Satomi Kagota

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..Enhanced NO production may result from a variety of factors, including increases in oxidative stress in the context of the metabolic syndrome...

..4 mg/h). These results indicate that persistent excessive NO exposure induces upregulation of the eNOS/NO pathway in the endothelium together with downregulation of the NO/sGC pathway...

..These results suggest that persistent but not acute excessive NO exposure in rats impairs EDHF-mediated relaxation in renal arteries, leading to a compensatory upregulation of the eNOS/NO pathway...

..Enhanced NO production may be a compensatory response to a variety of factors, including increases in oxidative stress...

..High salt intake may directly affect the vascular smooth muscle and cause impairment of the relaxation response to NO...

..These results suggest that 2-arachidonoylglycerol can cause relaxations via cannabinoid CB(1) receptors, but is not involved in EDHF-mediated relaxations...

..This additional anti-oxidative effect of fluvastatin may be beneficial for preventing the progression of atherosclerosis...

..Serum NO(2) plus NO(3) levels significantly increased in OLETF rats. These results suggest that impairment of relaxation in OLETF rat arteries is due to increased release of contractile factors but not decreased release of nitric oxide...

..It is notable that chronic high salt intake impairs the sGC/cyclic GMP pathway but not the eNOS/NO pathway...

..Reduced PDE-5 protein expression may act, in part, as a compensatory response to impairment of cGMP-mediated relaxation...

..Angiotensin receptor antagonists may be effective for preventing endothelial dysfunction in metabolic syndrome...

..These findings indicate that telmisartan protects against vasodilation disturbance through anti-oxidative and -nitrative stress independently of metabolic effects in SHRSP-fatty rats with metabolic syndrome...

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..These results suggest that cordycepin exerts an anti-metastatic action, in part, by inhibiting the invasiveness of mouse melanoma cells...

..These results demonstrated that GBE reduced salt-related elevation of blood pressure and restored the impaired acetylcholine-induced vasodilation in aortic segments...

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..These findings suggest that oxidative stress, as well as nitrative stress and inflammation, increases in the metabolic syndrome, which may contribute to the development of atherosclerosis...

..This accelerative effect of Ginkgo on Ca(2+) mobilization seemed to be associated with restoration of impaired dilatory function induced by acetylcholine in endothelial cells...

..Thus, PKC412 exerts an anti-metastatic action through inhibition of the invasiveness of melanoma cells in the extracellular matrix...

..We previously reported that extracellular ATP increased [Ca2+]i and enhanced macromolecular permeability via the P2Y receptor. In tumor metastasis, cancer cells may exploit these regulatory mechanisms in the endothelial cell layer...

..In addition, CoQ10 improved endothelial dysfunction in the mesenteric arteries. These findings suggest that the antioxidant properties of CoQ10 can be effective for ameliorating cardiovascular risk in MetS...

..This P1 dysfunction may play a role in the sympathetic hyperinnervation in metabolic syndrome...

..Thus, in the elderly population with hypertension, the use of GBE may need to be assessed for effects on heart rate and liver function...

..Fluvastatin may be potentially beneficial to hypercholesterolemic patients with oxidative stress such as smoking...

..These results suggest that ADP accelerated hematogenic metastasis and cordycepin has an inhibitory effect on hematogenic metastasis of B16-F1 melanoma cells via blocking of ADP-induced platelet aggregation in vivo...

..3. These results suggest that propolis and tochu produce an antihypertensive effect that may be mediated by potentiation of acetylcholine-induced vasodilatation...

..Such purinergic regulation of endothelial permeability may function in physiological and pathophysiological conditions...

..These results indicate that fluvastatin can exert an antioxidant effect in vivo, with a strong effect on oxidative stress such as smoking, a major risk factor of atherosclerosis...

..5. These findings suggest that nicorandil inhibits noradrenaline release via the K(ATP) channels of sympathetic nerves. These channels may be pharmacologically different from those of vascular smooth muscle...

..PKC412 is potentially a promising candidate for an anti-metastatic agent...

..These results suggest that DCF has a remarkable reinforcement effect on the antitumor activity of WECS. DCF is a potent adjuvant for WECS...

..4. These results indicate that orally administered cordycepin inhibits melanoma cell growth in mice with no adverse effects...

..Our data suggest that chronic cigarette smoking promotes and aggravates atherosclerosis and that the antioxidant vitamin E exerts an anti-atherogenic effect via reduction of oxidative stress...

..These results suggest that cordycepin exerts inhibitory effects on the growth of mouse melanoma and lung carcinoma cells by stimulating adenosine A3 receptors on tumor cells...

..In conclusion, this study demonstrated that cordycepin inhibits the proliferation of B16-BL6 cells by stimulating adenosine A3 receptors followed by the Wnt signaling pathway, including GSK-3beta activation and cyclin D1 inhibition...

..The aim of this study was to use time-lapse confocal laser scanning microscopy to establish a more sensitive and specific method for evaluating P-glycoprotein activity in Caco-2 cells...

..1 microM. Endogenously released ATP is known to induce various actions on endothelial cells. The present results suggest that vanadate exerts a regulatory influence on the function of vascular endothelial cells...

..These findings suggest that WECS exerts an anti-metastatic action, in part by inhibiting the HGF-accelerated tumor invasiveness of mouse melanoma cells...

..5. These findings indicate that Cl(-) channels play the most important role in ATP release from detached cancer cells and that gap junction hemichannels are also associated with ATP release...

..These results suggest that phosphorylation of the myosin light chain may play an important role in the purinergic regulation of macromolecular permeation through the vascular endothelium...

..SHRSP-fatty may be a useful rat model to study on cardiac abnormalities in metabolic syndrome...

..2 +/- 0.7, significantly longer than the control value. WECS might be beneficial in the prevention of tumor metastasis as an adjuvant agent in cancer chemotherapy...

..These results suggest that kinka-cha can help reduce the risk of developing metabolic syndrome, possibly due to the presence of antioxidants...

..These results suggest that mortal malignancy is not necessarily correlated with lung-colonizing potential and even only one-time selected B16-F0 mouse melanoma cells are useful as an experimental metastatic model in vivo...

..A similar increase of 3-nitrotyrosine occurred after incubation of LDL with a peroxynitrite generating agent, 3-morpholinosydnonimine, thus suggesting that prominent pro-oxidants in CSE are peroxynitrite-generating species...

..This method may also be useful for predicting P-glycoprotein-mediated alterations in the intestinal absorption of drugs...

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..From these findings, it was suggested that STZ-induced hyperglycemia caused the upregulation of Mdr1b P-gp expression through the activation of PKCalpha and NF-kappaB...

..5. These results indicate that, in SHR-cp, lipid peroxidation in the hippocampus would not be affected even if plasma levels of fatty acids and lipid peroxide increased markedly, when ageing is not a predicative factor...

..These data suggest that the novel unheated-animal tail-cuff method is a sensitive and accurate approach for the noninvasive measurement of blood pressure in conscious rats...