Affiliation: Nagahama Institute of Bio-Science and Technology
Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Nakano T. Inhibition of maintenance DNA methylation by Stella. Biochem Biophys Res Commun. 2014;453:455-60 pubmed publisher
..Considering that impaired DNA methylation profiles are associated with various developmental or disease phenomena, Stella may be a powerful tool with which to study the biological effects of global DNA hypomethylation. ..
Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, et al
. Global DNA hypomethylation coupled to cellular transformation and metastatic ability. FEBS Lett. 2015;589:4053-60 pubmed publisher
..These results provide new insights into the function of global DNA hypomethylation in carcinogenesis. ..
Furuta A, Nakamura T. DNA hypomethylation circuit of mouse rDNA repeats in the germ cell lineage. Biochem Biophys Res Commun. 2017;490:429-433 pubmed publisher
..5 and E18.5. In contrast, fetal somatic cells in gonad and liver acquired methylation on E13.5, which was maintained in adult tissues. These findings indicate a unique rDNA methylation signature in the germ cell lineage. ..
Nakamura T, Liu Y, Nakashima H, Umehara H, Inoue K, Matoba S, et al
. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature. 2012;486:415-9 pubmed publisher
..This type of regulatory mechanism could be involved in DNA modifications in somatic cells as well as in early embryos. ..