Yasuyoshi Miyata

Summary

Country: Japan

Publications

  1. ncbi request reprint Effects of vitamin D(3)-binding protein-derived macrophage activating factor (GcMAF) on angiogenesis
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    J Natl Cancer Inst 94:1311-9. 2002
  2. ncbi request reprint Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 9:1741-9. 2003
  3. doi request reprint Feline sarcoma-related protein expression correlates with malignant aggressiveness and poor prognosis in renal cell carcinoma
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Cancer Sci 104:681-6. 2013
  4. pmc Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Mol Sci 14:12249-72. 2013
  5. pmc High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    PLoS ONE 8:e59095. 2013
  6. doi request reprint Tumor-associated stromal cells expressing E-prostanoid 2 or 3 receptors in prostate cancer: correlation with tumor aggressiveness and outcome by angiogenesis and lymphangiogenesis
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, and Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan
    Urology 81:136-42. 2013
  7. pmc Thrombospondin-1-derived 4N1K peptide expression is negatively associated with malignant aggressiveness and prognosis in urothelial carcinoma of the upper urinary tract
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    BMC Cancer 12:372. 2012
  8. pmc Use of low-dose combined therapy with gemcitabine and paclitaxel for advanced urothelial cancer patients with resistance to cisplatin-containing therapy: a retrospective analysis
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Science, Japan
    Cancer Chemother Pharmacol 70:451-9. 2012
  9. ncbi request reprint Penile erection occurs when penile vascular resistance is decreased and corporal smooth muscle is relaxed
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Eur Urol 52:259. 2007
  10. ncbi request reprint Presence of phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor progression and survival in patients with conventional renal cell carcinoma
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 12:4876-81. 2006

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Effects of vitamin D(3)-binding protein-derived macrophage activating factor (GcMAF) on angiogenesis
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    J Natl Cancer Inst 94:1311-9. 2002
    ..We investigated whether GcMAF also acts as an antiangiogenic factor on endothelial cells...
  2. ncbi request reprint Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 9:1741-9. 2003
    ..However, the relationships between COX-2 expression and these biological processes, clinicopathological features, and survival rate in patients with renal cell carcinoma are not clear...
  3. doi request reprint Feline sarcoma-related protein expression correlates with malignant aggressiveness and poor prognosis in renal cell carcinoma
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Cancer Sci 104:681-6. 2013
    ..047). Fer expression correlates with RCC cell proliferation both in vitro and in vivo, and with tumor progression and survival. This represents useful information for discussing the pathological and clinical significance of Fer in RCC...
  4. pmc Thrombospondin-1 in urological cancer: pathological role, clinical significance, and therapeutic prospects
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Mol Sci 14:12249-72. 2013
    ..In addition, special attention is paid to TSP-1-derived peptide and TSP-1-based therapy for malignancies...
  5. pmc High expression of HuR in cytoplasm, but not nuclei, is associated with malignant aggressiveness and prognosis in bladder cancer
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    PLoS ONE 8:e59095. 2013
    ....
  6. doi request reprint Tumor-associated stromal cells expressing E-prostanoid 2 or 3 receptors in prostate cancer: correlation with tumor aggressiveness and outcome by angiogenesis and lymphangiogenesis
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, and Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan
    Urology 81:136-42. 2013
    ....
  7. pmc Thrombospondin-1-derived 4N1K peptide expression is negatively associated with malignant aggressiveness and prognosis in urothelial carcinoma of the upper urinary tract
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    BMC Cancer 12:372. 2012
    ..Our aim was to clarify clinical significance and prognostic value of 4N1K expression in patients with urothelial carcinoma of the upper urinary tract (UC-UUT)...
  8. pmc Use of low-dose combined therapy with gemcitabine and paclitaxel for advanced urothelial cancer patients with resistance to cisplatin-containing therapy: a retrospective analysis
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Science, Japan
    Cancer Chemother Pharmacol 70:451-9. 2012
    ..The aim was to evaluate the anti-tumoral effects, relief of pain, and toxicity of LD-GP therapy in patients with resistance to CDDP-containing therapy...
  9. ncbi request reprint Penile erection occurs when penile vascular resistance is decreased and corporal smooth muscle is relaxed
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Eur Urol 52:259. 2007
  10. ncbi request reprint Presence of phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor progression and survival in patients with conventional renal cell carcinoma
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 12:4876-81. 2006
    ....
  11. ncbi request reprint Tumor lymphangiogenesis in transitional cell carcinoma of the upper urinary tract: association with clinicopathological features and prognosis
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University Graduate School of Biomedical Science, Nagasaki 852 8501, Japan
    J Urol 176:348-53. 2006
    ..We investigated the clinical and prognostic significance of lymphangiogenesis in patients with transitional cell carcinoma of the upper urinary tract...
  12. ncbi request reprint Pathological function of prostaglandin E2 receptors in transitional cell carcinoma of the upper urinary tract
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Virchows Arch 448:822-9. 2006
    ..Our results suggest that EP1R-3R play a minimal role in cancer progression in patients with TCC-UUT. On the other hand, EP4R regulates tumor progression via cancer cell proliferation and MMP-2, distinct from COX-2...
  13. ncbi request reprint Lymphangiogenesis and angiogenesis in bladder cancer: prognostic implications and regulation by vascular endothelial growth factors-A, -C, and -D
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    Clin Cancer Res 12:800-6. 2006
    ..We investigated the clinical and prognostic significance of LVD and MVD on lymphangiogenic and angiogenic function of VEGF-A, VEGF-C, and VEGF-D in human bladder cancer...
  14. ncbi request reprint Expression of matrix metalloproteinase-7 on cancer cells and tissue endothelial cells in renal cell carcinoma: prognostic implications and clinical significance for invasion and metastasis
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 12:6998-7003. 2006
    ..We investigated the clinical and prognostic significance of MMP-7 expression in cancer cells and endothelial cells in human renal cell carcinoma (RCC)...
  15. ncbi request reprint Relationship between prostaglandin E2 receptors and clinicopathologic features in human prostate cancer tissue
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Urology 68:1360-5. 2006
    ..Although EPRs are overexpressed in a variety of cancers, their expression pattern varies among different cancer types. The aim of this study was to clarify the clinical significance of EPRs in prostate cancer...
  16. ncbi request reprint Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 852 8501 Nagasaki, Japan
    Eur Urol 52:791-7. 2007
    ..The purpose of this study was to determine the clinical significance and malignant potential of MMP-10 in human CRCC tissues...
  17. ncbi request reprint Editorial comment on: diagnostic accuracy of computed tomography-guided percutaneous biopsy of renal masses
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Eur Urol 53:1011-2. 2008
  18. doi request reprint Phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor growth and prognosis in patients with bladder cancer: correlation with matrix metalloproteinase-2 and -7 and E-cadherin
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Hum Pathol 40:496-504. 2009
    ..The results suggest that these activities are mediated, at least in part, by matrix metalloproteinase-2, matrix metalloproteinase-7, and E-cadherin...
  19. doi request reprint Pathological significance and predictive value for biochemical recurrence of c-Fes expression in prostate cancer
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Prostate 72:201-8. 2012
    ..However, genetic studies have indicated that it has anti-tumorigenic effects in certain cancers. The pathological and clinical significance of c-Fes in prostate cancer are unknown...
  20. ncbi request reprint Response of recurrent urachal cancer to gemcitabine and cisplatin therapy: a case report and literature review
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Anticancer Res 31:2335-8. 2011
    ..Although further studies are necessary to determine its therapeutic efficacy, GC therapy may be a useful option in the treatment of urachal tumors, including recurrent tumours...
  21. ncbi request reprint Relationship between changes in prostate cancer cell proliferation, apoptotic index, and expression of apoptosis-related proteins by neoadjuvant hormonal therapy and duration of such treatment
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Urology 65:1238-43. 2005
    ....
  22. ncbi request reprint Expression of cyclooxygenase-2 and EP4 receptor in transitional cell carcinoma of the upper urinary tract
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 851 8501, Japan
    J Urol 173:56-60. 2005
    ..We determined the relationships between clinicopathological features and prognosis with expressions of COX-2 and EP4R in nonmetastatic TCC-UUT...
  23. ncbi request reprint Effect of maintenance chemotherapy with gemcitabine and paclitaxel on recurrent squamous cell carcinoma of the bladder: a case report
    Yasuyoshi Miyata
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Anticancer Res 31:4465-8. 2011
    ..Although further studies are necessary to determine its therapeutic efficacy, we suggest that this combined therapy is a useful option in the treatment of this disease including recurrent cases...
  24. ncbi request reprint Erectile dysfunction in hemodialysis patients with diabetes mellitus: association with age and hemoglobin A1c levels
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Sakamoto, Nagasaki City, Japan
    Int J Urol 11:530-4. 2004
    ..In addition, we examined the relationship between erectile function and several risk factors, including presence of DM and hemoglobin A1c levels in HD patients...
  25. ncbi request reprint Pigment epithelium-derived factor inhibits fibroblast-growth-factor-2-induced capillary morphogenesis of endothelial cells through Fyn
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Cell Sci 118:961-70. 2005
    ..Our results suggest that PEDF downregulates Fyn through Fes, resulting in inhibition of FGF-2-induced capillary morphogenesis of endothelial cells...
  26. ncbi request reprint Expression of metalloproteinase-2, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in transitional cell carcinoma of upper urinary tract: correlation with tumor stage and survival
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki City, Nagasaki, Japan
    Urology 63:602-8. 2004
    ..TIMPs exert an anti-invasive effect by blocking MMP activity. Recent studies have shown, however, that TIMPs can also stimulate cell proliferation and angiogenesis...
  27. doi request reprint TFE3-renal carcinoma in an adult patient: a case with strong expression of phosphorylated hepatocyte growth factor (HGFR)/Met
    Yuji Sagara
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Pathol Res Pract 205:57-61. 2009
    ..We speculate that upregulated phosphorylation of HGFR/Met could be partly associated with the malignant aggressiveness and poor survival of this patient...
  28. pmc Downregulation of the c-Fes protein-tyrosine kinase inhibits the proliferation of human renal carcinoma cells
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1, Sakamoto, Nagasaki 851 0251, Japan
    Int J Oncol 34:89-96. 2009
    ....
  29. ncbi request reprint Downregulation of Fes inhibits VEGF-A-induced chemotaxis and capillary-like morphogenesis by cultured endothelial cells
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Cell Mol Med 11:495-501. 2007
    ..Taken together, our novel results indicate the involvement of Fes in VEGF-A-induced cellular responses by cultured endothelial cells...
  30. ncbi request reprint The role of c-Fes in vascular endothelial growth factor-A-mediated signaling by endothelial cells
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Biochem Biophys Res Commun 306:1056-63. 2003
    ..Considered collectively, VEGF-A activated PI3-kinase partly through c-Fes and increase in c-Fes kinase activity enhanced capillary morphogenesis by yet unknown signaling pathways...
  31. ncbi request reprint Overexpression of hepatocyte growth factor receptor in renal carcinoma cells indirectly stimulates tumor growth in vivo
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    Biochem Biophys Res Commun 302:892-7. 2003
    ..These results indicate for the first time that overexpression of HGFR tyrosine kinase in renal carcinoma cells participates in rapid tumor growth in vivo...
  32. doi request reprint Lymphangiogenesis and angiogenesis in conventional renal cell carcinoma: association with vascular endothelial growth factors A to D immunohistochemistry
    Takahisa Iwata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Urology 71:749-54. 2008
    ..We investigated the relationships between various clinicopathologic features and lymphangiogenesis, angiogenesis, and expression of VEGFs in RCC...
  33. ncbi request reprint Angiopoietin 1 is mitogenic for cultured endothelial cells
    Shigeru Kanda
    Division of Endothelial Cell Biology and Cytokine Signaling, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan
    Cancer Res 65:6820-7. 2005
    ..Taken together, these findings indicate that Ang1 exerts mitogenic activity on endothelial cells, which requires activation of both MAPK and p70 S6K...
  34. ncbi request reprint Expression of thrombospondin-derived 4N1K peptide-containing proteins in renal cell carcinoma tissues is associated with a decrease in tumor growth and angiogenesis
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University Graduate School of Medical Science, Japan
    Clin Cancer Res 9:1734-40. 2003
    ..The goal of this study was to examine whether the expression of 4N1K-containing proteins correlates with reduced growth of human renal cell carcinoma (RCC)...
  35. doi request reprint Loss of PTEN function may account for reduced proliferation pathway sensitivity to LY294002 in human prostate and bladder cancer cells
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki, 852 8501, Japan
    J Cancer Res Clin Oncol 135:303-11. 2009
    ..Inhibition of phosphoinositide 3 (PI3)-kinase pathway is attractive for cancer treatment. To examine the role of the phosphatase and tensin homolog (PTEN) in the development of resistance to the treatment...
  36. ncbi request reprint Non-receptor protein-tyrosine kinases as molecular targets for antiangiogenic therapy (Review)
    Shigeru Kanda
    National Hospital Organization, Nagasaki Hospital, Nagasaki, Japan
    Int J Mol Med 20:113-21. 2007
    ..In this review, we summarize the contributions of these kinase families to angiogenic pathways in endothelial cells, and discuss the potential of these kinases as new targets for antiangiogenic drug discovery...
  37. ncbi request reprint Expression of insulin-like growth factor binding protein-3 before and after neoadjuvant hormonal therapy in human prostate cancer tissues: correlation with histopathologic effects and biochemical recurrence
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    Urology 63:1184-90. 2004
    ..IGFBP-3 has pro-apoptotic activity, and its expression correlates negatively with prostate cancer cell growth. Castration induces IGFBP-3 expression and apoptosis in the rat prostate...
  38. doi request reprint Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal therapy
    Shin Ichi Watanabe
    Department of Urology, Nagasaki University School of Medicine, Japan
    J Cancer Res Clin Oncol 136:787-93. 2010
    ..The aim was to investigate whether NHT influences with XIAP expression in prostate cancer patients. In addition, the relationship between XIAP expression and apoptosis in patients who did or did not receive NHT was also investigated...
  39. ncbi request reprint Role of Src in angiopoietin 1-induced capillary morphogenesis of endothelial cells: Effect of chronic hypoxia on Src inhibition by PP2
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Cell Signal 19:472-80. 2007
    ..Taken together, our results suggest that Ang1 induces capillary morphogenesis in HUVECs through Src-dependent upregulation of endogenous VEGF-A. Conditions of chronic hypoxia impaired the effect of PP2, possibly via MRP 1...
  40. ncbi request reprint Clinical significance and predictive value of prostaglandin E2 receptors (EPR) 1 - 4 in patients with renal cell carcinoma
    Kojiro Ohba
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Anticancer Res 31:597-605. 2011
    ..The relationships between EPR immunoreactivity score (IS) and various pathological features and survival were then analyzed...
  41. doi request reprint High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2
    Shin Ichi Watanabe
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8591, Japan
    Hum Pathol 43:888-97. 2012
    ..The results suggest collaborative effects of stem cell factor, mast cell tryptase, and protease-activated receptor 2 on the malignant potential of hemodialysis-renal cell carcinoma...
  42. doi request reprint Pathologic significance and prognostic value of phosphorylated cortactin expression in patients with sarcomatoid renal cell carcinoma
    Tomohiro Matsuo
    Department of Nephro urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Urology 78:476.e9-15. 2011
    ..To clarify the clinical and prognostic significance of cortactin and phosphorylated cortactin in patients with sarcomatoid renal cell carcinoma (SRCC)...
  43. ncbi request reprint Fibroblast growth factor-2 induces the activation of Src through Fes, which regulates focal adhesion disassembly
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, Japan
    Exp Cell Res 312:3015-22. 2006
    ..These findings suggest that activation of Fes by FGF-2 enhances FAK-dependent activation of Src within FA, promoting FGF-2-induced disassembly of focal adhesions...
  44. ncbi request reprint Long-term exposure of human renal carcinoma cells to PD98059 induces epithelial-mesenchymal transition-like phenotype and enhanced motility
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Science, 1 7 1, Sakamoto, Nagasaki, Japan
    Mol Cell Biochem 309:69-76. 2008
    ..Our results suggest that long-term exposure of human renal carcinoma cells to PD98059 increases cell motility by upregulating Rho A-Rho kinase signaling...
  45. ncbi request reprint Expression of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and plasminogen activator inhibitors in patients with renal cell carcinoma: correlation with tumor associated macrophage and prognosis
    Kojiro Ohba
    Department of Urology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    J Urol 174:461-5. 2005
    ..However, to our knowledge the clinical significance of PAI-2 and the relationship between the uPA system and TAM in human renal cell carcinoma (RCC) tissues have not been investigated. We investigated and clarified these issues...
  46. ncbi request reprint T-cell factor-4-dependent up-regulation of fibronectin is involved in fibroblast growth factor-2-induced tube formation by endothelial cells
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Cell Biochem 94:835-47. 2005
    ..Taken together, interaction of alpha(5)beta(1) integrin and fibronectin is involved in FGF-2-induced tube formation by endothelial cells and up-regulation of fibronectin through TCF-4 seemed to be involved in this process...
  47. ncbi request reprint Role of focal adhesion formation in migration and morphogenesis of endothelial cells
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, 852 8501, Japan
    Cell Signal 16:1273-81. 2004
    ..Increase in focal adhesions was closely associated with capillary morphogenesis. Our results suggest that formation or disassembly of focal adhesions seems to determine the motility or morphogenesis of endothelial cells...
  48. doi request reprint Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer
    Yuji Sagara
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    Cancer Epidemiol 34:350-4. 2010
    ..This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN), with and without GTP...
  49. ncbi request reprint HGF-induced capillary morphogenesis of endothelial cells is regulated by Src
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki, Japan
    Biochem Biophys Res Commun 344:617-22. 2006
    ..These results suggest that HGF induces capillary morphogenesis of endothelial cells through Src...
  50. doi request reprint E1AF expression is associated with extra-prostatic growth and matrix metalloproteinase-7 expression in prostate cancer
    Sugure Maruta
    Department of Urology, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    APMIS 117:791-6. 2009
    ..This finding may be influenced by regulation of MMP-7. We speculate that E1AF is a possible target in treatment and prevention of tumor growth in prostate cancer...
  51. ncbi request reprint Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug
    Yasushi Hayashida
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, and Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Biol Chem 281:32469-84. 2006
    ....
  52. ncbi request reprint Multifocal transitional cell carcinoma associated with renal cell carcinoma in a patient on long-term haemodialysis
    Kousuke Takehara
    Department of Urology, Nagasaki University School of Medicine, Nagasaki University Hospital, Japan
    Nephrol Dial Transplant 17:1692-4. 2002
  53. ncbi request reprint Expression of nm23-H1 gene product in sarcomatous cancer cells of renal cell carcinoma: correlation with tumor stage and expression of matrix metalloproteinase-2, matrix metalloproteinase-9, sialyl Lewis X, and c-erbB-2
    Kojiro Ohba
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Urology 65:1029-34. 2005
    ..Renal cell carcinoma with sarcomatoid cancer cells is characterized by high malignant potential and a poor prognosis...
  54. ncbi request reprint Serum insulin-like growth factor binding protein-3/prostate-specific antigen ratio is a useful predictive marker in patients with advanced prostate cancer
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Prostate 54:125-32. 2003
    ..We studied the prognostic significance of serum IGF-1 and IGFBP-3 levels, and IGF-1/prostate-specific antigen (PSA) and IGFBP-3/PSA ratios in patients with prostate cancer...
  55. ncbi request reprint [Efficacy of periprostatic nerve blockade during ultrasound-guided transrectal 10-core biopsy of the prostate]
    Tomoaki Hakariya
    Division of Nephro Urology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Nihon Hinyokika Gakkai Zasshi 96:691-6. 2005
    ..We examined the efficacy and safety of periprostatic nerve blockade during transrectal ultrasound guided prostate biopsy...
  56. ncbi request reprint Current status and perspective of antiangiogenic therapy for cancer: urinary cancer
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Clin Oncol 11:90-107. 2006
    ..In this review, we summarize these unique mechanisms and review the results of clinical trials of antiangiogenic therapy for these cancers, discussing prospects and problems relating to antiangiogenic therapy...
  57. ncbi request reprint Elevated expression of ERK 2 in human tumor cells chronically treated with PD98059
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, Japan
    Biochem Biophys Res Commun 345:1481-6. 2006
    ..Taken together, chronic exposure of tumor cells to PD98059 induced elevated expression of ERK 2, which was associated with decreased sensitivity of cellular proliferation to PD98059...
  58. ncbi request reprint Fibroblast growth factor-2-mediated capillary morphogenesis of endothelial cells requires signals via Flt-1/vascular endothelial growth factor receptor-1: possible involvement of c-Akt
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Biol Chem 279:4007-16. 2004
    ..Taken together, signals via VEGFR-1 were required for FGF-2-induced capillary morphogenesis by endothelial cells, and c-Akt activity seemed to be involved in this process...
  59. ncbi request reprint Interstitial expression of heat-shock protein 47 correlates with capillary deposition of complement split product C4d in chronic allograft nephropathy
    Kojiro Ohba
    Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Clin Transplant 19:810-6. 2005
    ..This study was designed to examine the relationship between the expression of C4d and heat-shock protein 47 (HSP47, a collagen-specific chaperone) in the development of interstitial fibroproliferative lesions in CAN...
  60. ncbi request reprint Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Medicine, 1 7 1 Sakamoto, Japan
    J Biol Chem 278:8244-9. 2003
    ..Considered collectively, Shh induced capillary morphogenesis of endothelial cells through both rapid activation of c-Fes/PI3-kinase pathways and transcriptionally regulated pathways...
  61. ncbi request reprint Predictive value of serum macrophage colony-stimulating factor for development of aortic calcification in haemodialysis patients: a 6 year longitudinal study
    Toshiharu Kihara
    Division of Nephro Urology, Department of Translational Medical Science, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Nephrol Dial Transplant 20:1647-52. 2005
    ..However, the long-term predictive value of the serum MCSF level for the development of aortic calcification under HD conditions has not been reported...
  62. ncbi request reprint [Expression and function of e prostanoid receptors in urological cancer]
    Kojiro Ohba
    The Department of Nephro Urology, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Hinyokika Kiyo 59:83-9. 2013
    ..Finally, we speculate that some EPRs inhibitors may reduce adverse events and exert more intense effects on urological cancer...
  63. ncbi request reprint The c-Fes protein tyrosine kinase as a potential anti-angiogenic target in cancer
    Shigeru Kanda
    Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Front Biosci (Landmark Ed) 16:1024-35. 2011
    ..Roles for c-Fes during angiogenesis will be the focus of extensive research in the future...
  64. ncbi request reprint Donor-specific blood transfusion prolongs cardiac allograft survival in rats by low nitric oxide production and elevated serum levels of prostaglandin E(2)
    Shu Inuzuka
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki City, Japan
    Immunol Lett 83:119-24. 2002
    ..Our results suggest that DST prolongs graft survival by enhanced production of PGE(2) with a resultant suppression of immune activation. In addition, DST-induced prolongation of graft survival may be partially mediated by NO suppression...
  65. ncbi request reprint [Clinical study of sarcomatoid renal cell carcinoma]
    Kojiro Ohba
    Department of Urology, Nagasaki University Graduate School of Biochemical Science
    Hinyokika Kiyo 49:131-3. 2003
    ..We confirmed that renal cell carcinoma with a sarcomatoid component often showed local invasion, distant metastasis and poor prognosis...
  66. ncbi request reprint [A case of metastatic tumor of spermatic cord from ascending colon carcinoma]
    Yohei Shida
    The Division of Nephro Urology, Nagasaki University Graduate School of Biomedical Sciences
    Hinyokika Kiyo 52:733-5. 2006
    ..To our knowledge, a metastatic tumor of the spermatic cord from colon or rectal cancer is rare. As previously reported, the prognosis of this case was also poor...
  67. ncbi request reprint Editorial comment on: core biopsies of renal tumors: a study on diagnostic accuracy, interobserver, and intraobserver variability
    Yasuyoshi Miyata
    Eur Urol 53:1226. 2008