Takahiro Uchida

Summary

Affiliation: Mukogawa Women's University
Country: Japan

Publications

  1. doi request reprint Evaluation of palatability of 10 commercial amlodipine orally disintegrating tablets by gustatory sensation testing, OD-mate as a new disintegration apparatus and the artificial taste sensor
    Takahiro Uchida
    Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya City, Japan
    J Pharm Pharmacol 65:1312-20. 2013
  2. doi request reprint Effect of antioxidants on the stability of ONO-1301, a novel long-acting prostacyclin agonist, loaded in PLGA microspheres
    Takahiro Uchida
    Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya shi, Hyogo, Japan
    J Microencapsul 30:245-56. 2013
  3. ncbi request reprint Factors affecting the bitterness intensities of ten commercial formulations of ambroxol
    Takahiro Uchida
    School of Pharmaceutical Science, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya 663 8179, Japan
    Chem Pharm Bull (Tokyo) 60:949-54. 2012
  4. ncbi request reprint The suppression of enhanced bitterness intensity of macrolide dry syrup mixed with an acidic powder
    Toshihiko Ishizaka
    School of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Chem Pharm Bull (Tokyo) 55:1452-7. 2007
  5. ncbi request reprint Quality of twelve clarithromycin dry syrup formulations-bitterness, grittiness and uniformity of drug loading
    Toshihiko Ishizaka
    School of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Chem Pharm Bull (Tokyo) 56:1389-94. 2008
  6. ncbi request reprint Inhibitory effect of aroma on the bitterness of branched-chain amino acid solutions
    Junji Mukai
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 55:1581-4. 2007
  7. ncbi request reprint Quantitative taste evaluation of total enteral nutrients
    Junji Mukai
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya 663 8179, Japan
    Chem Pharm Bull (Tokyo) 52:1416-21. 2004
  8. ncbi request reprint Suppression of bitterness and improvement of palatability of commercial prednisolone powder
    Toshihiko Ishizaka
    School of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Chem Pharm Bull (Tokyo) 56:1395-9. 2008
  9. ncbi request reprint Evaluation of bitterness suppression of macrolide dry syrups by jellies
    Eriko Tsuji
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    Chem Pharm Bull (Tokyo) 54:310-4. 2006
  10. ncbi request reprint Synergistic effects of sour taste and low temperature in suppressing the bitterness of Aminoleban® EN
    Tamami Haraguchi
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 59:536-40. 2011

Collaborators

  • Kenji Matsuyama
  • Sumio Matzno
  • Kazumasa Shinozuka
  • Masaru Kunitomo
  • Hisakazu Sunada
  • Atsuko Fukui
  • Jun Haginaka
  • Makoto Kashiwayanagi
  • Toshiko Tanimoto
  • Chie Honda
  • Miyako Yoshida
  • Tamami Haraguchi
  • Emi Tokuyama
  • Mai Hazekawa
  • Yohko Miyanaga
  • Toshihiko Ishizaka
  • Junji Mukai
  • Yuka Nakai
  • Eriko Tsuji
  • Tomoko Nakamura
  • Masumi Kataoka
  • Mio Tange
  • Sachie Okada
  • Tazuko Ogawa
  • Yoshiki Sakai
  • Takeshi Akiyoshi
  • Atsu Tanigake
  • Koichi Yoshida
  • Naoko Tanaka
  • Kiyokazu Asaka
  • Airi Miyazaki
  • Keiichi Asahara
  • Yuko Takasu
  • Kaori Shimizu
  • Tomomi Morisaki
  • Chiharu Matsunaga
  • Jean Christophe Mifsud
  • Tetsumi Irie
  • Eri Takemoto
  • Hideo Kawabe
  • Takeshi Shibasaki
  • Ryuta Fujii
  • Kaori Hoshina
  • Tadashi Mukai
  • Hitomi Hirabayashi
  • Masaaki Odomi
  • Hiroyo Nakagawa
  • Emi Fujisawa
  • Ayako Ohnishi
  • Toshikatsu Nakabayashi
  • Maki Yamaguchi
  • Naoko Inoue
  • Hidekazu Ikezaki
  • Akira Taniguchi
  • Yoshikazu Kobayashi

Detail Information

Publications40

  1. doi request reprint Evaluation of palatability of 10 commercial amlodipine orally disintegrating tablets by gustatory sensation testing, OD-mate as a new disintegration apparatus and the artificial taste sensor
    Takahiro Uchida
    Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya City, Japan
    J Pharm Pharmacol 65:1312-20. 2013
    ....
  2. doi request reprint Effect of antioxidants on the stability of ONO-1301, a novel long-acting prostacyclin agonist, loaded in PLGA microspheres
    Takahiro Uchida
    Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya shi, Hyogo, Japan
    J Microencapsul 30:245-56. 2013
    ..In conclusion, BHT is an effective antioxidant on the stability of ONO-1301 in PLGA MS under storage...
  3. ncbi request reprint Factors affecting the bitterness intensities of ten commercial formulations of ambroxol
    Takahiro Uchida
    School of Pharmaceutical Science, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya 663 8179, Japan
    Chem Pharm Bull (Tokyo) 60:949-54. 2012
    ..The bitterness intensities obtained for the 10 ambroxol formulations with water at 20 and 37°C, coincided with the bitterness values predicted by the equation...
  4. ncbi request reprint The suppression of enhanced bitterness intensity of macrolide dry syrup mixed with an acidic powder
    Toshihiko Ishizaka
    School of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Chem Pharm Bull (Tokyo) 55:1452-7. 2007
    ..The chocolate jelly will be useful for taste masking of bitter macrolide drug formulations, when they need to be administered together with acidic drug formulations...
  5. ncbi request reprint Quality of twelve clarithromycin dry syrup formulations-bitterness, grittiness and uniformity of drug loading
    Toshihiko Ishizaka
    School of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Chem Pharm Bull (Tokyo) 56:1389-94. 2008
    ..Finally, there was less variation in the uniformity of drug loading for the branded product than for the generic products. These data may be useful when selecting which CAMDS formulation to prescribe...
  6. ncbi request reprint Inhibitory effect of aroma on the bitterness of branched-chain amino acid solutions
    Junji Mukai
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 55:1581-4. 2007
    ..Thus, a 'sweet' aroma suppresses the bitterness of BCAA, with coexisting sourness also participating in the bitterness inhibition...
  7. ncbi request reprint Quantitative taste evaluation of total enteral nutrients
    Junji Mukai
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya 663 8179, Japan
    Chem Pharm Bull (Tokyo) 52:1416-21. 2004
    ..The taste sensor could therefore be useful in predicting the taste or palatability of total enteral nutrients, and could contribute to attempts to improve compliance for such products and for enteral nutrients...
  8. ncbi request reprint Suppression of bitterness and improvement of palatability of commercial prednisolone powder
    Toshihiko Ishizaka
    School of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    Chem Pharm Bull (Tokyo) 56:1395-9. 2008
    ..The additions of orange juice or a carbonated lemon drink to simple syrup solution were most effective in suppressing bitterness and improving palatability of PP...
  9. ncbi request reprint Evaluation of bitterness suppression of macrolide dry syrups by jellies
    Eriko Tsuji
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    Chem Pharm Bull (Tokyo) 54:310-4. 2006
    ..Suitable jellies might be used to improve patient compliance, especially in children. The taste sensor may be used to predict the bitterness-suppressing effect of the jelly...
  10. ncbi request reprint Synergistic effects of sour taste and low temperature in suppressing the bitterness of Aminoleban® EN
    Tamami Haraguchi
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 59:536-40. 2011
    ....
  11. ncbi request reprint Bitterness evaluation of medicines for pediatric use by a taste sensor
    Toshihiko Ishizaka
    School of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo 663 8179, Japan
    Chem Pharm Bull (Tokyo) 52:943-8. 2004
    ..Thus, the taste sensor could predict whether or not suspension in an acidic sports drink would enhance or reduce the bitterness intensity of pediatric drug formulations, compared with suspensions in water...
  12. doi request reprint The effect of treatment with a sustained-release prostacyclin analogue (ONO-1301-loaded PLGA microsphere) on short-term memory impairment in rats with transient global cerebral ischemia
    Mai Hazekawa
    Faculty of Pharmaceutical Sciences, Department of Clinical Pharmaceutics, Mukogawa Women s University, Hyogo, Japan
    J Microencapsul 29:211-8. 2012
    ..These results suggest that ONO-1301 PLGA MS can limit short-term learning injury following global cerebral ischemia...
  13. ncbi request reprint Evaluation of the bitterness of antibiotics using a taste sensor
    Takahiro Uchida
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya City 663 8179, Japan
    J Pharm Pharmacol 55:1479-85. 2003
    ..The taste sensor results confirmed that the polymer was successful in almost completely masking the bitter taste of the dry syrup product...
  14. ncbi request reprint Famotidine orally disintegrating tablets: bitterness comparison of original and generic products
    Emi Tokuyama
    School of Pharmaceutical Science, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 57:382-7. 2009
    ..There was a good correlation between the taste predicted by principal component analysis and the Euclidean distance obtained by the taste sensor, and bitterness intensities obtained in the human gustatory tests...
  15. ncbi request reprint Incompatibility of ceftriaxone sodium with calcium-containing products
    Yuka Nakai
    School of Pharmaceutical Science, Mukogawa Women s University, Nishinomiya, Japan
    Yakugaku Zasshi 129:1385-92. 2009
    ..25 mmol/l. Overall, not only calcium ion concentration, but storage temperature and shaking affected the extent of precipitation of ceftriaxone with calcium...
  16. ncbi request reprint Effects of quinine on the intracellular calcium level and membrane potential of PC 12 cultures
    Takeshi Akiyoshi
    Department of Clinical Pharmaceutics, Pharmacology, Biochemistry, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    J Pharm Pharmacol 59:1521-6. 2007
    ..These results suggest that responses in PC 12 cultures may be used as a simple model of bitterness perception...
  17. ncbi request reprint The combination effect of L-arginine and NaCl on bitterness suppression of amino acid solutions
    Tazuko Ogawa
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 52:172-7. 2004
    ..It is conjectured that the guanidinium group of L-Arg may interact with sodium channels in taste bud membranes...
  18. doi request reprint Preparation of ONO-1301-loaded poly(lactide-co-glycolide) microspheres and their effect on nerve conduction velocity
    Mai Hazekawa
    Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Pharm Pharmacol 63:362-8. 2011
    ..The effect of optimized ONO-1301-loaded PLGA microspheres on delayed nerve condition velocity (NCV) was investigated in streptozotocin (STZ) induced diabetic rats...
  19. ncbi request reprint Bitterness suppression of BCAA solutions by L-ornithine
    Emi Tokuyama
    School of Pharmaceutical Science, Mukogawa Women s University, 11 68 Koshien, 9 Bancho, Nishinomiya, Hyogo 663 8179, Japan
    Chem Pharm Bull (Tokyo) 54:1288-92. 2006
    ..The relative response electric potential patterns of L-Val, L-Leu or L-Ile solutions containing 100 mM L-Orn in channels 5-8 (positively charged) are similar to that of single solution of 100 mM L-Orn...
  20. doi request reprint Evaluation of the odour of Aminoleban® EN, taste-masked with flavoured powders, by human and electronic noses
    Tamami Haraguchi
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya City, Japan
    J Pharm Pharmacol 65:503-11. 2013
    ..The purpose of this study was to evaluate the odour of Aminoleban® EN, taste-masked with various flavoured powders, by human testing and by using an electronic nose system (Alpha M.O.S.)...
  21. ncbi request reprint Effect of quinine solutions on intracellular Ca2+ levels in neuro-2a cells--conventional physiological method for the evaluation of bitterness
    Tomoko Nakamura
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    Biol Pharm Bull 26:1637-40. 2003
    ....
  22. doi request reprint Single injection of ONO-1301-loaded PLGA microspheres directly after ischaemia reduces ischaemic damage in rats subjected to middle cerebral artery occlusion
    Mai Hazekawa
    Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
    J Pharm Pharmacol 64:353-9. 2012
    ....
  23. ncbi request reprint Prediction of compatibility between ozagrel sodium preparation for injection and calcium on the basis of the solubility product
    Mio Tange
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyu Bancho, Nishinomiya 663 8179, Japan
    Chem Pharm Bull (Tokyo) 61:567-71. 2013
    ..These results suggest that mixing ozagrel sodium with calcium-containing products is safe and without appreciable risk of incompatibility under clinical conditions...
  24. ncbi request reprint The taste sensory evaluation of medicinal plants and Chinese medicines
    Masumi Kataoka
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya shi, Hyogo 663 8179, Japan
    Int J Pharm 351:36-44. 2008
    ..The berberine content in extracts of medicinal plants could be evaluated by the taste sensor, and it was shown to be possible to use the taste sensor for the quality control of medicinal plants...
  25. ncbi request reprint Screening of bitterness-suppressing agents for quinine: the use of molecularly imprinted polymers
    Tazuko Ogawa
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien 9 Bancho, Nishinomiya City 663 8179, Japan
    J Pharm Sci 94:353-62. 2005
    ..Finally, the results of human gustatory sensation tests correlated well with the MIP data. The proposed method using MIPs seems to have a potential for screening bitterness-suppressing agents for quinine...
  26. ncbi request reprint Prediction of incompatibility of ceftriaxone sodium with calcium ions using the ionic product
    Yuka Nakai
    School of Pharmaceutical Science, Mukogawa Women s University, Nishinomiya, Japan
    Yakugaku Zasshi 130:95-102. 2010
    ..There will still be insoluble microparticles caused by incompatibility in the sample solution when the Saturation Index of the solution is over 1.0...
  27. ncbi request reprint Bitterness suppression of the Kampo medicine 'Orengedokuto' using flavoured jellies
    Miyako Yoshida
    School of Pharmaceutical Science, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 58:449-53. 2010
    ..These results suggest that the sweetness intensity of various jellies inhibits the bitterness intensity of Orengedokuto...
  28. ncbi request reprint The effect of various substances on the suppression of the bitterness of quinine-human gustatory sensation, binding, and taste sensor studies
    Tomoko Nakamura
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 50:1589-93. 2002
    ..The sensor output profile was shown to reflect the depressant effect at the receptor site rather well. Therefore, the taste sensor is potentially useful for predicting the effectiveness of bitterness-depressant substances...
  29. ncbi request reprint Evaluation of the taste and smell of bottled nutritive drinks
    Masumi Kataoka
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya 663 8179, Japan
    Int J Pharm 305:13-21. 2005
    ..Finally, the combined usage of the taste and odor sensors gave rise to a three-group classification. Thus, not only the taste sensor but also the odor sensor may be useful in evaluating the palatability of bottled nutritive drinks...
  30. ncbi request reprint The bitterness intensity of clarithromycin evaluated by a taste sensor
    Atsu Tanigake
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 51:1241-5. 2003
    ..963, p<0.005). Co-administration of 1 g of Clarith dry syrup with an acidic sports drink was found to be the most bitter using either method...
  31. doi request reprint Bitterness evaluation of intact and crushed Vesicare orally disintegrating tablets using taste sensors
    Tamami Haraguchi
    Department of Clinical Pharmaceutics, Mukogawa Women s University, Nishinomiya, Japan
    J Pharm Pharmacol 65:980-7. 2013
    ..Vesicare tablets, whose main component is solifenacin succinate, are known to be extremely bitter. The purpose of this study was to evaluate the effect of crushing on the bitterness of the Vesicare orally disintegrating tablets (ODTs)...
  32. ncbi request reprint Quantitative prediction of the bitterness suppression of elemental diets by various flavors using a taste sensor
    Yohko Miyanaga
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien 9 Bancho, Nishinomiya City 663 8179, Japan
    Pharm Res 20:1932-8. 2003
    ....
  33. ncbi request reprint Influence of swallowing Aids on the adsorption and palatability of Kremezin®
    Miyako Yoshida
    School of Pharmaceutical Science, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 59:434-7. 2011
    ..The swallowing aid with the highest viscosity allowed the best dispersion of Kremezin®, and also improved the palatability of Kremezin® the most...
  34. ncbi request reprint Suppression of the bitterness of enteral nutrients using increased particle sizes of branched-chain amino acids (BCAAs) and various flavours: a taste sensor study
    Yohko Miyanaga
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 52:490-3. 2004
    ..Analysis of the taste sensor data suggests that the sourness and sweetness of the added flavours were critical in diminishing the bitterness of Aminoleban EN...
  35. ncbi request reprint Evaluation of bottled nutritive drinks using a taste sensor
    Masumi Kataoka
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya 663 8179, Japan
    Int J Pharm 279:107-14. 2004
    ..84). The taste sensor seems therefore to be a potentially useful tool in evaluating the palatability of bottled nutritive drinks...
  36. ncbi request reprint Comparison between original and generic versions of ceftriaxone sodium preparation for injection: compatibility with calcium-containing product
    Mio Tange
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya, Japan
    Chem Pharm Bull (Tokyo) 60:429-34. 2012
    ..The results show that there are differences in the appearance of insoluble microparticles between the original product and seven generic products, when calcium chloride injection 2% solution is added to the product...
  37. ncbi request reprint A novel long-acting prostacyclin agonist (ONO-1301) with an angiogenic effect: promoting synthesis of hepatocyte growth factor and increasing cyclic AMP concentration via IP-receptor signaling
    Takahiro Uchida
    Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Japan
    J Pharmacol Sci 123:392-401. 2013
    ..It is suggested that ONO-1301 induced angiogenesis by promoting the synthesis of HGF and upregulated c-Met expression, followed by an increase in cAMP concentrations mediated by IP-receptor signaling. ..
  38. ncbi request reprint Prediction of the stability of imipenem in intravenous mixtures
    Miyako Yoshida
    School of Pharmaceutical Science, Mukogawa Women s University, 11 68 Koshien 9 Bancho, Nishinomiya 663 8179, Japan
    Chem Pharm Bull (Tokyo) 61:1-7. 2013
    ..0-10.0. A high correlation was shown to exist between the estimated and determined residual ratios (%)...
  39. ncbi request reprint Evaluation of the synergistic adverse effects of concomitant therapy with statins and fibrates on rhabdomyolysis
    Sumio Matzno
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Kyuban cho, Koshien, Nishinomiya, Hyogo 663 8179, Japan
    J Pharm Pharmacol 55:795-802. 2003
    ..Combined application of fibrates enhanced atorvastatin-induced myopathy, which causes little apoptosis alone. These results suggest that statins and fibrates synergistically aggravate rhabdomyolysis...
  40. ncbi request reprint Prediction of the bitterness of single, binary- and multiple-component amino acid solutions using a taste sensor
    Yohko Miyanaga
    School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien 9 Bancho, Nishinomiya City 663 8179, Japan
    Int J Pharm 248:207-18. 2002
    ..Principal component analysis of the sensor output data suggested that the sourness, astringency and/or smell of the solutions also played a role in the perception of bitterness...