and play an important role in fibrogenesis...
  13. ncbi request reprint Drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benzbromarone
    Atsuko Hara
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Intern Med 49:435-8. 2010
    ..Here, we report this rare case of benzbromarone-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage...
  14. ncbi request reprint Alpha-defensin enhances expression of HSP47 and collagen-1 in human lung fibroblasts
    Sumako Yoshioka
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, 852 8501 Japan
    Life Sci 80:1839-45. 2007
    ....
  15. doi request reprint S100A9 in BALF is a candidate biomarker of idiopathic pulmonary fibrosis
    Atsuko Hara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Respir Med 106:571-80. 2012
    ....
  16. pmc Expression of HSP47 in usual interstitial pneumonia and nonspecific interstitial pneumonia
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respir Res 6:57. 2005
    ....
  17. pmc High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    BMC Pulm Med 8:23. 2008
    ..Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. HSP47 is increased in various fibrotic diseases. We investigated the autoantibodies to HSP47 in IIPs...
  18. ncbi request reprint Elevated tenascin-C levels in bronchoalveolar lavage fluid of patients with sarcoidosis
    Hanako Fujita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    Lung 190:537-43. 2012
    ..Tenascin-C is an extracellular matrix molecule expressed during wound healing in various tissues. The present study aimed to investigate the role of tenascin-C in sarcoidosis...
  19. doi request reprint Clinical differences between interstitial lung disease associated with clinically amyopathic dermatomyositis and classic dermatomyositis
    Hiroshi Mukae
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Chest 136:1341-7. 2009
    ..The aim of the present study was to clarify the differences in clinical characteristics and prognosis of patients with ILD associated with CADM (CADM-ILD) and classic dermatomyositis associated with ILD (DM-ILD)...
  20. doi request reprint Anti-inflammatory effects of garenoxacin on IL-8 production and ERK1/2 activation induced by lipopolysaccharides in A549 and THP-1 cells
    Shintaro Hara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Eur J Pharmacol 668:264-70. 2011
    ..Our findings suggest that GRNX is suitable for the treatment of LPS-induced respiratory infection and inflammatory airway diseases...
  21. ncbi request reprint [A case of multiple pulmonary infarctions associated with Sjögren's syndrome and antipsychotic agent administration]
    Seiko Nakayama
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 42:975-80. 2004
    ..The patient did not have any underlying disease or coagulation abnormalities, but Sjögren's syndrome and an antipsychotic agent were suspected to be background factors...
  22. ncbi request reprint [Case of nonspecific interstitial pneumonia associated with aortitis syndrome]
    Noriho Sakamoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 46:116-9. 2008
    ..In this case of NSIP pattern associated with aortitis syndrome we speculate that repeated pulmonary infarction and alveolar hemorrhages caused the NSIP pattern...
  23. ncbi request reprint A rare case of dilatation of pulmonary veins and pulmonary emphysema in both lower lobes
    Hiroshi Ishii
    Department of Internal Medicine, Health Insurance Isahaya General Hospital, Nagasaki, Japan
    Respirology 10:548-52. 2005
    ..This is a rare case of possible congenital or idiopathic diffuse dilatation of the pulmonary veins...
  24. ncbi request reprint [A case of endobronchial sarcoidosis presenting as a polypoid lesion]
    Hiroshi Ishii
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    Nihon Kokyuki Gakkai Zasshi 40:256-60. 2002
    ..However, biopsy specimens of normal mucosa in sarcoidosis often show a microscopic sarcoid process, so a diagnosis of endobronchial sarcoidosis in this case should be given prudently...
  25. ncbi request reprint High-BAL fluid concentrations of RANTES in nonspecific interstitial pneumonia compared with usual interstitial pneumonia
    Sumako Yoshioka
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Respir Med 98:945-51. 2004
    ..01). These results suggest that RANTES and MCP-1 in BAL fluid may play an important role in inflammatory cell recruitment to the lung in idiopathic NSIP as well as other interstitial lung diseases...
  26. doi request reprint Clinical, serologic and magnetic resonance imaging of 3 cases of inflammatory myopathy with abundant macrophages in the Japanese population
    Shintaro Hara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Rheumatol Int 33:1059-64. 2013
    ..Severe illness, namely macrophage activation syndrome and acute respiratory distress syndrome, occurred in case 1 but was resolved with intensive combination therapy. The other 2 cases also required glucocorticoids to achieve remission...
  27. ncbi request reprint [A case of drug-induced pneumonia possibly associated with simvastatin]
    Sumako Yoshioka
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 43:600-4. 2005
    ..Now hyperlipidemia is treated frequently with HMG-CoA reductase inhibitor, but there are few reports demonstrating lung injury by this drug. We should be aware of lung side effects of HMG-CoA reductase inhibitor...
  28. ncbi request reprint Soluble form of Fas and Fas ligand in serum and bronchoalveolar lavage fluid of individuals infected with human T-lymphotropic virus type 1
    Noriho Sakamoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto 1 7 1, Nagasaki 852 8501, Japan
    Respir Med 98:213-9. 2004
    ....
  29. ncbi request reprint Nonspecific interstitial pneumonia with poor prognosis associated with amyopathic dermatomyositis
    Noriho Sakamoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki
    Intern Med 43:838-42. 2004
    ..Although idiopathic NSIP is known to have a better prognosis, NSIP in ADM could be a fatal disease. Therefore, we should appropriately treat interstitial pneumonia in ADM even if it is NSIP...
  30. ncbi request reprint Giant cell interstitial pneumonia in a 15-year-old boy
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki
    Intern Med 41:1007-12. 2002
    ..The average age at onset was 46.2+/-15.0 years. Our patient is the youngest case of GIP reported in the world...
  31. ncbi request reprint [Comparison of bronchoalveolar lavage fluids from nonspecific interstitial pneumonia and from ordinary interstitial pneumonia]
    Noriho Sakamoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Nihon Kokyuki Gakkai Zasshi 40:564-8. 2002
    ..The CD4/CD8 ratio in BALF of idiopathic NSIP was lower than with idiopathic UIP. It is important that NSIP be distinguished from UIP clinically, and our results suggest that BALF cell findings may be useful for making this distinction...
  32. ncbi request reprint Differential effects of alpha- and beta-defensin on cytokine production by cultured human bronchial epithelial cells
    Noriho Sakamoto
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Sakamoto 1 7 1, Nagasaki 852 8501, Japan
    Am J Physiol Lung Cell Mol Physiol 288:L508-13. 2005
    ..These results suggest that alpha- and beta-defensins have different effects on cytokine synthesis by airway epithelial cells, and we speculate that they play different roles in inflammatory lung diseases...
  33. ncbi request reprint Increased expression of collagen-binding heat shock protein 47 in murine bleomycin-induced pneumopathy
    Hiroshi Ishii
    Second Dept of Internal Medicine, Nagasaki Univ School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan, 852 8501
    Am J Physiol Lung Cell Mol Physiol 285:L957-63. 2003
    ..406, P <0.05). Our results suggest that these cells may play a role in the fibrotic process of BLM-treated lungs through upregulation of HSP47...
  34. doi request reprint Direct hemoperfusion using immobilized polymyxin B in patients with rapidly progressive interstitial pneumonias: a retrospective study
    Shintaro Hara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respiration 81:107-17. 2011
    ..However, little is known about the effectiveness of PMX-DHP for rapidly progressive IP...
  35. ncbi request reprint [A case of pulmonary sarcoidosis with cavitation]
    Sumako Yoshioka
    Second Department of Internal Medicine, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    Nihon Kokyuki Gakkai Zasshi 41:486-90. 2003
    ..After treatment with prednisolone (30 mg/day), the multiple cavitary lesions, diffuse granular shadows and skin lesions showed obvious improvement...
  36. ncbi request reprint Bronchiolitis in a patient with ulcerative colitis treated with erythromycin
    Noriho Sakamoto
    The Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    Intern Med 53:875-7. 2014
    ..Small airway disease associated with UC is usually treated with steroids. Our experience shows that airway involvement in patients with inflammatory bowel disease can be treated with macrolides. ..
  37. doi request reprint A case of acute sarcoid myositis treated with weekly low-dose methotrexate
    Hanako Fujita
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Muscle Nerve 44:994-9. 2011
    ..Concurrent administration of methotrexate could be a therapeutic option for cases with acute sarcoid myositis refractory to steroid therapy...
  38. ncbi request reprint Primary ciliary dyskinesia that responded to long-term, low-dose clarithromycin
    Daisuke Yoshioka
    The Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Intern Med 49:1437-40. 2010
    ..Although the effects of macrolide therapy remain controversial, long-term treatment with low-dose clarithromycin might confer clinical benefits upon patients with PCD...
  39. ncbi request reprint Diffuse alveolar hemorrhage in a patient with ankylosing spondylitis
    Shintaro Hara
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    Intern Med 52:1963-6. 2013
    ..Further clinical case reports and investigations are needed to clarify whether DAH represents a possible pulmonary manifestation of AS. ..
  40. doi request reprint Interstitial pneumonia associated with linear immunoglobulin A/immunoglobulin G bullous dermatosis
    Tomoyuki Kakugawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Respiration 86:347-51. 2013
    ..Lung disorders associated with linear IgA/IgG bullous dermatosis are extremely rare and, to our knowledge, this is the first report of such a case of interstitial pneumonia. ..
  41. ncbi request reprint [A rare case of marked dilatation of the pulmonary veins and emphysematous lesions in both lower lung lobes]
    Hiroshi Ishii
    Department of Internal Medicine, Health Insurance Isahaya General Hospital, Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan
    Nihon Kokyuki Gakkai Zasshi 42:84-8. 2004
    ..This is a very rare case in which there is a possibility of congenital or idiopathic dilatation of the pulmonary veins...
  42. doi request reprint A case of Sjögren syndrome with pulmonary amyloidosis complicating microscopic polyangiitis
    Shin Ya Kawashiri
    Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Mod Rheumatol 21:646-50. 2011
    ..Nerve conduction velocity findings showed mononeuropathy multiplex. Livedo vasculitis was observed on bilateral lower legs, and skin biopsy showed leukoclastic vasculitis. We diagnosed the patient as having microscopic polyangiitis...
  43. doi request reprint Characteristics and disease severity of healthcare-associated pneumonia among patients in a hospital in Kitakyushu, Japan
    Masafumi Seki
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Infect Chemother 17:363-9. 2011
    ..This study provides additional evidence that HCAP should be distinguished from CAP and suggests the pathogenesis and therapeutic strategy for HCAP may be similar to those for hospital-acquired pneumonia...
  44. pmc Evaluation of a rapid immunochromatographic ODK0501 assay for detecting Streptococcus pneumoniae antigen in sputum samples from patients with lower respiratory tract infection
    Koichi Izumikawa
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Clin Vaccine Immunol 16:672-8. 2009
    ..pneumoniae antigen among patients with underlying chronic obstructive pulmonary disease. In conclusion, ODK0501 is noninvasive, rapid, and an accurate tool for diagnosing respiratory infection caused by S. pneumoniae...
  45. ncbi request reprint Severe Japanese spotted fever successfully treated with fluoroquinolone
    Masafumi Seki
    Nagasaki University Graduate School of Biomedical Sciences, Department of Molecular Microbiology and Immunology, The Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Intern Med 45:1323-6. 2006
    ..R. japonica-specific DNA was detected by PCR from the tick: Haemaphysalis hystricis larvae collected from a mountainous location in Fukuoka, Japan where the patient had been bitten...
  46. ncbi request reprint [Desquamative interstitial pneumonia--case report and review of literature]
    Hiroshi Ishii
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 40:160-5. 2002
    ..All patients have good prognoses and a high frequency of steroid responsiveness. Moreover, many patients were positive for antinuclear antibodies in serological tests, and there was a tendency toward increasing eosinophils in BAL fluids...