Research Topics
Genomes and Genes | Johji KatoSummaryAffiliation: Miyazaki Medical College Country: Japan Publications
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Publications
Adrenomedullin: a possible autocrine or paracrine hormone in the cardiac ventriclesJohji Kato
First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Hypertens Res 26:S113-9. 2003....- Plasma levels of adrenomedullin and atrial and brain natriuretic peptides in the general population: their relations to age and pulse pressureJohji Kato
First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
Hypertens Res 25:887-92. 2002.... - Antifibrotic effect of adrenomedullin on coronary adventitia in angiotensin II-induced hypertensive ratsToshihiro Tsuruda
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
Cardiovasc Res 65:921-9. 2005..The purpose of this study was to examine the biological actions of AM against the profibrotic factor angiotensin II (Ang II) in coronary adventitia... 
Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heartHiroyuki Masuyama
Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Hypertens Res 32:597-603. 2009..These results suggest that sGC stimulator BAY 41-2272 might be effective to reduce fibrosis in hypertensive heart disease by attenuating angiotensin II generation through myofibroblast transformation...- Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in ratsRyosai Nakamura
First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889-1692, Japan
Circulation 110:426-31. 2004..This beneficial effect was accompanied by reductions in oxidative stress and ACE mRNA expression in noninfarcted LV in the AM infusion period... - Chronic salt loading upregulates expression of adrenomedullin and its receptors in adrenal glands and kidneys of the ratYuan Ning Cao
First Department of Internal Medicine, Miyazaki Medical College, Japan
Hypertension 42:369-72. 2003..Taken together, these results suggest that AM plays a role in the regulation of water and electrolyte balance in animals chronically ingesting high levels of salt... - Overexpression of proadrenomedullin N-terminal 20 peptide blunts blood pressure rise and attenuates myocardial hypertrophy and fibrosis in hypertensive ratsYuan Ning Cao
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, 5200 Kihara, Miyazaki 889 1692, Japan
FEBS Lett 579:4997-5001. 2005..These results suggest that in addition to reducing blood pressure, PAMP suppresses cardiac hypertrophy through negative regulation of the local cardiac RAS... - Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin systemSayaka Nagata
Department of Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Hypertens Res 35:234-8. 2012..These results suggest that tissue concentrations of proang-12 and Ang II are regulated independently of the systemic RAS in WKY and SHR rats, which is consistent with the notion that proang-12 is a component of only the tissue RAS... - Adrenomedullin in mast cells of abdominal aortic aneurysmToshihiro Tsuruda
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
Cardiovasc Res 70:158-64. 2006..The purpose of this study was to examine the pathophysiological role of AM in the development of human abdominal aortic aneurysm (AAA)... - Adrenomedullin induces matrix metalloproteinase-2 activity in rat aortic adventitial fibroblastsToshihiro Tsuruda
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
Biochem Biophys Res Commun 325:80-4. 2004..In the present study, we examined the effect of the bioactive peptide adrenomedullin (AM) on activity and expression of matrix metalloproteinases (MMPs) in cultured aortic adventitial fibroblasts... - Angiotensin II modulates gene expression of adrenomedullin receptor components in rat cardiomyocytesKazuya Mishima
First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
Life Sci 73:1629-35. 2003..Thus, Ang II modulates gene expression of the AM receptor components via AT1 receptor, suggesting alteration of AM actions by Ang II in cultured rat cardiomyocytes... - The function of extracellular cysteines in the human adrenomedullin receptorKenji Kuwasako
First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Hypertens Res 26:S25-31. 2003..Cysteine residues in the extracellular loops of hCRLR and in the extracellular domain of hRAMP2 thus appear to play distinct roles in the cell surface expression and function of the receptor heterodimer... - Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2Kenji Kuwasako
Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Biochem Biophys Res Commun 392:380-5. 2010..Thus, the hCRLR C-tail is crucial for AM-evoked cAMP production and internalization of the CRLR/RAMP2, while the receptor internalization is dependent on the aforementioned GPCR kinases, but not Gs coupling... - [Potential of adrenomedullin as a therapeutic tool for left ventricular remodeling after myocardial infarction]Ryosai Nakamura
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
Nippon Rinsho 62:302-6. 2004 
The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signallingKenji Kuwasako
Frontier Science Research Center, University of Miyazaki, Miyazaki, Japan
Br J Pharmacol 166:137-50. 2012..Here, we examined the function of the ECL3 of human CLR within the CGRP and AM receptors...- Plasma and tissue levels of proangiotensin-12 and components of the renin-angiotensin system (RAS) following low- or high-salt feeding in ratsSayaka Nagata
Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Peptides 31:889-92. 2010..These results suggest that peptide levels of proang-12 in rat plasma and tissues are regulated in a manner independent of the circulating RAS... - Shared and separate functions of the RAMP-based adrenomedullin receptorsKenji Kuwasako
Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, Miyazaki 889 1692, Japan
Peptides 32:1540-50. 2011..In addition, we mention their possible function as receptors for AM2 (or intermedin), an AM-related peptide whose biological functions are similar to those of AM... - The calcitonin receptor-like receptor/receptor activity-modifying protein 1 heterodimer can function as a calcitonin gene-related peptide-(8-37)-sensitive adrenomedullin receptorYasuko Nagoshi
First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
Eur J Pharmacol 450:237-43. 2002..Thus, CRL receptor/RAMP1 likely functions as an adrenomedullin receptor as well as a CGRP receptor, which may explain why many of the actions of adrenomedullin are potently antagonized by alpha-CGRP-(8-37)... - Adrenomedullin alleviates not only neointimal formation but also perivascular hyperplasia following arterial injury in ratsToshihiro Tsuruda
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
Eur J Pharmacol 508:201-4. 2005.... - Flow cytometric analysis of the calcitonin receptor-like receptor domains responsible for cell-surface translocation of receptor activity-modifying proteinsKenji Kuwasako
Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Biochem Biophys Res Commun 384:249-54. 2009..Other regions within CRLR were not involved in trafficking interactions with RAMPs. These findings provide new insight into the trafficking interactions between accessory proteins such as RAMPs and their receptor partners... - Combined use of brain natriuretic peptide and C-reactive protein for predicting cardiovascular risk in outpatients with type 2 diabetes mellitusToshihiro Tsuruda
Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
Vasc Health Risk Manag 3:417-23. 2007..This study suggests that combination of plasma BNP and CRP measurement provides the additive prognostic information of cardiovascular events in patients with type 2 diabetes mellitus... - Three-year safety and effectiveness of fixed-dose losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension under clinical setting (PALM-1 Extension Study)Toshihiro Kita
Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
Clin Exp Hypertens 34:498-503. 2012..The losartan/HCTZ combination minimized diuretic-related adverse effects and thus may be useful for the treatment of Japanese patients with hypertension... - [Adrenomedullin in heart failure]Johji Kato
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
Nippon Rinsho 62:269-72. 2004 - Comparison of combination therapies, including the angiotensin receptor blocker olmesartan and either a calcium channel blocker or a thiazide diuretic, in elderly patients with hypertensionJohji Kato
Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Hypertens Res 34:331-5. 2011..0 mg per 100 ml, P<0.01). These results suggest that olmesartan plus a CCB is the preferable combination therapy in comparison with olmesartan plus a thiazide diuretic for elderly patients with hypertension... - Functions of the extracellular histidine residues of receptor activity-modifying proteins vary within adrenomedullin receptorsKenji Kuwasako
Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan
Biochem Biophys Res Commun 377:109-13. 2008..Other His residues appeared uninvolved in hCRLR-related functions. Thus, the His residues of hRAMP2 and -3 differentially govern AM receptor function... - Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysmToshihiro Tsuruda
Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
Circ Res 102:1368-77. 2008..Collectively, these data suggest that adventitial mast cells play a critical role in the progression of AAA... - Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in mice administered dextran sulphate sodiumShinya Ashizuka
First Department of Internal Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan
Microbiol Immunol 53:573-81. 2009..Collectively, these data indicate a broad spectrum of AM-induced effects with respect to protection against DSS-induced colitis, and suggest a potential therapeutic value of this treatment for IBD... - Beyond vasodilation: the antioxidant effect of adrenomedullin in Dahl salt-sensitive rat aortaYuan-Ning Cao
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
Biochem Biophys Res Commun 332:866-72. 2005..AM possesses significant antioxidant properties that improve endothelial function... - Characterization of the single transmembrane domain of human receptor activity-modifying protein 3 in adrenomedullin receptor internalizationKenji Kuwasako
Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, Miyazaki 889 1692, Japan
Biochem Biophys Res Commun 420:582-7. 2012.... - [Effect of adrenomedullin on cardiac myocytes and fibroblasts]Toshihiro Tsuruda
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
Nippon Rinsho 62:233-6. 2004 - Glycine-extended adrenomedullin exerts vasodilator effect through amidation in the rat aortaYuan-Ning Cao
First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
Regul Pept 113:109-14. 2003..These results suggest that the circulating AM-gly may play a role in regulating vascular tone and increased plasma AM-gly may be involved in the pathophysiology of cardiovascular diseases... - Development of an ultrasensitive enzyme immunoassay for human proadrenomedullin N-terminal 20 peptide and direct measurement of two molecular forms of PAMP in plasma from healthy subjects and patients with cardiovascular diseaseSeiichi Hashida
Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki 889 1692, Japan
Clin Biochem 37:14-21. 2004..To measure concentrations of PAMPs in human plasma directly, we have developed a highly sensitive enzyme immunoassay (immune complex transfer enzyme immunoassay, ICT-EIA)... - Aldosterone augments adrenomedullin production without stimulating pro-adrenomedullin N-terminal 20 peptide secretion in vascular smooth muscle cellsTomohiko Uemura
First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
J Hypertens 20:1209-14. 2002..CONCLUSIONS : AM production was stimulated by aldosterone in cultured human VSMC without an increase in PAMP secretion, suggesting a possible role of AM in modulating vascular remodeling by aldosterone... - Beneficial effects of adrenomedullin on left ventricular remodeling after myocardial infarction in ratsRyosai Nakamura
First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
Cardiovasc Res 56:373-80. 2002..CONCLUSIONS: Continuous administration of AM had beneficial effects on LV remodeling and hemodynamics in MI rats, suggesting the possibility that this peptide could be a useful therapeutic tool for acute MI... - Adrenomedullin: a protective factor for blood vesselsJohji Kato
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
Arterioscler Thromb Vasc Biol 25:2480-7. 2005..Collectively, a body of evidence suggests that AM participates in the mechanism against progression of vascular damage and remodeling, thereby alleviating the ischemia of tissues and organs... - One-year effectiveness and safety of open-label losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension uncontrolled with ARBs or ACE inhibitorsToshihiro Kita
Faculty of Medicine, Department of Internal Medicine, Division of Circulatory and Body Fluid Regulation, University of Miyazaki, Miyazaki, Japan
Hypertens Res 33:320-5. 2010..0 mg dl(-1)). Losartan/HCTZ combinations showed strong and steady hypotensive abilities and acceptable safety and tolerability in patients currently not at BP goals with regimens including ARBs or ACEIs in Japan... - Regulation of production and secretion of adrenomedullin in the cardiovascular systemTanenao Eto
The First Department of Internal Medicine, Miyazaki Medical School, 5200 Kihara, Kiyotake, 889 1692, Miyazaki, Japan
Regul Pept 112:61-9. 2003..Our recent studies have shown the importance of aldosterone and additional hormonal factor on AM secretion in vascular wall... - Atrial and brain natriuretic peptides as markers of cardiac load and volume retention in primary aldosteronismJohji Kato
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Am J Hypertens 18:354-7. 2005..The present study was carried out to determine the natriuretic peptide that is closely related to cardiac load and volume retention in patients with primary aldosteronism (PA)... - Structure-function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptorKenji Kuwasako
Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Peptides 32:144-9. 2011..Moreover, the Glu430-Val431 sequence may participate in the negative regulation of hAM(1) receptor internalization, which is not dependent on Gs coupling... - Effects of proangiotensin-12 infused continuously over 14 days in conscious ratsYoichi Komatsu
Department of Nutrition Science, Minami Kyusyu University, Miyazaki 880 0032, Japan
Eur J Pharmacol 683:186-9. 2012.... - Rat RAMP domains involved in adrenomedullin binding specificityKenji Kuwasako
First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
FEBS Lett 519:113-6. 2002..Consequently, their deletion yields peptides that are able to serve as negative regulators of AM receptor function... - Effect of adrenomedullin administration on acetic acid-induced colitis in ratsShinya Ashizuka
First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
Peptides 26:2610-5. 2005..AM reduces the severity of acetic acid-induced colitis in rats, probably by inhibiting the production and/or release of Th-2 cell-derived factors such as interleukin-6... - Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin systemSayaka Nagata
Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
Biochem Biophys Res Commun 350:1026-31. 2006..The identification of proangiotensin-12 suggests a processing cascade of the RA system, different from the cleavage of angiotensinogen to Ang I by renin... - Increased adrenomedullin concentration in cerebrospinal fluid in patients with septic shockNaoto Nagata
Intensive Care Division, Prefectural Nichinan Hospital, 1 9 5 Kiyama Nichinan City, Miyazaki 887 0013, Japan
J Med 34:59-66. 2003..01 P = 0.95). Taken together with the central actions of AM, these findings suggest that AM of the central nervous system may be involved in pathophysiology of sepsis of humans... - Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesityIkuo Nomura
Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
Regul Pept 158:127-31. 2009..These results suggest active roles for the two molecular forms of AM in metabolic disorders associated with obesity in subjects without overt cardiovascular disease... - Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in DrosophilaTakanori Ida
Interdisciplinary Research Organization, University of Miyazaki, Miyazaki 889 1692, Japan
Biochem Biophys Res Commun 414:44-8. 2011..The discovery of trissin provides an important lead to aid our understanding of cysteine-rich peptides and their functional interaction with GPCRs... - Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive ratsJewell A Jessup
Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Physiol Heart Circ Physiol 294:H2614-8. 2008..In addition, we show that increased cardiac angiotensin-(1-12) concentrations in SHR is associated with a small, but statistically significant, reduction in renal angiotensin-(1-12) levels... - [Should drug treatment be started with monotherapy or combination therapy for patients with hypertension]Johji Kato
First Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
Nippon Rinsho 64:254-7. 2006 - Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive ratsHiroyuki Masuyama
Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889-1692, Japan
Hypertension 48:972-8. 2006....