Takaharu Mizutani

Summary

Country: Japan

Publications

  1. ncbi request reprint Stability of non-Watson-Crick G-A/A-G base pair in synthetic DNA and RNA oligonucleotides
    Yuko Ito
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Mol Biol Rep 31:31-6. 2004
  2. ncbi request reprint Nitrogen-substitution effect on in vivo mutagenicity of chrysene
    Katsuya Yamada
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho ku, Nagoya 467 8603, Japan
    Mutat Res 586:1-17. 2005
  3. ncbi request reprint New horizon of MDR1 (P-glycoprotein) study
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 37:489-510. 2005
  4. ncbi request reprint Induction of human UDP-glucuronosyltransferase 1A1 by cortisol-GR
    Toru Usui
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467 8603, Japan
    Mol Biol Rep 33:91-6. 2006
  5. ncbi request reprint Induction of human UGT1A1 by bilirubin through AhR dependent pathway
    Hiroshi Togawa
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Drug Metab Lett 2:231-7. 2008
  6. pmc Toxicity of xanthene food dyes by inhibition of human drug-metabolizing enzymes in a noncompetitive manner
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    J Environ Public Health 2009:953952. 2009
  7. ncbi request reprint [Biochemical selenocysteine synthesis and the phylogenic study]
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Yakugaku Zasshi 128:989-96. 2008
  8. ncbi request reprint Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs
    Katsuya Yamada
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho ku, Nagoya 467 8603, Japan
    Mutat Res 586:87-95. 2005
  9. ncbi request reprint Influence of synthetic and natural food dyes on activities of CYP2A6, UGT1A6, and UGT2B7
    Nayumi Kuno
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Toxicol Environ Health A 68:1431-44. 2005
  10. ncbi request reprint Decreased valproate level caused by VPA-glucuronidase inhibition by carbapenem antibiotics
    Yutaka Nakamura
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Drug Metab Lett 2:280-5. 2008

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Stability of non-Watson-Crick G-A/A-G base pair in synthetic DNA and RNA oligonucleotides
    Yuko Ito
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Mol Biol Rep 31:31-6. 2004
    ..Finally, this study indicated that the intermediate rigidity imparted by Non-Watson-Crick base pair in SECIS element plays an important role in the selenocysteine expression by UGA codon...
  2. ncbi request reprint Nitrogen-substitution effect on in vivo mutagenicity of chrysene
    Katsuya Yamada
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho ku, Nagoya 467 8603, Japan
    Mutat Res 586:1-17. 2005
    ..These results suggest that the two types of nitrogen substitutions in the chrysene structure may enhance mutagenicity in the mouse lung, although they showed no difference in the target-organ specificity and the mutation spectrum...
  3. ncbi request reprint New horizon of MDR1 (P-glycoprotein) study
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 37:489-510. 2005
    ..There is an ambiguity about the function of MDR1 as GlcCer translocase...
  4. ncbi request reprint Induction of human UDP-glucuronosyltransferase 1A1 by cortisol-GR
    Toru Usui
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467 8603, Japan
    Mol Biol Rep 33:91-6. 2006
    ..These results suggest that the induction of UGT1A1 expression by GR is not mediated by PXR, unlike the induction of CYP3A4 through PXR...
  5. ncbi request reprint Induction of human UGT1A1 by bilirubin through AhR dependent pathway
    Hiroshi Togawa
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Drug Metab Lett 2:231-7. 2008
    ..This is the first report showing direct induction of UGT1A1 by a bilirubin through AhR pathway...
  6. pmc Toxicity of xanthene food dyes by inhibition of human drug-metabolizing enzymes in a noncompetitive manner
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    J Environ Public Health 2009:953952. 2009
    ..It is possible that red cosmetics containing phloxine, erythrosine, or rose bengal react with proteins on skin under lighting and may lead to rough skin...
  7. ncbi request reprint [Biochemical selenocysteine synthesis and the phylogenic study]
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Yakugaku Zasshi 128:989-96. 2008
    ..From comparison of the phylogeny trees of Sec synthesizing system and translation system, we concluded that the evolution of Sec synthesizing system is older than that of the translation system...
  8. ncbi request reprint Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs
    Katsuya Yamada
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho ku, Nagoya 467 8603, Japan
    Mutat Res 586:87-95. 2005
    ....
  9. ncbi request reprint Influence of synthetic and natural food dyes on activities of CYP2A6, UGT1A6, and UGT2B7
    Nayumi Kuno
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Toxicol Environ Health A 68:1431-44. 2005
    ..In the natural additive dyes just listed, only monascus inhibited UGT1A6 and UGT2B7...
  10. ncbi request reprint Decreased valproate level caused by VPA-glucuronidase inhibition by carbapenem antibiotics
    Yutaka Nakamura
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Drug Metab Lett 2:280-5. 2008
    ..These results showed that the inhibition in liver slices depended on the inhibition of VPA-glucuronidase by CP. We considered that the inhibition of VPA-glucuronidase by CP in cytosol is a key factor to decrease the plasma VPA level...
  11. ncbi request reprint Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 37:235-52. 2005
    ..Autoantibodies against CYP11A1, CYP17, and/or CYP21 involved in the synthesis of steroid hormones are also detected in patients with adrenal failure, gonadal failure, and/or Addison disease...
  12. ncbi request reprint Induction of human UGT1A1 by a complex of dexamethasone-GR dependent on proximal site and independent of PBREM
    Takuya Kuno
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Mol Biol Rep 35:361-7. 2008
    ..This supports that hPXR induced UGT1A1 through PBREM by DEX. These results showed that PBREM has no relation with the induction by DEX-GR but the proximal site of UGT1A1 may function in stimulation by DEX-GR...
  13. doi request reprint Inhibition of human CYP3A4, UGT1A6, and P-glycoprotein with halogenated xanthene food dyes and prevention by superoxide dismutase
    Kenji Furumiya
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    J Toxicol Environ Health A 71:1307-13. 2008
    ..It is possible that red cosmetics containing phloxine, erythrosine, or rose bengal react with proteins in skin and may lead to skin damage...
  14. ncbi request reprint Active bovine selenophosphate synthetase 2, not having selenocysteine
    Kenji Furumiya
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467 8603, Japan
    Mol Biol Rep 35:541-9. 2008
    ..Thus, bovine active SPS2 of molecular mass 33 kDa does not contain Sec...
  15. ncbi request reprint Proximal HNF1 element is essential for the induction of human UDP-glucuronosyltransferase 1A1 by glucocorticoid receptor
    Toru Usui
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tababe dori 3, Mizuhoku, Nagoya 467 8603, Japan
    Biochem Pharmacol 71:693-701. 2006
    ..Also given the lack of evidence of binding of DEX-GR to HNF1 in the EMSA, the data suggest that the mechanism of DEX-GRE effect on HNF1 is indirect by whatever mechanisms...
  16. ncbi request reprint The N-terminal of human UGT1A6 is on the outside, as evidenced by ELISA with autoantibody in autoimmune hepatitis sera
    Hitomi Mori
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Drug Metab Lett 1:261-6. 2007
    ..In conclusion, sera from AIH-1 patients reacted with the amino acids in the sequence 33-37 (PQDGS) of the N-terminal of UGT1A6...
  17. ncbi request reprint In vivo mutagenicity of benzo[f]quinoline, benzo[h]quinoline, and 1,7-phenanthroline using the lacZ transgenic mice
    Katsuya Yamada
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho ku, Nagoya 467 8603, Japan
    Mutat Res 559:83-95. 2004
    ..These results suggest that the in vivo mutagenicity of 1,7-Phe might be caused by the same mechanism as that of quinoline, which induced the same mutational spectrum change (G:C to C:G transversion)...
  18. ncbi request reprint Study of inhibition of CYP2A6 by some drugs derived from quinoline
    Yoshie Hirano
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya 467 8603, Japan
    J Pharm Pharmacol 55:1667-72. 2003
    ..These results also show that CYP2A6 discriminates the structure difference between the diastereoisomers quinidine and quinine...
  19. ncbi request reprint High levels of autoantibodies against drug-metabolizing enzymes in SLA/LP-positive AIH-1 sera
    Masakazu Shinoda
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Autoimmunity 37:473-80. 2004
    ..We found that the pattern of elevation in the Patient 3 serum was not parallel with that in Patient 4. Thus, we found high levels of autoantibodies against drug-metabolizing enzymes in AIH-1 patients...
  20. ncbi request reprint Interaction between valproic acid and carbapenem antibiotics
    Hitomi Mori
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
    Drug Metab Rev 39:647-57. 2007
    ..The increase of renal excretion of VPA as VPA-Glu depends on the increase of VPA-Glu level by UGT. One or a combination of some factors in these mechanisms might relate to the carbapenem-mediated decrease of the plasma VPA level...
  21. ncbi request reprint Genuine functions of P-glycoprotein (ABCB1)
    Takaharu Mizutani
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603 Japan
    Curr Drug Metab 9:167-74. 2008
    ..We also present information about P-gp polymorphism and new structural concepts, "gate" and "twist", of the P-gp structure...
  22. ncbi request reprint Study of oxidized lipids as endogenous substrates of P-gp (ABCB1)
    Masatoshi Masuda
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Drug Metab Lett 2:238-44. 2008
    ..This finding should be a milestone to search a new physiological P-gp function...
  23. ncbi request reprint Study of in vitro glucuronidation of hydroxyquinolines with bovine liver microsomes
    Masanobu Kanou
    Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Fundam Clin Pharmacol 16:513-7. 2002
    ..Fluoroquinoline (FQ) derivatives, such as 3FQ, 7.8diFQ and 6,7,8triFQ, did not show any substrate activities. These results suggest that there are therapeutic problems in administration of some quinoline drugs to patients with jaundice...
  24. ncbi request reprint A new method to measure P-gp (ABCB1) activity
    Masatoshi Masuda
    Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedo ri, Mizuho, Nagoya 467 8603, Japan
    Drug Metab Lett 1:306-10. 2007
    ..This method is also applicable to other ATP-binding cassette (ABC) transporters in phosphate buffer...
  25. ncbi request reprint Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomes
    Katsuya Yamada
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho ku, Nagoya 467 8603, Japan
    Mutat Res 557:159-65. 2004
    ..With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2...
  26. ncbi request reprint Inhibition of human cytochrome P450 2E1 by halogenated anilines, phenols, and thiophenols
    Yohei Ohashi
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biol Pharm Bull 28:1221-3. 2005
    ..3 and 5.2 microM, respectively. These results suggest that 3,4- and 3,5-dichlorophenyl derivatives may be useful as potent CYP2E1 inhibitors...
  27. ncbi request reprint Stimulation of transcriptional expression of human UDP-glucuronosyltransferase 1A1 by dexamethasone
    Masanobu Kanou
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Mol Biol Rep 31:151-8. 2004
    ..Thus, we clarified that UGT1A1 was induced by dexamethasone and the key position was the region (-97/-53) in UGT1A1 promoter...
  28. ncbi request reprint A survey of expressed tRNA genes in the chromosome I of Arabidopsis using an RNA polymerase III-dependent in vitro transcription system
    Yasushi Yukawa
    Graduate School of Natural Sciences, Nagoya City University, Nagoya 467 8501, Japan
    Gene 392:7-13. 2007
    ..Based on previous reports on pseudo-tRNA genes (e.g., Beier and Beier, Mol. Gen. Genet. 1992; 233: 201-208) and the present results, we estimated that 16% or more of the annotated tRNA genes in the chromosome I are not functional...
  29. ncbi request reprint The protozoa dinoflagellate Oxyrrhis marina contains selenoproteins and the relevant translation apparatus
    Takashi Osaka
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    Biochem Biophys Res Commun 300:236-40. 2003
    ..Altogether, our data showed that O. marina contains selenoproteins and suggests that the corresponding translation machinery is related to that found in animals...