Makoto Murakami


Country: Japan


  1. Murakami M, Lambeau G. Emerging roles of secreted phospholipase A(2) enzymes: an update. Biochimie. 2013;95:43-50 pubmed publisher
    ..In this review, we will highlight the newest understanding of the biological roles of sPLA(2)s in the past few years. ..
  2. Murakami M, Taketomi Y. Secreted phospholipase A2 and mast cells. Allergol Int. 2015;64:4-10 pubmed publisher
    ..In particular, we highlight group III sPLA2 (PLA2G3) as an "anaphylactic sPLA2" that promotes MC maturation and thereby anaphylaxis through a previously unrecognized lipid-orchestrated circuit. ..
  3. Murakami M, Yamamoto K, Miki Y, Murase R, Sato H, Taketomi Y. The Roles of the Secreted Phospholipase A2 Gene Family in Immunology. Adv Immunol. 2016;132:91-134 pubmed publisher
    ..In this review, we summarize our current knowledge of the roles of sPLA2s in various immune responses and associated diseases. ..
  4. Hwang S, Li X, Lu Y, Jin Y, Jeong Y, Kim Y, et al. AMP-activated protein kinase negatively regulates Fc?RI-mediated mast cell signaling and anaphylaxis in mice. J Allergy Clin Immunol. 2013;132:729-736.e12 pubmed publisher
    ..The Fyn-regulated LKB1-AMPK axis acts as a novel inhibitory module for mast cell activation, which points to AMPK activators as therapeutic drugs for allergic diseases. ..
  5. Yamamoto K, Miki Y, Sato M, Taketomi Y, Nishito Y, Taya C, et al. The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. J Exp Med. 2015;212:1901-19 pubmed publisher
    ..Our results highlight PLA2G2F as a previously unrecognized regulator of skin pathophysiology and point to this enzyme as a novel drug target for epidermal-hyperplasic diseases. ..
  6. Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, et al. Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility. J Biol Chem. 2016;291:6895-911 pubmed publisher
  7. Miki Y, Kidoguchi Y, Sato M, Taketomi Y, Taya C, Muramatsu K, et al. Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer. J Biol Chem. 2016;291:15588-601 pubmed publisher
  8. Yamamoto K, Miki Y, Sato H, Murase R, Taketomi Y, Murakami M. Secreted Phospholipase A2 Specificity on Natural Membrane Phospholipids. Methods Enzymol. 2017;583:101-117 pubmed publisher
    ..In this chapter, we will summarize current understanding of the in vivo substrate specificity of sPLA2s toward natural membrane phospholipids. ..
  9. Murakami M, Taketomi Y, Miki Y, Sato H, Hirabayashi T, Yamamoto K. Recent progress in phospholipase A? research: from cells to animals to humans. Prog Lipid Res. 2011;50:152-92 pubmed publisher
    ..This review focuses on current understanding of the emerging biological functions of PLA?s and related enzymes. ..

More Information


  1. Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, et al. The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity. Cell Metab. 2014;20:119-32 pubmed publisher
    ..Collectively, the identification of "metabolic sPLA2s" adds this gene family to a growing list of lipolytic enzymes that act as metabolic coordinators. ..
  2. Murakami M, Taketomi Y, Miki Y, Sato H, Yamamoto K, Lambeau G. Emerging roles of secreted phospholipase A2 enzymes: the 3rd edition. Biochimie. 2014;107 Pt A:105-13 pubmed publisher
    ..We will also describe the latest knowledge on PLA2R1, the best known sPLA2 receptor, which may serve either as a clearance or signaling receptor for sPLA2 or may even act independently of sPLA2 function. ..
  3. Yamamoto K, Miki Y, Sato H, Nishito Y, Gelb M, Taketomi Y, et al. Expression and Function of Group IIE Phospholipase A2 in Mouse Skin. J Biol Chem. 2016;291:15602-13 pubmed publisher