Research Topics
Genomes and Genes | M NakazatoSummaryAffiliation: Miyazaki Medical College Country: Japan Publications
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Publications
Central effects of neuromedin U in the regulation of energy homeostasisM Nakazato
Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
Biochem Biophys Res Commun 277:191-4. 2000..Further investigation of the biochemical and physiological functions of NMU will help our better understanding of the mechanisms of energy homeostasis...- A role for ghrelin in the central regulation of feedingM Nakazato
Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
Nature 409:194-8. 2001..We conclude that ghrelin is a physiological mediator of feeding, and probably has a function in growth regulation by stimulating feeding and release of growth hormone... - Tissue distribution, cellular source, and structural analysis of rat immunoreactive uroguanylinM Nakazato
Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
Endocrinology 139:5247-54. 1998..Uroguanylin may have physiological functions other than the regulation of fluid and electrolyte transport in the intestine and kidney... - Cloning and characterization of a cDNA encoding a precursor for human uroguanylinM Miyazato
Third Department of Medicine, Miyazaki Medical College, Kiyotake, Japan
Biochem Biophys Res Commun 219:644-8. 1996..Uroguanylin, as well as guanylin, may be a potent physiological regulator of intestinal fluid and electrolyte transport... - Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administrationK Toshinai
Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
Biochem Biophys Res Commun 281:1220-5. 2001..Conversely, db/db mice, which are deficient in the leptin receptor, had lower ghrelin mRNA levels than control mice. These findings suggest that this novel gastrointestinal hormone plays a role in the regulation of energy balance... - Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humansY Date
Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
Endocrinology 141:4255-61. 2000..Our findings provide clues to additional, as yet undefined, physiological functions of this novel gastrointestinal hormone... - Urine and plasma levels of uroguanylin and its molecular forms in renal diseasesH Kinoshita
First Department of Internal Medicine, Miyazaki Medical College, Japan
Kidney Int 52:1028-34. 1997..These findings suggest that bioactive uroguanylin-16 is involved in the regulation of electrolyte homeostasis and that the kidney participates in the metabolism and excretion of uroguanylin... - [A study of defensins in bronchoalveolar lavage fluid in patients with diffuse panbronchiolitis]H Mukae
Third Department of Internal Medicine, Miyazaki Medical College
Kansenshogaku Zasshi 69:975-81. 1995..These findings suggest that the lung injury in DPB could be caused by defensins released by neutrophils accumulated in the airways... - Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infectionJ Ashitani
National Sanatorium Miyazakihigashi Hospital, Miyazaki, Japan
Chest 119:1131-7. 2001.... - Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factorsN Nagaya
Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan
Circulation 104:2034-8. 2001..We sought to investigate the pathophysiology of ghrelin in the cachexia associated with chronic heart failure (CHF)... - Isolation and sequence determination of rat islet amyloid polypeptideJ Asai
Third Department of Internal Medicine, Miyazaki Medical College, Japan
Biochem Biophys Res Commun 164:400-5. 1989..Rat IAPP sequence was also 51% identical to those of alpha and beta rat calcitonin gene-related peptide sequences... - Neuropeptide W is present in antral G cells of rat, mouse, and human stomachM S Mondal
Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
J Endocrinol 188:49-57. 2006..In conclusion, NPW is produced in gastric antral G cells; our findings will provide clues to additional mechanisms of the regulation of gastric function by this novel brain/gut peptide... - Acute incremental exercise decreases plasma ghrelin level in healthy menK Toshinai
Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Horm Metab Res 39:849-51. 2007 - Nucleotide sequence and expression of rat beta-defensin-1: its significance in diabetic rodent modelsT Hiratsuka
3rd Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
Nephron 88:65-70. 2001..BD-1 reduction may be in part responsible for the high incidence of urinary tract infections in diabetes mellitus... - Significance of human beta-defensins in the epithelial lining fluid of patients with chronic lower respiratory tract infectionsS Yanagi
Third Department of Internal Medicine, Miyazaki University School of Medicine, Miyazaki, Japan
Clin Microbiol Infect 13:63-9. 2007..The findings indicate that hBDs, especially hBD-2 and hBD-4, are pathophysiologically important in infections caused by mucoid strains of P. aeruginosa... 
Increased concentrations of human beta-defensins in plasma and bronchoalveolar lavage fluid of patients with diffuse panbronchiolitisT Hiratsuka
Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
Thorax 58:425-30. 2003..The aim of this study was to elucidate the role of these antimicrobial peptides in this disease...- Regional distribution and molecular forms of rat islet amyloid polypeptideJ Asai
Department of Internal Medicine, Miyazaki Medical College, Japan
Biochem Biophys Res Commun 169:788-95. 1990..The content of rat IAPP in pancreas fell to 54% of control after 4 day fasting. The distribution of IAPP suggests its possible endocrine or paracrine function in pancreas and gastrointestinal tract... 
Telmisartan attenuates fatty-acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic beta-cellsY Saitoh
Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
Diabetes Metab 35:392-7. 2009....- A basic transthyretin variant (Glu61-->Lys) causes familial amyloidotic polyneuropathy: protein and DNA sequencing and PCR-induced mutation restriction analysisK Shiomi
Third Department of Medicine, Miyazaki Medical College, Japan
Biochem Biophys Res Commun 194:1090-6. 1993..TTR-Lys61 is the first variant TTR with a replacement of the acidic with basic amino acid to be found in the amyloid precursor proteins of FAP... - A 5'-splice site mutation in the cytochrome P450 steroid 17alpha-hydroxylase gene in 17alpha-hydroxylase deficiencyH Yamaguchi
Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
J Clin Endocrinol Metab 82:1934-8. 1997..Restriction enzyme analysis showed that the patient is homozygous for the mutated CYP17 gene, and the parents are heterozygotes. This is the first reported patient with 17OHD caused by the splice site mutation in the CYP17 gene... - Localization of human neutrophil peptide (HNP) and its messenger RNA in neutrophil seriesY Date
Third Department of Internal Medicine, Miyazaki Medical College, Japan
Ann Hematol 69:73-7. 1994..HNPs 1-3 are restricted to cells of neutrophil lineage and seem to function as microbicidal agents in the neutrophil-mediated defense system... - Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infectionsT Ihi
Third Department of Internal Medicine, Miyazaki Medical College, Japan
Clin Infect Dis 25:1134-40. 1997..Our results suggest that HNPs have physiological significance in infection and that this family of peptides may be useful in assessing neutrophil function during infection... - Guanylin family: new intestinal peptides regulating electrolyte and water homeostasisM Nakazato
Third Department of Internal Medicine, Miyazaki Medical College, Japan
J Gastroenterol 36:219-25. 2001..These peptides function in salt and water transport in the intestine and kidney by luminocrine and endocrine actions. The guanylin family is involved in the pathophysiology of some gastrointestinal, renal, and heart diseases... - Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGFK Toshinai
Neurology, Respirology, Endocrinology and Metabolism, Division of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, 889 1692, Japan
Cell Mol Life Sci 66:1939-45. 2009..Thus, VGF is a precursor of multiple bioactive peptides with diverse neuroendocrine functions, and NERPs are novel hypothalamic peptides involved in the control of body fluid homeostasis by regulating vasopressin release... - Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissueT Saito
Third Department of Internal Medicine, Yamanashi Medical University, Japan
J Clin Endocrinol Metab 82:3331-6. 1997..The amount of NIS protein was also increased 3.1-fold in Graves' thyroid tissue compared with that in normal thyroid tissue. The increased expression of NIS may thus contribute to the development of Graves' disease... - Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cellsY Saitoh
Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan
Diabetes Obes Metab 10:564-73. 2008..We have studied whether pioglitazone, a TZD, can exert a direct effect against pancreatic beta-cell lipoapoptosis... - [Aged onset of amyloidosis caused by transthyretin gene mutations]M Nakazato
Third Department of Internal Medicine, Miyazaki Medical College
Nippon Ronen Igakkai Zasshi 38:501-6. 2001..Molecular investigation of transthyretin is needed for elderly patients with etiology-unknown cardiac amyloidosis or amyloid polyneuropathy even if there is no family history of amyloidosis... - [A study of human beta-defensin-1 and human beta-defensin-2 in airway mucosal defense]T Hiratsuka
Third Department of Internal Medicine, Miyazaki Medical College
Kansenshogaku Zasshi 73:156-62. 1999..The presence of hBD-1 and hBD-2 in the airway tract and their bactericidal activity suggest that they function in innate airway mucosal defense... - Galanin-like peptide promotes feeding behaviour via activation of orexinergic neurones in the rat lateral hypothalamusH Kageyama
Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
J Neuroendocrinol 18:33-41. 2006..These results suggest that orexin/hypocretin-containing neurones in the lateral hypothalamus are targeted by GALP, and that GALP-induced hyperphagia is mediated via orexin/hypocretin neurones in the rat hypothalamus... - Ghrelin is a growth-hormone-releasing acylated peptide from stomachM Kojima
Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
Nature 402:656-60. 1999..Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin... - Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleusS Lu
Department of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan
Neurosci Lett 321:157-60. 2002..Ghrelin-LI presynaptic axon terminals often made synapses with unknown immunonegative neurons. These results suggest that ghrelin acts to regulate food intake through synaptic connections in hypothalamic neuronal networks... - Ghrelin in domestic animals: distribution in stomach and its possible roleT Hayashida
Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan
Domest Anim Endocrinol 21:17-24. 2001..These results suggest that ghrelin plays an important role in GH secretion and feeding regulation in domestic animals... - Ghrelin in neonatal rats: distribution in stomach and its possible roleT Hayashida
Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan
J Endocrinol 173:239-45. 2002..7+/-0.94 to day 27.9+/-0.05. These results suggest that ghrelin may be involved in neonatal development... - Uroguanylin gene expression in the alimentary tract and extra-gastrointestinal tissuesM Miyazato
National Cardiovascular Center Research Institute, Osaka, Japan
FEBS Lett 398:170-4. 1996..Evidence for uroguanylin expression in extra-gastrointestinal tissues indicates the possible existence of a novel system for water and electrolyte homeostasis, and a more global effect of uroguanylin on epithelial cell function... - A role for neuromedin U in stress responseR Hanada
First Department of Internal Medicine, Oita Medical University, Oita 879 5593, Japan
Biochem Biophys Res Commun 289:225-8. 2001..NMU did not induce locomotor activity in CRH knockout mice. NMU that interacts anatomically and/or functionally with the CRH system is a novel physiological regulator of stress response... - Genomic structure and chromosomal localization of human uroguanylinM Miyazato
National Cardiovascular Center Research Institute, Suita, Osaka, Japan
Genomics 43:359-65. 1997..Fluorescence in situ hybridization showed the uroguanylin gene at human chromosome 1p33-p34. RNA blot analysis showed that human uroguanylin mRNA is expressed in the gastric fundus and pylorus as well as in the intestine... - Role for central ghrelin in food intake and secretion profile of stomach ghrelin in ratsN Murakami
Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889 2155, Japan
J Endocrinol 174:283-8. 2002.... - Characterization of urinary peptide biomarkers of acute rejection in renal allograftsE O'Riordan
Renal Institute, New York Medical College, Valhalla, New York, USA
Am J Transplant 7:930-40. 2007..In conclusion, the ratio of beta-Defensin-1 and alpha-1-antichymotrypsin excretion in the urine is a novel, potentially useful candidate biomarkers of acute rejection... - Narcolepsy in orexin knockout mice: molecular genetics of sleep regulationR M Chemelli
Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
Cell 98:437-51. 1999..We propose that orexin regulates sleep/wakefulness states, and that orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation... - Uroguanylin level in umbilical cord bloodH Tsukahara
Department of Pediatrics, Fukui Medical University, Fukui, Japan
Pediatr Int 43:267-9. 2001..Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine... - Down regulation of the prepro-orexin gene expression in genetically obese miceY Yamamoto
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
Brain Res Mol Brain Res 65:14-22. 1999..These results suggest that the regulatory mechanism of orexins/hypocretins may be different from that of NPY in genetically obese mice...