Takashi Ito

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. pmc Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo
    Hitoshi Aihara
    Department of Biochemistry, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Genes Dev 18:877-88. 2004
  2. doi request reprint Core histone H2A ubiquitylation and transcriptional regulation
    Miki Higashi
    Department of Biochemistry, Nagasaki University School of Medicine, Nagasaki, Nagasaki, Japan
    Exp Cell Res 316:2707-12. 2010
  3. ncbi request reprint Nucleosome assembly and remodeling
    T Ito
    Department of Biochemistry, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Curr Top Microbiol Immunol 274:1-22. 2003
  4. ncbi request reprint Role of histone modification in chromatin dynamics
    Takashi Ito
    Department of Biochemistry, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki, Nagasaki 852 8523, Japan
    J Biochem 141:609-14. 2007
  5. ncbi request reprint Role of histone phosphorylation in chromatin dynamics and its implications in diseases
    Masaya Oki
    Department of Biochemistry, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki, Nagasaki 852 8523, Japan
    Subcell Biochem 41:319-36. 2007
  6. pmc Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation
    Takeya Nakagawa
    Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Genes Dev 22:37-49. 2008
  7. pmc DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
    Tsuyoshi Ikura
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryoumachi 2 1, Aobaku Sendai 980 8575, Japan
    Mol Cell Biol 27:7028-40. 2007
  8. ncbi request reprint A pitfall in diagnosis of human prion diseases using detection of protease-resistant prion protein in urine. Contamination with bacterial outer membrane proteins
    Hisako Furukawa
    Departments of Pharmacology 1, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Biol Chem 279:23661-7. 2004
  9. ncbi request reprint [Transcriptional regulation by post-translational modification of histone]
    Kiyoshi Yasui
    Department of Biochemistry, Nagasaki University, 1 12 4 Sakamoto, Nagasaki, Nagasaki 852 8523, Japan
    Seikagaku 77:498-504. 2005
  10. doi request reprint Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
    Yasutake Katoh
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    Mol Cell 41:554-66. 2011

Collaborators

Detail Information

Publications34

  1. pmc Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo
    Hitoshi Aihara
    Department of Biochemistry, Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Genes Dev 18:877-88. 2004
    ..These studies reveal that NHK-1-catalyzed phosphorylation of a conserved serine/threonine residue in H2A is a new component of the histone code that might be related to cell cycle progression...
  2. doi request reprint Core histone H2A ubiquitylation and transcriptional regulation
    Miki Higashi
    Department of Biochemistry, Nagasaki University School of Medicine, Nagasaki, Nagasaki, Japan
    Exp Cell Res 316:2707-12. 2010
    ..Recent advances concerning core histone H2A ubiquitylation and transcriptional regulation will be reviewed and the cellular functions of these histone modifications will be discussed...
  3. ncbi request reprint Nucleosome assembly and remodeling
    T Ito
    Department of Biochemistry, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Curr Top Microbiol Immunol 274:1-22. 2003
    ..In addition, modification of chromatin structure is an important regulatory mechanism. Here I review the mechanism of chromatin assembly in vitro and the changes of chromatin structure related to transcriptional activation...
  4. ncbi request reprint Role of histone modification in chromatin dynamics
    Takashi Ito
    Department of Biochemistry, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki, Nagasaki 852 8523, Japan
    J Biochem 141:609-14. 2007
    ..Histone phosphorylation is believed to play a direct role in mitosis, cell death, repair, replication and recombination. In this review, we discuss recent progress in studies of histone phosphorylation...
  5. ncbi request reprint Role of histone phosphorylation in chromatin dynamics and its implications in diseases
    Masaya Oki
    Department of Biochemistry, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki, Nagasaki 852 8523, Japan
    Subcell Biochem 41:319-36. 2007
    ..However, definitive roles for this modification in these processes have not yet been elucidated. In this review, we discuss recent progress in studies of histone phosphorylation...
  6. pmc Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation
    Takeya Nakagawa
    Nagasaki University School of Medicine, Nagasaki 852 8523, Japan
    Genes Dev 22:37-49. 2008
    ..Our studies revealed a novel mode of trans-histone cross-talk, in which H2A ubiquitylation controls the di- and trimethylation of H3K4, resulting in regulation of transcriptional initiation...
  7. pmc DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
    Tsuyoshi Ikura
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryoumachi 2 1, Aobaku Sendai 980 8575, Japan
    Mol Cell Biol 27:7028-40. 2007
    ..We conclude that the sequential acetylation and ubiquitination of H2AX by TIP60-UBC13 promote enhanced histone dynamics, which in turn stimulate a DNA damage response...
  8. ncbi request reprint A pitfall in diagnosis of human prion diseases using detection of protease-resistant prion protein in urine. Contamination with bacterial outer membrane proteins
    Hisako Furukawa
    Departments of Pharmacology 1, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Biol Chem 279:23661-7. 2004
    ..Therefore, the presence of Enterobacterial species should be excluded in the immunological tests for PrPSc in clinical samples, in particular, urine...
  9. ncbi request reprint [Transcriptional regulation by post-translational modification of histone]
    Kiyoshi Yasui
    Department of Biochemistry, Nagasaki University, 1 12 4 Sakamoto, Nagasaki, Nagasaki 852 8523, Japan
    Seikagaku 77:498-504. 2005
  10. doi request reprint Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
    Yasutake Katoh
    Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980 8575, Japan
    Mol Cell 41:554-66. 2011
    ..MATII serves as a transcriptional corepressor of MafK by interacting with chromatin regulators and supplying SAM for methyltransferases...
  11. doi request reprint Interferon regulatory factor-4 activates IL-2 and IL-4 promoters in cooperation with c-Rel
    Hisakazu Shindo
    Division of Cytokine Signaling, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cytokine 56:564-72. 2011
    ....
  12. pmc The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells
    Junya Hayase
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cell Biol 200:635-50. 2013
    ..Thus, Par6-aPKC recruitment to the premature apical membrane appears to be required for definition of apical identity of epithelial cells...
  13. ncbi request reprint Isoflavones stimulate estrogen receptor-mediated core histone acetylation
    Tao Hong
    Department of Biochemistry, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Biochem Biophys Res Commun 317:259-64. 2004
    ....
  14. pmc Concerted action of Aurora B, Polo and NHK-1 kinases in centromere-specific histone 2A phosphorylation
    Amy L Brittle
    The Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK
    Exp Cell Res 313:2780-5. 2007
    ..Epistasis analysis indicated that Polo functions upstream of the H2A kinase NHK-1 but parallel to Aurora B. Therefore, multiple mitotic kinases work together to specify the spatial and temporal pattern of H2A T119 phosphorylation...
  15. ncbi request reprint [Chromatin remodeling factors]
    Yasuaki Nanba
    Tanpakushitsu Kakusan Koso 51:2076-82. 2006
  16. pmc A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes
    Irena Ivanovska
    Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 19:2571-82. 2005
    ..These studies reveal a critical role for histone modifications in chromosome dynamics in meiosis and mitosis...
  17. ncbi request reprint The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome
    Hirochika Kitagawa
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, 113 0032, Tokyo, Japan
    Cell 113:905-17. 2003
    ..This suggests that WINAC dysfunction contributes to Williams syndrome, which could therefore be considered, at least in part, a chromatin-remodeling factor disease...
  18. ncbi request reprint [Signal transduction and chromatin]
    Takeya Nakagawa
    Tanpakushitsu Kakusan Koso 48:2234-40. 2003
  19. ncbi request reprint Sox9 and p300 cooperatively regulate chromatin-mediated transcription
    Takayuki Furumatsu
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 280:35203-8. 2005
    ..These findings suggest that Sox9 interacts with chromatin and activates transcription via regulation of chromatin modification...
  20. pmc Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation
    Tetsuro Ago
    Medical Institute of Bioregulation, Kyushu University, and Department of Molecular and Structural Biology, Kyushu University Graduate School of Medicine, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 100:4474-9. 2003
    ....
  21. ncbi request reprint Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2
    Hiroyuki Kubota
    Division of Genome Biology, Cancer Research Institute, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 0934, Japan
    J Biol Chem 278:20457-60. 2003
    ..However, in contrast with amino acid starvation, rapamycin activates GCN2 without increasing the amount of uncharged tRNAs, but presumably by modifying the tRNA binding affinity of GCN2...
  22. ncbi request reprint Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus
    Hiroyuki Kusuhara
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Pharm Res 20:720-7. 2003
    ..The purpose of this study is to compare the substrate specificity of the transporter in the CP with those of rat organic anion transporting polypeptide 1 (rOatp1) and rOatp3...
  23. ncbi request reprint Identification of Ser-386 of interferon regulatory factor 3 as critical target for inducible phosphorylation that determines activation
    Mitsuaki Mori
    Department of Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Japan
    J Biol Chem 279:9698-702. 2004
    ..These results strongly suggest that Ser-386 is the target of the IRF-3 kinase and critical determinant for the activation of IRF-3...
  24. ncbi request reprint Cytokine and inducible nitric oxide synthase gene expressions in peripheral blood mononuclear cells and related clinical characteristics in Theileria orientalis sergenti-infected calves
    Yukio Yagi
    Hokkaido Research Station, National Institute of Animal Health, Hokkaido, Japan
    J Vet Med Sci 65:1355-9. 2003
    ..Decreased plasma nitrite/nitrate level was observed in the groups. The results of this study indicate that Th1 response is the predominant response in Tos infection, and this response is also related with their clinical characteristics...
  25. pmc Barrier proteins remodel and modify chromatin to restrict silenced domains
    Masaya Oki
    Unit on Chromatin and Transcription, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Mol Cell Biol 24:1956-67. 2004
    ..Our data suggest that multiple overlapping mechanisms were involved in delimiting silenced and active domains in vivo...
  26. pmc Linker histone variants control chromatin dynamics during early embryogenesis
    Hideaki Saeki
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 102:5697-702. 2005
    ..We propose a model that holds that maternally expressed linker histones are key molecules specifying nuclear dynamics with respect to embryonic totipotency...
  27. ncbi request reprint Myogenic induction of taurine transporter prevents dexamethasone-induced muscle atrophy
    Yoriko Uozumi
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565 0871, Japan
    Adv Exp Med Biol 583:265-70. 2006
  28. ncbi request reprint TauT gene expression is regulated by TonEBP and plays a role in cell survival
    Takashi Ito
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Adv Exp Med Biol 583:91-8. 2006
  29. ncbi request reprint Diverse DNA methylation statuses at alternative promoters of human genes in various tissues
    Jieun Cheong
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 5 1 5 Kashiwanoha, Kashiwa, Chiba, Japan
    DNA Res 13:155-67. 2006
    ..DNA methylation appears to play a significant role in differential usage of alternative promoters and may be related to functional diversification between CpG-island-containing promoters and CpG-island-less promoters...
  30. ncbi request reprint Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2
    Chunyuan Jin
    Gene Engineering Division, Dept of Biological Systems, BioResource Center, RIKEN The Institute of Physical and Chemical Research, Tsukuba Science City, Ibaraki 305 0074, Japan
    Nat Struct Mol Biol 13:331-8. 2006
    ..These results suggest that the sequence-specific DNA-binding protein JDP2 may control transcription via direct regulation of the modification of histones and the assembly of chromatin...
  31. ncbi request reprint Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells
    Tomomi Mohri
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita City, Osaka, Japan
    J Biol Chem 281:6442-7. 2006
    ..Collectively, it is proposed that LIF regulates the commitment of cardiac stem cells into the endothelial cell lineage, contributing to neovascularization in the process of tissue remodeling and/or regeneration...
  32. pmc The conserved kinase NHK-1 is essential for mitotic progression and unifying acentrosomal meiotic spindles in Drosophila melanogaster
    C Fiona Cullen
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JR, Scotland, UK
    J Cell Biol 171:593-602. 2005
    ..NHK-1 itself is phosphorylated in mitosis and female meiosis, suggesting that this kinase is part of the regulatory system coordinating progression of mitosis and meiosis...
  33. ncbi request reprint The yeast eIF4E-associated protein Eap1p attenuates GCN4 translation upon TOR-inactivation
    Ryu Matsuo
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    FEBS Lett 579:2433-8. 2005
    ....
  34. pmc Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro
    Hiroshi Asahara
    Peptide Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Mol Cell Biol 22:2974-83. 2002
    ..As p300 acted cooperatively with NAP-1 in stimulating transcription from a chromatin template in vitro, our results suggest a dual role of NAP-1-p300 complexes in promoting chromatin assembly and transcriptional activation...