Yasuyoshi Miyata

Summary

Country: Japan

Publications

  1. ncbi request reprint Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 9:1741-9. 2003
  2. ncbi request reprint Pathological function of prostaglandin E2 receptors in transitional cell carcinoma of the upper urinary tract
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Virchows Arch 448:822-9. 2006
  3. ncbi request reprint Tumor lymphangiogenesis in transitional cell carcinoma of the upper urinary tract: association with clinicopathological features and prognosis
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University Graduate School of Biomedical Science, Nagasaki 852 8501, Japan
    J Urol 176:348-53. 2006
  4. ncbi request reprint Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 852 8501 Nagasaki, Japan
    Eur Urol 52:791-7. 2007
  5. doi request reprint TFE3-renal carcinoma in an adult patient: a case with strong expression of phosphorylated hepatocyte growth factor (HGFR)/Met
    Yuji Sagara
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Pathol Res Pract 205:57-61. 2009
  6. ncbi request reprint Lymphangiogenesis and angiogenesis in bladder cancer: prognostic implications and regulation by vascular endothelial growth factors-A, -C, and -D
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    Clin Cancer Res 12:800-6. 2006
  7. doi request reprint Lymphangiogenesis and angiogenesis in conventional renal cell carcinoma: association with vascular endothelial growth factors A to D immunohistochemistry
    Takahisa Iwata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Urology 71:749-54. 2008
  8. ncbi request reprint Expression of matrix metalloproteinase-7 on cancer cells and tissue endothelial cells in renal cell carcinoma: prognostic implications and clinical significance for invasion and metastasis
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 12:6998-7003. 2006
  9. ncbi request reprint Expression of cyclooxygenase-2 and EP4 receptor in transitional cell carcinoma of the upper urinary tract
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 851 8501, Japan
    J Urol 173:56-60. 2005
  10. ncbi request reprint Expression of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and plasminogen activator inhibitors in patients with renal cell carcinoma: correlation with tumor associated macrophage and prognosis
    Kojiro Ohba
    Department of Urology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    J Urol 174:461-5. 2005

Collaborators

  • Shigeru Kanda
  • Shigehiko Koga
  • Hideki Sakai
  • Tsukasa Igawa
  • Yutaka Saito
  • Taro Shuin
  • Hiroshi Kanetake
  • Kojiro Ohba
  • Tomayoshi Hayashi
  • Yuji Sagara
  • Masaharu Nishikido
  • Takahisa Iwata
  • Koichiro Nomata
  • Shin Ichi Watanabe
  • Sugure Maruta
  • Yasushi Hayashida
  • Akihiro Asai
  • Tomohiro Matsuo
  • Shu Inuzuka
  • Kousuke Takehara
  • Yohei Shida
  • Kensuke Mitsunari
  • Jiro Eguchi
  • Kuniko Abe
  • Takaaki Kono
  • Yoshishige Urata
  • Eiji Muroi
  • Takahito Kondo
  • Yoshito Ihara
  • Takashi Taguchi
  • Mohammed S Razzaque
  • Arifa Nazneen
  • Mitsuru Noguchi
  • Jun Yamada
  • Naoe Tamaru
  • Mitsuko Tanaka
  • Isao Shimokawa
  • Takashi Harada

Detail Information

Publications36

  1. ncbi request reprint Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 9:1741-9. 2003
    ..However, the relationships between COX-2 expression and these biological processes, clinicopathological features, and survival rate in patients with renal cell carcinoma are not clear...
  2. ncbi request reprint Pathological function of prostaglandin E2 receptors in transitional cell carcinoma of the upper urinary tract
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Virchows Arch 448:822-9. 2006
    ..Our results suggest that EP1R-3R play a minimal role in cancer progression in patients with TCC-UUT. On the other hand, EP4R regulates tumor progression via cancer cell proliferation and MMP-2, distinct from COX-2...
  3. ncbi request reprint Tumor lymphangiogenesis in transitional cell carcinoma of the upper urinary tract: association with clinicopathological features and prognosis
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University Graduate School of Biomedical Science, Nagasaki 852 8501, Japan
    J Urol 176:348-53. 2006
    ..We investigated the clinical and prognostic significance of lymphangiogenesis in patients with transitional cell carcinoma of the upper urinary tract...
  4. ncbi request reprint Expression of matrix metalloproteinase-10 in renal cell carcinoma and its prognostic role
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 852 8501 Nagasaki, Japan
    Eur Urol 52:791-7. 2007
    ..The purpose of this study was to determine the clinical significance and malignant potential of MMP-10 in human CRCC tissues...
  5. doi request reprint TFE3-renal carcinoma in an adult patient: a case with strong expression of phosphorylated hepatocyte growth factor (HGFR)/Met
    Yuji Sagara
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Pathol Res Pract 205:57-61. 2009
    ..We speculate that upregulated phosphorylation of HGFR/Met could be partly associated with the malignant aggressiveness and poor survival of this patient...
  6. ncbi request reprint Lymphangiogenesis and angiogenesis in bladder cancer: prognostic implications and regulation by vascular endothelial growth factors-A, -C, and -D
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    Clin Cancer Res 12:800-6. 2006
    ..We investigated the clinical and prognostic significance of LVD and MVD on lymphangiogenic and angiogenic function of VEGF-A, VEGF-C, and VEGF-D in human bladder cancer...
  7. doi request reprint Lymphangiogenesis and angiogenesis in conventional renal cell carcinoma: association with vascular endothelial growth factors A to D immunohistochemistry
    Takahisa Iwata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Urology 71:749-54. 2008
    ..We investigated the relationships between various clinicopathologic features and lymphangiogenesis, angiogenesis, and expression of VEGFs in RCC...
  8. ncbi request reprint Expression of matrix metalloproteinase-7 on cancer cells and tissue endothelial cells in renal cell carcinoma: prognostic implications and clinical significance for invasion and metastasis
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 12:6998-7003. 2006
    ..We investigated the clinical and prognostic significance of MMP-7 expression in cancer cells and endothelial cells in human renal cell carcinoma (RCC)...
  9. ncbi request reprint Expression of cyclooxygenase-2 and EP4 receptor in transitional cell carcinoma of the upper urinary tract
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 851 8501, Japan
    J Urol 173:56-60. 2005
    ..We determined the relationships between clinicopathological features and prognosis with expressions of COX-2 and EP4R in nonmetastatic TCC-UUT...
  10. ncbi request reprint Expression of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and plasminogen activator inhibitors in patients with renal cell carcinoma: correlation with tumor associated macrophage and prognosis
    Kojiro Ohba
    Department of Urology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    J Urol 174:461-5. 2005
    ..However, to our knowledge the clinical significance of PAI-2 and the relationship between the uPA system and TAM in human renal cell carcinoma (RCC) tissues have not been investigated. We investigated and clarified these issues...
  11. ncbi request reprint Relationship between prostaglandin E2 receptors and clinicopathologic features in human prostate cancer tissue
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Urology 68:1360-5. 2006
    ..Although EPRs are overexpressed in a variety of cancers, their expression pattern varies among different cancer types. The aim of this study was to clarify the clinical significance of EPRs in prostate cancer...
  12. ncbi request reprint Expression of thrombospondin-derived 4N1K peptide-containing proteins in renal cell carcinoma tissues is associated with a decrease in tumor growth and angiogenesis
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University Graduate School of Medical Science, Japan
    Clin Cancer Res 9:1734-40. 2003
    ..The goal of this study was to examine whether the expression of 4N1K-containing proteins correlates with reduced growth of human renal cell carcinoma (RCC)...
  13. doi request reprint Phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor growth and prognosis in patients with bladder cancer: correlation with matrix metalloproteinase-2 and -7 and E-cadherin
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki 852 8501, Japan
    Hum Pathol 40:496-504. 2009
    ..The results suggest that these activities are mediated, at least in part, by matrix metalloproteinase-2, matrix metalloproteinase-7, and E-cadherin...
  14. doi request reprint Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal therapy
    Shin Ichi Watanabe
    Department of Urology, Nagasaki University School of Medicine, Japan
    J Cancer Res Clin Oncol 136:787-93. 2010
    ..The aim was to investigate whether NHT influences with XIAP expression in prostate cancer patients. In addition, the relationship between XIAP expression and apoptosis in patients who did or did not receive NHT was also investigated...
  15. ncbi request reprint Expression of insulin-like growth factor binding protein-3 before and after neoadjuvant hormonal therapy in human prostate cancer tissues: correlation with histopathologic effects and biochemical recurrence
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    Urology 63:1184-90. 2004
    ..IGFBP-3 has pro-apoptotic activity, and its expression correlates negatively with prostate cancer cell growth. Castration induces IGFBP-3 expression and apoptosis in the rat prostate...
  16. ncbi request reprint E1AF expression is associated with extra-prostatic growth and matrix metalloproteinase-7 expression in prostate cancer
    Sugure Maruta
    Department of Urology, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    APMIS 117:791-6. 2009
    ..This finding may be influenced by regulation of MMP-7. We speculate that E1AF is a possible target in treatment and prevention of tumor growth in prostate cancer...
  17. ncbi request reprint Expression of metalloproteinase-2, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in transitional cell carcinoma of upper urinary tract: correlation with tumor stage and survival
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki City, Nagasaki, Japan
    Urology 63:602-8. 2004
    ..TIMPs exert an anti-invasive effect by blocking MMP activity. Recent studies have shown, however, that TIMPs can also stimulate cell proliferation and angiogenesis...
  18. ncbi request reprint Presence of phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor progression and survival in patients with conventional renal cell carcinoma
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Japan
    Clin Cancer Res 12:4876-81. 2006
    ....
  19. ncbi request reprint Relationship between changes in prostate cancer cell proliferation, apoptotic index, and expression of apoptosis-related proteins by neoadjuvant hormonal therapy and duration of such treatment
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Urology 65:1238-43. 2005
    ....
  20. ncbi request reprint Expression of nm23-H1 gene product in sarcomatous cancer cells of renal cell carcinoma: correlation with tumor stage and expression of matrix metalloproteinase-2, matrix metalloproteinase-9, sialyl Lewis X, and c-erbB-2
    Kojiro Ohba
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Urology 65:1029-34. 2005
    ..Renal cell carcinoma with sarcomatoid cancer cells is characterized by high malignant potential and a poor prognosis...
  21. ncbi request reprint Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer
    Yuji Sagara
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, Japan
    Cancer Epidemiol 34:350-4. 2010
    ..This study investigated the effect of GTP on bladder tumor size and angiogenesis in mice given N-butyl-(-4-hydroxybutyl) nitrosamine (BBN), with and without GTP...
  22. ncbi request reprint Multifocal transitional cell carcinoma associated with renal cell carcinoma in a patient on long-term haemodialysis
    Kousuke Takehara
    Department of Urology, Nagasaki University School of Medicine, Nagasaki University Hospital, Japan
    Nephrol Dial Transplant 17:1692-4. 2002
  23. pmc High expression of Twist is associated with tumor aggressiveness and poor prognosis in patients with renal cell carcinoma
    Kojiro Ohba
    Department of Urology, Nagasaki University Graduate School of Biomedical Sciences Nagasaki, Japan
    Int J Clin Exp Pathol 7:3158-65. 2014
    ..The present study was to clarify clinical significance and molecular functions of Twist in patients with RCC...
  24. ncbi request reprint Interstitial expression of heat-shock protein 47 correlates with capillary deposition of complement split product C4d in chronic allograft nephropathy
    Kojiro Ohba
    Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Clin Transplant 19:810-6. 2005
    ..This study was designed to examine the relationship between the expression of C4d and heat-shock protein 47 (HSP47, a collagen-specific chaperone) in the development of interstitial fibroproliferative lesions in CAN...
  25. ncbi request reprint Overexpression of hepatocyte growth factor receptor in renal carcinoma cells indirectly stimulates tumor growth in vivo
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University Graduate School of Medical Science, Nagasaki, Japan
    Biochem Biophys Res Commun 302:892-7. 2003
    ..These results indicate for the first time that overexpression of HGFR tyrosine kinase in renal carcinoma cells participates in rapid tumor growth in vivo...
  26. ncbi request reprint Erectile dysfunction in hemodialysis patients with diabetes mellitus: association with age and hemoglobin A1c levels
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Sakamoto, Nagasaki City, Japan
    Int J Urol 11:530-4. 2004
    ..In addition, we examined the relationship between erectile function and several risk factors, including presence of DM and hemoglobin A1c levels in HD patients...
  27. ncbi request reprint Donor-specific blood transfusion prolongs cardiac allograft survival in rats by low nitric oxide production and elevated serum levels of prostaglandin E(2)
    Shu Inuzuka
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki City, Japan
    Immunol Lett 83:119-24. 2002
    ..Our results suggest that DST prolongs graft survival by enhanced production of PGE(2) with a resultant suppression of immune activation. In addition, DST-induced prolongation of graft survival may be partially mediated by NO suppression...
  28. ncbi request reprint Serum insulin-like growth factor binding protein-3/prostate-specific antigen ratio is a useful predictive marker in patients with advanced prostate cancer
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Prostate 54:125-32. 2003
    ..We studied the prognostic significance of serum IGF-1 and IGFBP-3 levels, and IGF-1/prostate-specific antigen (PSA) and IGFBP-3/PSA ratios in patients with prostate cancer...
  29. ncbi request reprint Editorial comment on: diagnostic accuracy of computed tomography-guided percutaneous biopsy of renal masses
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
    Eur Urol 53:1011-2. 2008
  30. ncbi request reprint [Clinical study of sarcomatoid renal cell carcinoma]
    Kojiro Ohba
    Department of Urology, Nagasaki University Graduate School of Biochemical Science
    Hinyokika Kiyo 49:131-3. 2003
    ..We confirmed that renal cell carcinoma with a sarcomatoid component often showed local invasion, distant metastasis and poor prognosis...
  31. ncbi request reprint Effects of vitamin D(3)-binding protein-derived macrophage activating factor (GcMAF) on angiogenesis
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan
    J Natl Cancer Inst 94:1311-9. 2002
    ..We investigated whether GcMAF also acts as an antiangiogenic factor on endothelial cells...
  32. ncbi request reprint Pigment epithelium-derived factor inhibits fibroblast-growth-factor-2-induced capillary morphogenesis of endothelial cells through Fyn
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    J Cell Sci 118:961-70. 2005
    ..Our results suggest that PEDF downregulates Fyn through Fes, resulting in inhibition of FGF-2-induced capillary morphogenesis of endothelial cells...
  33. ncbi request reprint Editorial comment on: core biopsies of renal tumors: a study on diagnostic accuracy, interobserver, and intraobserver variability
    Yasuyoshi Miyata
    Eur Urol 53:1226. 2008
  34. ncbi request reprint Long-term exposure of human renal carcinoma cells to PD98059 induces epithelial-mesenchymal transition-like phenotype and enhanced motility
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Science, 1 7 1, Sakamoto, Nagasaki, Japan
    Mol Cell Biochem 309:69-76. 2008
    ..Our results suggest that long-term exposure of human renal carcinoma cells to PD98059 increases cell motility by upregulating Rho A-Rho kinase signaling...
  35. ncbi request reprint Current status and perspective of antiangiogenic therapy for cancer: urinary cancer
    Shigeru Kanda
    Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Int J Clin Oncol 11:90-107. 2006
    ..In this review, we summarize these unique mechanisms and review the results of clinical trials of antiangiogenic therapy for these cancers, discussing prospects and problems relating to antiangiogenic therapy...
  36. ncbi request reprint Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug
    Yasushi Hayashida
    Department of Biochemistry and Molecular Biology in Disease, Atomic Bomb Disease Institute, and Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    J Biol Chem 281:32469-84. 2006
    ....