Kazutoshi Watanabe

Summary

Affiliation: Mitsubishi Pharma Corporation
Country: Japan

Publications

  1. ncbi 5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity
    Kazutoshi Watanabe
    Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, 1000, Kamoshida cho, Aoba ku, Yokohama 227 0033, Japan
    Bioorg Med Chem Lett 18:1478-83. 2008
  2. ncbi Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone)
    Kazutoshi Watanabe
    Research and Development Division, Mitsubishi Pharma Corporation, Yokohama, Japan
    Redox Rep 8:151-5. 2003
  3. ncbi Synthesis of the metabolites of a free radical scavenger edaravone (MCI-186, Radicut)
    Kazutoshi Watanabe
    Research and Development Division, Mitsubishi Pharma Corporation, Yokohama, Japan
    Redox Rep 8:157-61. 2003
  4. ncbi [Research and development of the free radical scavenger edaravone as a neuroprotectant]
    Toshiaki Watanabe
    Mitsubishi Pharma Corporation, Sales and Marketing Division, 2 5 6 Awaji machi, Chuo Ku, Osaka 541 0047, Japan
    Yakugaku Zasshi 124:99-111. 2004

Collaborators

Detail Information

Publications4

  1. ncbi 5-Aryl-imidazolin-2-ones as a scaffold for potent antioxidant and memory-improving activity
    Kazutoshi Watanabe
    Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, 1000, Kamoshida cho, Aoba ku, Yokohama 227 0033, Japan
    Bioorg Med Chem Lett 18:1478-83. 2008
    ..Many of the compounds showed memory-improving effect in animal models independent of the inhibitory activity on lipid peroxidation...
  2. ncbi Structure-activity relationship of 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone)
    Kazutoshi Watanabe
    Research and Development Division, Mitsubishi Pharma Corporation, Yokohama, Japan
    Redox Rep 8:151-5. 2003
    ..In vivo studies revealed that edaravone showed brain-protective activity in a transient ischemia model...
  3. ncbi Synthesis of the metabolites of a free radical scavenger edaravone (MCI-186, Radicut)
    Kazutoshi Watanabe
    Research and Development Division, Mitsubishi Pharma Corporation, Yokohama, Japan
    Redox Rep 8:157-61. 2003
    ..The two synthesized metabolites were identical to isolated metabolites. X-ray analysis identified edaravone glucuronate as beta-O-glucuronate, although there were three possible edaravone glucuronate tautomers...
  4. ncbi [Research and development of the free radical scavenger edaravone as a neuroprotectant]
    Toshiaki Watanabe
    Mitsubishi Pharma Corporation, Sales and Marketing Division, 2 5 6 Awaji machi, Chuo Ku, Osaka 541 0047, Japan
    Yakugaku Zasshi 124:99-111. 2004
    ..We hope that edaravone represents a promising neuroprotectant for drug therapy in acute cerebral ischemia...