Yutaka Mizushima

Summary

Country: Japan

Publications

  1. ncbi request reprint A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release
    Mitsuko Takenaga
    Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, 216 8512, Kawasaki, Japan
    J Control Release 79:81-91. 2002
  2. ncbi request reprint Long-term safety study of iguratimod in patients with rheumatoid arthritis
    Masako Hara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    Mod Rheumatol 17:10-6. 2007
  3. ncbi request reprint Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs
    Yutaka Mizushima
    DDS Institute, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato, Tokyo 105 8461, Japan
    J Control Release 110:260-5. 2006
  4. doi request reprint Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Int J Pharm 365:200-5. 2009
  5. doi request reprint Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Pharm Res 25:1686-95. 2008
  6. ncbi request reprint Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate
    Tsutomu Sakai
    Department of Ophthalmology, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Exp Eye Res 82:657-63. 2006
  7. doi request reprint Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    J Pharm Sci 98:2357-63. 2009
  8. ncbi request reprint Transdermal delivery of CaCO3-nanoparticles containing insulin
    Megumu Higaki
    Institute of Drug Delivery System, Jikei University School of Medicine, Tokyo, Japan
    Diabetes Technol Ther 8:369-74. 2006
  9. doi request reprint Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Drug Deliv 16:153-9. 2009
  10. ncbi request reprint Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    J Control Release 105:68-76. 2005

Collaborators

Detail Information

Publications20

  1. ncbi request reprint A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release
    Mitsuko Takenaga
    Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, 216 8512, Kawasaki, Japan
    J Control Release 79:81-91. 2002
    ..2-140.7 microU/ml from day 1 to day 9. The AUC(0-24 h)/AUC(0-336 h) ratio was calculated to be 9.7%. The formulation prepared without additives gave such a rapid insulin release that animals receiving it became transiently hypoglycemic...
  2. ncbi request reprint Long-term safety study of iguratimod in patients with rheumatoid arthritis
    Masako Hara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    Mod Rheumatol 17:10-6. 2007
    ..The rate was 46.9% at week 28 and 41.0% at week 52. To use iguratimod safely for a long time, patients should be observed closely for adverse reactions such as increased hepatic enzymes...
  3. ncbi request reprint Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs
    Yutaka Mizushima
    DDS Institute, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato, Tokyo 105 8461, Japan
    J Control Release 110:260-5. 2006
    ..In conclusion, the SP-HAp seems to be useful as a biodegradable and subcutaneously injectable drug carrier. It is suggested that the reinforcement of the SP-HAp is very effective on the sustained release of drugs...
  4. doi request reprint Efficient encapsulation of a water-soluble corticosteroid in biodegradable nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Int J Pharm 365:200-5. 2009
    ..This technique for entrapment of water-soluble drugs in solid biodegradable nanoparticles may expand the use of nanoparticles for various therapeutic applications...
  5. doi request reprint Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Pharm Res 25:1686-95. 2008
    ..In order to modulate the pharmacokinetics of prostaglandin E(1) (PGE(1)), we prepared biodegradable nanoparticles as a drug carrier...
  6. ncbi request reprint Treatment of experimental autoimmune uveoretinitis with poly(lactic acid) nanoparticles encapsulating betamethasone phosphate
    Tsutomu Sakai
    Department of Ophthalmology, Jikei University School of Medicine, 3 25 8 Nishishinbashi, Minato ku, Tokyo 105 8461, Japan
    Exp Eye Res 82:657-63. 2006
    ..The results of these studies suggest that the systemic administration of BP-PLA NPs may lead to a new therapeutic strategy in controlling intraocular inflammation...
  7. doi request reprint Efficient entrapment of poorly water-soluble pharmaceuticals in hybrid nanoparticles
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    J Pharm Sci 98:2357-63. 2009
    ..These results suggested that such hybrid nanoparticles may be used to expand the availability of poorly water-soluble drugs for various therapeutic applications...
  8. ncbi request reprint Transdermal delivery of CaCO3-nanoparticles containing insulin
    Megumu Higaki
    Institute of Drug Delivery System, Jikei University School of Medicine, Tokyo, Japan
    Diabetes Technol Ther 8:369-74. 2006
    ..This study evaluates the pharmacokinetic and pharmacodynamic effects of a transdermally delivered insulin using novel CaCO(3)-nanoparticles in normal mice and those with diabetes...
  9. doi request reprint Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    Drug Deliv 16:153-9. 2009
    ..These different properties of CPPs emphasize the importance of careful peptide selection and design when attempting the application of CPP technology...
  10. ncbi request reprint Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profile
    Tsutomu Ishihara
    DDS Institute, The Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato, Tokyo 105 8461, Japan
    J Control Release 105:68-76. 2005
    ..These results suggest that zinc increases the efficiency of encapsulating betamethasone phosphate in nanoparticles and also promotes sustained release of betamethasone phosphate from the nanoparticles...
  11. ncbi request reprint Successful treatment of photo-damaged skin of nano-scale atRA particles using a novel transdermal delivery
    Yoko Yamaguchi
    Institute of Medical Science, St Marianna University, School of Medicine, School of Medicine, Japan
    J Control Release 104:29-40. 2005
    ..Severely injured human skin by chronic ultraviolet irradiation will completely repair due to the accelerated turnover of skin tissue, which is induced by Nano-atRA...
  12. ncbi request reprint Drug delivery to the cochlea using PLGA nanoparticles
    Tetsuya Tamura
    Department of Otolaryngology Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Laryngoscope 115:2000-5. 2005
    ..This study aimed to investigate the efficacy of encapsulating therapeutic molecules in poly lactic/glycolic acid (PLGA) nanoparticles for drug delivery to the cochlea...
  13. ncbi request reprint A novel insulin formulation can keep providing steady levels of insulin for much longer periods in-vivo
    Mitsuko Takenaga
    Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
    J Pharm Pharmacol 54:1189-94. 2002
    ..In the near future, therefore, this insulin formulation could become very beneficial as a provider of basal insulin levels for insulin-dependent diabetic patients...
  14. ncbi request reprint [Prolonged release microcapsules of insulin for complement of the basal secretion]
    Yasuaki Ogawa
    Institute of Medical Science, St Marianna University School of Medicine
    Nihon Rinsho 60:542-7. 2002
  15. ncbi request reprint Action of microparticles of heparin and alginate crosslinked gel when used as injectable artificial matrices to stabilize basic fibroblast growth factor and induce angiogenesis by controlling its release
    Naofumi Chinen
    Institute of Medical Science, St Marianna University School of Medicine, 2 16 1, Sugao, Miyamae ku, Kawasaki 216 8512, Japan
    J Biomed Mater Res A 67:61-8. 2003
    ....
  16. ncbi request reprint Drug-supported microparticles of calcium carbonate nanocrystals and its covering with hydroxyapatite
    Toshiyuki Ikoma
    National Institute for Materials Science, Biomaterials Center, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Nanosci Nanotechnol 7:822-7. 2007
    ..Spherical microparticles of calcite cores and petal-shaped hydroxyapatite (HAp) outer layers were fabricated by soaking calcite into the SBF, or a supersaturated solution of phosphate ions to enhance the crystal growth of HAp...
  17. ncbi request reprint Optimum formulation for sustained-release insulin
    Mitsuko Takenaga
    Institute of Medical Science, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Japan
    Int J Pharm 271:85-94. 2004
    ..The biological activity of insulin extracted from the formulation was similar to that of normal insulin. These experiments allowed us to prepare a desirable sustained-release insulin formulation...
  18. ncbi request reprint [Corticosteroid-loading PLA/PLGA-nanospheres]
    Nobuo Izumo
    Department of Pharmacology, Daiichi College of Pharmaceutical Sciencies
    Nihon Rinsho 64:329-34. 2006
    ..Moreover, the effect of nanospheres were stronger than clinical pharmaceutical preparation. We propose that these nanospheres are the pharmaceutical preparation to have efficient powerful inflammation action...
  19. ncbi request reprint Novel heparin/alginate gel combined with basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve
    Masayoshi Ohta
    Department of Plastic and Reconstructive Surgery, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Biomed Mater Res A 71:661-8. 2004
    ..These findings suggested that H/A gel with bFGF could serve not only as an efficient cellular scaffold, but also as a stabilizing matrix for bFGF for peripheral nerve regeneration...
  20. ncbi request reprint Efficacy and safety of iguratimod compared with placebo and salazosulfapyridine in active rheumatoid arthritis: a controlled, multicenter, double-blind, parallel-group study
    Masako Hara
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    Mod Rheumatol 17:1-9. 2007
    ..The study results suggest that iguratimod could become a new option for the treatment of rheumatoid arthritis...