Johji Kato

Summary

Affiliation: Miyazaki Medical College
Country: Japan

Publications

  1. ncbi request reprint Adrenomedullin: a possible autocrine or paracrine hormone in the cardiac ventricles
    Johji Kato
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Hypertens Res 26:S113-9. 2003
  2. ncbi request reprint Plasma levels of adrenomedullin and atrial and brain natriuretic peptides in the general population: their relations to age and pulse pressure
    Johji Kato
    First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Hypertens Res 25:887-92. 2002
  3. ncbi request reprint Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart
    Hiroyuki Masuyama
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Hypertens Res 32:597-603. 2009
  4. ncbi request reprint Antifibrotic effect of adrenomedullin on coronary adventitia in angiotensin II-induced hypertensive rats
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Cardiovasc Res 65:921-9. 2005
  5. ncbi request reprint Chronic salt loading upregulates expression of adrenomedullin and its receptors in adrenal glands and kidneys of the rat
    Yuan Ning Cao
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Hypertension 42:369-72. 2003
  6. ncbi request reprint Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in rats
    Ryosai Nakamura
    First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889 1692, Japan
    Circulation 110:426-31. 2004
  7. ncbi request reprint Overexpression of proadrenomedullin N-terminal 20 peptide blunts blood pressure rise and attenuates myocardial hypertrophy and fibrosis in hypertensive rats
    Yuan Ning Cao
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, 5200 Kihara, Miyazaki 889 1692, Japan
    FEBS Lett 579:4997-5001. 2005
  8. doi request reprint Differential blood pressure reductions by angiotensin receptor blocker plus calcium channel blocker or diuretic in elderly hypertension with or without obesity
    Johji Kato
    Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan
    J Am Soc Hypertens 6:393-8. 2012
  9. doi request reprint Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system
    Sayaka Nagata
    Department of Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Hypertens Res 35:234-8. 2012
  10. pmc Three-year safety and effectiveness of fixed-dose losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension under clinical setting (PALM-1 Extension Study)
    Toshihiro Kita
    Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Clin Exp Hypertens 34:498-503. 2012

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Adrenomedullin: a possible autocrine or paracrine hormone in the cardiac ventricles
    Johji Kato
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Hypertens Res 26:S113-9. 2003
    ....
  2. ncbi request reprint Plasma levels of adrenomedullin and atrial and brain natriuretic peptides in the general population: their relations to age and pulse pressure
    Johji Kato
    First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Hypertens Res 25:887-92. 2002
    ....
  3. ncbi request reprint Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart
    Hiroyuki Masuyama
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Hypertens Res 32:597-603. 2009
    ..These results suggest that sGC stimulator BAY 41-2272 might be effective to reduce fibrosis in hypertensive heart disease by attenuating angiotensin II generation through myofibroblast transformation...
  4. ncbi request reprint Antifibrotic effect of adrenomedullin on coronary adventitia in angiotensin II-induced hypertensive rats
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Cardiovasc Res 65:921-9. 2005
    ..The purpose of this study was to examine the biological actions of AM against the profibrotic factor angiotensin II (Ang II) in coronary adventitia...
  5. ncbi request reprint Chronic salt loading upregulates expression of adrenomedullin and its receptors in adrenal glands and kidneys of the rat
    Yuan Ning Cao
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Hypertension 42:369-72. 2003
    ..Taken together, these results suggest that AM plays a role in the regulation of water and electrolyte balance in animals chronically ingesting high levels of salt...
  6. ncbi request reprint Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in rats
    Ryosai Nakamura
    First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889 1692, Japan
    Circulation 110:426-31. 2004
    ..This study was performed to determine whether AM administration immediately after acute MI inhibits progression of heart failure in rats...
  7. ncbi request reprint Overexpression of proadrenomedullin N-terminal 20 peptide blunts blood pressure rise and attenuates myocardial hypertrophy and fibrosis in hypertensive rats
    Yuan Ning Cao
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, 5200 Kihara, Miyazaki 889 1692, Japan
    FEBS Lett 579:4997-5001. 2005
    ..These results suggest that in addition to reducing blood pressure, PAMP suppresses cardiac hypertrophy through negative regulation of the local cardiac RAS...
  8. doi request reprint Differential blood pressure reductions by angiotensin receptor blocker plus calcium channel blocker or diuretic in elderly hypertension with or without obesity
    Johji Kato
    Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan
    J Am Soc Hypertens 6:393-8. 2012
    ..ARB plus CCB combination therapy might be preferably chosen for nonobese elderly patients, whereas the influence of obesity seems smaller in the efficacy of ARB plus a diuretic...
  9. doi request reprint Plasma and tissue concentrations of proangiotensin-12 in rats treated with inhibitors of the renin-angiotensin system
    Sayaka Nagata
    Department of Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Hypertens Res 35:234-8. 2012
    ..These results suggest that tissue concentrations of proang-12 and Ang II are regulated independently of the systemic RAS in WKY and SHR rats, which is consistent with the notion that proang-12 is a component of only the tissue RAS...
  10. pmc Three-year safety and effectiveness of fixed-dose losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension under clinical setting (PALM-1 Extension Study)
    Toshihiro Kita
    Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Clin Exp Hypertens 34:498-503. 2012
    ..The losartan/HCTZ combination minimized diuretic-related adverse effects and thus may be useful for the treatment of Japanese patients with hypertension...
  11. ncbi request reprint Angiotensin II modulates gene expression of adrenomedullin receptor components in rat cardiomyocytes
    Kazuya Mishima
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
    Life Sci 73:1629-35. 2003
    ..Thus, Ang II modulates gene expression of the AM receptor components via AT1 receptor, suggesting alteration of AM actions by Ang II in cultured rat cardiomyocytes...
  12. ncbi request reprint The function of extracellular cysteines in the human adrenomedullin receptor
    Kenji Kuwasako
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Hypertens Res 26:S25-31. 2003
    ..Cysteine residues in the extracellular loops of hCRLR and in the extracellular domain of hRAMP2 thus appear to play distinct roles in the cell surface expression and function of the receptor heterodimer...
  13. ncbi request reprint Adrenomedullin in mast cells of abdominal aortic aneurysm
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Cardiovasc Res 70:158-64. 2006
    ..The purpose of this study was to examine the pathophysiological role of AM in the development of human abdominal aortic aneurysm (AAA)...
  14. ncbi request reprint Adrenomedullin induces matrix metalloproteinase-2 activity in rat aortic adventitial fibroblasts
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Biochem Biophys Res Commun 325:80-4. 2004
    ..In the present study, we examined the effect of the bioactive peptide adrenomedullin (AM) on activity and expression of matrix metalloproteinases (MMPs) in cultured aortic adventitial fibroblasts...
  15. doi request reprint Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2
    Kenji Kuwasako
    Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 392:380-5. 2010
    ..Thus, the hCRLR C-tail is crucial for AM-evoked cAMP production and internalization of the CRLR/RAMP2, while the receptor internalization is dependent on the aforementioned GPCR kinases, but not Gs coupling...
  16. ncbi request reprint [Potential of adrenomedullin as a therapeutic tool for left ventricular remodeling after myocardial infarction]
    Ryosai Nakamura
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
    Nihon Rinsho 62:302-6. 2004
  17. ncbi request reprint Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats
    Hiroyuki Masuyama
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Hypertension 48:972-8. 2006
    ....
  18. doi request reprint Big angiotensin-25: a novel glycosylated angiotensin-related peptide isolated from human urine
    Sayaka Nagata
    Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 441:757-62. 2013
    ..Although the physiological function of Bang-25 remains uncertain, our findings suggest it is processed from angiotensinogen and may represent an alternative, renin-independent path for Ang II synthesis in tissue. ..
  19. pmc The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling
    Kenji Kuwasako
    Frontier Science Research Center, University of Miyazaki, Miyazaki, Japan
    Br J Pharmacol 166:137-50. 2012
    ..Here, we examined the function of the ECL3 of human CLR within the CGRP and AM receptors...
  20. doi request reprint Plasma and tissue levels of proangiotensin-12 and components of the renin-angiotensin system (RAS) following low- or high-salt feeding in rats
    Sayaka Nagata
    Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Peptides 31:889-92. 2010
    ..These results suggest that peptide levels of proang-12 in rat plasma and tissues are regulated in a manner independent of the circulating RAS...
  21. doi request reprint Shared and separate functions of the RAMP-based adrenomedullin receptors
    Kenji Kuwasako
    Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, Miyazaki 889 1692, Japan
    Peptides 32:1540-50. 2011
    ..In addition, we mention their possible function as receptors for AM2 (or intermedin), an AM-related peptide whose biological functions are similar to those of AM...
  22. ncbi request reprint Adrenomedullin alleviates not only neointimal formation but also perivascular hyperplasia following arterial injury in rats
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Eur J Pharmacol 508:201-4. 2005
    ....
  23. ncbi request reprint The calcitonin receptor-like receptor/receptor activity-modifying protein 1 heterodimer can function as a calcitonin gene-related peptide-(8-37)-sensitive adrenomedullin receptor
    Yasuko Nagoshi
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Eur J Pharmacol 450:237-43. 2002
    ..Thus, CRL receptor/RAMP1 likely functions as an adrenomedullin receptor as well as a CGRP receptor, which may explain why many of the actions of adrenomedullin are potently antagonized by alpha-CGRP-(8-37)...
  24. pmc Combined use of brain natriuretic peptide and C-reactive protein for predicting cardiovascular risk in outpatients with type 2 diabetes mellitus
    Toshihiro Tsuruda
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Vasc Health Risk Manag 3:417-23. 2007
    ..This study suggests that combination of plasma BNP and CRP measurement provides the additive prognostic information of cardiovascular events in patients with type 2 diabetes mellitus...
  25. doi request reprint Flow cytometric analysis of the calcitonin receptor-like receptor domains responsible for cell-surface translocation of receptor activity-modifying proteins
    Kenji Kuwasako
    Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 384:249-54. 2009
    ..Other regions within CRLR were not involved in trafficking interactions with RAMPs. These findings provide new insight into the trafficking interactions between accessory proteins such as RAMPs and their receptor partners...
  26. doi request reprint Functions of the extracellular histidine residues of receptor activity-modifying proteins vary within adrenomedullin receptors
    Kenji Kuwasako
    Frontier Science Research Center, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Biochem Biophys Res Commun 377:109-13. 2008
    ..Other His residues appeared uninvolved in hCRLR-related functions. Thus, the His residues of hRAMP2 and -3 differentially govern AM receptor function...
  27. doi request reprint Adrenomedullin treatment reduces intestinal inflammation and maintains epithelial barrier function in mice administered dextran sulphate sodium
    Shinya Ashizuka
    First Department of Internal Medicine, University of Miyazaki, Miyazaki, 889 1692, Japan
    Microbiol Immunol 53:573-81. 2009
    ..Collectively, these data indicate a broad spectrum of AM-induced effects with respect to protection against DSS-induced colitis, and suggest a potential therapeutic value of this treatment for IBD...
  28. ncbi request reprint [Adrenomedullin in heart failure]
    Johji Kato
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
    Nihon Rinsho 62:269-72. 2004
  29. ncbi request reprint Beyond vasodilation: the antioxidant effect of adrenomedullin in Dahl salt-sensitive rat aorta
    Yuan Ning Cao
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Biochem Biophys Res Commun 332:866-72. 2005
    ..AM possesses significant antioxidant properties that improve endothelial function...
  30. doi request reprint Comparison of combination therapies, including the angiotensin receptor blocker olmesartan and either a calcium channel blocker or a thiazide diuretic, in elderly patients with hypertension
    Johji Kato
    Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Hypertens Res 34:331-5. 2011
    ..0 mg per 100 ml, P<0.01). These results suggest that olmesartan plus a CCB is the preferable combination therapy in comparison with olmesartan plus a thiazide diuretic for elderly patients with hypertension...
  31. doi request reprint Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm
    Toshihiro Tsuruda
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Circ Res 102:1368-77. 2008
    ..Collectively, these data suggest that adventitial mast cells play a critical role in the progression of AAA...
  32. doi request reprint Characterization of the single transmembrane domain of human receptor activity-modifying protein 3 in adrenomedullin receptor internalization
    Kenji Kuwasako
    Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 420:582-7. 2012
    ....
  33. ncbi request reprint Glycine-extended adrenomedullin exerts vasodilator effect through amidation in the rat aorta
    Yuan Ning Cao
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Regul Pept 113:109-14. 2003
    ..These results suggest that the circulating AM-gly may play a role in regulating vascular tone and increased plasma AM-gly may be involved in the pathophysiology of cardiovascular diseases...
  34. ncbi request reprint [Effect of adrenomedullin on cardiac myocytes and fibroblasts]
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki
    Nihon Rinsho 62:233-6. 2004
  35. ncbi request reprint Functions of third extracellular loop and helix 8 of Family B GPCRs complexed with RAMPs and characteristics of their receptor trafficking
    Kenji Kuwasako
    Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, Miyazaki 889 1692, Japan
    Curr Protein Pept Sci 14:416-28. 2013
    ..In this review, we describe these studies and consider their implications for other Family B GPCRs that can interact with RAMPs. ..
  36. ncbi request reprint Aldosterone augments adrenomedullin production without stimulating pro-adrenomedullin N-terminal 20 peptide secretion in vascular smooth muscle cells
    Tomohiko Uemura
    First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    J Hypertens 20:1209-14. 2002
    ..Since aldosterone has been shown to be involved in vascular remodeling, we examined the effects of aldosterone on AM and PAMP secretion and preproAM gene expression in human aortic vascular smooth muscle cells (VSMC)...
  37. ncbi request reprint Beneficial effects of adrenomedullin on left ventricular remodeling after myocardial infarction in rats
    Ryosai Nakamura
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
    Cardiovasc Res 56:373-80. 2002
    ..The aim of this study was to examine the effects of long-term administration of AM on left ventricular (LV) remodeling, hemodynamic and hormonal parameters in a rat model of MI...
  38. ncbi request reprint Development of an ultrasensitive enzyme immunoassay for human proadrenomedullin N-terminal 20 peptide and direct measurement of two molecular forms of PAMP in plasma from healthy subjects and patients with cardiovascular disease
    Seiichi Hashida
    Department of Biochemistry, Miyazaki Medical College, Kiyotake, Miyazaki 889 1692, Japan
    Clin Biochem 37:14-21. 2004
    ..To measure concentrations of PAMPs in human plasma directly, we have developed a highly sensitive enzyme immunoassay (immune complex transfer enzyme immunoassay, ICT-EIA)...
  39. ncbi request reprint Adrenomedullin: a protective factor for blood vessels
    Johji Kato
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Arterioscler Thromb Vasc Biol 25:2480-7. 2005
    ..Collectively, a body of evidence suggests that AM participates in the mechanism against progression of vascular damage and remodeling, thereby alleviating the ischemia of tissues and organs...
  40. doi request reprint Structure-function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor
    Kenji Kuwasako
    Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Peptides 32:144-9. 2011
    ..Moreover, the Glu430-Val431 sequence may participate in the negative regulation of hAM(1) receptor internalization, which is not dependent on Gs coupling...
  41. ncbi request reprint Atrial and brain natriuretic peptides as markers of cardiac load and volume retention in primary aldosteronism
    Johji Kato
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Am J Hypertens 18:354-7. 2005
    ..The present study was carried out to determine the natriuretic peptide that is closely related to cardiac load and volume retention in patients with primary aldosteronism (PA)...
  42. doi request reprint One-year effectiveness and safety of open-label losartan/hydrochlorothiazide combination therapy in Japanese patients with hypertension uncontrolled with ARBs or ACE inhibitors
    Toshihiro Kita
    Faculty of Medicine, Department of Internal Medicine, Division of Circulatory and Body Fluid Regulation, University of Miyazaki, Miyazaki, Japan
    Hypertens Res 33:320-5. 2010
    ..0 mg dl(-1)). Losartan/HCTZ combinations showed strong and steady hypotensive abilities and acceptable safety and tolerability in patients currently not at BP goals with regimens including ARBs or ACEIs in Japan...
  43. ncbi request reprint Regulation of production and secretion of adrenomedullin in the cardiovascular system
    Tanenao Eto
    The First Department of Internal Medicine, Miyazaki Medical School, 5200 Kihara, Kiyotake, 889 1692, Miyazaki, Japan
    Regul Pept 112:61-9. 2003
    ..Our recent studies have shown the importance of aldosterone and additional hormonal factor on AM secretion in vascular wall...
  44. ncbi request reprint Biological properties of adrenomedullin conjugated with polyethylene glycol
    Keishi Kubo
    Department of Internal Medicine, University of Miyazaki Faculty of Medicine, Miyazaki 889 1692, Japan
    Peptides 57:118-21. 2014
    ..In summary, N-terminal PEGylated AM stimulated cAMP production in vitro, showing lessened acute hypotensive action and a prolonged plasma half-life in comparison with native AM peptide in vivo. ..
  45. doi request reprint Effects of proangiotensin-12 infused continuously over 14 days in conscious rats
    Yoichi Komatsu
    Department of Nutrition Science, Minami Kyusyu University, Miyazaki 880 0032, Japan
    Eur J Pharmacol 683:186-9. 2012
    ....
  46. ncbi request reprint Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system
    Sayaka Nagata
    Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 350:1026-31. 2006
    ..The identification of proangiotensin-12 suggests a processing cascade of the RA system, different from the cleavage of angiotensinogen to Ang I by renin...
  47. ncbi request reprint Rat RAMP domains involved in adrenomedullin binding specificity
    Kenji Kuwasako
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
    FEBS Lett 519:113-6. 2002
    ..Consequently, their deletion yields peptides that are able to serve as negative regulators of AM receptor function...
  48. ncbi request reprint Effect of adrenomedullin administration on acetic acid-induced colitis in rats
    Shinya Ashizuka
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Peptides 26:2610-5. 2005
    ..AM reduces the severity of acetic acid-induced colitis in rats, probably by inhibiting the production and/or release of Th-2 cell-derived factors such as interleukin-6...
  49. ncbi request reprint Increased adrenomedullin concentration in cerebrospinal fluid in patients with septic shock
    Naoto Nagata
    Intensive Care Division, Prefectural Nichinan Hospital, 1 9 5 Kiyama Nichinan City, Miyazaki 887 0013, Japan
    J Med 34:59-66. 2003
    ..01 P = 0.95). Taken together with the central actions of AM, these findings suggest that AM of the central nervous system may be involved in pathophysiology of sepsis of humans...
  50. pmc Gender difference in relationship between body mass index and development of chronic kidney disease
    Hiroshi Komura
    Frontier Science Research Center, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    BMC Res Notes 6:463. 2013
    ..We conducted a community-based, cohort study to identify the factors associated with the development of CKD in the general population...
  51. ncbi request reprint Increased plasma levels of the mature and intermediate forms of adrenomedullin in obesity
    Ikuo Nomura
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Regul Pept 158:127-31. 2009
    ..These results suggest active roles for the two molecular forms of AM in metabolic disorders associated with obesity in subjects without overt cardiovascular disease...
  52. doi request reprint Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan G protein-coupled receptor in Drosophila
    Takanori Ida
    Interdisciplinary Research Organization, University of Miyazaki, Miyazaki 889 1692, Japan
    Biochem Biophys Res Commun 414:44-8. 2011
    ..The discovery of trissin provides an important lead to aid our understanding of cysteine-rich peptides and their functional interaction with GPCRs...
  53. ncbi request reprint [Should drug treatment be started with monotherapy or combination therapy for patients with hypertension]
    Johji Kato
    First Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
    Nihon Rinsho 64:254-7. 2006
  54. pmc Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats
    Jewell A Jessup
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 294:H2614-8. 2008
    ..In addition, we show that increased cardiac angiotensin-(1-12) concentrations in SHR is associated with a small, but statistically significant, reduction in renal angiotensin-(1-12) levels...