Isao Nagano

Summary

Country: Japan

Publications

  1. ncbi request reprint Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis
    Isao Nagano
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Neurol Sci 235:61-8. 2005
  2. ncbi request reprint Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Okayama, Japan
    J Neurosci Res 84:980-92. 2006
  3. ncbi request reprint The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers
    Feng Li
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1048:59-68. 2005
  4. ncbi request reprint Temporal profile of neural stem cell proliferation in the subventricular zone after ischemia/hypoxia in the neonatal rat brain
    Masanori Iwai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, 700 8558, Japan
    Neurol Res 28:461-8. 2006
  5. ncbi request reprint Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia
    Takeshi Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Neurol Res 28:822-5. 2006
  6. ncbi request reprint HMG CoA reductase inhibitors reduce ischemic brain injury of Wistar rats through decreasing oxidative stress on neurons
    Takeshi Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1037:52-8. 2005
  7. ncbi request reprint Temporal profile of stem cell division, migration, and differentiation from subventricular zone to olfactory bulb after transient forebrain ischemia in gerbils
    Masanori Iwai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    J Cereb Blood Flow Metab 23:331-41. 2003
  8. ncbi request reprint Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SODG93A transgenic mice
    Hisashi Narai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    J Neurosci Res 82:452-7. 2005
  9. ncbi request reprint Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO
    Feng Li
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 962:21-6. 2003
  10. ncbi request reprint Coordinate expression of survival p-ERK and proapoptotic cytochrome c signals in rat brain neurons after transient MCAO
    Feng Li
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, 700 8558 Okayama, Japan
    Brain Res 958:83-8. 2002

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of Amyotrophic Lateral Sclerosis
    Isao Nagano
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Neurol Sci 235:61-8. 2005
    ..Taken together, the results suggest that direct administration of IGF-1 into the intrathecal space may have a therapeutic benefit for ALS...
  2. ncbi request reprint Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Okayama, Japan
    J Neurosci Res 84:980-92. 2006
    ....
  3. ncbi request reprint The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers
    Feng Li
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1048:59-68. 2005
    ..The present results suggest that dantrolene significantly decreased infarct volume and provided neuroprotective effect on rats after transient MCAO by reducing ER stress-mediated apoptotic signal pathway activation in the ischemic area...
  4. ncbi request reprint Temporal profile of neural stem cell proliferation in the subventricular zone after ischemia/hypoxia in the neonatal rat brain
    Masanori Iwai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, 700 8558, Japan
    Neurol Res 28:461-8. 2006
    ..In order to elucidate the dynamic changes in neural stem cells in the neonatal brain after I/H, we investigated the proliferation of new cells in the subventricular zone (SVZ)...
  5. ncbi request reprint Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia
    Takeshi Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Neurol Res 28:822-5. 2006
    ..Reduction of brain plasticity underlies the poor outcome of aged stroke patients. The molecular mechanism of plasticity reduction by aging is uncertain, but disturbed lipid metabolism may be implicated...
  6. ncbi request reprint HMG CoA reductase inhibitors reduce ischemic brain injury of Wistar rats through decreasing oxidative stress on neurons
    Takeshi Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1037:52-8. 2005
    ..Reduction of oxidative stress by statins may be one main reason in ameliorating ischemic brain damage in rats...
  7. ncbi request reprint Temporal profile of stem cell division, migration, and differentiation from subventricular zone to olfactory bulb after transient forebrain ischemia in gerbils
    Masanori Iwai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    J Cereb Blood Flow Metab 23:331-41. 2003
    ....
  8. ncbi request reprint Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SODG93A transgenic mice
    Hisashi Narai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Japan
    J Neurosci Res 82:452-7. 2005
    ..These results suggest that IGF-1 treatment prevents motor neuron loss by affecting the signal transduction system through IGF-1R and the main downstream signal, IRS-1...
  9. ncbi request reprint Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO
    Feng Li
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Brain Res 962:21-6. 2003
    ....
  10. ncbi request reprint Coordinate expression of survival p-ERK and proapoptotic cytochrome c signals in rat brain neurons after transient MCAO
    Feng Li
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, 700 8558 Okayama, Japan
    Brain Res 958:83-8. 2002
    ....
  11. ncbi request reprint Spatiotemporal changes of apolipoprotein E immunoreactivity and apolipoprotein E mRNA expression after transient middle cerebral artery occlusion in rat brain
    Hiroshi Kamada
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Neurosci Res 73:545-56. 2003
    ....
  12. ncbi request reprint Sustained induction of survival p-AKT and p-ERK signals after transient hypoxia in mice spinal cord with G93A mutant human SOD1 protein
    Hristelina Ilieva
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, 700 8558 Okayama, Japan
    J Neurol Sci 215:57-62. 2003
    ..The current results suggest that the presence of mutant SOD1 alters survival p-AKT and p-ERK signals, possibly to compensate for the acquired gain-of-function of the mutant protein...
  13. ncbi request reprint Neural precursor cells division and migration in neonatal rat brain after ischemic/hypoxic injury
    Takeshi Hayashi
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1038:41-9. 2005
    ..Progenitor cells may have potential for treating perinatal brain disorders...
  14. ncbi request reprint Expression of neurocan after transient middle cerebral artery occlusion in adult rat brain
    Kentaro Deguchi
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 1037:194-9. 2005
    ..These results indicate that accumulation of the full-length neurocan produced by reactive astrocytes may be one of the processes for tissue repair and reconstruction of neural networks after focal brain ischemia as well...
  15. ncbi request reprint Elevation of MCP-1 and MCP-1/VEGF ratio in cerebrospinal fluid of amyotrophic lateral sclerosis patients
    Tetsuya Nagata
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Neurol Res 29:772-6. 2007
    ..Our data suggested that both MCP-1 levels and MCP-1/VEGF ratio in CSF may be useful markers for the clinical diagnosis of ALS...
  16. ncbi request reprint Deficiency of PAR-2 gene increases acute focal ischemic brain injury
    Guang Jin
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Cereb Blood Flow Metab 25:302-13. 2005
    ..These results show that the deficiency of PAR-2 gene increases the acute ischemic cerebral injury associating with suppression of neuronal ERK activation and reactive astroglial activation...
  17. ncbi request reprint Up-regulation of low-density lipoprotein receptor expression in the ischemic core and the peri-ischemic area after transient MCA occlusion in rats
    Hiroshi Kamada
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res Mol Brain Res 134:181-8. 2005
    ..These results suggest that LDL receptor, interacting with ApoE, is profoundly involved in lipid transport of CNS for tissue repair in the peri-ischemic area after brain ischemia...
  18. ncbi request reprint Age-related changes in peroxisomal membrane protein 70 and superoxide dismutase 1 in transgenic G93A mice
    Hristelina S Ilieva
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurol Res 25:423-6. 2003
    ..It is conceivable that reduction of PMP70 might underlie decrease in peroxisomal functions and increase in oxidative stress that is well documented in this animal model...
  19. ncbi request reprint Temporal and spatial changes of free cholesterol and neutral lipids in rat brain after transient middle cerebral artery occlusion
    Hiroshi Kamada
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Res 45:91-100. 2003
    ..These results suggest that changes of FC and NLs are different temporally and spatially between the core and penumbra in relation to degenerative and regenerative neural processes following brain ischemia...
  20. ncbi request reprint Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene
    Tetsuro Murakami
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 989:231-7. 2003
    ....
  21. ncbi request reprint Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress
    Shoko Nagotani
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Stroke 36:670-2. 2005
    ..This study aimed to clarify the effect of statins on spontaneous stroke and to examine the antioxidative effect in artificial transient middle cerebral artery occlusion (tMCAO)...
  22. ncbi request reprint Unique cerebellar-cerebral form of autosomal recessive ataxia
    Etsuro Matsubara
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Tohoku J Exp Med 207:81-5. 2005
    ..The mode of inheritance appears to be autosomal recessive. We think that the affected siblings may have a new type of autosomal recessive cerebellar ataxia...
  23. ncbi request reprint Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis
    Isao Nagano
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama, 700 8558 Japan
    Neurol Res 27:768-72. 2005
    ..We performed a double-blind clinical trial to assess the effect of intrathecal administration of IGF-1 on disease progression in patients with ALS...
  24. ncbi request reprint Protection against ischemic brain damage in rats by immunophilin ligand GPI-1046
    Feng Li
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Neurosci Res 76:383-9. 2004
    ....
  25. ncbi request reprint Early decrease of survival factors and DNA repair enzyme in spinal motor neurons of presymptomatic transgenic mice that express a mutant SOD1 gene
    Isao Nagano
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Life Sci 72:541-8. 2002
    ..These results suggest that an early decrease of survival signal proteins and a DNA repair enzyme in the spinal motor neurons may account for the mutant SOD1-mediated motor neuron death in this animal model of ALS...
  26. ncbi request reprint Extension of ischemic therapeutic time window by a free radical scavenger, Edaravone, reperfused with tPA in rat brain
    Wenri Zhang
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama, Japan
    Neurol Res 26:342-8. 2004
    ..Therefore, Edaravone combination is expected to extend the therapeutic time window of tPA in the clinical situation...
  27. ncbi request reprint Spatiotemporal changes of free cholesterol and neutral lipids after transient middle cerebral artery occlusion in rats
    Hiroshi Kamada
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 500 8558, Japan
    Ann N Y Acad Sci 977:115-22. 2002
  28. ncbi request reprint Two cases of spinocerebellar ataxia accompanied by involvement of the skeletal motor neuron system and bulbar palsy
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University
    Intern Med 46:751-5. 2007
    ..SCA type 1 (SCA1), SCA3 and SCA6 have been reported to involve the motor neuron system, but they were excluded by DNA analyses in the present two patients. These two patients may form a distinct disease entity among SCAs...
  29. ncbi request reprint Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia
    Kentaro Ohta
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Lett 335:159-62. 2003
    ..These results suggest that the young brain showed a higher potential of proliferation and process branching of OPCs than the aged brains...
  30. ncbi request reprint Changes of localization of highly polysialylated neural cell adhesion molecule (PSA-NCAM) in rat hippocampus with exposure to repeated kindled seizures
    Keiko Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Japan
    Brain Res 946:323-7. 2002
    ....
  31. pmc Early detachment of neuromuscular junction proteins in ALS mice with SODG93A mutation
    Hisashi Narai
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
    Neurol Int 1:e16. 2009
    ..The levels of AChR did not change throughout 5-20 weeks of age in both groups of mice, and AChR remains clustering at NMJs, suggesting that the muscle abnormality is the result of detachment of nerve terminals...
  32. ncbi request reprint Change in superoxide dismutase 1 protein localization towards mitochondria: an immunohistochemical study in transgenic G93A mice
    Hristelina Ilieva
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Neurosci Lett 332:53-6. 2002
    ..The present results suggest that loss of SOD1 protein from mitochondria could contribute to motor neuron damage...
  33. ncbi request reprint Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis
    Isao Nagano
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    Neurol Res 25:505-9. 2003
    ..These results suggest that deletion mutations in ALS2 gene detected in ALS2 patients seem to be uncommon in Japanese AR-ALS, and that SNPs in uncoding regions might possibly be relevant to predisposition to ALS...
  34. ncbi request reprint Potentiation of Akt and suppression of caspase-9 activations by electroacupuncture after transient middle cerebral artery occlusion in rats
    Shao Jun Wang
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikatacho, Okayama 700 8558, Japan
    Neurosci Lett 331:115-8. 2002
    ..These results suggest that EA potentiated the Akt and suppressed the caspase-9 activations, and may have a potential to reduce the number of neuronal cells undergoing apoptotic cell death...
  35. ncbi request reprint Selective colocalization of transglutaminase-like activity in ubiquitinated intranuclear inclusions of hereditary dentatorubral-pallidoluysian atrophy
    Keiko Sato
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Brain Res 952:327-30. 2002
    ..The selective and good colocalization of Ub-NII and TG in the cerebellar granule cells may reveal a role of TG in the neurodegenerative process in DRPLA...
  36. ncbi request reprint [A case of subacute myelitis associated with primary Sjögren syndrome showing no MRI abnormality and diagnosed by somatosensory evoked potentials]
    Soichiro Fushimi
    Department of Neurology, Okayama University Medical School, 2 5 1 Shikata cho, Okayama, Japan
    No To Shinkei 56:1029-34. 2004
    ..SEP can be a valuable tool for assessing the presence and severity of spinal cord involvement, and the efficacy of treatments...
  37. ncbi request reprint Clinical Features of CADASIL
    Koji Abe
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann N Y Acad Sci 977:266-72. 2002
    ..In the present study, we describe the clinical features of CADASIL, hoping to help reveal the mechanism of chronic ischemic brain diseases, including leukoaraiosis or Binswanger's disease...
  38. ncbi request reprint [A case of neuro-Behçet's disease with repeating isolated thoracic spinal cord lesion]
    Mito Shiote
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    No To Shinkei 55:521-5. 2003
    ..Another two big attacks occurred to him. No new lesion but thoracic spinal cord lesion was observed. We conclude that this case is the first reported example of neuro-Behçet's disease with repeating isolated thoracic spinal cord lesion...
  39. ncbi request reprint Nonparaneoplastic limbic encephalitis with relapsing polychondritis
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    J Neurol Sci 220:85-8. 2004
    ..This is thought to be the first case of RP presenting amnesic syndrome and mental disorder associated with nonparaneoplastic limbic encephalitis involving bilateral hippocampi and amygdaloidal bodies detected by MRI...
  40. ncbi request reprint Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia
    Masanori Iwai
    Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan
    J Cereb Blood Flow Metab 22:411-9. 2002
    ..The majority of these three steps finished in 2 months after transient global ischemia...
  41. ncbi request reprint Limited differentiation to neurons and astroglia from neural stem cells in the cortex and striatum after ischemia/hypoxia in the neonatal rat brain
    Tomoaki Ikeda
    Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Am J Obstet Gynecol 193:849-56. 2005
    ..We examined whether progenitor neural stem cells can differentiate successfully into mature neurons and astrocytes in a rat model of neonatal hypoxic-ischemic encephalopathy...
  42. ncbi request reprint Molecular cloning and characterization of a serine proteinase gene of Trichinella spiralis
    Isao Nagano
    Department of Parasitology, Gifu University School of Medicine, Tsukasa 40, Gifu 500 8705, Japan
    J Parasitol 89:92-8. 2003
    ..Intense staining with the anti-Ts23-2 serum was found within the parasites at the muscle stage of 30 days PI...
  43. ncbi request reprint Molecular cloning and characterisation of two kinds of proteins in excretory-secretory products of Trichinella pseudospiralis
    Isao Nagano
    Department of Parasitology, Gifu University School of Medicine, Tsukasa 40, Gifu 500 8705, Japan
    Int J Parasitol 34:491-500. 2004
    ..An immunolocalisation study showed the Tp38 (Ts43) and Tp53 (Ts53) proteins were present within the alpha-stichocyte and the beta-stichocyte of muscle larvae, respectively...
  44. pmc Molecular expression of a cysteine proteinase of Clonorchis sinensis and its application to an enzyme-linked immunosorbent assay for immunodiagnosis of clonorchiasis
    Isao Nagano
    Department of Parasitology, Gifu University School of Medicine, Gifu, 500 8705 Japan
    Clin Diagn Lab Immunol 11:411-6. 2004
    ..sinensis adult worm crude extracts were 96.2 and 100%, respectively. The results suggested that the recombinant cysteine proteinase-based ELISA could provide a highly sensitive and specific assay for diagnosis of clonorchiasis...