H Hotokezaka

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. ncbi request reprint Severe dental open bite malocclusion with tongue reduction after orthodontic treatment
    H Hotokezaka
    Department of Orthodontics, Nagasaki University School of Dentistry, Japan
    Angle Orthod 71:228-36. 2001
  2. ncbi request reprint U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells
    Hitoshi Hotokezaka
    Division of Orthodontics and Biomedical Engineering, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
    J Biol Chem 277:47366-72. 2002
  3. ncbi request reprint Interleukin-4 directly inhibits tumor necrosis factor-alpha-mediated osteoclast formation in mouse bone marrow macrophages
    Hideki Kitaura
    Division of Orthodontic and Biomedical Engineering, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Immunol Lett 88:193-8. 2003
  4. ncbi request reprint Infection-induced up-regulation of the costimulatory molecule 4-1BB in osteoblastic cells and its inhibitory effect on M-CSF/RANKL-induced in vitro osteoclastogenesis
    Kan Saito
    Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    J Biol Chem 279:13555-63. 2004
  5. pmc The hemoglobin receptor protein of porphyromonas gingivalis inhibits receptor activator NF-kappaB ligand-induced osteoclastogenesis from bone marrow macrophages
    Yuji Fujimura
    Division of Microbiology and Oral Infection, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Infect Immun 74:2544-51. 2006
  6. ncbi request reprint Molecular analysis of a new insertion sequence from Actinobacillus (Haemophilus) actinomycetemcomitans FDC Y4
    H Hayashida
    Laboratory of Preventive Dentistry, Nagasaki University School of Dentistry, Japan
    Microbiology 142:2449-52. 1996
  7. doi request reprint Effect of celecoxib on emotional stress and pain-related behaviors evoked by experimental tooth movement in the rat
    Tatsunori Shibazaki
    Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University, Nagasaki, Japan
    Angle Orthod 79:1169-74. 2009
  8. ncbi request reprint A calcium-receptor agonist induces gustatory neural responses in bullfrogs
    Yukio Okada
    Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, Nagasaki 852 8588, Japan
    Cell Mol Neurobiol 27:771-81. 2007
  9. ncbi request reprint Molecular analysis of RANKL-independent cell fusion of osteoclast-like cells induced by TNF-alpha, lipopolysaccharide, or peptidoglycan
    Hitoshi Hotokezaka
    Department of Developmental and Reconstructive Medicine, Division of Orthodontics and Biomedical Engineering, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    J Cell Biochem 101:122-34. 2007
  10. ncbi request reprint Biophysical properties of voltage-gated Na+ channels in frog parathyroid cells and their modulation by cannabinoids
    Yukio Okada
    Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki 852 8588, Japan
    J Exp Biol 208:4747-56. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Severe dental open bite malocclusion with tongue reduction after orthodontic treatment
    H Hotokezaka
    Department of Orthodontics, Nagasaki University School of Dentistry, Japan
    Angle Orthod 71:228-36. 2001
    ..Most of the recovery changes occurred within 4 months. This case highlights the importance of the teeth tending to move toward a balance between the tongue pressure from the inside and labio-buccal pressure from the outside...
  2. ncbi request reprint U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells
    Hitoshi Hotokezaka
    Division of Orthodontics and Biomedical Engineering, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan
    J Biol Chem 277:47366-72. 2002
    ..This is the first report that an inhibitor of signal transduction enhanced osteoclastogenesis...
  3. ncbi request reprint Interleukin-4 directly inhibits tumor necrosis factor-alpha-mediated osteoclast formation in mouse bone marrow macrophages
    Hideki Kitaura
    Division of Orthodontic and Biomedical Engineering, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Immunol Lett 88:193-8. 2003
    ..We conclude that IL-4 can strongly inhibit osteoclast formation that is related to both physiological bone resorption induced by RANKL and pathological bone resorption induced by TNF-alpha...
  4. ncbi request reprint Infection-induced up-regulation of the costimulatory molecule 4-1BB in osteoblastic cells and its inhibitory effect on M-CSF/RANKL-induced in vitro osteoclastogenesis
    Kan Saito
    Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    J Biol Chem 279:13555-63. 2004
    ..r4-1BB also abolished RANKL-mediated induction of nuclear factor of activated T cells-2. This study may elucidate a novel role of 4-1BB in cell metabolism, especially osteoclastogenesis...
  5. pmc The hemoglobin receptor protein of porphyromonas gingivalis inhibits receptor activator NF-kappaB ligand-induced osteoclastogenesis from bone marrow macrophages
    Yuji Fujimura
    Division of Microbiology and Oral Infection, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Infect Immun 74:2544-51. 2006
    ..gingivalis, the suppressive effect of HbR on osteoclastogenesis may help the microorganism exist long in the niche...
  6. ncbi request reprint Molecular analysis of a new insertion sequence from Actinobacillus (Haemophilus) actinomycetemcomitans FDC Y4
    H Hayashida
    Laboratory of Preventive Dentistry, Nagasaki University School of Dentistry, Japan
    Microbiology 142:2449-52. 1996
    ..Hybridization patterns of genomic DNA of seven A. actinomycetemcomitans strains with an internal ISAa1 probe varied depending on the serotypes, suggesting that ISAa1 might be a useful tool for epidemiological studies...
  7. doi request reprint Effect of celecoxib on emotional stress and pain-related behaviors evoked by experimental tooth movement in the rat
    Tatsunori Shibazaki
    Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University, Nagasaki, Japan
    Angle Orthod 79:1169-74. 2009
    ..To test the efficacy of an animal model of pain and stress and evaluate the effects of celecoxib administered when orthodontic force is applied...
  8. ncbi request reprint A calcium-receptor agonist induces gustatory neural responses in bullfrogs
    Yukio Okada
    Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki, Nagasaki 852 8588, Japan
    Cell Mol Neurobiol 27:771-81. 2007
    ..The results suggest that NPS R-467 induces neural responses through cell responses unrelated to a resting K(+) conductance decrease...
  9. ncbi request reprint Molecular analysis of RANKL-independent cell fusion of osteoclast-like cells induced by TNF-alpha, lipopolysaccharide, or peptidoglycan
    Hitoshi Hotokezaka
    Department of Developmental and Reconstructive Medicine, Division of Orthodontics and Biomedical Engineering, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    J Cell Biochem 101:122-34. 2007
    ..Although DC-STAMP is considered to be a requisite for cell fusion of osteoclasts, cell fusion-inducing factors other than DC-STAMP might be necessary for the cell fusion...
  10. ncbi request reprint Biophysical properties of voltage-gated Na+ channels in frog parathyroid cells and their modulation by cannabinoids
    Yukio Okada
    Integrative Sensory Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Nagasaki 852 8588, Japan
    J Exp Biol 208:4747-56. 2005
    ..The results suggest that the Na+ currents in frog parathyroid cells can be modulated by cannabinoids via a G protein-dependent mechanism...
  11. ncbi request reprint Effect of IL-12 on TNF-alpha-mediated osteoclast formation in bone marrow cells: apoptosis mediated by Fas/Fas ligand interaction
    Hideki Kitaura
    Division of Orthodontic and Biomedical Engineering, Department of Developmental and Reconstructive Medicine, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan
    J Immunol 169:4732-8. 2002
    ..These results implied that apoptosis of the adherent cells in bone marrow cells might be caused by interaction between TNF-alpha-induced Fas on the adherent cells and IL-12-induced FasL on the nonadherent cells...
  12. ncbi request reprint Analysis of amphotericin B-induced cell signaling with chemical inhibitors of signaling molecules
    Kenichiro Matsuo
    Microbiology and Oral Infection, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Microbiol Immunol 50:337-47. 2006
    ..These signaling molecules may become a target for chemotherapy suppressing AmB-induced proinflammatory cytokine production...
  13. ncbi request reprint Pepstatin A, an aspartic proteinase inhibitor, suppresses RANKL-induced osteoclast differentiation
    Hajime Yoshida
    Division of Oral and Maxillofacial Surgery, Department of Development and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8588
    J Biochem 139:583-90. 2006
    ..These results suggest that pepstatin A suppresses the differentiation of osteoclasts through the blockade of ERK signaling and the inhibition of NFATc1 expression...
  14. ncbi request reprint Cloning and sequencing of a unique antigen MPT70 from Mycobacterium tuberculosis H37Rv and expression in BCG using E. coli-mycobacteria shuttle vector
    S Matsumoto
    Nagasaki University, School of Dentistry, Japan
    Scand J Immunol 41:281-7. 1995
    ..7kbp upstream of the 5' end of them were able to be expressed in BCG Pasteur which is a MPB70 low-producer, but the extent of the expression was not that of a high-producer...
  15. pmc Construction of recombinant hemagglutinin derived from the gingipain-encoding gene of Porphyromonas gingivalis, identification of its target protein on erythrocytes, and inhibition of hemagglutination by an interdomain regional peptide
    Eiko Sakai
    Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Sakamoto 1 7 1, Nagasaki 852 8588, Japan
    J Bacteriol 189:3977-86. 2007
    ..0 x 10(-7) M. These results indicate that the target of HGP44 on the erythrocyte membrane appears to be glycophorin A...