Yumi Watanabe

Summary

Affiliation: Mitsubishi Tanabe Pharma Corporation
Country: Japan

Publications

  1. ncbi request reprint Long-lasting anti-emetic effect of T-2328, a novel NK(1) antagonist
    Yumi Watanabe
    Pharmacology Laboratory, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
    J Pharmacol Sci 107:151-8. 2008
  2. ncbi request reprint Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor
    Yumi Watanabe
    Pharmacology Laboratory, Mitsubishi Tanabe Pharma Corporation, Kamoshida cho, Aoba ku, Yokohama, Kanagawa, Japan
    J Pharmacol Sci 106:121-7. 2008
  3. ncbi request reprint pH-dependent inhibition of mushroom tyrosinase by N-substituted N-nitrosohydroxylamines
    Mitsuhiro Shiino
    School of Medicine, Keio University, Yokohama, Japan
    J Enzyme Inhib Med Chem 23:16-20. 2008
  4. doi request reprint Synthetic retinoid CD437 induces mitochondria-mediated apoptosis in hepatocellular carcinoma cells
    Kazue Gonda
    Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Nishi cho 86, Yonago 683 8504, Japan
    Biochem Biophys Res Commun 370:629-33. 2008
  5. ncbi request reprint CD437 induces apoptosis in ovarian adenocarcinoma cells via ER stress signaling
    Yumi Watanabe
    Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Nishi cho 86, Yonago 683 8504, Japan
    Biochem Biophys Res Commun 366:840-7. 2008
  6. ncbi request reprint Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injury
    Tomoyuki Yoshihara
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Neurotrauma 24:1026-36. 2007
  7. ncbi request reprint Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migration
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Exp Cell Res 312:1381-9. 2006
  8. ncbi request reprint JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration
    Takahisa Takino
    Department of Molecular Virology, Cancer Research Institute, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Japan
    J Biol Chem 280:37772-81. 2005
  9. ncbi request reprint Development of a genetic system in chitinase-producing streptomyces and the application of an allosamidin-insensitive chitinase gene to homologous overexpression
    Ryu Kawachi
    Department of Biological Chemistry, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Mol Biotechnol 26:179-86. 2004
  10. ncbi request reprint Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration
    Takahisa Takino
    Department of Molecular Virology and Oncology and Cell Cycle Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 64:1044-9. 2004

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Long-lasting anti-emetic effect of T-2328, a novel NK(1) antagonist
    Yumi Watanabe
    Pharmacology Laboratory, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
    J Pharmacol Sci 107:151-8. 2008
    ..4 nM in an insurmountable manner. It is likely that T-2328 exerts the long-lasting anti-emetic effect by not only long-term presence in the brain but also its insurmountable inhibition of NK(1) receptors...
  2. ncbi request reprint Pharmacological characterization of T-2328, 2-fluoro-4'-methoxy-3'-[[[(2S,3S)-2-phenyl-3-piperidinyl]amino]methyl]-[1,1'-biphenyl]-4-carbonitrile dihydrochloride, as a brain-penetrating antagonist of tachykinin NK1 receptor
    Yumi Watanabe
    Pharmacology Laboratory, Mitsubishi Tanabe Pharma Corporation, Kamoshida cho, Aoba ku, Yokohama, Kanagawa, Japan
    J Pharmacol Sci 106:121-7. 2008
    ..p.) in ferrets. It is concluded that T-2328 is a potent, centrally active NK(1) antagonist. T-2328 may have potential as a novel therapeutic agent for the treatment of chemotherapy-induced emesis...
  3. ncbi request reprint pH-dependent inhibition of mushroom tyrosinase by N-substituted N-nitrosohydroxylamines
    Mitsuhiro Shiino
    School of Medicine, Keio University, Yokohama, Japan
    J Enzyme Inhib Med Chem 23:16-20. 2008
    ..Furthermore, the mechanism of inhibition depends on the interaction between the inhibitor and the active site of tyrosinase at different pH values...
  4. doi request reprint Synthetic retinoid CD437 induces mitochondria-mediated apoptosis in hepatocellular carcinoma cells
    Kazue Gonda
    Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Nishi cho 86, Yonago 683 8504, Japan
    Biochem Biophys Res Commun 370:629-33. 2008
    ..Moreover, rhodamine123 staining revealed mitochondrial depolarization in the cells treated with CD437. These data of the present study suggest that CD437 induces apoptosis in HCC cells via mitochondrial pathways...
  5. ncbi request reprint CD437 induces apoptosis in ovarian adenocarcinoma cells via ER stress signaling
    Yumi Watanabe
    Division of Molecular and Genetic Medicine, Department of Genetic Medicine and Regenerative Therapeutics, Graduate School of Medicine, Tottori University, Nishi cho 86, Yonago 683 8504, Japan
    Biochem Biophys Res Commun 366:840-7. 2008
    ..These results suggest that ER stress plays an important role in the mechanism by which CD437 induces apoptosis in ovarian adenocarcinoma cells...
  6. ncbi request reprint Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injury
    Tomoyuki Yoshihara
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Neurotrauma 24:1026-36. 2007
    ..Our results suggest that transplantation of BM-MNC via the CSF is a potentially effective means of enhancing functional recovery after SCI in humans...
  7. ncbi request reprint Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migration
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Exp Cell Res 312:1381-9. 2006
    ..These results suggest that lysis of the extracellular matrix by MT1-MMP promotes focal adhesion turnover and subsequent ERK activation, which in turn stimulates cell migration...
  8. ncbi request reprint JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration
    Takahisa Takino
    Department of Molecular Virology, Cancer Research Institute, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Japan
    J Biol Chem 280:37772-81. 2005
    ..We propose that the JSAP1.FAK complex functions cooperatively as a scaffold for the JNK signaling pathway and regulator of cell migration on FN, and we suggest that JSAP1 is also associated with malignancy in brain tumors...
  9. ncbi request reprint Development of a genetic system in chitinase-producing streptomyces and the application of an allosamidin-insensitive chitinase gene to homologous overexpression
    Ryu Kawachi
    Department of Biological Chemistry, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252 8510, Japan
    Mol Biotechnol 26:179-86. 2004
    ..Moreover, the pYK1-introduced strain gave a five-fold higher chitinase activity than the wild-type, suggesting that this system can be widely applied for the overexpression and gene functional analysis...
  10. ncbi request reprint Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration
    Takahisa Takino
    Department of Molecular Virology and Oncology and Cell Cycle Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 64:1044-9. 2004
    ..Thus, adhesion of HT1080 cells to type I collagen induces MT1-MMP-dependent ERK activation, which in turn causes an increase in MT1-MMP levels and subsequent cell migration...