Makoto Iwata

Summary

Affiliation: Mitsubishi Kagaku Institute of Life Sciences
Country: Japan

Publications

  1. ncbi request reprint A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells
    Yoshiharu Amasaki
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Japan
    J Biol Chem 277:25640-8. 2002
  2. ncbi request reprint Retinoic acid imprints gut-homing specificity on T cells
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunity 21:527-38. 2004
  3. ncbi request reprint The endocrine disruptors nonylphenol and octylphenol exert direct effects on T cells to suppress Th1 development and enhance Th2 development
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunol Lett 94:135-9. 2004
  4. ncbi request reprint Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Int Immunol 15:1017-25. 2003
  5. ncbi request reprint Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids
    Hideki Miyaura
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    J Immunol 168:1087-94. 2002
  6. ncbi request reprint Duration of calcineurin and Erk signals regulates CD4/CD8 lineage commitment of thymocytes
    Satoko Adachi
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Cell Immunol 215:45-53. 2002
  7. ncbi request reprint Skewed differentiation of thymocytes toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo- p-dioxin requires activation of the extracellular signal-related kinase pathway
    Shin ichi Tsukumo
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Arch Toxicol 76:335-43. 2002
  8. ncbi request reprint [Role and mechanism of action of vitamin A in gut immunity]
    Makoto Iwata
    Laboratory of Biodefense Research, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Japan
    Seikagaku 78:738-48. 2006
  9. ncbi request reprint Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis
    Noriko Tosa
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    Int Immunol 15:741-9. 2003
  10. ncbi request reprint Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 314:1157-60. 2006

Collaborators

Detail Information

Publications24

  1. ncbi request reprint A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells
    Yoshiharu Amasaki
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Japan
    J Biol Chem 277:25640-8. 2002
    ..Our data suggest that NFATx is involved in the regulation of co-receptor expression during differentiation into the CD4 single-positive stage...
  2. ncbi request reprint Retinoic acid imprints gut-homing specificity on T cells
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunity 21:527-38. 2004
    ..These findings revealed a novel role for retinoic acid in the imprinting of gut-homing specificity on T cells...
  3. ncbi request reprint The endocrine disruptors nonylphenol and octylphenol exert direct effects on T cells to suppress Th1 development and enhance Th2 development
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Immunol Lett 94:135-9. 2004
    ..These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR...
  4. ncbi request reprint Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors
    Makoto Iwata
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Int Immunol 15:1017-25. 2003
    ..The RXR agonists enhanced the effect of the RAR agonists only slightly, if at all. These results indicate that, via RAR, RA directly suppresses Th1 development and directly enhances Th2 development with its timely addition...
  5. ncbi request reprint Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids
    Hideki Miyaura
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    J Immunol 168:1087-94. 2002
    ..These results suggest that progesterone as well as glucocorticoids directly inhibit Th1 development and enhance Th2 development...
  6. ncbi request reprint Duration of calcineurin and Erk signals regulates CD4/CD8 lineage commitment of thymocytes
    Satoko Adachi
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo 194 8511, Japan
    Cell Immunol 215:45-53. 2002
    ..These results suggest that the intensity of calcineurin activity and the duration of both calcineurin and Erk pathway activation are crucial for thymocyte lineage commitment...
  7. ncbi request reprint Skewed differentiation of thymocytes toward CD8 T cells by 2,3,7,8-tetrachlorodibenzo- p-dioxin requires activation of the extracellular signal-related kinase pathway
    Shin ichi Tsukumo
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Arch Toxicol 76:335-43. 2002
    ..In conclusion, our results suggest that activation of the ERK pathway is required for TCDD-induced differentiation to mature CD8 T cells, but not for reduction of thymocyte numbers...
  8. ncbi request reprint [Role and mechanism of action of vitamin A in gut immunity]
    Makoto Iwata
    Laboratory of Biodefense Research, Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, Japan
    Seikagaku 78:738-48. 2006
  9. ncbi request reprint Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis
    Noriko Tosa
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    Int Immunol 15:741-9. 2003
    ..In conclusion, TDAG8 expression is involved in glucocorticoid-induced signals to activate caspase-9, -8 and -3 for subsequent apoptosis induction in CD4(+)CD8(+) double-positive thymocytes...
  10. ncbi request reprint Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 314:1157-60. 2006
    ..Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators...
  11. ncbi request reprint Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
    Noriyuki Shibata
    Department of Pathology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Neuropathology 27:49-61. 2007
    ....
  12. ncbi request reprint Motor neuron disease in transgenic mice with an H46R mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    J Neuropathol Exp Neurol 66:517-24. 2007
    ..The close pathologic similarity makes this animal model suitable for the investigation of human familial amyotrophic lateral sclerosis with the mutation...
  13. ncbi request reprint Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
    Hiroyuki Tezuka
    Department of Immunology, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Nature 448:929-33. 2007
    ..The presence of a naturally occurring TNF-alpha/iNOS-producing dendritic-cell subset may explain the predominance of IgA production in the MALT, critical for gut homeostasis...
  14. ncbi request reprint [Stroke in cancer patients]
    Hiromi Terashi
    Department of Neurology, Tokyo Women s University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Nerve 60:143-7. 2008
    ..Understanding these factors is important for stroke prevention and provision in this population...
  15. ncbi request reprint Parvalbumin and calbindin D-28k immunoreactivity in transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Res 1083:196-203. 2006
    ....
  16. ncbi request reprint Impairment of axonal transport in the axon hillock and the initial segment of anterior horn neurons in transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Shinjuku ku, Japan
    Acta Neuropathol 110:48-56. 2005
    ..These findings suggest that both the slow axonal transport of neurofilaments and the fast axonal transport of mitochondria are impaired in AH and IS before the onset of disease in this animal model...
  17. ncbi request reprint Effect of remnant-like particle on shear-induced platelet activation and its inhibition by antiplatelet agents
    Masako Yamazaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1, Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Thromb Res 115:211-8. 2005
    ..Aspirin inhibited only the enhancement of SIPA by RLPs, while cilostazol inhibited the enhancement of not only SIPA but also p-selectin expression and PMP generation by RLPs...
  18. ncbi request reprint Ultrastructural study of aggregates in the spinal cord of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Acta Neuropathol 109:247-55. 2005
    ....
  19. ncbi request reprint Neuronal nitric oxide synthase (nNOS) immunoreactivity in the spinal cord of transgenic mice with G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical College, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Neuropathol 103:421-7. 2002
    ....
  20. ncbi request reprint Slow component of axonal transport is impaired in the proximal axon of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666 Tokyo, Japan
    Acta Neuropathol 107:452-60. 2004
    ....
  21. ncbi request reprint Ultrastructural study of mitochondria in the spinal cord of transgenic mice with a G93A mutant SOD1 gene
    Shoichi Sasaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, 162 8666, Tokyo, Japan
    Acta Neuropathol 107:461-74. 2004
    ..Moreover, giant mitochondrial vacuoles occupying almost the entire axonal caliber could be another contributing factor in motor neuron degeneration, in that they could physically block axonal transport...
  22. pmc 15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis
    Mitsuhiro Kondo
    Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    Proc Natl Acad Sci U S A 99:7367-72. 2002
    ..The 15d-PGJ(2)-induced accumulation of p53 resulted in the activation of a death-inducing caspase cascade mediated by Fas and the Fas ligand...
  23. ncbi request reprint Flow cytometric analysis of reticulated platelets in patients with ischemic stroke
    Tomomi Nakamura
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Thromb Res 106:171-7. 2002
    ..We concluded that %RP is increased in patients with cardioembolic stroke, which may reflect increased platelet turnover as a consequence of platelet consumption during thrombogenesis...
  24. ncbi request reprint [QuantiFERON: an early diagnostic tool for cerebral tuberculosis]
    Masahiro Iguchi
    Department of Neurology, Tokyo Women s Medical University School of Medicine
    Rinsho Shinkeigaku 48:259-62. 2008
    ..QuantiFERON were positive prior to the culture results in both cases. This reaction suggested tuberculous infection. QuantiFERON is useful for diagnosing cerebral tuberculosis at an early stage...