Tomohiro Nabekura

Summary

Country: Japan

Publications

  1. ncbi Overcoming multidrug resistance in human cancer cells by natural compounds
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Toxins (Basel) 2:1207-24. 2010
  2. ncbi Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Pharmacol Res 61:259-63. 2010
  3. ncbi Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Eur J Pharmacol 600:45-9. 2008
  4. ncbi Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Cancer Chemother Pharmacol 62:867-73. 2008
  5. ncbi Effect of triterpenoids isolated from the floral spikes of Betula platyphylla var. japonica on P-glycoprotein function
    Michiko Sekiya
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Planta Med 73:1558-62. 2007
  6. ncbi Enhanced skin permeation of diclofenac by ion-pair formation and further enhancement by microemulsion
    Mohammad Abu Hena Mostofa Kamal
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Chem Pharm Bull (Tokyo) 55:368-71. 2007
  7. ncbi Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biol Pharm Bull 28:2274-8. 2005
  8. ncbi Effects of dietary chemopreventive phytochemicals on P-glycoprotein function
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Biochem Biophys Res Commun 327:866-70. 2005
  9. ncbi Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Biochem Biophys Res Commun 369:363-8. 2008
  10. ncbi Effects of alkyl gallates on P-glycoprotein function
    Shuji Kitagawa
    Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biochem Pharmacol 70:1262-6. 2005

Collaborators

Detail Information

Publications13

  1. ncbi Overcoming multidrug resistance in human cancer cells by natural compounds
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Toxins (Basel) 2:1207-24. 2010
    ..In this review, studies on the effects of natural compounds on P-glycoprotein and anticancer drug efflux transporters are summarized...
  2. ncbi Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Pharmacol Res 61:259-63. 2010
    ..These results suggest that rosemary phytochemicals, such as carnosic acid, have inhibitory effects on anticancer drug efflux transporter P-glycoprotein and may become useful to enhance the efficacy of cancer chemotherapy...
  3. ncbi Effects of chemopreventive citrus phytochemicals on human P-glycoprotein and multidrug resistance protein 1
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Eur J Pharmacol 600:45-9. 2008
    ..These results suggest that chemopreventive citrus phytochemicals, such as nobiletin found in oranges, have inhibitory effects on P-glycoprotein and/or MRP1, and may cause food-drug interactions...
  4. ncbi Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Cancer Chemother Pharmacol 62:867-73. 2008
    ....
  5. ncbi Effect of triterpenoids isolated from the floral spikes of Betula platyphylla var. japonica on P-glycoprotein function
    Michiko Sekiya
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Planta Med 73:1558-62. 2007
    ..In addition, compounds 13 and 20 showed a weak inhibitory activity of P-gp ATPase. These results suggested that MDR reversing effects of compounds 13 and 20 are partly involved in inhibition of P-gp ATPase...
  6. ncbi Enhanced skin permeation of diclofenac by ion-pair formation and further enhancement by microemulsion
    Mohammad Abu Hena Mostofa Kamal
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Chem Pharm Bull (Tokyo) 55:368-71. 2007
    ..The present findings suggest the usefulness of combined use of ion-pairs with microemulsions for enhancement of skin permeation of ionic drugs...
  7. ncbi Structure-activity relationships of the inhibitory effects of flavonoids on P-glycoprotein-mediated transport in KB-C2 cells
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biol Pharm Bull 28:2274-8. 2005
    ..These results suggested that hydrophobicity as well as planar structure is important for the inhibitory effects of flavonoids on P-gp-mediated transport...
  8. ncbi Effects of dietary chemopreventive phytochemicals on P-glycoprotein function
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Biochem Biophys Res Commun 327:866-70. 2005
    ..These results suggest that dietary phytochemicals, such as capsaicin, curcumin, [6]-gingerol, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactions...
  9. ncbi Effects of plant sterols on human multidrug transporters ABCB1 and ABCC1
    Tomohiro Nabekura
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Higashi jima, Akiha ku, Niigata 956 8603, Japan
    Biochem Biophys Res Commun 369:363-8. 2008
    ..These results suggest that guggulsterone, a natural dietary hypolipidemic agent have dual inhibitory effects on P-gp and MRP1 and the potencies to cause food-drug interactions...
  10. ncbi Effects of alkyl gallates on P-glycoprotein function
    Shuji Kitagawa
    Laboratory of Pharmaceutics, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biochem Pharmacol 70:1262-6. 2005
    ..The cytotoxicity of daunorubicin was recovered in the presence of alkyl gallates possibly due to their inhibition of P-gp function...
  11. ncbi Inhibition of P-glycoprotein function by tea catechins in KB-C2 cells
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Kamishin ei cho 5 13 2, 950 2081, Japan
    J Pharm Pharmacol 56:1001-5. 2004
    ....
  12. ncbi Enhanced skin permeation of salicylate by ion-pair formation in non-aqueous vehicle and further enhancement by ethanol and l-menthol
    Mohammad Abu Hena Mostofa Kamal
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Chem Pharm Bull (Tokyo) 54:481-4. 2006
    ....
  13. ncbi Permeability of ionized salicylate derivatives through guinea pig dorsal skin
    Mohammad Abu Hena Mostofa Kamal
    Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
    Chem Pharm Bull (Tokyo) 53:441-3. 2005
    ..These findings suggested that the ionic permeation pathway of salicylate derivatives is controlled by hydrophobic as well as hydrophilic properties...