Research Topics
| Takaharu MizutaniSummaryCountry: Japan Publications
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Publications
Stability of non-Watson-Crick G-A/A-G base pair in synthetic DNA and RNA oligonucleotidesYuko Ito
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan
Mol Biol Rep 31:31-6. 2004..Finally, this study indicated that the intermediate rigidity imparted by Non-Watson-Crick base pair in SECIS element plays an important role in the selenocysteine expression by UGA codon...- Nitrogen-substitution effect on in vivo mutagenicity of chryseneKatsuya Yamada
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho-ku, Nagoya 467-8603, Japan
Mutat Res 586:1-17. 2005..These results suggest that the two types of nitrogen substitutions in the chrysene structure may enhance mutagenicity in the mouse lung, although they showed no difference in the target-organ specificity and the mutation spectrum... - New horizon of MDR1 (P-glycoprotein) studyTakaharu Mizutani
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Drug Metab Rev 37:489-510. 2005..There is an ambiguity about the function of MDR1 as GlcCer translocase... - Induction of human UDP-glucuronosyltransferase 1A1 by cortisol-GRToru Usui
Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467-8603, Japan
Mol Biol Rep 33:91-6. 2006..These results suggest that the induction of UGT1A1 expression by GR is not mediated by PXR, unlike the induction of CYP3A4 through PXR... - Induction of human UGT1A1 by bilirubin through AhR dependent pathwayHiroshi Togawa
Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
Drug Metab Lett 2:231-7. 2008..This is the first report showing direct induction of UGT1A1 by a bilirubin through AhR pathway... 
Toxicity of xanthene food dyes by inhibition of human drug-metabolizing enzymes in a noncompetitive mannerTakaharu Mizutani
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
J Environ Public Health 2009:953952. 2009..It is possible that red cosmetics containing phloxine, erythrosine, or rose bengal react with proteins on skin under lighting and may lead to rough skin...- [Biochemical selenocysteine synthesis and the phylogenic study]Takaharu Mizutani
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Yakugaku Zasshi 128:989-96. 2008..From comparison of the phylogeny trees of Sec synthesizing system and translation system, we concluded that the evolution of Sec synthesizing system is older than that of the translation system... - Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogsKatsuya Yamada
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho-ku, Nagoya 467-8603, Japan
Mutat Res 586:87-95. 2005.... - Influence of synthetic and natural food dyes on activities of CYP2A6, UGT1A6, and UGT2B7Nayumi Kuno
Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
J Toxicol Environ Health A 68:1431-44. 2005..In the natural additive dyes just listed, only monascus inhibited UGT1A6 and UGT2B7... - Decreased valproate level caused by VPA-glucuronidase inhibition by carbapenem antibioticsYutaka Nakamura
Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
Drug Metab Lett 2:280-5. 2008..These results showed that the inhibition in liver slices depended on the inhibition of VPA-glucuronidase by CP. We considered that the inhibition of VPA-glucuronidase by CP in cytosol is a key factor to decrease the plasma VPA level... - Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2Takaharu Mizutani
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Drug Metab Rev 37:235-52. 2005..Autoantibodies against CYP11A1, CYP17, and/or CYP21 involved in the synthesis of steroid hormones are also detected in patients with adrenal failure, gonadal failure, and/or Addison disease... - Induction of human UGT1A1 by a complex of dexamethasone-GR dependent on proximal site and independent of PBREMTakuya Kuno
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Mol Biol Rep 35:361-7. 2008..This supports that hPXR induced UGT1A1 through PBREM by DEX. These results showed that PBREM has no relation with the induction by DEX-GR but the proximal site of UGT1A1 may function in stimulation by DEX-GR... 
Inhibition of human CYP3A4, UGT1A6, and P-glycoprotein with halogenated xanthene food dyes and prevention by superoxide dismutaseKenji Furumiya
Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
J Toxicol Environ Health A 71:1307-13. 2008..It is possible that red cosmetics containing phloxine, erythrosine, or rose bengal react with proteins in skin and may lead to skin damage...- Active bovine selenophosphate synthetase 2, not having selenocysteineKenji Furumiya
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, 467 8603, Japan
Mol Biol Rep 35:541-9. 2008..Thus, bovine active SPS2 of molecular mass 33 kDa does not contain Sec... - Proximal HNF1 element is essential for the induction of human UDP-glucuronosyltransferase 1A1 by glucocorticoid receptorToru Usui
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tababe-dori 3, Mizuhoku, Nagoya 467-8603, Japan
Biochem Pharmacol 71:693-701. 2006..Also given the lack of evidence of binding of DEX-GR to HNF1 in the EMSA, the data suggest that the mechanism of DEX-GRE effect on HNF1 is indirect by whatever mechanisms... - The N-terminal of human UGT1A6 is on the outside, as evidenced by ELISA with autoantibody in autoimmune hepatitis seraHitomi Mori
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
Drug Metab Lett 1:261-6. 2007..In conclusion, sera from AIH-1 patients reacted with the amino acids in the sequence 33-37 (PQDGS) of the N-terminal of UGT1A6... - In vivo mutagenicity of benzo[f]quinoline, benzo[h]quinoline, and 1,7-phenanthroline using the lacZ transgenic miceKatsuya Yamada
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho-ku, Nagoya 467-8603, Japan
Mutat Res 559:83-95. 2004..These results suggest that the in vivo mutagenicity of 1,7-Phe might be caused by the same mechanism as that of quinoline, which induced the same mutational spectrum change (G:C to C:G transversion)... - Study of inhibition of CYP2A6 by some drugs derived from quinolineYoshie Hirano
Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8603, Japan
J Pharm Pharmacol 55:1667-72. 2003..These results also show that CYP2A6 discriminates the structure difference between the diastereoisomers quinidine and quinine... - High levels of autoantibodies against drug-metabolizing enzymes in SLA/LP-positive AIH-1 seraMasakazu Shinoda
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
Autoimmunity 37:473-80. 2004..We found that the pattern of elevation in the Patient 3 serum was not parallel with that in Patient 4. Thus, we found high levels of autoantibodies against drug-metabolizing enzymes in AIH-1 patients... - Interaction between valproic acid and carbapenem antibioticsHitomi Mori
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Drug Metab Rev 39:647-57. 2007..The increase of renal excretion of VPA as VPA-Glu depends on the increase of VPA-Glu level by UGT. One or a combination of some factors in these mechanisms might relate to the carbapenem-mediated decrease of the plasma VPA level... - Genuine functions of P-glycoprotein (ABCB1)Takaharu Mizutani
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603 Japan
Curr Drug Metab 9:167-74. 2008..We also present information about P-gp polymorphism and new structural concepts, "gate" and "twist", of the P-gp structure... - Study of oxidized lipids as endogenous substrates of P-gp (ABCB1)Masatoshi Masuda
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
Drug Metab Lett 2:238-44. 2008..This finding should be a milestone to search a new physiological P-gp function... - Study of in vitro glucuronidation of hydroxyquinolines with bovine liver microsomesMasanobu Kanou
Department of Drug Metabolism and Disposition, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan
Fundam Clin Pharmacol 16:513-7. 2002..Fluoroquinoline (FQ) derivatives, such as 3FQ, 7.8diFQ and 6,7,8triFQ, did not show any substrate activities. These results suggest that there are therapeutic problems in administration of some quinoline drugs to patients with jaundice... - A new method to measure P-gp (ABCB1) activityMasatoshi Masuda
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedo ri, Mizuho, Nagoya 467 8603, Japan
Drug Metab Lett 1:306-10. 2007..This method is also applicable to other ATP-binding cassette (ABC) transporters in phosphate buffer... - Metabolic activation of 10-aza-substituted benzo[a]pyrene by cytochrome P450 1A2 in human liver microsomesKatsuya Yamada
Graduate School of Pharmaceutical Sciences, Nagoya City University, Tanabedori, Mizuho-ku, Nagoya 467-8603, Japan
Mutat Res 557:159-65. 2004..With regard to the proposal that BaP may be activated by human CYP1A1, our results suggest that the nitrogen-substitution at position-10 of BaP may cause the CYP enzyme-specificity in metabolic activation to change from CYP1A1 to CYP1A2... - Inhibition of human cytochrome P450 2E1 by halogenated anilines, phenols, and thiophenolsYohei Ohashi
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
Biol Pharm Bull 28:1221-3. 2005..3 and 5.2 microM, respectively. These results suggest that 3,4- and 3,5-dichlorophenyl derivatives may be useful as potent CYP2E1 inhibitors... - Stimulation of transcriptional expression of human UDP-glucuronosyltransferase 1A1 by dexamethasoneMasanobu Kanou
Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
Mol Biol Rep 31:151-8. 2004..Thus, we clarified that UGT1A1 was induced by dexamethasone and the key position was the region (-97/-53) in UGT1A1 promoter... - A survey of expressed tRNA genes in the chromosome I of Arabidopsis using an RNA polymerase III-dependent in vitro transcription systemYasushi Yukawa
Graduate School of Natural Sciences, Nagoya City University, Nagoya 467 8501, Japan
Gene 392:7-13. 2007..Based on previous reports on pseudo-tRNA genes (e.g., Beier and Beier, Mol. Gen. Genet. 1992; 233: 201-208) and the present results, we estimated that 16% or more of the annotated tRNA genes in the chromosome I are not functional... - The protozoa dinoflagellate Oxyrrhis marina contains selenoproteins and the relevant translation apparatusTakashi Osaka
Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
Biochem Biophys Res Commun 300:236-40. 2003..Altogether, our data showed that O. marina contains selenoproteins and suggests that the corresponding translation machinery is related to that found in animals...