Hiroyuki Wakabayashi

Summary

Affiliation: Morinaga Milk Industry Co
Country: Japan

Publications

  1. ncbi request reprint Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Zama, Kanagawa 228 8583, Japan
    J Antimicrob Chemother 46:595-602. 2000
  2. ncbi request reprint Lactoferrin feeding augments peritoneal macrophage activities in mice intraperitoneally injected with inactivated Candida albicans
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa 228 8583, Japan
    Microbiol Immunol 47:37-43. 2003
  3. pmc Modulation of immunity-related gene expression in small intestines of mice by oral administration of lactoferrin
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Clin Vaccine Immunol 13:239-45. 2006
  4. ncbi request reprint No detectable transfer of dietary lactoferrin or its functional fragments to portal blood in healthy adult rats
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan
    Biosci Biotechnol Biochem 68:853-60. 2004
  5. ncbi request reprint Oral lactoferrin prevents body weight loss and increases cytokine responses during herpes simplex virus type 1 infection of mice
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan
    Biosci Biotechnol Biochem 68:537-44. 2004
  6. ncbi request reprint Lactoferricin derived from milk protein lactoferrin
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Curr Pharm Des 9:1277-87. 2003
  7. ncbi request reprint Increased Staphylococcus-killing activity of an antimicrobial peptide, lactoferricin B, with minocycline and monoacylglycerol
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa 228 8583, Japan
    Biosci Biotechnol Biochem 66:2161-7. 2002
  8. ncbi request reprint Effect of lactoferrin feeding on the host antifungal response in guinea-pigs infected or immunised with Trichophyton mentagrophytes
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan
    J Med Microbiol 51:844-50. 2002
  9. doi request reprint Periodontitis, periodontopathic bacteria and lactoferrin
    Hiroyuki Wakabayashi
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Biometals 23:419-24. 2010
  10. pmc Inhibitory effects of lactoferrin on growth and biofilm formation of Porphyromonas gingivalis and Prevotella intermedia
    Hiroyuki Wakabayashi
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Antimicrob Agents Chemother 53:3308-16. 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Zama, Kanagawa 228 8583, Japan
    J Antimicrob Chemother 46:595-602. 2000
    ..These results suggest the potential usefulness of lactoferrin as a food component for promoting dermatophytosis cure...
  2. ncbi request reprint Lactoferrin feeding augments peritoneal macrophage activities in mice intraperitoneally injected with inactivated Candida albicans
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa 228 8583, Japan
    Microbiol Immunol 47:37-43. 2003
    ..In conclusion, LF feeding augmented the activities of macrophages in a manner dependent on Candida-priming and these effects may be related to enhanced cytokine levels...
  3. pmc Modulation of immunity-related gene expression in small intestines of mice by oral administration of lactoferrin
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Clin Vaccine Immunol 13:239-45. 2006
    ..The expression levels of these three genes were correlated. This study indicated that oral administration of LF modulates the small intestinal expression of genes closely related to the host defense in a specific or a nonspecific manner...
  4. ncbi request reprint No detectable transfer of dietary lactoferrin or its functional fragments to portal blood in healthy adult rats
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan
    Biosci Biotechnol Biochem 68:853-60. 2004
    ..The level of LF or its functional fragments transferred to the portal blood was therefore extremely low, if any...
  5. ncbi request reprint Oral lactoferrin prevents body weight loss and increases cytokine responses during herpes simplex virus type 1 infection of mice
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan
    Biosci Biotechnol Biochem 68:537-44. 2004
    ..These results suggest that LF feeding was not effective for eradication of the virus, but may contribute to the maintenance of homeostasis and the concomitant increases of cytokine responses during HSV-1 infection...
  6. ncbi request reprint Lactoferricin derived from milk protein lactoferrin
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Curr Pharm Des 9:1277-87. 2003
    ..Here we present a comprehensive review of investigations of LFcin and related peptides...
  7. ncbi request reprint Increased Staphylococcus-killing activity of an antimicrobial peptide, lactoferricin B, with minocycline and monoacylglycerol
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa 228 8583, Japan
    Biosci Biotechnol Biochem 66:2161-7. 2002
    ..aureus more rapidly than either agent alone. These findings may be helpful in the application of antimicrobial peptides in medical or other situations...
  8. ncbi request reprint Effect of lactoferrin feeding on the host antifungal response in guinea-pigs infected or immunised with Trichophyton mentagrophytes
    Hiroyuki Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Zama, Kanagawa, Japan
    J Med Microbiol 51:844-50. 2002
    ..In conclusion, LF feeding may potentiate the host antifungal defence systems by modulating MNC function rather than plasma antifungal activity or peripheral blood neutrophil PMNL activity...
  9. doi request reprint Periodontitis, periodontopathic bacteria and lactoferrin
    Hiroyuki Wakabayashi
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Biometals 23:419-24. 2010
    ..gingivalis and P. intermedia in the subgingival plaque of chronic periodontitis patients. LF seems to be a biofilm inhibitor of periodontopathic bacteria in vitro and in vivo...
  10. pmc Inhibitory effects of lactoferrin on growth and biofilm formation of Porphyromonas gingivalis and Prevotella intermedia
    Hiroyuki Wakabayashi
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Antimicrob Agents Chemother 53:3308-16. 2009
    ..gingivalis and P. intermedia and the potential usefulness of LF for the prevention and treatment of periodontal diseases and as adjunct therapy for periodontal diseases...
  11. ncbi request reprint Orally administered lactoperoxidase increases expression of the FK506 binding protein 5 gene in epithelial cells of the small intestine of mice: a DNA microarray study
    Hiroyuki Wakabayashi
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa 228 8583, Japan
    Biosci Biotechnol Biochem 71:2274-82. 2007
    ..These results suggest that ingested LPO modulates gene expression in the small intestine and especially increases FKBP5 gene expression in the epithelial cells of the intestine...
  12. ncbi request reprint Effect of orally administered bovine lactoferrin on the immune response in the oral candidiasis murine model
    Natsuko Takakura
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    J Med Microbiol 53:495-500. 2004
    ..In conclusion, the alleviation of oral candidiasis by LF feeding in this model may correlate with the enhancement of the number of leukocytes and their cytokine responses in regional lymph nodes against Candida infection...
  13. ncbi request reprint Effects of orally administered bovine lactoferrin and lactoperoxidase on influenza virus infection in mice
    Kouichirou Shin
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    J Med Microbiol 54:717-23. 2005
    ..These results suggest the potential of oral administration of LF or LPO to attenuate pneumonia in influenza-virus-infected mice through the suppression of infiltration of inflammatory cells in the lung...
  14. ncbi request reprint Influences of orally administered lactoferrin on IFN-gamma and IL-10 production by intestinal intraepithelial lymphocytes and mesenteric lymph-node cells
    Natsuko Takakura
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    Biochem Cell Biol 84:363-8. 2006
    ..The production level of IFN-gamma by MLN cells was correlated with that of IL-10. These results suggest that oral LF enhances the production of both Th1-type and Th2/Tr-type cytokines in the small intestine of healthy animals...
  15. ncbi request reprint Recombinant human intelectin binds bovine lactoferrin and its peptides
    Kouichirou Shin
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, Kanagawa, Japan
    Biol Pharm Bull 31:1605-8. 2008
    ..A very low binding of rhIntL was observed for bovine serum albumin or transferrin. These findings suggest that hIntL acts as a receptor for bLF and its digested fragments...
  16. ncbi request reprint Bovine lactoferrin: benefits and mechanism of action against infections
    Koji Yamauchi
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Zama, Kanagawa 228 8583, Japan
    Biochem Cell Biol 84:291-6. 2006
    ..Thus, oral bLF activates the transcription of important immune-related genes in the small intestine, and such transcriptional activation may promote systemic host immunity...
  17. ncbi request reprint Protection against infections by oral lactoferrin: evaluation in animal models
    Susumu Teraguchi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa 228 8583, Japan
    Biometals 17:231-4. 2004
    ..These enhanced immune responses may contribute to eradication of the pathogen, resolution of the symptoms, and maintenance of the homeostasis during infectious diseases...
  18. pmc Isolation of a bifidogenic peptide from the pepsin hydrolysate of bovine lactoferrin
    Hirotsugu Oda
    Food Science and Technology Institute, Morinaga Milk Industry Company, Ltd, Zama City, Kanagawa Prefecture, Japan
    Appl Environ Microbiol 79:1843-9. 2013
    ..breve and B. longum subsp. infantis; furthermore, we isolated its active peptide. This is the first report about a bifidogenic peptide derived from bLF...
  19. pmc Oral lactoferrin treatment of experimental oral candidiasis in mice
    Natsuko Takakura
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan
    Antimicrob Agents Chemother 47:2619-23. 2003
    ..These results suggest that the effect of LF in this oral candidiasis model is not due to direct antifungal action. In conclusion, LF could have potential as a food component supporting antifungal drug treatment...
  20. ncbi request reprint Inhibitory effects of bovine lactoferrin and lactoferricin B on Enterobacter sakazakii
    Hiroyuki Wakabayashi
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa 228 8583, Japan
    Biocontrol Sci 13:29-32. 2008
    ..5 to 8 mg/ml. Even after being heated at 80 degrees C, LF at above 1 mg/ml inhibited the bacterial growth. These results suggest that bovine LF-related compounds may be useful for the inhibition of E. sakazakii in foods...
  21. ncbi request reprint In vitro and in vivo effects of a composition containing lactoperoxidase on oral bacteria and breath odor
    Kouichirou Shin
    Food Science and Technology Institute, Morinaga Milk Industry Co, Ltd, 5 1 83 Higashihara, Zama, Kanagawa 228 8583, Japan
    J Breath Res 2:017014. 2008
    ..These results suggest that the composition shows bactericidal activity through the formation of OSCN(-) in saliva and is effective for reducing breath odor, although further clinical studies are needed...
  22. pmc N-Acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa 228 8583, Japan
    Antimicrob Agents Chemother 43:1267-9. 1999
    ..The most potent peptide, conjugated with an 11-carbon-chain acyl group, showed two to eight times lower MIC than lactoferricin B...
  23. ncbi request reprint Bovine lactoferrin and lactoferricin derived from milk: production and applications
    M Tomita
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Zama, Kanagawa, Japan
    Biochem Cell Biol 80:109-12. 2002
    ..Further elucidation of the clinical efficacy and mechanism of action of lactoferrin will increase the value of lactoferrin-containing products...
  24. ncbi request reprint Antimicrobial peptides of lactoferrin
    M Tomita
    Nutritional Science Laboratory, Morinaga Milk Industry Co Ltd, Kanagawa, Japan
    Adv Exp Med Biol 357:209-18. 1994
    ..The evidence also suggests the possibility that active peptides produced by enzymatic digestion of lactoferrin may contribute to the host defense against microbial disease...
  25. ncbi request reprint Inhibition of iron/ascorbate-induced lipid peroxidation by an N-terminal peptide of bovine lactoferrin and its acylated derivatives
    H Wakabayashi
    Nutritional Science Laboratory, Morinaga Milk Industry Co, Ltd, Kanagawa, Japan
    Biosci Biotechnol Biochem 63:955-7. 1999
    ..The inhibition of TBARS formation occurred with N-acylated 9-mer peptides with a core sequence of LFcin B and, compared to LFcin B, their antioxidant effect was clearly observed at a concentration almost 100 times lower...