Satomi Kagota

Summary

Affiliation: Mukogawa Women's University
Country: Japan

Publications

  1. ncbi Characterization of nitric oxide- and prostaglandin-independent relaxation in response to acetylcholine in rabbit renal artery
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 26:790-6. 1999
  2. ncbi Disturbances in nitric oxide/cyclic guanosine monophosphate system in SHR/NDmcr-cp rats, a model of metabolic syndrome
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Life Sci 78:1187-96. 2006
  3. ncbi Characteristics of vasorelaxation responses in a rat model of metabolic syndrome
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 31:S54-6. 2004
  4. ncbi Sustaining excessive nitric oxide upregulates protein expression of nitric oxide synthase via soluble guanylyl cyclase: an in vivo study in rats
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Cardiovasc Pharmacol 44:42-9. 2004
  5. ncbi Chronic nitric oxide exposure alters the balance between endothelium-derived relaxing factors released from rat renal arteries: prevention by treatment with NOX-100, a NO scavenger
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho Nishinomiya 663 8179, Japan
    Life Sci 74:2757-67. 2004
  6. ncbi High salt intake impairs vascular nitric oxide/cyclic guanosine monophosphate system in spontaneously hypertensive rats
    Satomi Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    J Pharmacol Exp Ther 302:344-51. 2002
  7. ncbi 2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Eur J Pharmacol 415:233-8. 2001
  8. pmc Downregulation of vascular soluble guanylate cyclase induced by high salt intake in spontaneously hypertensive rats
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Br J Pharmacol 134:737-44. 2001
  9. ncbi Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, 663 8179, Nishinomiya, Japan
    Gen Pharmacol 34:201-9. 2000
  10. ncbi Functional evidence for anti-oxidant action of fluvastatin on low-density lipoprotein using isolated macrophages and aorta
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 27:401-5. 2000

Collaborators

Detail Information

Publications53

  1. ncbi Characterization of nitric oxide- and prostaglandin-independent relaxation in response to acetylcholine in rabbit renal artery
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 26:790-6. 1999
    ....
  2. ncbi Disturbances in nitric oxide/cyclic guanosine monophosphate system in SHR/NDmcr-cp rats, a model of metabolic syndrome
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Life Sci 78:1187-96. 2006
    ..Enhanced NO production may be a compensatory response to a variety of factors, including increases in oxidative stress...
  3. ncbi Characteristics of vasorelaxation responses in a rat model of metabolic syndrome
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 31:S54-6. 2004
    ..Enhanced NO production may result from a variety of factors, including increases in oxidative stress in the context of the metabolic syndrome...
  4. ncbi Sustaining excessive nitric oxide upregulates protein expression of nitric oxide synthase via soluble guanylyl cyclase: an in vivo study in rats
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Cardiovasc Pharmacol 44:42-9. 2004
    ..4 mg/h). These results indicate that persistent excessive NO exposure induces upregulation of the eNOS/NO pathway in the endothelium together with downregulation of the NO/sGC pathway...
  5. ncbi Chronic nitric oxide exposure alters the balance between endothelium-derived relaxing factors released from rat renal arteries: prevention by treatment with NOX-100, a NO scavenger
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho Nishinomiya 663 8179, Japan
    Life Sci 74:2757-67. 2004
    ..These results suggest that persistent but not acute excessive NO exposure in rats impairs EDHF-mediated relaxation in renal arteries, leading to a compensatory upregulation of the eNOS/NO pathway...
  6. ncbi High salt intake impairs vascular nitric oxide/cyclic guanosine monophosphate system in spontaneously hypertensive rats
    Satomi Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    J Pharmacol Exp Ther 302:344-51. 2002
    ..High salt intake may directly affect the vascular smooth muscle and cause impairment of the relaxation response to NO...
  7. ncbi 2-Arachidonoylglycerol, a candidate of endothelium-derived hyperpolarizing factor
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Eur J Pharmacol 415:233-8. 2001
    ..These results suggest that 2-arachidonoylglycerol can cause relaxations via cannabinoid CB(1) receptors, but is not involved in EDHF-mediated relaxations...
  8. pmc Downregulation of vascular soluble guanylate cyclase induced by high salt intake in spontaneously hypertensive rats
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Br J Pharmacol 134:737-44. 2001
    ..It is notable that chronic high salt intake impairs the sGC/cyclic GMP pathway but not the eNOS/NO pathway...
  9. ncbi Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, 663 8179, Nishinomiya, Japan
    Gen Pharmacol 34:201-9. 2000
    ..Serum NO(2) plus NO(3) levels significantly increased in OLETF rats. These results suggest that impairment of relaxation in OLETF rat arteries is due to increased release of contractile factors but not decreased release of nitric oxide...
  10. ncbi Functional evidence for anti-oxidant action of fluvastatin on low-density lipoprotein using isolated macrophages and aorta
    S Kagota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 27:401-5. 2000
    ..This additional anti-oxidative effect of fluvastatin may be beneficial for preventing the progression of atherosclerosis...
  11. ncbi Impaired effect of salt loading on nitric oxide-mediated relaxation in aortas from stroke-prone spontaneously hypertensive rats
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 34:48-54. 2007
    ..Reduced PDE-5 protein expression may act, in part, as a compensatory response to impairment of cGMP-mediated relaxation...
  12. doi Telmisartan provides protection against development of impaired vasodilation independently of metabolic effects in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome
    Satomi Kagota
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Can J Physiol Pharmacol 89:355-64. 2011
    ..These findings indicate that telmisartan protects against vasodilation disturbance through anti-oxidative and -nitrative stress independently of metabolic effects in SHRSP-fatty rats with metabolic syndrome...
  13. ncbi Peroxynitrite is Involved in the dysfunction of vasorelaxation in SHR/NDmcr-cp rats, spontaneously hypertensive obese rats
    Satomi Kagota
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Cardiovasc Pharmacol 50:677-85. 2007
    ..Angiotensin receptor antagonists may be effective for preventing endothelial dysfunction in metabolic syndrome...
  14. doi Coronary vascular dysfunction promoted by oxidative-nitrative stress in SHRSP.Z-Lepr(fa) /IzmDmcr rats with metabolic syndrome
    Satomi Kagota
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 37:1035-43. 2010
    ....
  15. ncbi Effects of Ginkgo biloba extract feeding on salt-induced hypertensive Dahl rats
    Yoko Kubota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    Biol Pharm Bull 29:266-9. 2006
    ..These results demonstrated that GBE reduced salt-related elevation of blood pressure and restored the impaired acetylcholine-induced vasodilation in aortic segments...
  16. ncbi Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice
    Kazuki Nakamura
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo 663 8179, Japan
    In Vivo 19:137-41. 2005
    ..These results suggest that cordycepin exerts an anti-metastatic action, in part, by inhibiting the invasiveness of mouse melanoma cells...
  17. ncbi Chronic production of peroxynitrite in the vascular wall impairs vasorelaxation function in SHR/NDmcr-cp rats, an animal model of metabolic syndrome
    Satomi Kagota
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Pharmacol Sci 109:556-64. 2009
    ....
  18. ncbi Elevated circulating levels of markers of oxidative-nitrative stress and inflammation in a genetic rat model of metabolic syndrome
    Yu Yamaguchi
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Nitric Oxide 15:380-6. 2006
    ..These findings suggest that oxidative stress, as well as nitrative stress and inflammation, increases in the metabolic syndrome, which may contribute to the development of atherosclerosis...
  19. ncbi Effects of Ginkgo biloba extract on blood pressure and vascular endothelial response by acetylcholine in spontaneously hypertensive rats
    Yoko Kubota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    J Pharm Pharmacol 58:243-9. 2006
    ..This accelerative effect of Ginkgo on Ca(2+) mobilization seemed to be associated with restoration of impaired dilatory function induced by acetylcholine in endothelial cells...
  20. ncbi Effect of PKC412, an inhibitor of protein kinase C, on spontaneous metastatic model mice
    Kazuki Nakamura
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo 663 8179, Japan
    Anticancer Res 23:1395-9. 2003
    ..Thus, PKC412 exerts an anti-metastatic action through inhibition of the invasiveness of melanoma cells in the extracellular matrix...
  21. doi Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction
    Satomi Kagota
    Department of Pharmacology II, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    Can J Physiol Pharmacol 91:124-33. 2013
    ..Telmisartan may be beneficial in protecting against disturbances in cardiac function associated with metabolic syndrome...
  22. doi Effect of P2 receptor on the intracellular calcium increase by cancer cells in human umbilical vein endothelial cells
    Namie Nejime
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, 663 8179, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:429-36. 2008
    ..We previously reported that extracellular ATP increased [Ca2+]i and enhanced macromolecular permeability via the P2Y receptor. In tumor metastasis, cancer cells may exploit these regulatory mechanisms in the endothelial cell layer...
  23. ncbi Dysfunction of purinergic regulation of sympathetic neurotransmission in SHR/NDmcr-cp (SHR-cp) rat
    Naoko Tanaka
    First Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Miyazaki, Japan
    Clin Exp Pharmacol Physiol 31:S60-1. 2004
    ..This P1 dysfunction may play a role in the sympathetic hyperinnervation in metabolic syndrome...
  24. ncbi Long-term feeding of Ginkgo biloba extract impairs peripheral circulation and hepatic function in aged spontaneously hypertensive rats
    Yukari Tada
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    Biol Pharm Bull 31:68-72. 2008
    ..Thus, in the elderly population with hypertension, the use of GBE may need to be assessed for effects on heart rate and liver function...
  25. ncbi Peroxynitrite-mediated oxidative modification of low-density lipoprotein by aqueous extracts of cigarette smoke and the preventive effect of fluvastatin
    Yu Yamaguchi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya 663 8179, Japan
    Atherosclerosis 172:259-65. 2004
    ..Fluvastatin may be potentially beneficial to hypercholesterolemic patients with oxidative stress such as smoking...
  26. ncbi Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome
    Masaru Kunitomo
    School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    J Pharmacol Sci 107:128-37. 2008
    ..In addition, CoQ10 improved endothelial dysfunction in the mesenteric arteries. These findings suggest that the antioxidant properties of CoQ10 can be effective for ameliorating cardiovascular risk in MetS...
  27. doi Effects of nicorandil on sympathetic neurotransmission in rat caudal artery
    Ami Tei
    Department of Pharmacology and Pharmaceutics, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    Clin Exp Pharmacol Physiol 37:619-23. 2010
    ..5. These findings suggest that nicorandil inhibits noradrenaline release via the K(ATP) channels of sympathetic nerves. These channels may be pharmacologically different from those of vascular smooth muscle...
  28. ncbi Inhibitory effect of cordycepin on hematogenic metastasis of B16-F1 mouse melanoma cells accelerated by adenosine-5'-diphosphate
    Noriko Yoshikawa
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Anticancer Res 29:3857-60. 2009
    ..These results suggest that ADP accelerated hematogenic metastasis and cordycepin has an inhibitory effect on hematogenic metastasis of B16-F1 melanoma cells via blocking of ADP-induced platelet aggregation in vivo...
  29. ncbi ATP participates in the regulation of microvessel permeability
    Naoko Tanaka
    First Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Miyazaki 882 8508, Japan
    J Pharm Pharmacol 58:481-7. 2006
    ..Such purinergic regulation of endothelial permeability may function in physiological and pathophysiological conditions...
  30. ncbi Fluvastatin reduces modification of low-density lipoprotein in hyperlipidemic rabbit loaded with oxidative stress
    Yu Yamaguchi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, 663 8179, Nishinomiya, Japan
    Eur J Pharmacol 436:97-105. 2002
    ..These results indicate that fluvastatin can exert an antioxidant effect in vivo, with a strong effect on oxidative stress such as smoking, a major risk factor of atherosclerosis...
  31. ncbi Anti-hypertensive effects of Brazilian propolis in spontaneously hypertensive rats
    Yoko Kubota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 31:S29-30. 2004
    ..3. These results suggest that propolis and tochu produce an antihypertensive effect that may be mediated by potentiation of acetylcholine-induced vasodilatation...
  32. ncbi Reinforcement of antitumor effect of Cordyceps sinensis by 2'-deoxycoformycin, an adenosine deaminase inhibitor
    Noriko Yoshikawa
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo 663 8179, Japan
    In Vivo 21:291-5. 2007
    ..These results suggest that DCF has a remarkable reinforcement effect on the antitumor activity of WECS. DCF is a potent adjuvant for WECS...
  33. ncbi Effect of PKC412, a selective inhibitor of protein kinase C, on lung metastasis in mice injected with B16 melanoma cells
    Noriko Yoshikawa
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Life Sci 72:1377-87. 2003
    ..PKC412 is potentially a promising candidate for an anti-metastatic agent...
  34. ncbi Antitumour activity of cordycepin in mice
    Noriko Yoshikawa
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukpgawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 31:S51-3. 2004
    ..4. These results indicate that orally administered cordycepin inhibits melanoma cell growth in mice with no adverse effects...
  35. ncbi Cordycepin (3'-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression
    Noriko Yoshikawa
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, 11 68, Koshien Kyuban cho, Nishinomiya, Hyogo, 663 8179, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:591-5. 2008
    ..In conclusion, this study demonstrated that cordycepin inhibits the proliferation of B16-BL6 cells by stimulating adenosine A3 receptors followed by the Wnt signaling pathway, including GSK-3beta activation and cyclin D1 inhibition...
  36. ncbi Antitumor effect of cordycepin (3'-deoxyadenosine) on mouse melanoma and lung carcinoma cells involves adenosine A3 receptor stimulation
    Kazuki Nakamura
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo 663 8179, Japan
    Anticancer Res 26:43-7. 2006
    ..These results suggest that cordycepin exerts inhibitory effects on the growth of mouse melanoma and lung carcinoma cells by stimulating adenosine A3 receptors on tumor cells...
  37. ncbi Biochemical evidence of atherosclerosis progression mediated by increased oxidative stress in apolipoprotein E-deficient spontaneously hyperlipidemic mice exposed to chronic cigarette smoke
    Masaru Kunitomo
    School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Japan
    J Pharmacol Sci 110:354-61. 2009
    ..Our data suggest that chronic cigarette smoking promotes and aggravates atherosclerosis and that the antioxidant vitamin E exerts an anti-atherogenic effect via reduction of oxidative stress...
  38. doi Possible participation of chloride ion channels in ATP release from cancer cells in suspension
    Namie Nejime
    Department of Pharmacology, Mukogawa Women s University, Nishinomiya, Japan
    Clin Exp Pharmacol Physiol 36:278-82. 2009
    ..5. These findings indicate that Cl(-) channels play the most important role in ATP release from detached cancer cells and that gap junction hemichannels are also associated with ATP release...
  39. doi A novel method using confocal laser scanning microscopy for sensitive measurement of P-glycoprotein-mediated transport activity in Caco-2 cells
    Hirokazu Wakuda
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Pharm Pharmacol 63:1015-21. 2011
    ..The aim of this study was to use time-lapse confocal laser scanning microscopy to establish a more sensitive and specific method for evaluating P-glycoprotein activity in Caco-2 cells...
  40. ncbi Inhibitory effect of Cordyceps sinensis on experimental hepatic metastasis of melanoma by suppressing tumor cell invasion
    Erika Kubo
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and Institute for Biosciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, Nishinomiya, Hyogo 663 8179, Japan
    Anticancer Res 30:3429-33. 2010
    ..These findings suggest that WECS exerts an anti-metastatic action, in part by inhibiting the HGF-accelerated tumor invasiveness of mouse melanoma cells...
  41. ncbi Effect of vanadate on ATP-induced increase in intracellular calcium ion levels in human umbilical vein endothelial cells
    Namie Nejime
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo 663 8179, Japan
    Biol Pharm Bull 33:1060-2. 2010
    ..1 microM. Endogenously released ATP is known to induce various actions on endothelial cells. The present results suggest that vanadate exerts a regulatory influence on the function of vascular endothelial cells...
  42. ncbi Myosin light chain kinase and Rho-kinase participate in P2Y receptor-mediated acceleration of permeability through the endothelial cell layer
    Naoko Tanaka
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    J Pharm Pharmacol 57:335-40. 2005
    ..These results suggest that phosphorylation of the myosin light chain may play an important role in the purinergic regulation of macromolecular permeation through the vascular endothelium...
  43. doi Chronic oxidative-nitrosative stress impairs coronary vasodilation in metabolic syndrome model rats
    Satomi Kagota
    Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Microvasc Res 88:70-8. 2013
    ..ZF rats with MetS. Down-regulated sGC expression may be linked to dysfunction, while reduced NO bioavailability/eNOS activity and modified sGC activity due to superoxide production were excluded as pivotal mechanisms...
  44. ncbi Combined effects of Cordyceps sinensis and methotrexate on hematogenic lung metastasis in mice
    Kazuki Nakamura
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Hyogo, Japan
    Receptors Channels 9:329-34. 2003
    ..2 +/- 0.7, significantly longer than the control value. WECS might be beneficial in the prevention of tumor metastasis as an adjuvant agent in cancer chemotherapy...
  45. ncbi Characterization of cardiac size and function in SHRSP.Z-Lepr(fa)/IzmDmcr rats, a new animal model of metabolic syndrome
    Yukari Tada
    Department of Pharmacology, Mukogawa Women s University, Nishinomiya, Japan
    Biol Pharm Bull 33:1971-6. 2010
    ..SHRSP-fatty may be a useful rat model to study on cardiac abnormalities in metabolic syndrome...
  46. ncbi Participation of peroxynitrite in oxidative modification of LDL by aqueous extracts of cigarette smoke
    Yu Yamaguchi
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, 11 68 Koshien Kyuban cho, 663 8179, Nishinomiya, Japan
    FEBS Lett 512:218-22. 2002
    ..A similar increase of 3-nitrotyrosine occurred after incubation of LDL with a peroxynitrite generating agent, 3-morpholinosydnonimine, thus suggesting that prominent pro-oxidants in CSE are peroxynitrite-generating species...
  47. doi Preventive effects of the extract of kinka-cha, a folk tea, on a rat model of metabolic syndrome
    Hisae Oku
    School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    J Nat Med 65:610-6. 2011
    ..These results suggest that kinka-cha can help reduce the risk of developing metabolic syndrome, possibly due to the presence of antioxidants...
  48. ncbi Characterization of mouse melanoma cell lines by their mortal malignancy using an experimental metastatic model
    Kazuki Nakamura
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya, Japan
    Life Sci 70:791-8. 2002
    ..These results suggest that mortal malignancy is not necessarily correlated with lung-colonizing potential and even only one-time selected B16-F0 mouse melanoma cells are useful as an experimental metastatic model in vivo...
  49. ncbi Highly sensitive measurement of P-glycoprotein-mediated transport activity in Caco-2 cells
    Hirokazu Wakuda
    Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women s University, Nishinomiya 663 8179, Japan
    Biol Pharm Bull 33:1238-41. 2010
    ..This method may also be useful for predicting P-glycoprotein-mediated alterations in the intestinal absorption of drugs...
  50. ncbi Up-regulation of angiotensin II type 2 receptor in rat thoracic aorta by pressure-overload
    Katsutoshi Yayama
    Department of Pharmacology, Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University, Japan
    J Pharmacol Exp Ther 308:736-43. 2004
    ....
  51. doi Increase in P-glycoprotein accompanied by activation of protein kinase Calpha and NF-kappaB p65 in the livers of rats with streptozotocin-induced diabetes
    Natsumi Kameyama
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 1 20 Daikominami, Nagoya 461 8673, Japan
    Biochim Biophys Acta 1782:355-60. 2008
    ..From these findings, it was suggested that STZ-induced hyperglycemia caused the upregulation of Mdr1b P-gp expression through the activation of PKCalpha and NF-kappaB...
  52. ncbi Relationship between plasma and hippocampal lipid peroxidation in obese and hypertensive SHR/NDmcr-cp rats
    Michio Hashimoto
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo, Japan
    Clin Exp Pharmacol Physiol 31:S62-4. 2004
    ..5. These results indicate that, in SHR-cp, lipid peroxidation in the hippocampus would not be affected even if plasma levels of fatty acids and lipid peroxide increased markedly, when ageing is not a predicative factor...
  53. ncbi Evaluation of blood pressure measured by tail-cuff methods (without heating) in spontaneously hypertensive rats
    Yoko Kubota
    Department of Biopharmaceutics, Nihon Pharmaceutical University
    Biol Pharm Bull 29:1756-8. 2006
    ..These data suggest that the novel unheated-animal tail-cuff method is a sensitive and accurate approach for the noninvasive measurement of blood pressure in conscious rats...