Research Topics

Tomomitsu Hatakeyama

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. request reprint
    Hatakeyama T, Ishimine T, Baba T, Kimura M, Unno H, Goda S. Alteration of the carbohydrate-binding specificity of a C-type lectin CEL-I mutant with an EPN carbohydrate-binding motif. Protein Pept Lett. 2013;20:796-801 pubmed
    ..Additional mutations in the recombinant CEL-I binding site may further increase its specificity for mannose, and should provide insights into designing novel carbohydrate-recognition proteins...
  2. request reprint
    Hatakeyama T, Unno H, Kouzuma Y, Uchida T, Eto S, Hidemura H, et al. C-type lectin-like carbohydrate recognition of the hemolytic lectin CEL-III containing ricin-type -trefoil folds. J Biol Chem. 2007;282:37826-35 pubmed
    ..Binding of GalNAc also induced a slight change in the main chain structure of domain 3, which could be related to the conformational change upon binding of specific carbohydrates to induce oligomerization of the protein...

Detail Information

Publications2

  1. request reprint
    Hatakeyama T, Ishimine T, Baba T, Kimura M, Unno H, Goda S. Alteration of the carbohydrate-binding specificity of a C-type lectin CEL-I mutant with an EPN carbohydrate-binding motif. Protein Pept Lett. 2013;20:796-801 pubmed
    ..Additional mutations in the recombinant CEL-I binding site may further increase its specificity for mannose, and should provide insights into designing novel carbohydrate-recognition proteins...
  2. request reprint
    Hatakeyama T, Unno H, Kouzuma Y, Uchida T, Eto S, Hidemura H, et al. C-type lectin-like carbohydrate recognition of the hemolytic lectin CEL-III containing ricin-type -trefoil folds. J Biol Chem. 2007;282:37826-35 pubmed
    ..Binding of GalNAc also induced a slight change in the main chain structure of domain 3, which could be related to the conformational change upon binding of specific carbohydrates to induce oligomerization of the protein...